BacMet Experimenatlly Confirmed database

This database contains 704 resistance genes

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
abeM
  • BacMet ID: BAC0001
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs.
  • Length (amino acid): 448
  • Reference: Su et al. 2005; Pubmed- 16189122

    		• Similar resistance genes in 'BacMet Predicted database'
    abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

    		• Similar resistance genes in 'BacMet Predicted database'
    acn
  • BacMet ID: BAC0003
  • Code for: Enzyme
  • Family: Aconitase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis H37Rv
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Aconitate hydratase, Acn
  • Length (amino acid): 943
  • Reference: Wong et al. 1999; Pubmed- 9864233

    		• Similar resistance genes in 'BacMet Predicted database'
    acr3
  • BacMet ID: BAC0004
  • Code for: Efflux
  • Family: Acr3 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Arsenical-resistance membrane transporter; part of the an arsenic (ars) four-gene operon, containing genes encoding a putative membrane permease (ArsP), a transcriptional repressor (ArsR), an arsenate reductase (ArsC) and an arsenical-resistance membrane transporter (Acr3)
  • Length (amino acid): 347
  • Reference: Wang et al. 2009; Pubmed- 19502436

    		• Similar resistance genes in 'BacMet Predicted database'
    acrA
  • BacMet ID: BAC0005
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 397
  • Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    acrB
  • BacMet ID: BAC0006
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 1049
  • Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    acrC
  • BacMet ID: BAC0007
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine]
  • Description: Cation/multidrug efflux system outer membrane porin arcC.
  • Length (amino acid): 486
  • Reference: Nakamura et al. 1979; Pubmed- 378962

    		• Similar resistance genes in 'BacMet Predicted database'
    acrD
  • BacMet ID: BAC0563
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn)
  • Description: Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances. It contributes to copper and zinc resistance in Salmonella.
  • Length (amino acid): 1037
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    acrD/yffA
  • BacMet ID: BAC0008
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances.
  • Length (amino acid): 1037
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Nakamura et al. 1979; Pubmed- 378962

    		• Similar resistance genes in 'BacMet Predicted database'
    acrE/envC
  • BacMet ID: BAC0009
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein E; May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability. It can confer resistance to novomycin.
  • Length (amino acid): 385
  • Reference: Klein et al. 1991; Pubmed- 1720861, Ma et al. 1993; Pubmed- 8407802, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    acrF/envD
  • BacMet ID: BAC0010
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein F; Involved in cell envelope formation. It is produced in extremely low amounts.
  • Length (amino acid): 1034
  • Reference: Klein et al. 1991; Pubmed- 1720861, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    acrR/ybaH
  • BacMet ID: BAC0011
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine]
  • Description: HTH-type potential regulator protein for the acrAB genes.
  • Length (amino acid): 215
  • Reference: Ma et al. 1996; Pubmed- 8821940

    		• Similar resistance genes in 'BacMet Predicted database'
    actA
  • BacMet ID: BAC0567
  • Code for: Enzyme
  • Family: CN hydrolase family. Apolipoprotein N-acyltransferase subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti TG2-6
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid]
  • Description: Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti.
  • Length (amino acid): 531
  • Reference: Tiwari et al. 1996; Pubmed- 8868435, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actP
  • BacMet ID: BAC0012
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
  • Location: Plasmid pSMED01 (Sinorhizobium medicae (strain WSM419))
  • Compound: Copper (Cu), Sodium acetate [class: Acetate]
  • Description: Copper-transporting P-type ATPase; Involved in copper efflux; Transcriptionally regulated by HmrR in response to Cu+ ions.
  • Length (amino acid): 827
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actP
  • BacMet ID: BAC0568
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-transporting P-type ATPase. Involved in copper efflux. Transcriptionally regulated by HmrR in response to Cu+ ions.
  • Length (amino acid): 841
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actP
  • BacMet ID: BAC0570
  • Code for: Membrane transporter/Enzyme
  • Family: Sodium:solute symporter (SSF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus B100
  • Location: Chromosome
  • Compound: Tellurium (Te)
  • Description: Acetate Permease (ActP) is responsible for tellurite uptake and resistance in cells of the facultative phototroph Rhodobacter capsulatus.
  • Length (amino acid): 551
  • Reference: Borghese et al. 2010; Pubmed- 19966028

    		• Similar resistance genes in 'BacMet Predicted database'
    actP/yjcG
  • BacMet ID: BAC0564
  • Code for: Membrane transporter/Enzyme
  • Family: Sodium:solute symporter (SSF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium acetate [class: Acetate]
  • Description: Transports acetate. Also able to transport glycolate.
  • Length (amino acid): 549
  • Reference: Gimenez et al. 2003; Pubmed- 14563880

    		• Similar resistance genes in 'BacMet Predicted database'
    actR
  • BacMet ID: BAC0565
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 194
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actS
  • BacMet ID: BAC0566
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 433
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    adeA
  • BacMet ID: BAC0471
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 396
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeB
  • BacMet ID: BAC0472
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128.
  • Description: AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 1035
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeC
  • BacMet ID: BAC0473
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 465
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeD
  • BacMet ID: BAC0474
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter sp. 4365
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Resistance-nodulation-cell division efflux system AdeDE in Acinetobacter; AdeDE increases the host resistance to ceftazidime and rifampicin. The outer-membrane protein (OMP) for AdeDE has not been identified yet (Oct 2013).
  • Length (amino acid): 374
  • Reference: Chau et al. 2004; Pubmed- 15388479

    		• Similar resistance genes in 'BacMet Predicted database'
    adeE
  • BacMet ID: BAC0013
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter sp. 4356
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine]
  • Description: Resistance-nodulation-cell division efflux system AdeDE in Acinetobacter. AdeDE increases the host resistance to ceftazidime and rifampicin. The outer-membrane protein (OMP) for AdeDE has not been identified yet (Oct 2013).
  • Length (amino acid): 1036
  • Reference: Chau et al. 2004; Pubmed- 15388479

    		• Similar resistance genes in 'BacMet Predicted database'
    adeF
  • BacMet ID: BAC0014
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine]
  • Description: Putative RND family drug transporter AdeF; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents.
  • Length (amino acid): 406
  • Reference: Coyne et al. 2010; Pubmed- 20696879

    		• Similar resistance genes in 'BacMet Predicted database'
    adeG
  • BacMet ID: BAC0015
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine]
  • Description: Cation/multidrug efflux pump AdeG; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents.
  • Length (amino acid): 1059
  • Reference: Coyne et al. 2010; Pubmed- 20696879

    		• Similar resistance genes in 'BacMet Predicted database'
    adeH
  • BacMet ID: BAC0016
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine]
  • Description: Putative RND family drug transporter AdeH; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents.
  • Length (amino acid): 483
  • Reference: Coyne et al. 2010; Pubmed- 20696879

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeJ
  • BacMet ID: BAC0018
  • Code for: efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 1058
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeK
  • BacMet ID: BAC0019
  • Code for: efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detregents such as sodium dodecyl sulfate.
  • Length (amino acid): 484
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeL
  • BacMet ID: BAC0508
  • Code for: Regulator
  • Family: LysR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine]
  • Description: Regulator of adeFGH efflux system
  • Length (amino acid): 337
  • Reference: Coyne et al. 2010; Pubmed: 20696879

    		• Similar resistance genes in 'BacMet Predicted database'
    adeN
  • BacMet ID: BAC0496
  • Code for: Regulator
  • Family: TetR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Safranin O [class: Azin], Acridine Orange [class: Acridine], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Repressor of AdeIJK expression
  • Length (amino acid): 217
  • Reference: Rosenfield et al. 2012; Pubmed: 22371895

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT1
  • BacMet ID: BAC0478
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni AC0037
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, tetracycline etc.
  • Length (amino acid): 304
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT2
  • BacMet ID: BAC0479
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc.
  • Length (amino acid): 238
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    aioA/aoxB
  • BacMet ID: BAC0020
  • Code for: Enzyme
  • Family: Prokaryotic molybdopterin-containing oxidoreductase family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Herminiimonas arsenicoxydans
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: It is a structural gene which codes for small subunit of Arsenite oxidase aioAB; Involved in the detoxification of arsenic. Oxidizes As(III)O3- (arsenite) to the somewhat less toxic As(V)O4- (arsenate).
  • Length (amino acid): 826
  • Reference: Muller et al. 2003; Pubmed- 12486049, Cai et al. 2009; Pubmed- 19283378, Drewniak et al. 2013 Pubmed- 23454063,

    		• Similar resistance genes in 'BacMet Predicted database'
    aioB/aoxA
  • BacMet ID: BAC0021
  • Code for: Enzyme
  • Family: Contains 1 Rieske domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Herminiimonas arsenicoxydans
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: It is a structural gene which codes for small subunit of Arsenite oxidase, AioAB; Involved in the detoxification of arsenic. Oxidizes As(III)O3- (arsenite) to the somewhat less toxic As(V)O4- (arsenate).
  • Length (amino acid): 173
  • Reference: Muller et al. 2003; Pubmed- 12486049, Cai et al. 2009; Pubmed- 19283378, Drewniak et al. 2013 Pubmed- 23454063

    		• Similar resistance genes in 'BacMet Predicted database'
    aioR/aoxR
  • BacMet ID: BAC0022
  • Code for: Regulator
  • Family: Contains 1 sigma-54 factor interaction and 1 sigma-5factor interaction domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Transcriptional regulator. Part of a two-component As(III) responsive system (AioSR)
  • Length (amino acid): 442
  • Reference: Kashyap et al. 2006; Pubmed- 16428412; Drewniak et al. 2013 Pubmed- 23454063, Muller et al. 2003; Pubmed- 12486049

    		• Similar resistance genes in 'BacMet Predicted database'
    aioS/aoxS
  • BacMet ID: BAC0023
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Sensor histidine kinase; signal transduction protein
  • Length (amino acid): 488
  • Reference: Kashyap et al. 2006; Pubmed- 16428412; Drewniak et al. 2013 Pubmed- 23454063, Muller et al. 2003; Pubmed- 12486049

    		• Similar resistance genes in 'BacMet Predicted database'
    aioX/aoxX
  • BacMet ID: BAC0024
  • Code for: Binding protein
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: A periplasmic oxyanion-binding protein involved in regulating arsenite oxidation
  • Length (amino acid): 306
  • Reference: Liu et al. 2012; Pubmed- 22176720, Cai et al. 2009; Pubmed- 19283378

    		• Similar resistance genes in 'BacMet Predicted database'
    ALU1-P
  • BacMet ID: BAC0489
  • Code for: Enzyme
  • Family: QueC family protein
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Arthrobacter viscosus ALRJJ6
  • Location: Chromosome
  • Compound: Aluminium (Al)
  • Description: Fragment of the ALU1 resistance gene called ALU1-P but the frament has the potential to confer tolerance to aluminium . It has 65% identity in amino acid level with the protein of YbaX gene in Escherichia coli, and 51.1% identity with YB91 Haein hypothetical protein of HI1191 gene in Haemophilus influenzae.
  • Length (amino acid): 192
  • Reference: Jo et al. 1997; Pubmed- 9367855

    		• Similar resistance genes in 'BacMet Predicted database'
    amvA
  • BacMet ID: BAC0025
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance
  • Length (amino acid): 492
  • Reference: Rajamohan et al. 2010; Pubmed- 20573661

    		• Similar resistance genes in 'BacMet Predicted database'
    arsA
  • BacMet ID: BAC0030
  • Code for: Enzyme
  • Family: ArsA ATPase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncN R46
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Anion-transporting ATPase; Determinants of a membrane-associated oxyanion-stimulated ATPase protein; energizes the arsenite efflux pump by ATP hydrolysis; Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents.
  • Length (amino acid): 583
  • Reference: Bruhn et al. 1996; Pubmed- 8674982

    		• Similar resistance genes in 'BacMet Predicted database'
    arsA
  • BacMet ID: BAC0571
  • Code for: Enzyme
  • Family: ArsA ATPase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
  • Location: Plasmid pKW301
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents.
  • Length (amino acid): 583
  • Reference: Suzuki et al. 1998; Pubmed- 9464374

    		• Similar resistance genes in 'BacMet Predicted database'
    arsA
  • BacMet ID: BAC0572
  • Code for: Enzyme
  • Family: ArsA ATPase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid R773
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents.
  • Length (amino acid): 583
  • Reference: Chen et al. 1986; Pubmed- 3021763

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0031
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid R773 (E. coli), Plasmid IncN R46 (E. coli), Plasmid R46 (Salmonella typhimurium)
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Arsenic pump membrane protein, located in cell inner membrane. Involved in arsenite and antimonite resistance. Thought to form a channel of an arsenite pump.
  • Length (amino acid): 429
  • Reference: Tisa et al. 1990; Pubmed- 1688427, Chen et al. 1986; Pubmed- 3021763

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0573
  • Code for: Regulator
  • Family: ACR3 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. Deletion of the arsB gene results in both an aresenite- and arsenate-sensitive phenotype in the absence of IPTG.
  • Length (amino acid): 346
  • Reference: Sato et al. 1998; Pubmed- 9537360

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0574
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
  • Length (amino acid): 429
  • Reference: Ji and Silver 1992; Pubmed- 1534328

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0575
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus xylosus
  • Location: Plasmid pSX267
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
  • Length (amino acid): 429
  • Reference: Rosenstein et al. 1992; Pubmed- 1534327

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0576
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncN R46
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
  • Length (amino acid): 429
  • Reference: Bruhn et al. 1996; Pubmed- 8674982

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0577
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia enterocolitica
  • Location: Plasmid pYV
  • Compound: Arsenic (As)
  • Description: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
  • Length (amino acid): 429
  • Reference: Neyt et al. 1997; Pubmed- 9006011

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0578
  • Code for: Efflux
  • Family: ArsB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
  • Location: Plasmid pKW301
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Part of arsenic resistance operon of Acidiphilium multivorum AIU 301 plasmid pKW301.
  • Length (amino acid): 429
  • Reference: Suzuki et al. 1998; Pubmed- 9464374

    		• Similar resistance genes in 'BacMet Predicted database'
    arsB
  • BacMet ID: BAC0579
  • Code for: Efflux
  • Family: ACR3 family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. PCC 6803
  • Location: Chromosome
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Able to export both As(III) and Sb(III) and providies a example of convergent evolution between both families of arsenite transporters.
  • Length (amino acid): 383
  • Reference: Lopez-Maury et al. 2003; Pubmed- 12949088

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0032
  • Code for: Enzyme
  • Family: Low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Arsenic (As)
  • Description: Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.
  • Length (amino acid): 131
  • Reference: Ji and Silver 1992; Pubmed- 1534328; Chen et al. 1986; Pubmed- 3021763

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0580
  • Code for: Enzyme
  • Family: Low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus xylosus
  • Location: Plasmid pSX267
  • Compound: Arsenic (As)
  • Description: Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.
  • Length (amino acid): 131
  • Reference: Rosenstein et al. 1992; Pubmed- 1534327

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0581
  • Code for: Enzyme
  • Family: Low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.
  • Length (amino acid): 139
  • Reference: Sato et al. 1998; Pubmed- 9537360

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0582
  • Code for: Enzyme
  • Family: arsC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid R773
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
  • Length (amino acid): 141
  • Reference: Tisa et al. 1990; Pubmed- 1688427, Chen et al. 1986; Pubmed- 3021763

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0583
  • Code for: Enzyme
  • Family: arsC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncN R46
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
  • Length (amino acid): 141
  • Reference: Bruhn et al. 1996; Pubmed- 8674982

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0584
  • Code for: Enzyme
  • Family: arsC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301)
  • Location: Plasmid pKW301
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance
  • Length (amino acid): 141
  • Reference: Suzuki et al. 1998; Pubmed- 9464374

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0585
  • Code for: Enzyme
  • Family: arsC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia enterocolitica
  • Location: Plasmid pYV
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
  • Length (amino acid): 141
  • Reference: Neyt et al. 1997; Pubmed- 9006011

    		• Similar resistance genes in 'BacMet Predicted database'
    arsC
  • BacMet ID: BAC0586
  • Code for: Enzyme
  • Family: arsC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. PCC 6803
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)].
  • Length (amino acid): 131
  • Reference: Lopez-Maury et al. 2003; Pubmed- 12949088

    		• Similar resistance genes in 'BacMet Predicted database'
    arsD
  • BacMet ID: BAC0033
  • Code for: Chaperone
  • Family: ArsD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid R773 (E. coli), Plasmid R64 (Salmonella typhimurium)
  • Compound: Arsenic (As)
  • Description: An arsenic metallochaperone for an arsenic detoxification pump
  • Length (amino acid): 120
  • Reference: Wu et al. 1993; Pubmed- 8326869, Lin et al. 2006; Pubmed- 17030823

    		• Similar resistance genes in 'BacMet Predicted database'
    arsD
  • BacMet ID: BAC0587
  • Code for: Regulator
  • Family: ArsD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncN R46
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Arsenical resistance operon trans-acting repressor ArsD.
  • Length (amino acid): 120
  • Reference: Bruhn et al. 1996; Pubmed- 8674982

    		• Similar resistance genes in 'BacMet Predicted database'
    arsH
  • BacMet ID: BAC0034
  • Code for: Enzyme
  • Family: NADPH-dependent FMN reductases family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis Java 9
  • Location: Plasmid pKPN-IT (Klebsiella pneumoniae), Plasmid R485 (Morganella morganii (Proteus morganii))
  • Compound: Arsenic (As)
  • Description: Arsenical resistance protein ArsH; ArsH is not required for arsenate resistance in some systems; arsH encodes an NADPH-flavin mononucleotide oxidoreductase and has been shown to be involved in arsenic resistance in Yersinia enterocolitica and Sinorhizobium meliloti. It is an essential component in a new four gene arsenical resistance transposon associated operon, arsHRBC.
  • Length (amino acid): 232
  • Reference: Neyt et al. 1997; Pubmed- 9006011, Eppinger et al. 2012; Pubmed- 22479347

    		• Similar resistance genes in 'BacMet Predicted database'
    arsH
  • BacMet ID: BAC0595
  • Code for: Enzyme
  • Family: NADPH-dependent FMN reductases family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. PCC 6803
  • Location: Chromosome
  • Compound: Menadione [class: Naphthoquinone]
  • Description: ArsH from Synechocystis sp. does not cofer resistance to arsenic (reduction of arsenate) as the arsH of Synechocystis sp. lacks cyestein residues. arsH encodes an NADPH-flavin mononucleotide oxidoreductase. ArsH plays a role in the response to oxidative stress caused by arsenite.
  • Length (amino acid): 206
  • Reference: Hervas et al. 2012; Pubmed- 22304305, Lopez-Maury et al. 2003; Pubmed- 12949088

    		• Similar resistance genes in 'BacMet Predicted database'
    arsM
  • BacMet ID: BAC0035
  • Code for: Enzyme
  • Family: Methyltransferase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodopseudomonas palustris CGA009
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Arsenite S-adenosylmethyltransferase; involved in arsenite methyltransferase activity; arsM encodes an arsenite S-adenosylmethionine methyltransferase that methylates arsenite to volatile trimethylarsine, contributing to arsenic detoxification in bacteria.
  • Length (amino acid): 283
  • Reference: Qin et al. 2006; Pubmed- 16452170

    		• Similar resistance genes in 'BacMet Predicted database'
    arsP
  • BacMet ID: BAC0036
  • Code for: Enzyme
  • Family: Major Facilitator Protein (MFP) Family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: arsenic resistance membrane permease
  • Length (amino acid): 315
  • Reference: Wang et al. 2009; Pubmed- 19502436

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0588
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia enterocolitica
  • Location: Plasmid pYV
  • Compound: Arsenic (As)
  • Description: Arsenite inducible repressor ArsR
  • Length (amino acid): 117
  • Reference: Neyt et al. 1997; Pubmed- 9006011

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0589
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid R773
  • Compound: Arsenic (As), Antimony (Sb), Bismuth (Bi)
  • Description: Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
  • Length (amino acid): 117
  • Reference: Wu and Rosen 1991; Pubmed- 1838573

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0590
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Arsenic (As), Antimony (Sb), Bismuth (Bi)
  • Description: Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
  • Length (amino acid): 104
  • Reference: Ji and Silver 1992; Pubmed- 1534328

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0591
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncN R46
  • Compound: Arsenic (As), Antimony (Sb), Bismuth (Bi)
  • Description: Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
  • Length (amino acid): 117
  • Reference: Bruhn et al. 1996; Pubmed- 8674982

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0592
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus xylosus
  • Location: Plasmid pSX267
  • Compound: Arsenic (As), Antimony (Sb), Bismuth (Bi)
  • Description: Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
  • Length (amino acid): 117
  • Reference: Rosenstein et al. 1992; Pubmed- 1534327

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0593
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Transcriptional repressor for the ars operon.
  • Length (amino acid): 105
  • Reference: Sato et al. 1998; Pubmed- 9537360

    		• Similar resistance genes in 'BacMet Predicted database'
    arsR
  • BacMet ID: BAC0594
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)).
  • Length (amino acid): 117
  • Reference: Diorio et al. 1995; Pubmed- 7721697

    		• Similar resistance genes in 'BacMet Predicted database'
    asr
  • BacMet ID: BAC0038
  • Code for: Unknown
  • Family: asr family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid shock protein Asr; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0).
  • Length (amino acid): 102
  • Reference: Seputiene et al. 2003; Pubmed- 12670971

    		• Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0039
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. Overexpression of BaeR increases resistance to novobiocin and deoxycholate. BaeR upregulates the mdtABCD locus and acrD and thereby increases the resistance to deoxycholate, metals and antibiotics.
  • Length (amino acid): 240
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

    		• Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0596
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 240
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0040
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

    		• Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0597
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    bcr
  • BacMet ID: BAC0041
  • Code for: Enzyme
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine]
  • Description: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase.
  • Length (amino acid): 396
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    bepC
  • BacMet ID: BAC0042
  • Code for: Efflux
  • Family: RND superfamily, OMP/TolC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. It can form a tripartite pump with BepD and BepE or with BepF and BepG.
  • Length (amino acid): 456
  • Reference: Posada et al. 2007; Pubmed- 17088356

    		• Similar resistance genes in 'BacMet Predicted database'
    bepD
  • BacMet ID: BAC0043
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump periplasmic linker BepD. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics such as ampicillin, norfloxacin, ciprofloxacin, tetracycline, and doxycycline.
  • Length (amino acid): 397
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    bepE
  • BacMet ID: BAC0044
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump membrane transporter BepE. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics.
  • Length (amino acid): 1051
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    bepF
  • BacMet ID: BAC0045
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux pump periplasmic linker BepF; Contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE
  • Length (amino acid): 411
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    bepG
  • BacMet ID: BAC0046
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux pump membrane transporter BepG; Contributes to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.
  • Length (amino acid): 1074
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    bexA
  • BacMet ID: BAC0047
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacteroides thetaiotaomicron
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: A MATE family multidrug efflux transporter pump bexA; Confers resistance to norfloxacin, ciprofloxacin, and ethidium bromide
  • Length (amino acid): 443
  • Reference: Miyamae et al. 2001; Pubmed- 11709306

    		• Similar resistance genes in 'BacMet Predicted database'
    bfrA
  • BacMet ID: BAC0048
  • Code for: Binding protein
  • Family: Bacterioferritin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Bacterioferritin bfrA; Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex
  • Length (amino acid): 159
  • Reference: Gold et al. 2001; Pubmed- 11722747

    		• Similar resistance genes in 'BacMet Predicted database'
    bhsA/ycfR/comC
  • BacMet ID: BAC0049
  • Code for: Regulator
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction
  • Length (amino acid): 85
  • Reference: Zhang et al. 2007; Pubmed- 17293424, Mermod et al. 2012; Pubmed- 22089859

    		• Similar resistance genes in 'BacMet Predicted database'
    blt
  • BacMet ID: BAC0050
  • Code for: Efflux
  • Family: MFS Superfamily (TCR/tet family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 400
  • Reference: Ahmed et al. 1995; Pubmed- 7608059

    		• Similar resistance genes in 'BacMet Predicted database'
    bltD
  • BacMet ID: BAC0051
  • Code for: Enzyme
  • Family: Contains 1 N-acetyltransferase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Spermidine [class: Polyamines], Spermine [class: Polyamines]
  • Description: Spermine/spermidine acetyltransferase bltD; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate.
  • Length (amino acid): 152
  • Reference: Ahmed et al. 1995; Pubmed- 7608059

    		• Similar resistance genes in 'BacMet Predicted database'
    bltR
  • BacMet ID: BAC0052
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine]
  • Description: Multidrug-efflux transporter 2 regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs.
  • Length (amino acid): 273
  • Reference: Ahmed et al. 1995; Pubmed- 7608059

    		• Similar resistance genes in 'BacMet Predicted database'
    bmr
  • BacMet ID: BAC0053
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 389
  • Reference: Neyfakh et al. 1991; Pubmed- 1675788

    		• Similar resistance genes in 'BacMet Predicted database'
    bmrR
  • BacMet ID: BAC0054
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine]
  • Description: Multidrug-efflux transporter 1 regulator; Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
  • Length (amino acid): 278
  • Reference: Ahmed et al. 1994; Pubmed- 7961792

    		• Similar resistance genes in 'BacMet Predicted database'
    cadA/yvgW
  • BacMet ID: BAC0055
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392/26695)(Campylobacter pylori)
  • Location: Plasmids pI258 (S. aureus), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium efflux ATPase, has two domains (phosphatase, aspartyl kinase); Cadmium, zinc and cobalt-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell
  • Length (amino acid): 686
  • Reference: Herrman et al. 1999; Pubmed- 10417643, Nucifera et al. 1989; Pubmed- 2524829, Lee et al. 2001; Pubmed- 11282588

    		• Similar resistance genes in 'BacMet Predicted database'
    cadC
  • BacMet ID: BAC0056
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258 (Staphylococcus aureus)
  • Compound: Cadmium (Cd), Bismuth (Bi), Zinc (Zn), Lead (Pb)
  • Description: Found in cad operon; bind to cad operator/promoter, its a repressor protein in the operon; Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA
  • Length (amino acid): 122
  • Reference: Endo et al. 1995; Pubmed- 7543476

    		• Similar resistance genes in 'BacMet Predicted database'
    cadD
  • BacMet ID: BAC0057
  • Code for: Enzyme
  • Family: CadD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain N315)
  • Location: Plasmid pN315 (Staphylococcus aureus (strain N315)), Plasmid pLUH02 (Staphylococcus aureus (strain ECT-R 2) ), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance permease; These proteins are members of the Cadmium Resistance (CadD) Family. To date, this family of proteins has only been found in Gram-positive bacteria. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, and another staphylococcal protein that has been reported to possibly function in quaternary ammonium ion Export.
  • Length (amino acid): 205
  • Reference: Crupper et al. 1999; Pubmed- 10383976, Kuroda et al. 2001; Pubmed- 11418146

    		• Similar resistance genes in 'BacMet Predicted database'
    cadR
  • BacMet ID: BAC0058
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pECd1 (uncultured bacterium), Chromosome
  • Compound: Cadmium (Cd)
  • Description: Transcriptional regulator CadR; Responsible for cadmium resistance
  • Length (amino acid): 147
  • Reference: Lee et al. 2001; Pubmed- 11282588

    		• Similar resistance genes in 'BacMet Predicted database'
    cadX
  • BacMet ID: BAC0059
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus salivarius
  • Location: Plasmid pLUG10 (Staphylococcus lugdunensis)
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance regulatory protein CadX
  • Length (amino acid): 112
  • Reference: Chen et al. 2008; Pubmed- 18165364

    		• Similar resistance genes in 'BacMet Predicted database'
    cdeA
  • BacMet ID: BAC0060
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Clostridium difficile
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine]
  • Description: A multidrug efflux transporter of the MATE family, CdeA
  • Length (amino acid): 441
  • Reference: Dridi et al. 2004; Pubmed- 15383161

    		• Similar resistance genes in 'BacMet Predicted database'
    cepA
  • BacMet ID: BAC0061
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family (FieF subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides]
  • Description: Cation-efflux pump cepA, Cation-efflux transporter that may have a role in detoxification by similarity. Associated with chlorhexidine resistance.
  • Length (amino acid): 300
  • Reference: Fang et al. 2002; Pubmed- 12019132

    		• Similar resistance genes in 'BacMet Predicted database'
    ceuE
  • BacMet ID: BAC0062
  • Code for: Membrane Transporter
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Psudomonas aeruginosa
  • Location: Plasmid pUM505 (pseudomonas aeruginosa), Plasmid pB4 (uncultured bacterium), Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839))
  • Compound: Chromium (Cr)
  • Description: Periplasmic iron-binding protein Iron(III) ABC transporter CeuE; Encodes for membrane proteins; This protein reduces chromate (CrO4) accumulation and is essential for chromate resistance.
  • Length (amino acid): 313
  • Reference: Cervantes et al. 1990; Pubmed- 2152903, Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrA
  • BacMet ID: BAC0063
  • Code for: Efflux
  • Family: Chromate ion transporter (CHR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Psudomonas aeruginosa
  • Location: Plasmid pUM505 (pseudomonas aeruginosa)
  • Compound: Chromium (Cr)
  • Description: Chromate (CrO4) transport protein ChrA; Responsible for the inducibility of the resistance
  • Length (amino acid): 416
  • Reference: Cervantes et al. 1990; Pubmed- 2152903

    		• Similar resistance genes in 'BacMet Predicted database'
    chrA
  • BacMet ID: BAC0026
  • Code for: Efflux
  • Family: Chromate Ion Transporter (CHR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ochrobactrum tritici
  • Location: Chromosome (transposon TnOtChr)
  • Compound: Chromium (Cr)
  • Description: Part of chrBACF operon from the transposable element TnOtChr. It pumps chromate out of the cell.
  • Length (amino acid): 458
  • Reference: Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrA1
  • BacMet ID: BAC0548
  • Code for: Efflux
  • Family: Chromate ion transporter (CHR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: This protein reduces chromate accumulation and is essential for chromate resistance.
  • Length (amino acid): 401
  • Reference: Juhnke et al. 2002; Pubmed- 12471500, Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrB
  • BacMet ID: BAC0027
  • Code for: Regulator
  • Family: Contains 1 Chromate resistance exported protein domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ochrobactrum tritici
  • Location: Chromosome (transposon TnOtChr)
  • Compound: Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone]
  • Description: Part of chrBACF operon from the transposable element TnOtChr. Has a regulatory role for expression of the ChrA transporter.
  • Length (amino acid): 312
  • Reference: Branco et al. 2013; Pubmed- 24223748, Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrB1
  • BacMet ID: BAC0064
  • Code for: Regulator
  • Family: Chromate ion transporter (CHR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: Together with ChrA, this protein reduces chromate accumulation and is essential for chromate (CrO4) resistance, possibly as a regulatory protein.
  • Length (amino acid): 324
  • Reference: Juhnke et al. 2002; Pubmed- 12471500, Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrC
  • BacMet ID: BAC0547
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: Fe-dependent Superoxide dismutase. This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions. Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Length (amino acid): 197
  • Reference: Juhnke et al. 2002; Pubmed- 12471500

    		• Similar resistance genes in 'BacMet Predicted database'
    chrC
  • BacMet ID: BAC0028
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ochrobactrum tritici
  • Location: Chromosome (transposon TnOtChr)
  • Compound: Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone]
  • Description: Part of chrBACF operon from the transposable element TnOtChr. ChrC encodes a superoxide dismutase.
  • Length (amino acid): 202
  • Reference: Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrE
  • BacMet ID: BAC0065
  • Code for: Enzyme
  • Family: Rhodanese family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: ChrE, involved in the processing of chromium-glutathione-complexes
  • Length (amino acid): 113
  • Reference: Juhnke et al. 2002; Pubmed- 12471500, Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrF
  • BacMet ID: BAC0066
  • Code for: Regulator
  • Family: Chrome_Resist family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: ChrF, regulatory protein, involved in Chromate (CrO4) resistance
  • Length (amino acid): 140
  • Reference: Juhnke et al. 2002; Pubmed- 12471500

    		• Similar resistance genes in 'BacMet Predicted database'
    chrF
  • BacMet ID: BAC0029
  • Code for: Unknown
  • Family: Contains 1 Chromate resistance exported protein domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ochrobactrum tritici
  • Location: Chromosome (transposon TnOtChr)
  • Compound: Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone]
  • Description: Part of chrBACF operon from the transposable element TnOtChr.
  • Length (amino acid): 150
  • Reference: Branco et al. 2008; Pubmed- 18776016

    		• Similar resistance genes in 'BacMet Predicted database'
    chrI
  • BacMet ID: BAC0361
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium)
  • Compound: Chromium (Cr)
  • Description: ChrI, regulatory protein, involved in Chromate resistance.
  • Length (amino acid): 164
  • Reference: Juhnke et al. 2002; Pubmed- 12471500

    		• Similar resistance genes in 'BacMet Predicted database'
    chrR
  • BacMet ID: BAC0538
  • Code for: Enzyme
  • Family: NADH_dh2 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Chromium (Cr), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], 2,6-dichloroindophenol [class: Phenolic Compounds]
  • Description: A soluble quinone reductase of Pseudomonas putida that defends against H2O2. ChrR is a dimeric flavin mononucleotide-binding flavoprotein that is able to catalyze a full reduction of Cr(VI) to Cr(III). ChrR may also contribute to the survival of P. putida in the environment by preventing redox cycling of soluble quinones. Confers resistance to Pottasium Ferricyanide (Fe++ salt) as well.
  • Length (amino acid): 186
  • Reference: Gonzalez et al. 2005; Pubmed- 15840577, Ackerley et al. 2004; Pubmed- 14766567, Park et al. 2000; Pubmed- 10788340

    		• Similar resistance genes in 'BacMet Predicted database'
    chrR
  • BacMet ID: BAC0539
  • Code for: Enzyme
  • Family: NADH_dh2 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. (strain G-1)
  • Location: Chromosome
  • Compound: Chromium (Cr)
  • Description: Cr(VI) reductase. Absent in P. putida.
  • Length (amino acid): 243
  • Reference: Suzuki et al. Pubmed- 1992; Pubmed- 1322884

    		• Similar resistance genes in 'BacMet Predicted database'
    cinA
  • BacMet ID: BAC0067
  • Code for: unknown
  • Family: Azurin-plastocyanin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa PAO1
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-containing azurin-like protein cinA; CinA is similar to the P. fluorescens DF57 Cot protein which is involved in copper tolerance; cinA Influences the ability of Pseudomonas aeruginosa PAO1 to resist the bactericidal effect of copper
  • Length (amino acid): 205
  • Reference: Elquindi et al. 2009; Pubmed- 19239551, Quaranta et al. 2007; Pubmed- 17483220

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeA
  • BacMet ID: BAC0068
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: RND efflux system, a periplasmic fusion protein CmeA. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 367
  • Reference: Lin et al. 2002; Pubmed- 12069964

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeB
  • BacMet ID: BAC0613
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Acridine orange [class: Acridine]
  • Description: An inner membrane efflux transporter. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 1040
  • Reference: Lin et al. 2002; Pubmed- 12069965, Pumbwe et al. 2004; Pubmed- 15201231

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeC
  • BacMet ID: BAC0614
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: An outer membrane protein (CmeC). Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 492
  • Reference: Lin et al. 2002; Pubmed- 12069966

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeD
  • BacMet ID: BAC0615
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeD is the outer membrane protein.
  • Length (amino acid): 424
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeE
  • BacMet ID: BAC0616
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeE is a periplasmic fusion protein
  • Length (amino acid): 246
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeF
  • BacMet ID: BAC0069
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: Integral membrane component of efflux system (Multidrug efflux system CmeDEF)
  • Length (amino acid): 1005
  • Reference: Akiba et al. 2006, Pubmed- 16303882

    		• Similar resistance genes in 'BacMet Predicted database'
    cmeR
  • BacMet ID: BAC0070
  • Code for: Regulator
  • Family: TetR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni 81-176
  • Location: Chromosome
  • Compound: Sodium Cholate [class: Acid]
  • Description: Transcriptional repressor. CmeABC is controlled by CmeR, a transcriptional repressor encoded by a gene located immediately upstream of cmeABC. CmeR binds to the inverted repeat in the promoter region of cmeABC and inhibits the expression of the efflux operon.
  • Length (amino acid): 210
  • Reference: Lin et al. 2005; Pubmed- 15728904

    		• Similar resistance genes in 'BacMet Predicted database'
    cmtR
  • BacMet ID: BAC0071
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.
  • Length (amino acid): 118
  • Reference: Cavet et al. 2003; Pubmed- 12939264

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0203
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrA. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 1076
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0542
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2465
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0543
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2464
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0544
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2457
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0545
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2460
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrA
  • BacMet ID: BAC0546
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bradyrhizobium sp. STM 2458
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Fragment of nccA-like protein
  • Length (amino acid): 304
  • Reference: Chaintreuil et al. 2007; Pubmed- 17951443

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrB
  • BacMet ID: BAC0204
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrB. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 395
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrC
  • BacMet ID: BAC0072
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrC; The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.
  • Length (amino acid): 418
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrH
  • BacMet ID: BAC0073
  • Code for: Regulator
  • Family: Sigma-70 factor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: RNA polymerase sigma factor CnrH; CnrH alone is able to activate cnr Expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.
  • Length (amino acid): 191
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrR/cnrX
  • BacMet ID: BAC0291
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance operon regulator CnrR. CnrH alone is able to activate cnr expression, while both CnrY and CnrR (CnrX) are needed for nickel induction of CnrH. Has been suggested to bind nickel.
  • Length (amino acid): 148
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463, Tibazarwa et al. 2000; Pubmed- 10671464

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrT
  • BacMet ID: BAC0074
  • Code for: Membrane Transporter
  • Family: EamA-like transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Cupriavidus metallidurans)
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: CnrT, Cation Diffusion Facilitator, involved in Co(II), Ni(II) resistance
  • Length (amino acid): 351
  • Reference: Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    cnrY
  • BacMet ID: BAC0075
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL28 (Cupriavidus metallidurans)
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel and cobalt resistance protein CnrY; CnrY and CnrX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift) or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.
  • Length (amino acid): 95
  • Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463

    		• Similar resistance genes in 'BacMet Predicted database'
    comR/ycfQ
  • BacMet ID: BAC0076
  • Code for: Regulator
  • Family: TetR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.
  • Length (amino acid): 210
  • Reference: Deng et al. 2011; Pubmed- 21498759

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0077
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pRJ1004 (E. coli)
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Encode for copper uptake ATPases; also resistant to Ag+ ; periplasmic protein; Probably involved in copper and silver Export. Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity.
  • Length (amino acid): 609
  • Reference: Cha and Cooksey 1991; Pubmed- 1924351, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0078
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in copper export; The copZA operon is activated by CueR and indirectly repressed by YfmP
  • Length (amino acid): 802
  • Reference: Banci et al. 2003; Pubmed- 14514665, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0619
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida PNL-MK25
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Part of copABCD operon, that encodes copper-binding and sequestering proteins for copper homeostasis in the copper-sensitive strain Pseudomonas putida PNL-MK25.
  • Length (amino acid): 564
  • Reference: Adaikkalam et al. 2005; Pubmed- 15920618

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0620
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Probably involved in copper import under copper limiting conditions.
  • Length (amino acid): 727
  • Reference: Odermatt et al. 1994; Pubmed- 8037745, Solioz et al. 1995; Pubmed- 7721839

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0621
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein A.
  • Length (amino acid): 623
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0622
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Involved in copper and silver export.
  • Length (amino acid): 804
  • Reference: Mandal et al. 2002; Pubmed- 11756450

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0623
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Probably involved in copper export. Part of copAP operons of Helicobacter pylori and Helicobacter felis.
  • Length (amino acid): 741
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0624
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-transporting ATPase. part of copAP operon.
  • Length (amino acid): 732
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copA
  • BacMet ID: BAC0625
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas alfalfae subsp. Citrumelonis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein A. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 622
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0626
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B. It mediates copper resistance by its sequestration in the outer membrane. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 328
  • Reference: Mellano et al. 1988; Pubmed- 3372485, Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0627
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas alfalfae subsp. Citrumelonis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B.
  • Length (amino acid): 422
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0628
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein B. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 422
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0629
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: It is a thermophilic Cu2+-ATPase in Archaeoglobus fulgidus. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 690
  • Reference: Mana-Capelli et al. 2003; Pubmed- 12876283,

    		• Similar resistance genes in 'BacMet Predicted database'
    copB
  • BacMet ID: BAC0079
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Efflux ATPases, located in same operone with copA; outer membrane protein, have 4 impefect repeats of octapeptide Asp-His-Ser-Gln/Lys-Met-Gln-Met; Required for the copper-inducible Expression of copper resistance. It is a pump for the extrusion of monovalent copper and silver ions, with copper probably being the natural substrate.
  • Length (amino acid): 745
  • Reference: Odermatt et al. 1994; Pubmed- 8037745, Solioz et al. 1995; Pubmed- 7721839

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0630
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 126
  • Reference: Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0631
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas citri subsp. Citri
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein C.
  • Length (amino acid): 127
  • Reference: Behlau et al. 2011; Pubmed- 21515725

    		• Similar resistance genes in 'BacMet Predicted database'
    copC
  • BacMet ID: BAC0639
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion binding protein copC. Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 127
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0632
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D
  • Compound: Copper (Cu)
  • Description: Involved in copper resistance. Appears to be involved in copper uptake in conjunction with CopC. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 310
  • Reference: Mellano et al. 1988; Pubmed- 3372485, Bender et al. 1987; Pubmed- 3027030

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0633
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida PNL-MK25
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system.
  • Length (amino acid): 291
  • Reference: Adaikkalam et al. 2005; Pubmed- 15920618

    		• Similar resistance genes in 'BacMet Predicted database'
    copD
  • BacMet ID: BAC0640
  • Code for: Membrane transpoter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 312
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copJ
  • BacMet ID: BAC0080
  • Code for: Enzyme
  • Family: Cytochrome C family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Copper (Cu)
  • Description: CopJ cytochrome c protein involved in Cu(II)/Cu(I) resistance; Structural genes like copA and copB; periplasmic protein; Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA
  • Length (amino acid): 174
  • Reference: Cha et al. 1991; Pubmed- 1924351

    		• Similar resistance genes in 'BacMet Predicted database'
    copK
  • BacMet ID: BAC0081
  • Code for: Binding protein
  • Family: CopK family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )
  • Compound: Copper (Cu)
  • Description: Copper resistance protein K; Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+
  • Length (amino acid): 94
  • Reference: Bersch et al 2008; Pubmed- 18533181

    		• Similar resistance genes in 'BacMet Predicted database'
    copL
  • BacMet ID: BAC0082
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Xanthomonas perforans
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+.
  • Length (amino acid): 122
  • Reference: Behlau et al. 2011; Pubmed- 21515725, Voloudakis et al. 2005; Pubmed- 15691931

    		• Similar resistance genes in 'BacMet Predicted database'
    copP
  • BacMet ID: BAC0634
  • Code for: Binding protein
  • Family: Contains Heavy-metal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the cells.
  • Length (amino acid): 66
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copP
  • BacMet ID: BAC0635
  • Code for: Binding protein
  • Family: Contains Heavy-metal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H. pylori cells.
  • Length (amino acid): 66
  • Reference: Bayle et al. 1998; Pubmed- 9440521

    		• Similar resistance genes in 'BacMet Predicted database'
    copR
  • BacMet ID: BAC0083
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae pv. Tomato
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae)
  • Compound: Copper (Cu)
  • Description: Transcriptional activator protein CopR; Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce Expression of the cop operon by binding to a specific site on the cop operon promoter (cop box) and possibly by facilitating the binding of RNA polymerase to the cop promoter. CopR also binds to the chromosomally encoded cop operon promoter. May also be involved in basic copper metabolism.
  • Length (amino acid): 227
  • Reference: Mills et al. 1993; Pubmed- 8449873

    		• Similar resistance genes in 'BacMet Predicted database'
    copR
  • BacMet ID: BAC0638
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens.
  • Length (amino acid): 231
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copS
  • BacMet ID: BAC0637
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism.
  • Length (amino acid): 462
  • Reference: Hu et al. 2009; Pubmed- 19557345

    		• Similar resistance genes in 'BacMet Predicted database'
    copS
  • BacMet ID: BAC0537
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas syringae
  • Location: Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae)
  • Compound: Copper (Cu)
  • Description: Sensor protein CopS. Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cytoplasm. CopS/CopR may also regulate chromosomally encoded genes. May also be involved in basic copper metabolism.
  • Length (amino acid): 487
  • Reference: Mills et al. 1993; Pubmed- 8449873

    		• Similar resistance genes in 'BacMet Predicted database'
    copY/tcrY
  • BacMet ID: BAC0084
  • Code for: Regulator
  • Family: BlaI transcriptional regulatory family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: CopA and CopB upstream repressor CopY, regulates the cop operon; Binds to DNA in complex with Zn2+, repressing the transcription of the CopYZAB operon. Exchange of the bound zinc by two copper ions delivered by CopZ Cu1+-bound form causes release of CopY from the promoter, leading to the transcription of the operon
  • Length (amino acid): 145
  • Reference: Strusak et al. 1997; Pubmed- 9083014, Wunderli-Ye et al. 1999; Pubmed- 10362527

    		• Similar resistance genes in 'BacMet Predicted database'
    copZ
  • BacMet ID: BAC0085
  • Code for: Chaperone
  • Family: HMA (Heavy metal Associated) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus hirae
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper chaperone CopZ; copA and copB anti-repressor, regulates the cop operon
  • Length (amino acid): 69
  • Reference: Cobine et al. 1999; Pubmed- 10069368

    		• Similar resistance genes in 'BacMet Predicted database'
    corA
  • BacMet ID: BAC0086
  • Code for: Membrane Transporter
  • Family: CorA metal ion transporter (MIT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)
  • Description: Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.
  • Length (amino acid): 316
  • Reference: Park et al. 1976; Pubmed- 780341

    		• Similar resistance genes in 'BacMet Predicted database'
    corA
  • BacMet ID: BAC0641
  • Code for: Membrane Transporter
  • Family: CorA metal ion transporter (MIT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)
  • Description: Mediates both influx and efflux of magnesium ions. Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.
  • Length (amino acid): 316
  • Reference: Smith et al. 1998; Pubmed- 9786860, Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998

    		• Similar resistance genes in 'BacMet Predicted database'
    corB
  • BacMet ID: BAC0643
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol.
  • Length (amino acid): 227
  • Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998

    		• Similar resistance genes in 'BacMet Predicted database'
    corC
  • BacMet ID: BAC0088
  • Code for: Efflux
  • Family: UPF0053 family. Contains 2 CBS domains.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: Magnesium and cobalt efflux protein CorC; Plays a role in the transport of magnesium and cobalt ions
  • Length (amino acid): 292
  • Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998

    		• Similar resistance genes in 'BacMet Predicted database'
    corD
  • BacMet ID: BAC0644
  • Code for: Unknown
  • Family: Contains 1 apaG domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: mutations in apaG/corD give a phenotype of low-level Co2+ resistance. They also decrease Mg2+ efflux but not influx via the CorA Mg2+ transport system.
  • Length (amino acid): 125
  • Reference: Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998

    		• Similar resistance genes in 'BacMet Predicted database'
    corR
  • BacMet ID: BAC0089
  • Code for: Regulator
  • Family: Contains 1 sigma-54 factor interaction domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Myxococcus xanthus (strain DK 1622)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Sigma-54 dependent DNA-binding response regulator CorR; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB.
  • Length (amino acid): 466
  • Reference: Sanchez-Sutil et al. 2013; Pubmed- 23874560

    		• Similar resistance genes in 'BacMet Predicted database'
    corR/coaR
  • BacMet ID: BAC0090
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. PCC 6803 substr. GT-I
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: Cobalt-dependent transcriptional regulator, CorR
  • Length (amino acid): 370
  • Reference: Rutherford et al. 1999; Pubmed- 10464323, Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    corS
  • BacMet ID: BAC0091
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Myxococcus xanthus (strain DK 1622)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Sensor histidine kinase CorS; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB.
  • Length (amino acid): 491
  • Reference: Sanchez-Sutil et al. 2013; Pubmed- 23874560

    		• Similar resistance genes in 'BacMet Predicted database'
    corT/coaT
  • BacMet ID: BAC0092
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. PCC 6803 substr. GT-I
  • Location: Chromosome
  • Compound: Cobalt (Co)
  • Description: Cation-transporting ATPase E1-E2 ATPase, CorT
  • Length (amino acid): 642
  • Reference: Rutherford et al. 1999; Pubmed- 10464323, Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxA
  • BacMet ID: BAC0532
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Sensor protein of stress-related two-component regulatory system of CpxAR. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 457
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxR
  • BacMet ID: BAC0533
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Response regulator of stress-related two-component regulatory system. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 232
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    crdA
  • BacMet ID: BAC0093
  • Code for: Efflux
  • Family: Contains a YtkA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper resistance determinant, CrdA. It is required for adaptation to copper-rich environmental conditions.
  • Length (amino acid): 125
  • Reference: Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    crdB
  • BacMet ID: BAC0094
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Putative copper resistance determinant, CrdC. It is required for adaptation to copper-rich environmental conditions.
  • Length (amino acid): 412
  • Reference: Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    crdR
  • BacMet ID: BAC0095
  • Code for: Regulator
  • Family: Contains 1 Response_reg domain, 1 Trans_reg_C domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Response regulator; part of two-component regulatory system crdR/crdS
  • Length (amino acid): 213
  • Reference: Waidner et al. 2005; Pubmed- 15968080

    		• Similar resistance genes in 'BacMet Predicted database'
    crdS
  • BacMet ID: BAC0096
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Histidine kinase sensor protein; part of two-component regulatory system crdR/crdS
  • Length (amino acid): 397
  • Reference: Waidner et al. 2005; Pubmed- 15968080

    		• Similar resistance genes in 'BacMet Predicted database'
    csoR
  • BacMet ID: BAC0558
  • Code for: Regulator
  • Family: CsoR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis 168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-sensing transcriptional repressor CsoR. Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu1+, which significantly decreases its DNA binding affinity and leads to the transcription of the genes. Cells lacking this gene display a slightly enhanced ability to grow into medium containing high levels of copper.
  • Length (amino acid): 101
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpC
  • BacMet ID: BAC0098
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Manganese (Mn), Zinc (Zn)
  • Description: Probable manganese/zinc-exporting P-type ATPase
  • Length (amino acid): 718
  • Reference: Padilla-Benavides et al. 2013; Pubmed- 23482562

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpD
  • BacMet ID: BAC0099
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium smegmatis
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Probable cobalt/nickel-exporting P-type ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell.
  • Length (amino acid): 657
  • Reference: Raimunda et al. 2012; Pubmed- 22591178

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpG
  • BacMet ID: BAC0100
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Cation-transporting ATPase G; Response to copper ion
  • Length (amino acid): 771
  • Reference: Liu et al. 2007; Pubmed- 17143269, Sakamoto et al. 2010; Pubmed- 20395270

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpV
  • BacMet ID: BAC0101
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper-exporting P-type ATPase V; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence.
  • Length (amino acid): 770
  • Reference: Ward et al. 2010; Pubmed- 20624225

    		• Similar resistance genes in 'BacMet Predicted database'
    cueA
  • BacMet ID: BAC0102
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper transporter CueA; Periplasmic protein
  • Length (amino acid): 797
  • Reference: Adaikkalam et al. 2002; Pubmed- 12213931

    		• Similar resistance genes in 'BacMet Predicted database'
    cueO
  • BacMet ID: BAC0103
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper efflux oxidase (blue copper oxidase); Involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm.
  • Length (amino acid): 516
  • Reference: Grass et al. 2001; Pubmed- 11222619, Outten et al. 2001; Pubmed- 11399769

    		• Similar resistance genes in 'BacMet Predicted database'
    cueP
  • BacMet ID: BAC0104
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Periplasmic copper-binding protein and has been implicated in the transfer of copper ions to SodCII in the periplasm; evolved to survive in the phagosomes of macrophages in Salmonella enterica serovar Typhimurium; CueP can functionally replace the Cus complex for periplasmic copper resistance, in particular under anaerobic conditions; CueP does not confer silver or gold resistance to Salmonella
  • Length (amino acid): 179
  • Reference: Pontel et al. 2009; Pubmed- 19538445, Osman et al. 2010; Pubmed- 20534583

    		• Similar resistance genes in 'BacMet Predicted database'
    cueR/ybbI
  • BacMet ID: BAC0105
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. CueR is a direct regulator of copZA transcription that mediates copper induction
  • Length (amino acid): 135
  • Reference: Stoyanov et al. 2001; Pubmed- 11136469, Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    cuiD
  • BacMet ID: BAC0106
  • Code for: Enzyme
  • Family: Multicopper oxidase (MCO) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: A multi-copper oxidase gene code for Cu-inducible periplasmic protein; CuiD is required for both copper homeostasis and the copper resistance response in the presence and in the absence of oxygen; Probably involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm; cuiD may be involved in oxidative stress response
  • Length (amino acid): 536
  • Reference: Lim et al 2002; Pubmed- 12442888

    		• Similar resistance genes in 'BacMet Predicted database'
    cusA/ybdE
  • BacMet ID: BAC0107
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; located in cell inner membrane; Belongs to the AcrB/AcrD/AcrF family
  • Length (amino acid): 1047
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusB
  • BacMet ID: BAC0108
  • Code for: Efflux
  • Family: Membrane fusion protein(MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; Belongs to the membrane fusion protein (MFP) family
  • Length (amino acid): 407
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusC/ylcB
  • BacMet ID: BAC0109
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver
  • Length (amino acid): 457
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusF/cusX
  • BacMet ID: BAC0110
  • Code for: Efflux
  • Family: Contains 1 CusF_Ec domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pkPN3 (Klebsiella pneumoniae subsp. pneumoniae MGH 78578), Plasmid pAPEC-O2-R
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Cation efflux system periplasmic protein CusF; Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver. Binds one copper per polypeptide ; located in Periplasm
  • Length (amino acid): 110
  • Reference: Franke et al. 2003; Pubmed- 12813074

    		• Similar resistance genes in 'BacMet Predicted database'
    cusR/ylcA
  • BacMet ID: BAC0111
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56))
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Member of the two-component regulatory system CusS/CusR. Activates the Expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level Expression of copper resistance gene operon pcoABCD; located in cytoplasm
  • Length (amino acid): 227
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    cusS
  • BacMet ID: BAC0112
  • Code for: Regulator
  • Family: Contains 1 HAMP domain and 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Sensor kinase CusS; Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation; located in inner cell membrane
  • Length (amino acid): 480
  • Reference: Munson et al. 2000; Pubmed- 11004187

    		• Similar resistance genes in 'BacMet Predicted database'
    cutA
  • BacMet ID: BAC0113
  • Code for: Binding protein
  • Family: CutA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Divalent-cation tolerance protein CutA; Involved in resistance toward heavy metals
  • Length (amino acid): 112
  • Reference: Fong et al. 1995; Pubmed- 7623666

    		• Similar resistance genes in 'BacMet Predicted database'
    cutC
  • BacMet ID: BAC0114
  • Code for: Binding protein
  • Family: CutC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper homeostasis protein CutC; Involved in copper homeostasis; Located in cytoplasm
  • Length (amino acid): 248
  • Reference: Gupta et al. 1995; Pubmed- 7635807

    		• Similar resistance genes in 'BacMet Predicted database'
    cutE/lnt
  • BacMet ID: BAC0115
  • Code for: Enzyme
  • Family: CN hydrolase (Apolipoprotein N-acyltransferase subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Apolipoprotein N-acyltransferas, it attaches a fatty acid to apo-nlpE (cutF)
  • Length (amino acid): 512
  • Reference: Rogers et al. 1991; Pubmed- 1938881

    		• Similar resistance genes in 'BacMet Predicted database'
    cutF/nlpE
  • BacMet ID: BAC0116
  • Code for: Outer membrane lipoprotein
  • Family: Contains 1 NlpE domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper homeostasis protein CutF, encodes for outer membrane lipoprotein might affect on copper permeability; Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR
  • Length (amino acid): 236
  • Reference: Gupta et al. 1995; Pubmed- 7635807

    		• Similar resistance genes in 'BacMet Predicted database'
    cutO
  • BacMet ID: BAC0117
  • Code for: Enzyme
  • Family: Multocopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Multi copper oxidase CutO; Involved in copper resistance; CutO confers copper tolerance not only under aerobic conditions, as described for the well-characterized E. coli multicopper oxidase CueO, but also under anaerobic conditions.
  • Length (amino acid): 491
  • Reference: Wiethaus et al. 2006; Pubmed- 16487321

    		• Similar resistance genes in 'BacMet Predicted database'
    cutR
  • BacMet ID: BAC0118
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: CutR acts as a repressor of cutO Expression under low copper concentrations; Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism.
  • Length (amino acid): 118
  • Reference: Wiethaus et al. 2006; Pubmed- 16487321

    		• Similar resistance genes in 'BacMet Predicted database'
    czcA
  • BacMet ID: BAC0119
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein; the basic inner membrane transport protein; Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC).
  • Length (amino acid): 1063
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcB
  • BacMet ID: BAC0120
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein CzcB; Membrane fusion protein bridges inner and outer cell membranes (in periplasm); CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
  • Length (amino acid): 520
  • Reference: Nies et al. 1989; Pubmed- 2678100, Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    czcC
  • BacMet ID: BAC0121
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Muter membrane protein; CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt.
  • Length (amino acid): 418
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcD
  • BacMet ID: BAC0122
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transporter gene influence Zn++ and Cd++ resistance; Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter.
  • Length (amino acid): 316
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcE
  • BacMet ID: BAC0123
  • Code for: Binding protein
  • Family: Cation efflux family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: CzcE, involved in Cd(II), Zn(II), Co(II) resistance; copH like protein; Co/Zn/Cd efflux system transmembrane protein
  • Length (amino acid): 133
  • Reference: Zoropogui et al. 2007; Pubmed- 18029263

    		• Similar resistance genes in 'BacMet Predicted database'
    czcP
  • BacMet ID: BAC0124
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cupriavidus metallidurans CH34
  • Location: Plasmid pMOL30 (Cupriavidus metallidurans CH34)
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: P(IB4)-type ATPases; CzcP seemed to enhance metal resistance but relies on the action of the P(IB2)-type ATPases such as zntA, cadA, pbrA etc.
  • Length (amino acid): 829
  • Reference: Scherer et al. 2009; Pubmed- 19602147

    		• Similar resistance genes in 'BacMet Predicted database'
    czcR
  • BacMet ID: BAC0125
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transcriptional activator protein CzcR; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis
  • Length (amino acid): 225
  • Reference: Nies et al. 1992; Pubmed- 1459958

    		• Similar resistance genes in 'BacMet Predicted database'
    czcS
  • BacMet ID: BAC0126
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Sensor protein CzcS; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation.
  • Length (amino acid): 476
  • Reference: Van der Lelie et al. 1997; Pubmed- 9044283

    		• Similar resistance genes in 'BacMet Predicted database'
    cznA
  • BacMet ID: BAC0127
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznA
  • Length (amino acid): 1019
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznB
  • BacMet ID: BAC0128
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznB
  • Length (amino acid): 351
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznC
  • BacMet ID: BAC0129
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel outer membrane efflux protein cznC
  • Length (amino acid): 424
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    czrA
  • BacMet ID: BAC0130
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: A repressor for thr czr operon; part of the czrSRCBA resistance operon
  • Length (amino acid): 1051
  • Reference: Valencia et al. 2013; Pubmed- 23578014; Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    czrB
  • BacMet ID: BAC0131
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: czrB involved in cadmium and zinc resistance; part of the czrSRCBA resistance operon
  • Length (amino acid): 405
  • Reference: Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeF
  • BacMet ID: BAC0132
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Wautersia metallidurans CH34
  • Location: Plasmid pMOL28 (Wautersia metallidurans CH34)
  • Compound: Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34.
  • Length (amino acid): 382
  • Reference: Scherer et al. 2009; Pubmed- 19602147, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeF
  • BacMet ID: BAC0482
  • Code for: Efflux
  • Family: Cation Diffusion Facilitator (CDF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions.
  • Length (amino acid): 323
  • Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501

    		• Similar resistance genes in 'BacMet Predicted database'
    dmeR
  • BacMet ID: BAC0475
  • Code for: Efflux
  • Family: Cation Diffusion Facilitator (CDF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions.
  • Length (amino acid): 90
  • Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501

    		• Similar resistance genes in 'BacMet Predicted database'
    dnaK
  • BacMet ID: BAC0133
  • Code for: Chaperone
  • Family: Heat shock protein 70 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Chaperone protein DnaK
  • Length (amino acid): 625
  • Reference: Graubner et al. 2007; Pubmed- 17215254

    		• Similar resistance genes in 'BacMet Predicted database'
    dpr/dps
  • BacMet ID: BAC0134
  • Code for: Binding protein
  • Family: Dps famaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus suis
  • Location: Chromosome
  • Compound: Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: DNA protection during starvation protein; Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction. It binds and incorporates Fe2+ iron. Is responsible for hydrogen peroxide resistance. Does not bind DNA.
  • Length (amino acid): 172
  • Reference: Pulliainen et al. 2005; Pubmed- 16091046

    		• Similar resistance genes in 'BacMet Predicted database'
    dpsA
  • BacMet ID: BAC0135
  • Code for: Binding protein
  • Family: Dps famaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei 1710b
  • Location: Chromosome
  • Compound: Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: dpsA respsonses to stress, iron-binding protein; has role in iron ion homeostasis
  • Length (amino acid): 162
  • Reference: Loprasert et al. 2004; Pubmed- 15241582

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbA
  • BacMet ID: BAC0136
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbA subfamily.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Mercury (Hg)
  • Description: Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis
  • Length (amino acid): 208
  • Reference: Rensing et al. 1997; Pubmed- 9098080, Bardwell et al. 1991; Pubmed- 1934062; Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbB
  • BacMet ID: BAC0137
  • Code for: Enzyme
  • Family: DsbB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg)
  • Description: Disulfide oxidoreductase; The dsbB gene codes for a transmembrane protein that is responsible for reoxidizing the periplasmic dsbA-encoded disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA
  • Length (amino acid): 176
  • Reference: Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbC
  • BacMet ID: BAC0138
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Disulfide isomerase; DsbC rearranges incorrect disulfide bonds formed by dsbA during oxidative protein folding under non-stress conditions. DsbC, a periplasmic thiol-disulfide oxidoreductase, appears to function as a disulfide isomerase both in vitro and in vivo. In vitro, DsbC has been shown to rearrange non-native disulfides in well studied isomerization substrates such as BPTI and RNase A. In vivo, DsbC is required for full activity of a handful of proteins containing at least one non-consecutive disulfide bond.
  • Length (amino acid): 236
  • Reference: Hiniker et al. 2005; Pubmed- 16087673

    		• Similar resistance genes in 'BacMet Predicted database'
    ebrA
  • BacMet ID: BAC0139
  • Code for: Efflux
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Pyronin Y [class: Xanthene], Safranin O [class: Azin]
  • Description: Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, Acriflavine, pyronin Y and safranin O. The efflux is probably coupled to an influx of proton
  • Length (amino acid): 105
  • Reference: Masaoka et al. 2000; Pubmed- 10735876, Kikukawa et al. 2006; Pubmed- 16750162, Zhang et al. 2007; Pubmed- 17417881

    		• Similar resistance genes in 'BacMet Predicted database'
    ebrB
  • BacMet ID: BAC0140
  • Code for: Efflux
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Pyronin Y [class: Xanthene], Safranin O [class: Azin]
  • Description: Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, Acriflavine, pyronin Y and safranin O. The efflux is probably coupled to an influx of protons
  • Length (amino acid): 117
  • Reference: Masaoka et al. 2000; Pubmed- 10735876, Kikukawa et al. 2006; Pubmed- 16750162, Zhang et al. 2007; Pubmed- 17417881

    		• Similar resistance genes in 'BacMet Predicted database'
    eefA
  • BacMet ID: BAC0494
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: A periplasmic intermediate, EefA. Part of the EefXABC operon. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 374
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

    		• Similar resistance genes in 'BacMet Predicted database'
    eefX
  • BacMet ID: BAC0495
  • Code for: Unknown
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Part of eefXABC operon in K. pneumoniae. This gene is absent in the similar efflux system eefABC in other bacteria (such as Enterobacter aerogenes). Comaparative study suggests that it could be a regulator of the EefABC tripartite efflux system. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 61
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

    		• Similar resistance genes in 'BacMet Predicted database'
    emeA
  • BacMet ID: BAC0141
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Enterococcus faecalis (Streptococcus faecalis)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump emeA
  • Length (amino acid): 393
  • Reference: Lee et al. 2003 ; Pubmed- 12576692

    		• Similar resistance genes in 'BacMet Predicted database'
    emhA
  • BacMet ID: BAC0142
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux transporter, membrane fusion protein subunit EmhA
  • Length (amino acid): 385
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhB
  • BacMet ID: BAC0143
  • Code for: Efflux
  • Family: Hydrophobe/amphiphile efflux-1 (HAE1) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Protein export membrane protein emhB
  • Length (amino acid): 1054
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhC
  • BacMet ID: BAC0144
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux transporter, outer membrane factor lipoprotein EmhC
  • Length (amino acid): 486
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhR
  • BacMet ID: BAC0145
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Regulator of emhABC efflux system, EmhR
  • Length (amino acid): 210
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emmdR
  • BacMet ID: BAC0146
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterobacter cloacae
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: MATE efflux family protein; EmmdR is an H+-drug antiporter but not a Na+ driven efflux pump
  • Length (amino acid): 462
  • Reference: He et al. 2011; Pubmed- 21822795

    		• Similar resistance genes in 'BacMet Predicted database'
    emrA
  • BacMet ID: BAC0147
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell.
  • Length (amino acid): 390
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    emrAsm
  • BacMet ID: BAC0499
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 393
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrB
  • BacMet ID: BAC0148
  • Code for: Enzyme
  • Family: Major facilitator superfamily (MFS)-EmrB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]
  • Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
  • Length (amino acid): 512
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    emrBsm
  • BacMet ID: BAC0500
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 528
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrCsm
  • BacMet ID: BAC0501
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Outer membrane protein EmrCsm. Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 497
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrD
  • BacMet ID: BAC0149
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Multidrug resistance pump that participates in a low energy shock adaptative response
  • Length (amino acid): 394
  • Reference: Naroditskaya et al. 1993; Pubmed- 8240355, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    emrD-3
  • BacMet ID: BAC0534
  • Code for: Efflux
  • Family: MFS superfamiy, Bcr/CflA subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae O395
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It is an intrinsic membrane protein. Multidrug resistance protein D. EmrD-3-mediated efflux is potentiated by a proton gradient across the membrane. It can confer resistance to antibiotics such as linezolid, rifampin, minocycline etc.
  • Length (amino acid): 379
  • Reference: Smith et al. 2009; Pubmed- 19876617

    		• Similar resistance genes in 'BacMet Predicted database'
    emrE/mvrC
  • BacMet ID: BAC0150
  • Code for: Efflux/Membrane protein
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium.
  • Length (amino acid): 110
  • Reference: Morimyo et al. 1992; Pubmed- 1320256, Yerushalmi et al. 1995; Pubmed- 7896833, Yerushalmi et al. 2000; Pubmed- 10681497, Rotem et al. 2004; Pumed- 15371426

    		• Similar resistance genes in 'BacMet Predicted database'
    emrK
  • BacMet ID: BAC0151
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate
  • Length (amino acid): 387
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791

    		• Similar resistance genes in 'BacMet Predicted database'
    emrR
  • BacMet ID: BAC0559
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone]
  • Description: Negative regulator of the multidrug operon emrAB.
  • Length (amino acid): 176
  • Reference: Lomovskaya et al. 1995; Pubmed- 7730261

    		• Similar resistance genes in 'BacMet Predicted database'
    emrRsm
  • BacMet ID: BAC0502
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: EmrRCABsm operon is negatively regulated by a MarR-type regulator EmrRsm.
  • Length (amino acid): 147
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrY
  • BacMet ID: BAC0153
  • Code for: Efflux
  • Family: MFS superfamily (EmrB family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug resistance protein Y
  • Length (amino acid): 512
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791, Han et al. 2010; Pubmed- 20128927

    		• Similar resistance genes in 'BacMet Predicted database'
    evgA
  • BacMet ID: BAC0154
  • Code for: Regulator
  • Family: Contains 1 HTH luxR-type DNA-binding domain, Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon.
  • Length (amino acid): 204
  • Reference: Kato et al. 2000; Pubmed- 10923791, Nishino et al. 2001; Pubmed- 11157960

    		• Similar resistance genes in 'BacMet Predicted database'
    evgS
  • BacMet ID: BAC0155
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain, 1 response regulatory domain, 1 HPt domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Sensor protein EvgS; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals
  • Length (amino acid): 1197
  • Reference: Kato et al. 2000; Pubmed- 10923791, Nishino et al. 2001; Pubmed- 11157960

    		• Similar resistance genes in 'BacMet Predicted database'
    fabI
  • BacMet ID: BAC0156
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis; enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan; some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK, FabV and FabL.
  • Length (amino acid): 262
  • Reference: McMurry et al. 1998; Pubmed- 9707111

    		• Similar resistance genes in 'BacMet Predicted database'
    fabK
  • BacMet ID: BAC0157
  • Code for: Enzyme
  • Family: Nitronate monooxygenase (NMO) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus pneumoniae
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Trans-2-enoyl-ACP reductase II; a TIM barrel triclosan-resistannt flavoprotein; It is one of the taret sites for antibacterial triclosan; expression of FabK confers triclosan resistance.
  • Length (amino acid): 324
  • Reference: Heath et al. 2000; Pubmed- 10910344

    		• Similar resistance genes in 'BacMet Predicted database'
    fabL/ygaA
  • BacMet ID: BAC0158
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-(acyl-carrier-protein) reductase (NADPH) FabL; It catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It confers resistance to triclosan. It is an alternative target site where fabI is absent for antibacterial compound triclosan.
  • Length (amino acid): 250
  • Reference: Heath et al. 2000; Pubmed- 11007778

    		• Similar resistance genes in 'BacMet Predicted database'
    fabV
  • BacMet ID: BAC0159
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio chloerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-(acyl-carrier-protein) (ACP) reductase is a key enzyme in type II fatty-acid synthases that catalyzes the last step in each elongation cycle; Predominately found in Vibrio species and closely related organisms where it seems to be the sole enoyl-ACP reductase. It is a antibacterial target site for triclosan where fabI and other isoforms such as fabL, fabI or fabK are absent. Triclosan expression of FabV in organism results in markedly increased resistance to triclosan. There may be bacteria that have both FabV and FabK such as various of the Clostridia such as Clostridium tetani.
  • Length (amino acid): 401
  • Reference: Massengo-Tiasse et al. 2008; Pubmed- 18032386, Zhu et al. 2010; Pubmed- 19933806,

    		• Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farR
  • BacMet ID: BAC0505
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae, Neisseria meningitidis serogroup B (strain MC58)
  • Location: Chromosome
  • Compound: Palmitic acid [class: Free Fatty Acids]
  • Description: FarR negatively controls expression of farAB by directly binding to the farAB promoter. MtrR binds to the farR promoter, thereby repressing farR expression. MtrR regulates farAB in a positive fashion by modulating farR expression.
  • Length (amino acid): 146
  • Reference: Lee et al. 2003; Pubmed- 14645274

    		• Similar resistance genes in 'BacMet Predicted database'
    fbpA
  • BacMet ID: BAC0160
  • Code for: Binding protein
  • Family: ATP-binding Cassette (ABC)-type ATPase superfamily. Bacterial solute-binding protein 1 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
  • Location: Chromosome
  • Compound: Iron (Fe), Gallium (Ga)
  • Description: Fe(3+)-binding/Iron-utilization periplasmic protein FbpA; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport
  • Length (amino acid): 332
  • Reference: Anderson et al. 2004; Pubmed- 15342592

    		• Similar resistance genes in 'BacMet Predicted database'
    fbpB
  • BacMet ID: BAC0161
  • Code for: Binding protein
  • Family: ATP-binding Cassette (ABC)-type ATPase superfamily. Binding-protein-dependent transport system permease family. FbpB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
  • Location: Chromosome
  • Compound: Iron (Fe), Gallium (Ga)
  • Description: Fe(3+)-transport system permease protein FbpB; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport
  • Length (amino acid): 506
  • Reference: Anderson et al. 2004; Pubmed- 15342592

    		• Similar resistance genes in 'BacMet Predicted database'
    fbpC
  • BacMet ID: BAC0162
  • Code for: Binding protein
  • Family: ATP-binding Cassette (ABC)-type ATPase superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
  • Location: Chromosome
  • Compound: Iron (Fe), Gallium (Ga)
  • Description: Fe(3+) ions import ATP-binding protein FbpC; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. Responsible for energy coupling to the transport system
  • Length (amino acid): 356
  • Reference: Anderson et al. 2004; Pubmed- 15342592

    		• Similar resistance genes in 'BacMet Predicted database'
    fecD
  • BacMet ID: BAC0163
  • Code for: Enzyme
  • Family: Binding-protein-dependent transport system permease family. FecCD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Fe(3+) dicitrate transport system permease protein FecD; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 318
  • Reference: Stoof et al. 2010; Pubmed- 20643857

    		• Similar resistance genes in 'BacMet Predicted database'
    fecE
  • BacMet ID: BAC0164
  • Code for: Membrane Transporter
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for energy coupling to the transport system
  • Length (amino acid): 255
  • Reference: Stoof et al. 2010; Pubmed- 20643857

    		• Similar resistance genes in 'BacMet Predicted database'
    fetA/ybbL
  • BacMet ID: BAC0165
  • Code for: Binding protein
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: FetA, the ATP binding component subunit; FetAB allows for increased resistance to oxidative stress in the presence of iron
  • Length (amino acid): 225
  • Reference: Nicolaou et al. 2013; Pubmed- 24038693

    		• Similar resistance genes in 'BacMet Predicted database'
    fetB/ybbM
  • BacMet ID: BAC0166
  • Code for: Membrane protein
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: FetB/YbbM is a membrane protein. FetAB allows for increased resistance to oxidative stress in the presence of iron
  • Length (amino acid): 259
  • Reference: Nicolaou et al. 2013; Pubmed- 24038693

    		• Similar resistance genes in 'BacMet Predicted database'
    fieF/yiip
  • BacMet ID: BAC0167
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.
  • Length (amino acid): 300
  • Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    fptA
  • BacMet ID: BAC0168
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Iron (Fe), Cobalt (Co), Nickel (Ni), Gallium (Ga)
  • Description: Fe(3+)-pyochelin receptor FptA; High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin
  • Length (amino acid): 720
  • Reference: Braud et al. 2009; Pubmed- 19329644

    		• Similar resistance genes in 'BacMet Predicted database'
    fpvA
  • BacMet ID: BAC0169
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)
  • Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane
  • Length (amino acid): 815
  • Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567

    		• Similar resistance genes in 'BacMet Predicted database'
    frnE
  • BacMet ID: BAC0170
  • Code for: Enzyme
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Deinococcus radiodurans
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Disulfide Isomerase Chaperone; It is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation; is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation
  • Length (amino acid): 252
  • Reference: Khairnar et al. 2013; Pubmed- 23603741

    		• Similar resistance genes in 'BacMet Predicted database'
    furA
  • BacMet ID: BAC0171
  • Code for: Regulator
  • Family: Fur family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Transcriptional regulator FurA; Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner
  • Length (amino acid): 147
  • Reference: Wong et al. 1999; Pubmed- 9864233

    		• Similar resistance genes in 'BacMet Predicted database'
    G2alt
  • BacMet ID: BAC0490
  • Code for: Enzyme
  • Family: PP-loop ATPase superfamily/QueC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Anoxybacillus gonensis G2
  • Location: Chromosome
  • Compound: Aluminium (Al)
  • Description: The ATPase activity of G2alt requires Mg2+ and Na+ ions, while Zn2+ and Al3+ stimulate the activity, Cd2+ and Ag+ reduces the activity and Li+, Cu2+ and Co2+ inhibits the activity.
  • Length (amino acid): 221
  • Reference: Beris et al. 2011; Pubmed- 21887649

    		• Similar resistance genes in 'BacMet Predicted database'
    gadA
  • BacMet ID: BAC0172
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

    		• Similar resistance genes in 'BacMet Predicted database'
    gadB
  • BacMet ID: BAC0173
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

    		• Similar resistance genes in 'BacMet Predicted database'
    gadC/xasA
  • BacMet ID: BAC0174
  • Code for: Enzyme
  • Family: Amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: GadC functions as a transporter for the product of glutamate decarboxylase, g-aminobutyrate
  • Length (amino acid): 511
  • Reference: Hersh et al. 1996; Pubmed- 8682809, Waterman et al. 1996; Pubmed- 8885264

    		• Similar resistance genes in 'BacMet Predicted database'
    gadE/yhiE
  • BacMet ID: BAC0175
  • Code for: Regulator
  • Family: Contains 1 HTH luxR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci.
  • Length (amino acid): 175
  • Reference: Ma et al. 2003; Pubmed- 12940989, Hommais et al. 2004; Pubmed- 14702398

    		• Similar resistance genes in 'BacMet Predicted database'
    gadW/yhiW
  • BacMet ID: BAC0176
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters.
  • Length (amino acid): 242
  • Reference: Ma et al. 2002; Pubmed- 12446650

    		• Similar resistance genes in 'BacMet Predicted database'
    gadX
  • BacMet ID: BAC0177
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Role in acid resistance, increases multidrug resistance in E. coli by activating the MdtEF multidrug efflux pump; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. It can confer resistance to antibiotics such as oxacillin, cloxacillin, nafcillin, erythromycin etc.
  • Length (amino acid): 274
  • Reference: Nishino et al. 2008; Pubmed- 18297445, Shin et al. 2001; Pubmed- 11555293

    		• Similar resistance genes in 'BacMet Predicted database'
    gesA
  • BacMet ID: BAC0178
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 408
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    gesB
  • BacMet ID: BAC0179
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 1055
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    gesC
  • BacMet ID: BAC0180
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 503
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    glpF
  • BacMet ID: BAC0181
  • Code for: Channel
  • Family: Major Intrinsic protein (MIP) superfamily. MIP/aquaporin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Antimony (Sb), Arsenic (As), Glycerol [class: Alcohol]
  • Description: Glycerol uptake facilitator protein GlpF; Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols
  • Length (amino acid): 281
  • Reference: Sanders et al. 1997; Pubmed- 9150238, Meng et al. 2004; Pubmed- 14970228

    		• Similar resistance genes in 'BacMet Predicted database'
    golS
  • BacMet ID: BAC0182
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au)
  • Description: merR-type regulator; GolS directly controls the expression of golT and golB; Each component of the GolS regulon, i.e. the P-type ATPase GolT; and the metal-binding polypeptide GolB, are required for full gold-tolerance
  • Length (amino acid): 154
  • Reference: Checa et al. 2007, Pubmed- 17244194, Espariz et al. 2007, Pubmed- 17768242

    		• Similar resistance genes in 'BacMet Predicted database'
    golT
  • BacMet ID: BAC0183
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Copper (Cu), Gold (Au)
  • Description: Cation transporting P-type ATPase; belongs to the gold-responsive, gol regulon; In the absence of CopA, GolS becomes responsive to copper, inducing the expression of golT, which functionally substitutes CopA for cytosolic copper export
  • Length (amino acid): 762
  • Reference: Espariz et al. 2007, Pubmed- 17768242

    		• Similar resistance genes in 'BacMet Predicted database'
    hasF
  • BacMet ID: BAC0184
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: TolC-homologue hasF involved in energy-dependent efflux
  • Length (amino acid): 505
  • Reference: Kumar et al. 2005; Pubmed- 16121228

    		• Similar resistance genes in 'BacMet Predicted database'
    hdeA/yhiB
  • BacMet ID: BAC0185
  • Code for: Chaperone
  • Family: HdeA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeA; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 110
  • Reference: Hong et al. 2005; Pubmed- 15911614

    		• Similar resistance genes in 'BacMet Predicted database'
    hdeB/yhiC
  • BacMet ID: BAC0186
  • Code for: Chaperone
  • Family: HdeB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeB; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.
  • Length (amino acid): 108
  • Reference: Kern et al. 2007; Pubmed- 17085547

    		• Similar resistance genes in 'BacMet Predicted database'
    hefA
  • BacMet ID: BAC0187
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer-membrane protein of the HefABC efflux system HefA; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 477
  • Reference: Liu et al. 2008; Pubmed- 18777600

    		• Similar resistance genes in 'BacMet Predicted database'
    hefC
  • BacMet ID: BAC0188
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Cytoplasmic pump protein of the HefABC efflux system HefC
  • Length (amino acid): 1028
  • Reference: Kutschke et al. 2005; Pubmed- 15980386

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrM
  • BacMet ID: BAC0189
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate
  • Length (amino acid): 464
  • Reference: Xu et al. 2003; Pubmed- 14695443

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0569
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 129
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0190
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae), Plasmid pSymA (Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti))
  • Location: Plasmid pSMED01
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 147
  • Reference: Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    hoxN
  • BacMet ID: BAC0191
  • Code for: Enzyme
  • Family: NiCo transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)
  • Location: Plasmid megaplasmid pHG1 (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)),
  • Compound: Nickel (Ni)
  • Description: High-affinity nickel transporter hoxN responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease.
  • Length (amino acid): 351
  • Reference: Eitinger et al. 1991; Pubmed- 1847142, Wolfram et al. 1995; Pubmed- 7896709

    		• Similar resistance genes in 'BacMet Predicted database'
    hpcopA
  • BacMet ID: BAC0617
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in copper export.
  • Length (amino acid): 745
  • Reference: Ge et al. 1995; Pubmed- 7752900, Ge et al. 1996; Pubmed- 8961555

    		• Similar resistance genes in 'BacMet Predicted database'
    hpcopP
  • BacMet ID: BAC0618
  • Code for: Enzyme
  • Family: Contains Heavy-matal-associated (HMA) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (Campylobacter pylori)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.
  • Length (amino acid): 66
  • Reference: Ge et al. 1995; Pubmed- 7752900, Ge et al. 1996; Pubmed- 8961555

    		• Similar resistance genes in 'BacMet Predicted database'
    hsmR
  • BacMet ID: BAC0192
  • Code for: Efflux
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Small multidrug export protein HsmR
  • Length (amino acid): 112
  • Reference: Ninio et al. 2003; Pubmed- 12551892

    		• Similar resistance genes in 'BacMet Predicted database'
    hupE
  • BacMet ID: BAC0483
  • Code for: Enzyme
  • Family: HupE/UreJ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Plasmid pSym (Rhizobium leguminosarum bv. viciae)
  • Compound: Nickel (Ni)
  • Description: It is a metal permease. hupE gene, part of a highly conserved hup cluster and evolutionarily related to hydrogenase genes. It has a potential role as a nickel permease. It encodes a nickel transporter required for hydrogenase activity.
  • Length (amino acid): 191
  • Reference: Brito et al. 2010; Pubmed- 20023036

    		• Similar resistance genes in 'BacMet Predicted database'
    hupE2
  • BacMet ID: BAC0484
  • Code for: Enzyme
  • Family: HupE/UreJ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. viciae UPM791
  • Location: Plasmid pRLUPM791b (Rhizobium leguminosarum bv. viciae UPM791b)
  • Compound: Nickel (Ni)
  • Description: A hupE-homolog. It is a metal permease. There is a low level of amino acid sequence identity between hupE and hupE2. It is involved in hydrogen oxidation in R. leguminosarum bv. Viciae.
  • Length (amino acid): 199
  • Reference: Brito et al. 2010; Pubmed- 20023036

    		• Similar resistance genes in 'BacMet Predicted database'
    hupN
  • BacMet ID: BAC0193
  • Code for: Enzyme
  • Family: HupF/HypC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Azotobacter chroococcum mcd 1
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Hydrogenase nickel incorporation protein HupN
  • Length (amino acid): 108
  • Reference: Fu et al. 1994; Pubmed- 8197192

    		• Similar resistance genes in 'BacMet Predicted database'
    ibpA
  • BacMet ID: BAC0194
  • Code for: Heat shock protein
  • Family: Small heat shock protein (HSP20)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Small heat shock protein IbpA; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; Its activity is ATP-independent
  • Length (amino acid): 137
  • Reference: Kitagawa et al. 2000; Pubmed- 10713416

    		• Similar resistance genes in 'BacMet Predicted database'
    ibpB
  • BacMet ID: BAC0195
  • Code for: Heat shock protein
  • Family: Small heat shock protein (HSP20)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Small heat shock protein IbpA; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Its activity is ATP-independent.
  • Length (amino acid): 142
  • Reference: Kitagawa et al. 2000; Pubmed- 10713416

    		• Similar resistance genes in 'BacMet Predicted database'
    iclR
  • BacMet ID: BAC0196
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium acetate [class: Acetate]
  • Description: Acetate operon repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form.
  • Length (amino acid): 274
  • Reference: Spencer et al. 2007; Pubmed- 17238290, Sunnarborg et al. 1990; Pubmed- 2185227

    		• Similar resistance genes in 'BacMet Predicted database'
    ideR
  • BacMet ID: BAC0498
  • Code for: Regulator
  • Family: Contains 1 HTH dtxR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], Plumbagin [class: Naphthoquinone]
  • Description: Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a Positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. Has a role in oxidative streee tolerance.
  • Length (amino acid): 230
  • Reference: Rodriguez et al. 2002; Pubmed- 12065475

    		• Similar resistance genes in 'BacMet Predicted database'
    irlR
  • BacMet ID: BAC0197
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Transcriptional activator protein IrlR; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance
  • Length (amino acid): 229
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    irlS
  • BacMet ID: BAC0198
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain, 1 HAMP domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Sensor protein IrlS; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation.
  • Length (amino acid): 464
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    kdeA
  • BacMet ID: BAC0491
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae (strain MGH 78578)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It can confer resistance to antibiotics such as chloramphenicol, Kanamycin, norfloxacin, puromycin, daunomycin etc.
  • Length (amino acid): 410
  • Reference: Ping et al. 2007; Pubmed- 17917272

    		• Similar resistance genes in 'BacMet Predicted database'
    kexD
  • BacMet ID: BAC0492
  • Code for: Effflux
  • Family: Restriction Nodulation Division (RND) superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: KexD was shown to function with AcrAEc and TolC from E. coli and AcrAKp and KocC from K. pneumoniae, like AcrD from E. coli
  • Length (amino acid): 1038
  • Reference: Ogawa et al. 2012; Pubmed- 22391093

    		• Similar resistance genes in 'BacMet Predicted database'
    klaB/telA/kilB
  • BacMet ID: BAC0199
  • Code for: Unknown
  • Family: TelA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncP-alpha RK2 (E. coli), Plasmid pBS228 (Pseudomonas aeruginosa)
  • Compound: Tellurium (Te)
  • Description: Protein KlaB; Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition.
  • Length (amino acid): 378
  • Reference: Goncharoff et al. 1991; Pubmed- 2045366

    		• Similar resistance genes in 'BacMet Predicted database'
    klaC/telB
  • BacMet ID: BAC0200
  • Code for: Unknown
  • Family: TrbC/VIRB2 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid IncP-alpha RK2 (E. coli), Plasmid pBS228 (Pseudomonas aeruginosa)
  • Compound: Tellurium (Te)
  • Description: Protein KlaC; Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition.
  • Length (amino acid): 317
  • Reference: Goncharoff et al. 1991; Pubmed- 2045366

    		• Similar resistance genes in 'BacMet Predicted database'
    kmrA
  • BacMet ID: BAC0493
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Hoechst 33342 [class: Bisbenzimide], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It can confer resistance to Antibiotics such as kanamycin, gentamycin, erythromycin etc.
  • Length (amino acid): 499
  • Reference: Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    kmtR
  • BacMet ID: BAC0201
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: HTH-type transcriptional regulator KmtR; response to cobalt and nickel ions; Negatively auto-regulated
  • Length (amino acid): 130
  • Reference: Campbell et al. 2007; Pubmed- 17726022

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnE
  • BacMet ID: BAC0476
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin.
  • Length (amino acid): 120
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnF
  • BacMet ID: BAC0477
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnO
  • BacMet ID: BAC0529
  • Code for: Porin
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites]
  • Description: KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae.
  • Length (amino acid): 365
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    lde
  • BacMet ID: BAC0202
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Listeria monocytogenes
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Ethidium Bromide [class: Phenanthridine]
  • Description: Efflux pump Lde
  • Length (amino acid): 402
  • Reference: Godreuil et al. 2003; Pubmed- 12543681

    		• Similar resistance genes in 'BacMet Predicted database'
    lmrS
  • BacMet ID: BAC0535
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus subsp. aureus COL
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: LmrS is an efflux protein capable of extruding multiple and structurally unrelated antimicrobial compounds. It can confer resistance to antobiotics such as linezolid, trimethoprim, chloramphenicol etc.
  • Length (amino acid): 480
  • Reference: Floyd et al 2010; Pubmed- 20855745

    		• Similar resistance genes in 'BacMet Predicted database'
    marA
  • BacMet ID: BAC0560
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 127
  • Reference: Asako et al. 1997; Pubmed- 9097440

    		• Similar resistance genes in 'BacMet Predicted database'
    marR
  • BacMet ID: BAC0561
  • Code for: Regulator
  • Family: Contains 1 HTH marR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 144
  • Reference: Asako et al. 1997; Pubmed- 9097440

    		• Similar resistance genes in 'BacMet Predicted database'
    mco
  • BacMet ID: BAC0205
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co)
  • Description: Multicopper oxidase Mco; Involved in copper homeostasis and oxidative stress response. Oxidizes the substrate 3,3'-dimethoxybenzidine in vitro. Also possesses low levels of phenoloxidase and ferroxidase activities. A transposon-induced mutant showed copper and cobalt sensitivity and H2O2 tolerance.
  • Length (amino acid): 447
  • Reference: Sitthisak et al. 2005; Pubmed- 16151171

    		• Similar resistance genes in 'BacMet Predicted database'
    mctB
  • BacMet ID: BAC0206
  • Code for: Efflux
  • Family: MctB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Pore-forming protein MctB, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence.
  • Length (amino acid): 314
  • Reference: Wolschendorf et al. 2010; Pubmed- 21205886

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mdfA/cmr
  • BacMet ID: BAC0208
  • Code for: Effux
  • Family: Major facilitator Superfamily (MdfA family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, E. coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Hydroxide (NaOH) [class: Base], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug transporter MdfA, Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzylkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. OverExpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na+ or K+; also known as Chloramphenicol resistance pump Cmr
  • Length (amino acid): 410
  • Reference: Edgar et al. 1997; Pubmed- 9079913, Nishino et al. 2001; Pubmed- 11566977, Sulavik et al 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    mdrL/yfmO
  • BacMet ID: BAC0209
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Listeria monocytogenes
  • Location: Chromosome
  • Compound: Zinc (Zn), Cobalt (Cobalt), Chromium (Cr), Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance transporter mdrL/YfmO. It can confer resistance to antibiotics such as erythromycin, josamycin, clindamycin etc.
  • Length (amino acid): 397
  • Reference: Mata et al. 2000; Pubmed- 10856655

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtA
  • BacMet ID: BAC0645
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtA. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 413
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtA/yegM
  • BacMet ID: BAC0210
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtA; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function
  • Length (amino acid): 415
  • Reference: Baranova et al. 2002; Pubmed- 12107134,

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtB
  • BacMet ID: BAC0646
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtB. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 1040
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtB/yegN
  • BacMet ID: BAC0211
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Hydrochloric acid (HCl) [class: Acid]
  • Description: Multidrug resistance protein MdtB; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
  • Length (amino acid): 1040
  • Reference: Deininger et al. 2011; Pubmed- 21541325

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtC
  • BacMet ID: BAC0647
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtC. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 1026
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtC/yegO
  • BacMet ID: BAC0212
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtC; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdABC requires TolC for its function.
  • Length (amino acid): 1025
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Nagakubo et al. 2002; Pubmed- 12107133

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtE/yhiU
  • BacMet ID: BAC0213
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12.
  • Length (amino acid): 385
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtF/yhiV
  • BacMet ID: BAC0214
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC.
  • Length (amino acid): 1037
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtG/yceE
  • BacMet ID: BAC0215
  • Code for: Membrane Transporter
  • Family: MFS superfamily, DHA1 family, MdtG subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtG; Confers resistance to fosfomycin and deoxycholate
  • Length (amino acid): 408
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtI/ydgE
  • BacMet ID: BAC0216
  • Code for: Enzyme
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Spermidine [class: Polyamines]
  • Description: Spermidine export protein MdtI; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS
  • Length (amino acid): 109
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Higashi et al. 2008; Pubmed- 18039771

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtJ/ebrB/ydgF
  • BacMet ID: BAC0217
  • Code for: Enzyme
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Shigella sonnei (strain Ss046)
  • Location: Chromosome
  • Compound: Spermidine [class: Polyamines]
  • Description: Spermidine export protein MdtJ; Catalyzes the excretion of spermidine
  • Length (amino acid): 121
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Higashi et al. 2008; Pubmed- 18039771

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtK/ydhE
  • BacMet ID: BAC0218
  • Code for: Efflux
  • Family: MATE family, MdtK subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein MdtK; It functions as a Na+/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin), tetraphenylphosphonium ion (TPP), deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, Acriflavine, ethidium bromide and benzylkonium
  • Length (amino acid): 457
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtM/yjiO
  • BacMet ID: BAC0219
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtM; Confers resistance to Acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP, tetraphenylarsonium chloride ; part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 410
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtN/yjcR
  • BacMet ID: BAC0220
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtN; Involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 343
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mepB
  • BacMet ID: BAC0222
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump membrane transporter MepB; the inner membrane transporter component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 1050
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

    		• Similar resistance genes in 'BacMet Predicted database'
    mepC
  • BacMet ID: BAC0223
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons] [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump outer membrane protein MepC; the outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 484
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0224
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus cereus R6007
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 631
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0648
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 460
  • Reference: Griffin et al. 1987; Pubmed- 3033633

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0649
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 568
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0650
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 569
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0651
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 547
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0652
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 561
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0653
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 562
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0657
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 212
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0658
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: plasmid pI258
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 216
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0659
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 212
  • Reference: Griffin et al. 1987; Pubmed- 3033633,

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0660
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 219
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0654
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the first mer operon. MerB1, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0663
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1.
  • Length (amino acid): 214
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0655
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the second mer operon. MerB2, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 209
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0661
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 209
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0656
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the third mer operon. MerB3, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0662
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 242
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merC
  • BacMet ID: BAC0664
  • Code for: Membrane Transporter
  • Family: MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerC. This protein is located in the inner membrane and mediates mercury transport into the cytoplasm.
  • Length (amino acid): 141
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merC
  • BacMet ID: BAC0226
  • Code for: Membrane Transporter
  • Family: MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans (Acidithiobacillus ferrooxidans)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerC; Occurs separately from mer operon; encodes for mercury transport system; This protein is located in the inner membrane and mediates mercury transport into the cytoplasm. Additional alternative to merT; commonly found in E. coli, missing in pseudomonas and other gram negative bacteria; found more often in brackish water than fresh water samples still less in marine environments.
  • Length (amino acid): 144
  • Reference: Inoue et al. 1990; Pubmed- 2265748, Wilson et al. 2000; Pubmed- 10781809, Salhman et al. 1997; Pubmed- 9368013

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0665
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 121
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0666
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 121
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0227
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Brown et al. 1986; Pubmed- 3007931

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0667
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Mukhopadhyay et al. 1991; Pubmed- 1917975, Griffin et al. 1987; Pubmed- 3033633, Nucifora et al. 1989; Pubmed- 2691875

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0668
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans CH34
  • Location: Plasmid pMOL28, Plasmid pMOL30
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Champier et al. 2004; Pubmed- 15165248

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0669
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0670
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon.
  • Length (amino acid): 78
  • Reference: Griffin et al. 1987; Pubmed- 3033633

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0671
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE. Part of the first pPB mer operon.
  • Length (amino acid): 78
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0672
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE. Part of the second pPB mer operon.
  • Length (amino acid): 78
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0673
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE.
  • Length (amino acid): 78
  • Reference: Brown et al. 1986; Pubmed- 3007931

    		• Similar resistance genes in 'BacMet Predicted database'
    merF
  • BacMet ID: BAC0228
  • Code for: Membrane Transporter
  • Family: MerF Transpoter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. CT14 
  • Location: Plasmid pMER327/419 (Pseudomonas fluorescens), Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56))
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein F; Additional alternative to merT.
  • Length (amino acid): 81
  • Reference: Wilson et al. 2000; Pubmed- 10781809

    		• Similar resistance genes in 'BacMet Predicted database'
    merG
  • BacMet ID: BAC0229
  • Code for: Membrane Transporter
  • Family: Contains 1 TPR-like helical , 1 Sel1-like repeat
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62), Plasmid pIJB1 (Burkholderia cepacia (Pseudomonas cepacia))
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercuric resistance protein MerG; Known to confer resistance to phenylmercury
  • Length (amino acid): 217
  • Reference: Kiyono et al. 1999; Pubmed- 9922233, Kiyono et al. 1997; Pubmed- 9168120,

    		• Similar resistance genes in 'BacMet Predicted database'
    merH
  • BacMet ID: BAC0230
  • Code for: Enzyme
  • Family: Mercuric Ion Transporter (Mer) superfamily. MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)
  • Location: Plasmid pMM23 (Mycobacterium marinum), Plasmid pMAB (Mycobacterium abscessus (strain ATCC 19977 / DSM 44196))
  • Compound: Mercury (Hg)
  • Description: Mercuric ion transport protein, MerH
  • Length (amino acid): 171
  • Reference: Schue et al. 2009; Pubmed- 18931130, Barkay et al. 2003; Pubmed- 12829275

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0674
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Periplasmic mercuric ion binding protein.
  • Length (amino acid): 92
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0231
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein periplasmic component; hypersensitivity to the mercuric ions are associated with the merP gene; MerP does not act to transport Hg(II) directly. Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (merA) via the merT protein.
  • Length (amino acid): 91
  • Reference: Hamlett et al. 1992; Pubmed- 1328156

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0675
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercury-binding protein. Mercuric transport protein periplasmic component.
  • Length (amino acid): 91
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0676
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury-binding protein. Mercuric transport protein periplasmic component.
  • Length (amino acid): 116
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0677
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein periplasmic component.
  • Length (amino acid): 113
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0678
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 91
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0679
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 91
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0680
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
  • Length (amino acid): 135
  • Reference: Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0232
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1 (Pseudomonas aeruginosa)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory gene whose product is a unique positively acting activator protein that twists and bends the operator DNA region in the presence of Hg++ allowing RNA polymerse to synthesize mRNA.
  • Length (amino acid): 144
  • Reference: Shewchuk et al. 1989; Pubmed- 2551364, Ni'Bhriain et al. 1983; Pubmed- 6307976

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0685
  • Code for: Regulator
  • Family: ArsR/Smt family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 124
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0686
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
  • Length (amino acid): 144
  • Reference: Yu et al. 1994; Pubmed- 8195221, Nucifora et al. 1989; Pubmed- 2666393

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0687
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0689
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 151
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merR1
  • BacMet ID: BAC0682
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 132
  • Reference: Helmann et al. 1989; Pubmed- 2492496

    		• Similar resistance genes in 'BacMet Predicted database'
    merR1
  • BacMet ID: BAC0683
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0681
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury resistance operon negative regulator MerR2
  • Length (amino acid): 129
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0684
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Kiyono et al. 1997; Pubmed- 9168120, Kiyono et al. 1999; Pubmed- 10513611

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0688
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial resistance regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0690
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercuric ion transport protein.
  • Length (amino acid): 116
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0691
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 116
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0692
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 116
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0693
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA).
  • Length (amino acid): 116
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0233
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2, pMER610 (Alcaligenes spp.)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA).
  • Length (amino acid): 116
  • Reference: Hamlett et al. 1992; Pubmed- 1328156, Kiyono et al. 2000; Pubmed- 10726879

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0695
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Inner mebrane protein. Involved in mercuric transport. Passes a mercury ion from the periplasmic MerP protein to the mercuric reductase (MerA).
  • Length (amino acid): 116
  • Reference: Nucifora et al. 1989; Pubmed- 2691875

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0696
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Involved in mercuric transport. Passes a mercury ion from the MerP protein to the mercuric reductase MerA.
  • Length (amino acid): 128
  • Reference: Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0697
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury transport protein
  • Length (amino acid): 98
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merT-P
  • BacMet ID: BAC0694
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: A novel putative transport protein consisting of a fusion between the integral membrane Hg(II) transporter MerT and the periplasmic Hg(II)-binding protein MerP.
  • Length (amino acid): 204
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    mexA
  • BacMet ID: BAC0234
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.
  • Length (amino acid): 383
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexB
  • BacMet ID: BAC0235
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.
  • Length (amino acid): 1046
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexC
  • BacMet ID: BAC0236
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 387
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexD
  • BacMet ID: BAC0237
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 1042
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexE
  • BacMet ID: BAC0238
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas entomophila (strain L48)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 413
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexF
  • BacMet ID: BAC0239
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 1059
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexI
  • BacMet ID: BAC0240
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa 138244
  • Location: Chromosome
  • Compound: Vanadium (V), Triclosan [class: Phenolic compounds]
  • Description: RND Multidrug efflux transporter mexI; Part of mexGHI-ompD efflux pump operon. The efflux pump also involved in N-acyl-homoserine lactones (AHLs) homeostsis in Pseudomonas aeruginosa.
  • Length (amino acid): 1029
  • Reference: Aendekerk et al. 2002; Pubmed- 12177331

    		• Similar resistance genes in 'BacMet Predicted database'
    mexJ
  • BacMet ID: BAC0241
  • Code for: Efflux
  • Family: RND Superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein mexJ; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system
  • Length (amino acid): 367
  • Reference: Chuanchuen et al. 2002; Pubmed- 12193619

    		• Similar resistance genes in 'BacMet Predicted database'
    mexK
  • BacMet ID: BAC0242
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: RND efflux transporter mexK; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system
  • Length (amino acid): 1025
  • Reference: Chuanchuen et al. 2002; Pubmed- 12193619

    		• Similar resistance genes in 'BacMet Predicted database'
    mexR
  • BacMet ID: BAC0243
  • Code for: Regulator
  • Family: RND superfamily, MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Repressor of the mexAB-oprM multidrug resistance operon mexR. Also represses its own Expression. Many variants lead to increased Expression of the mexAB-oprM operon
  • Length (amino acid): 147
  • Reference: Poole et al. 1996; Pubmed- 8878574

    		• Similar resistance genes in 'BacMet Predicted database'
    mexT
  • BacMet ID: BAC0244
  • Code for: Regulator
  • Family: Contains 1 HTH lysR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Transcriptional regulator MexT; the regulator of the MexEF-OprN efflux operon
  • Length (amino acid): 304
  • Reference: Kohler et al. 1999; Pubmed- 10515918

    		• Similar resistance genes in 'BacMet Predicted database'
    mexV
  • BacMet ID: BAC0245
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein mexV; part of mexVW-oprM efflux system
  • Length (amino acid): 376
  • Reference: Li et al. 2003: Pubmed- 12951344

    		• Similar resistance genes in 'BacMet Predicted database'
    mexW
  • BacMet ID: BAC0246
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux transporter mexW; part of mexVW-oprM efflux system
  • Length (amino acid): 1018
  • Reference: Li et al. 2003: Pubmed- 12951344

    		• Similar resistance genes in 'BacMet Predicted database'
    mexX
  • BacMet ID: BAC0247
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux transporter mexX; E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system
  • Length (amino acid): 389
  • Reference: Mine et al. 1999, Pubmed- 9925549

    		• Similar resistance genes in 'BacMet Predicted database'
    mexY
  • BacMet ID: BAC0248
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux transporter mexY; E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system
  • Length (amino acid): 1046
  • Reference: Mine et al. 1999, Pubmed- 9925549

    		• Similar resistance genes in 'BacMet Predicted database'
    mgtA
  • BacMet ID: BAC0642
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: Mediates magnesium influx to the cytosol.
  • Length (amino acid): 902
  • Reference: Tao et al. 1995; Pubmed- 7751273

    		• Similar resistance genes in 'BacMet Predicted database'
    mgtA
  • BacMet ID: BAC0087
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cobalt (Co), Magnesium (Mg)
  • Description: Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol.
  • Length (amino acid): 898
  • Reference: Park et al. 1976; Pubmed- 780341, Minagawa et al. 2003; Pubmed- 12813061,

    		• Similar resistance genes in 'BacMet Predicted database'
    mmco
  • BacMet ID: BAC0480
  • Code for: Enzyme
  • Family: Multicopper oxidase (mco) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Mmco is required for copper resistance in Mycobacterium tuberculosis. It acts by oxidation of toxic Cu(I) in the periplasm.
  • Length (amino acid): 504
  • Reference: Rowland et al. 2013; Pubmed- 23772064

    		• Similar resistance genes in 'BacMet Predicted database'
    mmR
  • BacMet ID: BAC0249
  • Code for: Efflux
  • Family: SMR family, mmr subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene]
  • Description: Multidrug efflux pump mmR. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y.
  • Length (amino acid): 107
  • Reference: Rossi et al. 1998; Pubmed- 9811672

    		• Similar resistance genes in 'BacMet Predicted database'
    mntA/ytgA
  • BacMet ID: BAC0250
  • Code for: Binding protein
  • Family: Bacterial solute-binding protein 9 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Manganese (Mn), Cadmium (Cd)
  • Description: Manganese-binding lipoprotein MntA; This protein is a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. May be the major manganese uptake system during sporulation
  • Length (amino acid): 306
  • Reference: Hao et al. 1999; Pubmed- 10543781, Que et al. 2000; Pubmed- 10760146

    		• Similar resistance genes in 'BacMet Predicted database'
    mntH/yfeP
  • BacMet ID: BAC0251
  • Code for: Membrane Transporter
  • Family: NRAMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cadmium (Cd), Cobalt (Co), Zinc (Zn)
  • Description: Divalent metal cation transporter MntH; H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.
  • Length (amino acid): 412
  • Reference: Makui et al. 2000; Pubmed- 10712688

    		• Similar resistance genes in 'BacMet Predicted database'
    mntP/yebN
  • BacMet ID: BAC0252
  • Code for: Efflux
  • Family: MntP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli K-12
  • Location: Chromosome
  • Compound: Manganese (Mn), Magnesium (Mg), Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: MntP; Functions as a manganese efflux pump
  • Length (amino acid): 188
  • Reference: Li et al. 2011; Pubmed- 21789199, Waters et al. 2011; Pubmed- 21908668

    		• Similar resistance genes in 'BacMet Predicted database'
    mntR
  • BacMet ID: BAC0253
  • Code for: Regulator
  • Family: Contains 1 HTH dtxR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Chromosome
  • Compound: Manganese (Mn), Magnesium (Mg)
  • Description: Manganese transport regulator mntR; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP
  • Length (amino acid): 155
  • Reference: Waters et al. 2011; Pubmed- 21908668, Que et al. 2000; Pubmed- 10760146

    		• Similar resistance genes in 'BacMet Predicted database'
    modA
  • BacMet ID: BAC0598
  • Code for: Binding protein
  • Family: ABC superfamily, bacterial solute-binding protein ModA family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Desulfovibrio vulgaris Hildenborough (strain GZ6027)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdenum ABC transporter, periplasmic molybdenum-binding protein. Part of the ModABC transport system.
  • Length (amino acid): 269
  • Reference: Kazarov et al. 2013; Pubmed- 23913324

    		• Similar resistance genes in 'BacMet Predicted database'
    modA
  • BacMet ID: BAC0609
  • Code for: Binding protein
  • Family: ABC superfamily, bacterial solute-binding protein ModA family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdate-binding periplasmic protein. Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity.
  • Length (amino acid): 257
  • Reference: Rech et al. 1995; Pubmed- 7860583, Walkenhorst et al. 1995; Pubmed- 8564363

    		• Similar resistance genes in 'BacMet Predicted database'
    modB
  • BacMet ID: BAC0599
  • Code for: Enzyme
  • Family: ABC superfamily, binding-protein-dependent transport system permease family. CysTW subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Desulfovibrio vulgaris Hildenborough (strain GZ6027)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdenum ABC transporter, permease protein. Part of the ModABC transport system. Responsible for the translocation of the substrate across the membrane. modB gene encodes the integral membrane protein ModB, which builds the membrane channel of the ModABC transporter.
  • Length (amino acid): 233
  • Reference: Kazarov et al. 2013; Pubmed- 23913324

    		• Similar resistance genes in 'BacMet Predicted database'
    modB
  • BacMet ID: BAC0610
  • Code for: Enzyme
  • Family: ABC superfamily, binding-protein-dependent transport system permease family. CysTW subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdenum transport system permease protein ModB. Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 229
  • Reference: Rech et al. 1995; Pubmed- 7860583, Walkenhorst et al. 1995; Pubmed- 8564363

    		• Similar resistance genes in 'BacMet Predicted database'
    modC
  • BacMet ID: BAC0600
  • Code for: Enzyme
  • Family: ABC superfamily, Molybdate importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Desulfovibrio vulgaris Hildenborough (strain GZ6027)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdenum ABC transporter, ATPase subunit of the ModABC complex. Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 253
  • Reference: Kazarov et al. 2013; Pubmed- 23913324

    		• Similar resistance genes in 'BacMet Predicted database'
    modC
  • BacMet ID: BAC0611
  • Code for: Enzyme
  • Family: ABC transporter superfamily. Molybdate importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdenum import ATP-binding protein ModC. Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 352
  • Reference: Rech et al. 1995; Pubmed- 7860583, Walkenhorst et al. 1995; Pubmed- 8564363

    		• Similar resistance genes in 'BacMet Predicted database'
    modE
  • BacMet ID: BAC0608
  • Code for: Regulator
  • Family: ModE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Transcriptional regulator ModE. The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. It controls tungstate and molybdate homeostasis in bacteria.
  • Length (amino acid): 262
  • Reference: Rech et al. 1995; Pubmed- 7860583, Walkenhorst et al. 1995; Pubmed- 8564363, Grunden et al. 1996; Pubmed- 8550508

    		• Similar resistance genes in 'BacMet Predicted database'
    mrdH
  • BacMet ID: BAC0254
  • Code for: Membrane Transporter
  • Family: NicO family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Membrane protein transpoeter mrdH
  • Length (amino acid): 377
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mreA
  • BacMet ID: BAC0255
  • Code for: Regulator
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Chromosome
  • Compound: Nickel (Ni), Zinc (Zn)
  • Description: Metal-sensitive repressor mreA, involved in resistance to metal ions. Bind nickel or zinc ions via conserved cysteine and histidine residues. In the absence of metal ions, this protein bind to promoter regions and repress transcription
  • Length (amino acid): 95
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrA
  • BacMet ID: BAC0256
  • Code for: Regulator
  • Family: AraC/XylS family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Two component sensory transduction transcriptional regulatory protein MtrA; play an important role in enhancing transcription of the mtrCDE operon
  • Length (amino acid): 301
  • Reference: Rouquette et al. 1999; Pubmed- 10417654

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrC
  • BacMet ID: BAC0257
  • Code for: Efflux
  • Family: MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: Membrane fusion protein MtrC; part of MtrCDE efflux pump; Cell membrane lipoprotein, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents
  • Length (amino acid): 412
  • Reference: Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176, Veal et al. 1998; Pubmed- 9534233

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrD
  • BacMet ID: BAC0258
  • Code for: Efflux
  • Family: AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Antibiotic resistance efflux pump component mtrD; part of MtrCDE efflux pump
  • Length (amino acid): 1067
  • Reference: Veal et al. 1998; Pubmed- 9534233, Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrE
  • BacMet ID: BAC0259
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain NCCP11945)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid]
  • Description: Antibiotic resistance efflux pump component ; Outer membrane protein mtrE; part of MtrCDE efflux pump
  • Length (amino acid): 467
  • Reference: Delahay et al. 1997; Pubmed- 9245802, Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrF
  • BacMet ID: BAC0260
  • Code for: Efflux
  • Family: ABG ransporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain NCCP11945)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol]
  • Description: Antibiotic resistance efflux pump component mtrF; inner membrane protein
  • Length (amino acid): 533
  • Reference: Veal et al. 2003; Pubmed- 12493784, Folster et al. 2006; Pubmed- 15901695

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrR
  • BacMet ID: BAC0261
  • Code for: Regulator
  • Family: TetR (tetracycline resistance) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: HTH-type transcriptional regulator MtrR; Repressor of the mtrC gene. the major repressor of mtrCDE expression; Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents
  • Length (amino acid): 210
  • Reference: Pan et al. 1994; Pubmed- 8196548, Hagman et al. 1995; Pubmed- 7711899

    		• Similar resistance genes in 'BacMet Predicted database'
    mymT
  • BacMet ID: BAC0262
  • Code for: Binding protein
  • Family: Metallothionein superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu), Nickel (Ni), Zinc (Zn)
  • Description: Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese.
  • Length (amino acid): 53
  • Reference: Gold et al. 2011; Pubmed- 18724363, Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    nccA
  • BacMet ID: BAC0549
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.
  • Length (amino acid): 1076
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccB
  • BacMet ID: BAC0550
  • Code for: Efflux
  • Family: RND superfamily, Membrane Fusion Protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 397
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccC
  • BacMet ID: BAC0551
  • Code for: Efflux
  • Family: RND superfamily, Outer Membrane factor (OMF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 437
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccH
  • BacMet ID: BAC0555
  • Code for: Regulator
  • Family: Sigma-70 factor family. ECF subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium.
  • Length (amino acid): 186
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccN
  • BacMet ID: BAC0554
  • Code for: Membrane Transporter
  • Family: Contains 1 Phospholipid methyltransferase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport.
  • Length (amino acid): 213
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccX
  • BacMet ID: BAC0553
  • Code for: Regulator
  • Family: contains 1 heavy-metal resistance domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 148
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    nccY
  • BacMet ID: BAC0552
  • Code for: Regulator
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxidans 31A
  • Location: Plasmid pTOM9
  • Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)
  • Description: Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.
  • Length (amino acid): 95
  • Reference: Schmidt et al. 1994; Pubmed- 7961470

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0263
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant determinant ncrA found both in chromosome and plasmids. Part of ncrABCY nickel resistance Chromosomal determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrC.
  • Length (amino acid): 432
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0698
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Part of the ncrABC determinant sytem. NcrA contributes to nickel and cobalt resistance in this bacterium.
  • Length (amino acid): 432
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrA
  • BacMet ID: BAC0702
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrA protein. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 277
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0264
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant determinant ncrB which is cytoplasmic, histidine-rich protein found in both chromosome and plasmids; probabale metal-sensitive repressor, involved in resistance to nickel ions
  • Length (amino acid): 89
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0699
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 89
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrB
  • BacMet ID: BAC0703
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrB protein. Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.
  • Length (amino acid): 301
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0265
  • Code for: Efflux
  • Family: NicOT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel-resistant membrane protein NcrC found both in chromosome and plasmids. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 376
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0700
  • Code for: Efflux
  • Family: Nickel-cobalt transport (NicOT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens strain C-1
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 231
  • Reference: Marrero et al. 2007; Pubmed- 17186148

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrC
  • BacMet ID: BAC0704
  • Code for: Efflux
  • Family: Nickel-cobalt transport (NicOT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne ncrC protein. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.
  • Length (amino acid): 152
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrY
  • BacMet ID: BAC0266
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leptospirillum ferriphilum
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosoaml nickel-resistant determinant ncrY found both in chromosome and plasmids; some claims it has a negative effect on nickel resistance.
  • Length (amino acid): 140
  • Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010

    		• Similar resistance genes in 'BacMet Predicted database'
    ncrY
  • BacMet ID: BAC0701
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Hafnia alvei 5-5
  • Location: Plasmid pNRS148
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Plasmid-borne NcrY protein. Part of ncrABCY nickel resistance determinant system. Some claims it has a negative effect on nickel resistance.
  • Length (amino acid): 63
  • Reference: Park et al. 2004; Pubmed- 15179604

    		• Similar resistance genes in 'BacMet Predicted database'
    nczA
  • BacMet ID: BAC0267
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Caulobacter crescentus (strain NA1000 / CB15N)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co), Zinc (Zn)
  • Description: Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+
  • Length (amino acid): 1057
  • Reference: Valencia et al. 2013; Pubmed- 23578014

    		• Similar resistance genes in 'BacMet Predicted database'
    nfsA
  • BacMet ID: BAC0540
  • Code for: Enzyme
  • Family: Flavin oxidoreductase frp family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli K12
  • Location: Chromosome
  • Compound: Chromium (Cr)
  • Description: A major oxygen-insensitive nitroreductase of Escherichia coli, is a flavoprotein that is able to reduce chromate to less soluble and less toxic Cr(III). Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen-insensitive nitroreductase activity in E.coli.
  • Length (amino acid): 240
  • Reference: Ackerley et al. 2004; Pubmed- 15250887

    		• Similar resistance genes in 'BacMet Predicted database'
    nhlF
  • BacMet ID: BAC0268
  • Code for: Enzyme
  • Family: Nickel-cobalt transport (NicOT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodococcus rhodochrous
  • Location: Chromosome
  • Compound: Cobalt (Co)
  • Description: Cobalt transporter nhlF. It has a significant sequence similarity to hoxN from Alcaligenes eutrophus, hupN from Bradyrhizobium japonicum, nixA from Helicobacter pylori etc. The protein has eight hydrophobic putative membrane-spanning domains.
  • Length (amino acid): 352
  • Reference: Komeda et al. 1997; Pubmed- 8990157

    		• Similar resistance genes in 'BacMet Predicted database'
    nia
  • BacMet ID: BAC0269
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium melitoli
  • Location: Plasmid pSymA (Sinorhizobium melitoli)
  • Compound: Iron (Fe), Nickel (Ni)
  • Description: P1B-5-ATPase; Has role in detoxification of Fe (II)+ and Ni (II)+ under free living conditions as well as in symbiosis.
  • Length (amino acid): 799
  • Reference: Zielazinski et al. 2013; Pubmed- 24056637

    		• Similar resistance genes in 'BacMet Predicted database'
    nikA
  • BacMet ID: BAC0270
  • Code for: Binding protein
  • Family: Bacterial solute-binding protein 5 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel-binding periplasmic protein nikA; Involved in a nickel transport system, represents the nickel binder. Part of the Nik operon (NikABCDE), Solute-binding protein
  • Length (amino acid): 524
  • Reference: Wu et al. 1991; Pubmed- 1743519, De Pina et al. 1995; Pubmed- 7867647

    		• Similar resistance genes in 'BacMet Predicted database'
    nikB
  • BacMet ID: BAC0271
  • Code for: Membrane Transporter
  • Family: Binding-protein-dependent transport system permease family. OppBC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel transport system permease protein NikB; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 314
  • Reference: Wu et al. 1991; Pubmed- 1743519, Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikC
  • BacMet ID: BAC0272
  • Code for: Membrane Transporter
  • Family: Binding-protein-dependent transport system permease family. OppBC subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel transport system permease protein NikC; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 277
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikD
  • BacMet ID: BAC0273
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Nickel importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel import ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Part of the Nik operon (NikABCDE)
  • Length (amino acid): 254
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikE
  • BacMet ID: BAC0274
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Nickel importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel import ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 268
  • Reference: Navarro et al. 1993; Pubmed- 7934931

    		• Similar resistance genes in 'BacMet Predicted database'
    nikR
  • BacMet ID: BAC0275
  • Code for: Regulator
  • Family: Transcriptional regulatory CopG/NikR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Nickel-responsive regulator nikR; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.
  • Length (amino acid): 133
  • Reference: De Pina et al. 1999; Pubmed- 9882686, Contreras et al. 2003; Pubmed- 12890020

    		• Similar resistance genes in 'BacMet Predicted database'
    nirA
  • BacMet ID: BAC0276
  • Code for: Membrane Transporter
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirA. C-terminal of the nirA protien contains a histidine rich region tat might possess high affinity to nickel.
  • Length (amino acid): 356
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirB
  • BacMet ID: BAC0277
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirB. It has 98% amino acid sequence similarity to chromosomal ncrB.
  • Length (amino acid): 89
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirC
  • BacMet ID: BAC0278
  • Code for: Membrane Transporter
  • Family: NicO transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirC. It is a memebrane protein like ABC-type transport proteins and also possess a histidine rich region with high affinity for nickel binding.
  • Length (amino acid): 307
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nirD
  • BacMet ID: BAC0279
  • Code for: Regulator
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella oxytoca
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Chromosomal nickel resistance determinant nirD; has 75% amino acid sequence similarity to chromomosomal ncrY.
  • Length (amino acid): 164
  • Reference: Park et al. 2008; Pubmed- 18600044

    		• Similar resistance genes in 'BacMet Predicted database'
    nixA
  • BacMet ID: BAC0280
  • Code for: Enzyme
  • Family: NiCo transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
  • Location: Plasmid pRHL2 (Rhodococcus sp. (strain RHA1))
  • Compound: Nickel (Ni)
  • Description: High-affinity nickel intake protein nixA. Imports nickel ions in an energy-dependent fashion. Necessary for the Expression of catalytically active urease.
  • Length (amino acid): 331
  • Reference: Mobley et al. 1995; Pubmed- 7651142

    		• Similar resistance genes in 'BacMet Predicted database'
    nmtR
  • BacMet ID: BAC0281
  • Code for: Regulator
  • Family: ArsR-SmtB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Nickel (Ni), Cadmium (Cd), Lead (Pb)
  • Description: Represses transcription of ctpJ/nmtA, by binding to its promoter region
  • Length (amino acid): 120
  • Reference: Cavet et al. 2002; Pubmed- 12163508

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    norB
  • BacMet ID: BAC0283
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain MW2)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norB, Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds By similarity. Can facilitate bacterial survival in vivo when overexpressed in an abscess and may contribute to the relative resistance of staphylococcal abscesses to antimicrobial therapy
  • Length (amino acid): 463
  • Reference: Ding et al. 2008; Pubmed- 18723624

    		• Similar resistance genes in 'BacMet Predicted database'
    norM/pmpM
  • BacMet ID: BAC0284
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, N. gonorrhoeae, N. meningitidis, Burkholderia vietnamiensis
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein NorM, inner cell-membrane, Multidrug efflux pump. Confers probably resistance to the cationic peptide polymyxin B (PMB).
  • Length (amino acid): 462
  • Reference: Fehlner-Gardiner et al. 2002; Pubmed- 1239904

    		• Similar resistance genes in 'BacMet Predicted database'
    nreB
  • BacMet ID: BAC0285
  • Code for: Enzyme
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acromobacter xylosoxidans 31A, Synechocystis spp.
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Cobalt (Co), Nickel (Ni)
  • Description: Nickel resistance protein nreB (also known as nrsD or entS); nickel permease involved in nickel and cobalt tolerance. The histidine-rich C-terminal region of the nreB is not essential but contributes to maximal Ni(II) resistance.
  • Length (amino acid): 416
  • Reference: Grass et al. 2001; Pubmed- 11292799

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsA
  • BacMet ID: BAC0286
  • Code for: Membrane Transporter
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Cation or drug efflux system protein nrsA
  • Length (amino acid): 1054
  • Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsD/nreB
  • BacMet ID: BAC0287
  • Code for: Enzyme
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter calcoaceticus (strain PHEA-2), Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: nrsD gene encodes a Ni(II) permease whose carboxy-terminal region is a metal binding domain; nickel permease involved in nickel and cobalt tolerance
  • Length (amino acid): 445
  • Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsR
  • BacMet ID: BAC0288
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / GT-S)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: OmpR subfamily protein NrsR/RppA/Rre33
  • Length (amino acid): 234
  • Reference: Lopez-Maury et al. 2002; Pubmed- 11849552

    		• Similar resistance genes in 'BacMet Predicted database'
    nrsS
  • BacMet ID: BAC0289
  • Code for: Enzyme
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / GT-S)
  • Location: Chromosome
  • Compound: Nickel (Ni)
  • Description: Sensory transduction histidine kinase NrsS/RppB/Hik30
  • Length (amino acid): 454
  • Reference: Lopez-Maury et al. 2002; Pubmed- 11849552

    		• Similar resistance genes in 'BacMet Predicted database'
    opmD/nmpC
  • BacMet ID: BAC0290
  • Code for: Porin
  • Family: Gram-negative porin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat]
  • Description: Outer membrane porin protein OmpD; Forms pores that allow passive diffusion of small molecules across the outer membrane
  • Length (amino acid): 362
  • Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834

    		• Similar resistance genes in 'BacMet Predicted database'
    oprJ
  • BacMet ID: BAC0291
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon.
  • Length (amino acid): 479
  • Reference: Li et al. 1998; Pubmed- 9603892, Poole et al. 1996; Pubmed- 8878035

    		• Similar resistance genes in 'BacMet Predicted database'
    oprM/oprK
  • BacMet ID: BAC0292
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter
  • Length (amino acid): 485
  • Reference: Li et al. 1995; Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    oprN
  • BacMet ID: BAC0562
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa.
  • Length (amino acid): 472
  • Reference: Li et al. 1998; Pubmed- 9603892, Kohler et al. 1997; Pubmed- 9044268

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxA
  • BacMet ID: BAC0294
  • Code for: Enzyme
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid p0LA52 (E. coli), Plasmid pGDGK3 (Klebsiella pneumoniae)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxA; part of oqxAB efflux system, can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 391
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxB
  • BacMet ID: BAC0295
  • Code for: Enzyme
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pOLA52 (E. coli),
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxB; part of the oqxAB efflux system; can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 1050
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    oscA
  • BacMet ID: BAC0358
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr), Dodine [class: Acetate]
  • Description: oscA gene involved in the sulphur starvation response and in Cr(VI) resistance in Pseudomonas corrugata 28. oscA is located upstream of a gene cluster that encodes the components of the sulphate ABC transporter, and it forms a single transcriptional unit with sbp, which encodes the periplasmic sulphate-binding protein. It has been shown that oscA is essential for the utilization of various organosulphur compounds and that it induces upregulation of the cysTWA operon under conditions of chromate exposure. oscA may also have a regulatory role in the sulphur starvation response, but the exact mechanism through which it acts is not well understood.
  • Length (amino acid): 60
  • Reference: Viti et al. 2009; Pubmed- 19118350

    		• Similar resistance genes in 'BacMet Predicted database'
    ostA/lptD
  • BacMet ID: BAC0296
  • Code for: Porin
  • Family: LptD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane]
  • Description: Organic solvent tolerance protein ostA/lptD; Together with LptE, is involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis
  • Length (amino acid): 784
  • Reference: Aono et al. 1994; Pubmed- 7811102

    		• Similar resistance genes in 'BacMet Predicted database'
    oxyRkp
  • BacMet ID: BAC0536
  • Code for: Regulator
  • Family: LysR-family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Sodium Deoxycholate (SDC) [class: Acid], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Activator of hydrogen peroxide-inducible genes. It has contributory role towards varied stress tolerance in K. pneumoniae.
  • Length (amino acid): 305
  • Reference: Srinivasan et al. 2013; Pubmed- 23619002

    		• Similar resistance genes in 'BacMet Predicted database'
    PA0320
  • BacMet ID: BAC0297
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species
  • Length (amino acid): 116
  • Reference: Fukushima et al. 2012; Pubmed- 22990488

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrA
  • BacMet ID: BAC0298
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Lead (Pb)
  • Description: pbrA, a P-type ATPase (involved in efflux); involved in Pb(II) resistance; part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 799
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrB/pbrC
  • BacMet ID: BAC0299
  • Code for: Enzyme
  • Family: Peptidase A8 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Lead (Pb)
  • Description: Lipoprotein signal peptidase 3 (pbrB); a predicted integral membrane protein and a putative signal peptidase (involved in efflux); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 358
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrD
  • BacMet ID: BAC0300
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))
  • Compound: Lead (Pb)
  • Description: PbrD, Pb(II) binding protein involved in Pb(II) resistance; a intracellular Pb binding protein (involved in Pb++ accumulation); function as a chaperone for Pb(II) or involved in Pb(II) sequestration ; PbrD is not absolutely required for Pb(II) resistance, but cells lacking PbrD show a decreased accumulation of Pb(II); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II)
  • Length (amino acid): 289
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrR
  • BacMet ID: BAC0301
  • Code for: Regulator
  • Family: MerR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Herbaspirillum seropedicae (strain SmR1)
  • Location: Plasmid pLVPK (Klebsiella pneumoniae), Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839))
  • Compound: Lead (Pb)
  • Description: A transcription factor, pbrR belonging to the merR family
  • Length (amino acid): 150
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pbrT
  • BacMet ID: BAC0302
  • Code for: Membrane Transporter
  • Family: Contains 1 cytochrome C domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes xylosoxydans xylosoxydans
  • Location: Plasmid pA81
  • Compound: Lead (Pb)
  • Description: A lead (Pb++) uptake protein PbrT
  • Length (amino acid): 630
  • Reference: Borremans et al. 2001; Pubmed- 11544228

    		• Similar resistance genes in 'BacMet Predicted database'
    pcm
  • BacMet ID: BAC0506
  • Code for: Enzyme
  • Family: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Acriflavine [class: Acridine]
  • Description: Protein-L-isoaspartate O-methyltransferase. pcm and tolCsm genes form an operon. pcm deletion affects on the expression of tolCsm. pcm alone makes little contribution to resistance.
  • Length (amino acid): 215
  • Reference: Huang et al. 2013; Pubmed- 23629016

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoA
  • BacMet ID: BAC0303
  • Code for: Enzyme
  • Family: Multi-copper oxidase family (CopA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoA; required for the copper-inducible expression of copper resistance. May have oxidase activity; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 605
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoB
  • BacMet ID: BAC0304
  • Code for: Enzyme
  • Family: CopB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoB; required for the copper-inducible expression of copper resistance; located in cell outer membrane; it's peripheral membrane protein
  • Length (amino acid): 296
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoC
  • BacMet ID: BAC0305
  • Code for: Binding protein
  • Family: CopC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein PcoC; required for the copper-inducible expression of copper resistance; located in periplasm; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 126
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoD
  • BacMet ID: BAC0306
  • Code for: Membrane Transporter
  • Family: CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 309
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoE
  • BacMet ID: BAC0307
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu), Silver (Ag)
  • Description: Copper-binding protein PcoE; lies distal, downstram from the regulatory genes (gene order in the operon- pcoABCDRSE); Required for the copper-inducible Expression of copper resistance. Activated by the two-component regulatory system CusS/CusR; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 144
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoR
  • BacMet ID: BAC0308
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Transcriptional regulatory protein PcoR; member of a two-component regulatory system pcoS/pcoR. Involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box). part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 226
  • Reference: Rouch & Brown. 1997; Pubmed- 9141682

    		• Similar resistance genes in 'BacMet Predicted database'
    pcoS
  • BacMet ID: BAC0309
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pRJ1004
  • Compound: Copper (Cu)
  • Description: Sensor protein PcoS; member of a two-component regulatory system PcoS/PcoR. Activate PcoR by phosphorylation; part of the copper resistance determinant system (pcoABCDRSE)
  • Length (amino acid): 466
  • Reference: Brown et al. 1995; Pubmed- 8594334

    		• Similar resistance genes in 'BacMet Predicted database'
    pdrM
  • BacMet ID: BAC0481
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus pneumoniae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine]
  • Description: It is a Na(+)/drug antiporter in Streptococcus pneumoniae
  • Length (amino acid): 453
  • Reference: Hashimoto et al. 2013; Pubmed- 23555691

    		• Similar resistance genes in 'BacMet Predicted database'
    perO
  • BacMet ID: BAC0612
  • Code for: Enzyme
  • Family: ArsB/NhaD permeases family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter capsulatus
  • Location: Chromosome
  • Compound: Molybdenum (Mo), Tungsten (W), Vanadium (V)
  • Description: PerO is involved in molybdate uptake. In addition to importing molybdate, PerO probably importssulfate, tungstate, and vanadate.
  • Length (amino acid): 595
  • Reference: Gisin et al. 2010; Pubmed- 20851900

    		• Similar resistance genes in 'BacMet Predicted database'
    perR
  • BacMet ID: BAC0310
  • Code for: Regulator
  • Family: Fur family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain NCTC 8325)
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Peroxide-responsive repressor PerR; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection
  • Length (amino acid): 148
  • Reference: Horsburgh et al. 2001; Pubmed- 11349039

    		• Similar resistance genes in 'BacMet Predicted database'
    pfr
  • BacMet ID: BAC0497
  • Code for: Binding protein
  • Family: Ferritin family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori
  • Location: Chromosome
  • Compound: Iron (Fe), Copper (Cu), Manganese (Mn)
  • Description: pfr gene encodes ferritin protein. Has role in iron metabolism of H. pylori. Binding and sequestration of metals by Pfr is not specific for iron. Iron resistance mediated by ferritin might be important for survival of the pathogen within its natural habitat, where it is faced with iron and other metals which originate from the diet.
  • Length (amino acid): 167
  • Reference: Bereswill et al. 1998; Pubmed- 9782498

    		• Similar resistance genes in 'BacMet Predicted database'
    pgpA/ltpgpA
  • BacMet ID: BAC0311
  • Code for: Enzyme
  • Family: ABC transporter superfamily. ABCB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Leishmania tarentolae (Sauroleishmania tarentolae)
  • Location: Chromosome
  • Compound: Arsenic (As), Antimony (Sb)
  • Description: Multidrug resistance protein PgpA
  • Length (amino acid): 1548
  • Reference: Papadopoulou et al. 1994; Pubmed- 7909316, Callahan et al. 1994; Pubmed- 7891738

    		• Similar resistance genes in 'BacMet Predicted database'
    phoB
  • BacMet ID: BAC0530
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges. (NB: THIS GENE IS MORE LIKELY TO BE 'PhoP' THOUGH AUTHORS MENTIONED IT AS 'PhoB'. THE SYSTEM MIGHT BE 'PhoPQ' INSTEAD OF 'PhoBR'.)
  • Length (amino acid): 237
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    phoR
  • BacMet ID: BAC0531
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges.
  • Length (amino acid): 488
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    pitA
  • BacMet ID: BAC0312
  • Code for: Porter
  • Family: Inorganic-Phospahte Transporter (PiT) family, Pit subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tellurium (Te)
  • Description: Low-affinity inorganic phosphate transporter 1, PitA; Can also transport arsenate
  • Length (amino acid): 499
  • Reference: Elias et al. 2012; Pubmed- 23189244, Willsky & Malamy 1980; Pubmed- 6998959, Beard et al. 2000; Pubmed- 10713426

    		• Similar resistance genes in 'BacMet Predicted database'
    pmpM
  • BacMet ID: BAC0313
  • Code for: Efflux
  • Family: Member of the MATE family of transporters
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein PmpM, Multidrug efflux pump that functions as an H+/drug antiporter. Confers resistance to benzylkonium chloride (BAC), fluoroquinolones, ethidium bromide, Acriflavine and tetraphenylphosphonium chloride.
  • Length (amino acid): 477
  • Reference: He et al. 2004; Pubmed- 14679249

    		• Similar resistance genes in 'BacMet Predicted database'
    pmrA
  • BacMet ID: BAC0314
  • Code for: Efflux
  • Family: Major facilitator superfamily. TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine]
  • Description: Multi-drug resistance efflux pump PmrA; Efflux pump for various substrates. It is associated with fluoroquinolone resistance in Streptococcus pneumoniae.
  • Length (amino acid): 399
  • Reference: Gill et al. 1999; Pubmed- 9869592

    		• Similar resistance genes in 'BacMet Predicted database'
    pmrA
  • BacMet ID: BAC0487
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Erwinia carotovora ssp. Carotovora
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. It is involved in controlling of bacterial response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments. Unphosphorylated PmrA represses extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves such repression, which leads to activation of extracellular enzyme genes. Phosphorylated PmrA seems to repress expression of the pmrCAB operon.
  • Length (amino acid): 222
  • Reference: Hyytiainen et al. 2003; Pubmed- 14617142; Wosten et al. 2000; Pubmed- 11051552

    		• Similar resistance genes in 'BacMet Predicted database'
    pmrB
  • BacMet ID: BAC0488
  • Code for: Regulator
  • Family: Contains a sensor kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Erwinia carotovora ssp. Carotovora
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PmrA in response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments.
  • Length (amino acid): 364
  • Reference: Hyytiainen et al. 2003; Pubmed- 14617142, Wosten et al. 2000; Pubmed- 1105155

    		• Similar resistance genes in 'BacMet Predicted database'
    pmrC
  • BacMet ID: BAC0485
  • Code for: Membrane protein
  • Family: Contains 1 sulfatase, 1 DUF1705 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Putative cytoplasmic membrane protein pmrC. PmrA-activated pmrC gene is required for Fe(III) resistance.
  • Length (amino acid): 548
  • Reference: Nishino et al. 2006; Pubmed- 16803591, Hyytiainen et al. 2003; Pubmed- 14617142

    		• Similar resistance genes in 'BacMet Predicted database'
    pmrG
  • BacMet ID: BAC0486
  • Code for: Enzyme
  • Family: Phosphoglycerate mutase family. Ais subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: It is a phodphatase and catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core and localizes to the periplasm. Required for iron(III)+ resistance.
  • Length (amino acid): 201
  • Reference: Nishino et al. 2006; Pubmed- 16803591

    		• Similar resistance genes in 'BacMet Predicted database'
    pstA
  • BacMet ID: BAC0315
  • Code for: Enzyme
  • Family: binding-protein-dependent transport system permease family. CysTW subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: An integral membrane protein. Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 296
  • Reference: Willsky et al. 1980; Pubmed- 6998959, Willsky et al. 1980; Pubmed- 6998957, Surin et al. 1985; Pubmed- 3881386

    		• Similar resistance genes in 'BacMet Predicted database'
    pstB
  • BacMet ID: BAC0316
  • Code for: Enzyme
  • Family: ABC transporter superfamily. Phospahte importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: Phosphate transporting ATPase; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 257
  • Reference: Willsky et al. 1980; Pubmed- 6998959, Willsky et al. 1980; Pubmed- 6998957, Surin et al. 1985; Pubmed- 3881386

    		• Similar resistance genes in 'BacMet Predicted database'
    pstC
  • BacMet ID: BAC0317
  • Code for: Enzyme
  • Family: Binding-protein-dependent transport system permease family. CysTW subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: An integral membrane permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 319
  • Reference: Willsky et al. 1980; Pubmed- 6998959, Willsky et al. 1980; Pubmed- 6998957, Surin et al. 1985; Pubmed- 3881386

    		• Similar resistance genes in 'BacMet Predicted database'
    pstS
  • BacMet ID: BAC0318
  • Code for: Binding protein
  • Family: PstS family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Arsenic (As)
  • Description: A periplasmic phosphate binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import.
  • Length (amino acid): 346
  • Reference: Willsky et al. 1980; Pubmed- 6998959, Willsky et al. 1980; Pubmed- 6998957, Surin et al. 1984; Pubmed- 6321434

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacB
  • BacMet ID: BAC0320
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid pTZ2162 (S. Aureus)
  • Compound: Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones]
  • Description: Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Alam et al. (2003), Pubmed- 12820795, Nakaminami, H. et al. (2008); Littlejon et al. 1992; Pubmed- 1526458, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacC/qacD/smr
  • BacMet ID: BAC0321
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pTZ20, pWBG32, pTZ22, pKH8
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein QacC (also called as QacD or smr); Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide. It confers resistance to toxic organic cations via proton-dependent export.
  • Length (amino acid): 107
  • Reference: Paulsen et al. 1995; Pubmed- 7751293, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacE
  • BacMet ID: BAC0322
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa
  • Location: Plasmid IncP-beta R751 (E. coli), Plasmid IncP-beta R751 (Enterobacter aerogenes)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein qacE, Multidrug exporter. It is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
  • Length (amino acid): 110
  • Reference: Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacF
  • BacMet ID: BAC0324
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, E. aerogenes, E. cloacae
  • Location: Plasmid pIP833 (E. aerogenes)
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein qacF, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds
  • Length (amino acid): 110
  • Reference: Ploy et al. 1998; Pubmed- 9756755

    		• Similar resistance genes in 'BacMet Predicted database'
    qacG
  • BacMet ID: BAC0325
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: both gram +ve (s. aureus) and gram -ve (p.aeruginosa, A. salmonicida)
  • Location: Plasmid pST94 (Staphylococcus spp.)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: Quaternary ammonium compound-resistance protein qacG, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds
  • Length (amino acid): 107
  • Reference: Heir et al. 1997; Pubmed- 10196743

    		• Similar resistance genes in 'BacMet Predicted database'
    qacH/qacI
  • BacMet ID: BAC0326
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram +ve, Staphylococcus aureus
  • Location: Plasmid pST2H6 ( Staphylococcus saprophyticus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine]
  • Description: Quaternary ammonium compound-resistance protein qacH (also known as qacI), Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
  • Length (amino acid): 107
  • Reference: Heir et al. 1998; Pubmed- 9631545

    		• Similar resistance genes in 'BacMet Predicted database'
    qacJ
  • BacMet ID: BAC0327
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram +ve, Staphylococcus spp.
  • Location: Plasmid pNVH01(S. aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein QacJ
  • Length (amino acid): 107
  • Reference: Bjorland et al. 2003; Pubmed- 14506007

    		• Similar resistance genes in 'BacMet Predicted database'
    qacR
  • BacMet ID: BAC0328
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pSK1 (S. aureus)
  • Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]
  • Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
  • Length (amino acid): 188
  • Reference: Grkovic et al. 1998; Pubmed- 9660841

    		• Similar resistance genes in 'BacMet Predicted database'
    qacZ
  • BacMet ID: BAC0329
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus faecalis (strain ATCC 700802 / V583)
  • Location: Plasmid pTEF1
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance transporter qacZ; qacZ gene in tolerance to the quaternary ammonium compound benzylkonium chloride, but not ethidium bromide or chlorhexidine.
  • Length (amino acid): 107
  • Reference: Braga et al. 2011: Pubmed- 21147826

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnA/yohM
  • BacMet ID: BAC0330
  • Code for: Efflux
  • Family: NicO transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni), Iron (Fe)
  • Description: Efflux system rcnA for nickel and cobalt; Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcription
  • Length (amino acid): 274
  • Reference: Rodrigue et al. 2005; Pubmed- 15805538, Koch et al. 2007; Pubmed- 17120142

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnB/yohN
  • BacMet ID: BAC0331
  • Code for: Efflux
  • Family: RcnB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co)
  • Description: Nickel/cobalt homeostasis protein RcnB; Act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. Repressed by RcnR. Induced by nickel and cobalt
  • Length (amino acid): 112
  • Reference: Bleriot et al. 2011; Pubmed- 21665978

    		• Similar resistance genes in 'BacMet Predicted database'
    rcnR/yohL
  • BacMet ID: BAC0332
  • Code for: Regulator
  • Family: FrmR/RcnR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cobalt (Co), Nickel (Ni), Iron (Fe)
  • Description: Repressor of rcnA, rcnR. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Can repress the rcnB expression as well.
  • Length (amino acid): 90
  • Reference: Koch et al. 2007; Pubmed- 17120142

    		• Similar resistance genes in 'BacMet Predicted database'
    recG
  • BacMet ID: BAC0356
  • Code for: Enzyme
  • Family: Contains 1 DEAD/DEAH box helicase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa PAO1
  • Location: Chromosome
  • Compound: Chromium (Cr), Tellurium (Te), Selenium (Se)
  • Description: ATP-dependent DNA helicase RecG. It is involved in repairing DNA damage caused by chromate or its derivatives. Can confer resistant to tellurite, selenite but not arsenite, paraquat or hydrogen peroxide.
  • Length (amino acid): 691
  • Reference: Miranda et al. 2005; Pubmed- 16105671, Decorosi et al. 2009; Pubmed- 19768364

    		• Similar resistance genes in 'BacMet Predicted database'
    recG
  • BacMet ID: BAC0357
  • Code for: Enzyme
  • Family: Contains 1 DEAD/DEAH box helicase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr)
  • Description: fragment of the recG helicase.
  • Length (amino acid): 156
  • Reference: Decorosi et al. 2009; Pubmed- 19768364

    		• Similar resistance genes in 'BacMet Predicted database'
    ricR
  • BacMet ID: BAC0333
  • Code for: Regulator
  • Family: Transcriptional repressor metal family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis H37Rv
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Copper repressor ricR
  • Length (amino acid): 96
  • Reference: Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

    		• Similar resistance genes in 'BacMet Predicted database'
    rpoS
  • BacMet ID: BAC0335
  • Code for: Regulator
  • Family: sigma-70 factor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli, Shigella flexneri
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Sodium hydroxide (NaOH) [class: Base]
  • Description: RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RpoS is required for optimal maintenance of pH homeostasis of stationary phase cells exposed to extreme acid.
  • Length (amino acid): 330
  • Reference: Small et al. 1994; Pubmed- 8132468

    		• Similar resistance genes in 'BacMet Predicted database'
    ruvB
  • BacMet ID: BAC0355
  • Code for: Enzyme
  • Family: RuvB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa PAO1
  • Location: Chromosome
  • Compound: Chromium (Cr), Tellurium (Te), Selenium (Se)
  • Description: ATP-dependent DNA helicase RuvB. It is involved in repairing DNA damage caused by chromate or its derivatives. Can confer resistant to tellurite, selenite but not arsenite, paraquat or hydrogen peroxide.
  • Length (amino acid): 352
  • Reference: Miranda et al. 2005; Pubmed- 16105671, Decorosi et al. 2009; Pubmed- 19768364

    		• Similar resistance genes in 'BacMet Predicted database'
    ruvB
  • BacMet ID: BAC0293
  • Code for: Enzyme
  • Family: Malic enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr), Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dodine [class: Acetate], 2-nitroimidazole [class: imidazole]
  • Description: It is a fragment of ruvB gene product. It is a oxidoreductase from malic enzyme family.
  • Length (amino acid): 379
  • Reference: Decorosi et al. 2009; Pubmed- 19768364

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeA
  • BacMet ID: BAC0336
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Legionella longbeachae D-4968
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance secretion protein SdeA; part of the sdeAB-tolC efflux system
  • Length (amino acid): 336
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2002; Pubmed- 12356807, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeB
  • BacMet ID: BAC0337
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. marcescens
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein SdeB; part of the sdeAB-tolC efflux system
  • Length (amino acid): 1047
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeX
  • BacMet ID: BAC0338
  • Code for: Efflux
  • Family: RND superfmaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeX 
  • Length (amino acid): 393
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeY
  • BacMet ID: BAC0339
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeY
  • Length (amino acid): 1051
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sepA
  • BacMet ID: BAC0340
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug resistance efflux pump sepA; Involved in multidrug efflux. Confers low level resistance to drugs such as Acriflavine, benzylkonium chloride (BAC), chlorhexidine gluconate and ethidium bromide
  • Length (amino acid): 382
  • Reference: Narui et al. 2002; Pubmed- 12499635

    		• Similar resistance genes in 'BacMet Predicted database'
    silA
  • BacMet ID: BAC0341
  • Code for: Efflux
  • Family: AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilA is a inner membrane chemiosmotic, cation/proton antiporter; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 1048
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silB
  • BacMet ID: BAC0342
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilB, a membrane fusion protein that brings together the inner and outer membranes of Gram-negative bacteria; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 430
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silC
  • BacMet ID: BAC0343
  • Code for: Efflux
  • Family: Outer Membrane Protein (OMP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: SilC is an outer membrane lipoprotein; Component of the sil cation-efflux system (silABC) that confers resistance to silver
  • Length (amino acid): 461
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silE
  • BacMet ID: BAC0344
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: Component of the sil cation-efflux system that confers resistance to silver; it also can participate in resistance to Ag+ individually
  • Length (amino acid): 143
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silF
  • BacMet ID: BAC0345
  • Code for: Chaperone
  • Family: Contains a CusF domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: Silver efflux system periplasmic chaperone; It is a small gene resides in between SilC and SilB of SilCFBA(ORF105)P operon; It carries Ag+ from its periplasmic site of release by SilP to the periplasmic uptake site of SilA, as part of the SilCBA complex
  • Length (amino acid): 96
  • Reference: Gupta et al. 1999; Pubmed- 9930866, Silver et al. 2006; Pubmed- 16761169

    		• Similar resistance genes in 'BacMet Predicted database'
    silP
  • BacMet ID: BAC0346
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family (Type IB subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium), Plasmid pLVPK (Klebsiella pneumoniae)
  • Compound: Silver (Ag)
  • Description: Silver exporting P-type ATPase silP; Component of the sil cation-efflux system that confers resistance to silver; silP can participate in resistance to Ag+ individually; located in cell membrane.
  • Length (amino acid): 824
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silR
  • BacMet ID: BAC0347
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: silR encodes an transcriptional regulator; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR.
  • Length (amino acid): 228
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    silS
  • BacMet ID: BAC0348
  • Code for: Regulator
  • Family: Contains 1 HAMP domain and 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Plasmid pMG101 (Salmonella typhimurium)
  • Compound: Silver (Ag)
  • Description: silS encodes a membrane sensor kinase; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR. May activate SilR by phosphorylation
  • Length (amino acid): 497
  • Reference: Gupta et al. 1999; Pubmed- 9930866

    		• Similar resistance genes in 'BacMet Predicted database'
    sitA
  • BacMet ID: BAC0349
  • Code for: Binding protein
  • Family: ABC superfamily ( bacterial solute-binding protein 9 family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O45:K1 (strain S88 / ExPEC)
  • Location: Plasmid pECOS88 (Escherichia coli O45:K1 (strain S88 / ExPEC)), Plasmid pCVM29188_146 (Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188)
  • Compound: Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Iron/Mn transport protein, periplasmic-binding protein SitA; sitA gene encodes a periplasmic binding protein
  • Length (amino acid): 305
  • Reference: Kehres et al. 2002; Pubmed- 12029031, Sabri et al. 2006; Pubmed- 16514154

    		• Similar resistance genes in 'BacMet Predicted database'
    sitB
  • BacMet ID: BAC0350
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain SMS-3-5 / SECEC)
  • Location: Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pCS0010A (Salmonella enterica subsp. enterica serovar Kentucky)
  • Compound: Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: sitB encodes an ATP-binding protein
  • Length (amino acid): 273
  • Reference: Kehres et al. 2002; Pubmed- 12029031, Sabri et al. 2006; Pubmed- 16514154

    		• Similar resistance genes in 'BacMet Predicted database'
    sitC
  • BacMet ID: BAC0351
  • Code for: Enzyme
  • Family: ABC superfamily ( ABC-3 integral membrane protein family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain SMS-3-5 / SECEC)
  • Location: Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: sitC encodes a permease (integral membrane protein); part of the sitABCD transport system
  • Length (amino acid): 286
  • Reference: Kehres et al. 2002; Pubmed- 12029031, Sabri et al. 2006; Pubmed- 16514154

    		• Similar resistance genes in 'BacMet Predicted database'
    sitD
  • BacMet ID: BAC0352
  • Code for: Enzyme
  • Family: ABC superfamily ( ABC-3 integral membrane protein family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain SMS-3-5 / SECEC
  • Location: Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: sitD encode a permease (integral membrane protein); part of the sitABCD transport system
  • Length (amino acid): 282
  • Reference: Kehres et al. 2002; Pubmed- 12029031, Sabri et al. 2006; Pubmed- 16514154

    		• Similar resistance genes in 'BacMet Predicted database'
    smdA
  • BacMet ID: BAC0353
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdA
  • Length (amino acid): 591
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smdB
  • BacMet ID: BAC0354
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdB
  • Length (amino acid): 592
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smeD
  • BacMet ID: BAC0358
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Membrane fusion protein of RND family multidrug efflux pump smeD; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 394
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeE
  • BacMet ID: BAC0359
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: RND efflux system, inner membrane transporter smeE; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 1040
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeF
  • BacMet ID: BAC0360
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Multidrug resistance outer membrane protein smeF; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 466
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeT
  • BacMet ID: BAC0362
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: SmeT repressor protein for the the multidrug efflux system smeDEF
  • Length (amino acid): 219
  • Reference: Sanchez et al. 2002; Pubmed- 12384340, Hernandez et al. 2011; Pubmed- 21738470

    		• Similar resistance genes in 'BacMet Predicted database'
    smfY
  • BacMet ID: BAC0363
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump SmfY
  • Length (amino acid): 490
  • Reference: Shahcheraghi et al. 2007; Pubmed- 17409524

    		• Similar resistance genes in 'BacMet Predicted database'
    smrA
  • BacMet ID: BAC0364
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine]
  • Description: ABC-type multidrug efflux pump protein SmrA
  • Length (amino acid): 610
  • Reference: Al-Hamad et al. 2009; Pubmed- 19643774

    		• Similar resistance genes in 'BacMet Predicted database'
    smtA
  • BacMet ID: BAC0365
  • Code for: Binding protein
  • Family: Metallothionein superfamily. Type 14 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)); Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Mercury (Hg)
  • Description: Metallothionein SmtA; Contain 9 cysteine residues; plays a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions. Metallothioneins have a high content of cysteine residues that bind various heavy metals. Cells that lack of metallothionein have reduced uptake of Zn++ and reduced tolerance to high Zn++ concentrations (althogh the Cu++ and Hg++ tolerances are unchanged); often Cd++ resistant when cells grow in high level of Cd++.
  • Length (amino acid): 56
  • Reference: Shi et al. 1992, Pubmed- 1607014

    		• Similar resistance genes in 'BacMet Predicted database'
    smtB/ziaR
  • BacMet ID: BAC0366
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2))
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Repressor protein smtB; regulates the metallothionein synthesis in transcrition level negatively; its a helix-turn-helix protein in the same family of arsR and cadC; binds at imperfect inverted repeat TGAAACA-GT-TATTCA between the transcription initiation site and the ribosome binding site for smtA; Transcriptional repressor of the Expression of the smtA gene. Binds two zinc ions per dimer. The complex of DNA and smtB is dissociated by zinc ions.
  • Length (amino acid): 122
  • Reference: Huckle et al. 1993; Pubmed- 8446025

    		• Similar resistance genes in 'BacMet Predicted database'
    smvA/emrB
  • BacMet ID: BAC0367
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine.
  • Length (amino acid): 495
  • Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834, Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    sodA
  • BacMet ID: BAC0368
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli K12
  • Location: Chromosome
  • Compound: Selenium (Se), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Mn-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Length (amino acid): 206
  • Reference: Bebien et al. 2002; Pubmed- 11872706

    		• Similar resistance genes in 'BacMet Predicted database'
    sodA
  • BacMet ID: BAC0705
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Mn-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Length (amino acid): 203
  • Reference: Hassett et al. 1993; Pubmed- 8244935

    		• Similar resistance genes in 'BacMet Predicted database'
    sodB
  • BacMet ID: BAC0706
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Fe-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Length (amino acid): 193
  • Reference: Hassett et al. 1993; Pubmed- 8244935

    		• Similar resistance genes in 'BacMet Predicted database'
    sodB
  • BacMet ID: BAC0707
  • Code for: Enzyme
  • Family: Iron/manganese superoxide dismutase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli K12
  • Location: Chromosome
  • Compound: Selenium (Se), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Fe-dependent superoxide dismutase. Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • Length (amino acid): 193
  • Reference: Bebien et al. 2002; Pubmed- 11872706

    		• Similar resistance genes in 'BacMet Predicted database'
    soxR
  • BacMet ID: BAC0370
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat]
  • Description: Redox-sensitive transcriptional activator SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.
  • Length (amino acid): 154
  • Reference: Nakajima et al. 1995; Pubmed- 7670195, Wu et al. 1991; Pubmed- 1708380

    		• Similar resistance genes in 'BacMet Predicted database'
    soxS
  • BacMet ID: BAC0371
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cyclohexane [class: Cycloalkane]
  • Description: Regulatory protein SoxS; Increases the Zn uptake system znuACB; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.
  • Length (amino acid): 107
  • Reference: Nakajima et al. 1995; Pubmed- 7670195, Warner et al. 2012; Pubmed- 22210763

    		• Similar resistance genes in 'BacMet Predicted database'
    srpA
  • BacMet ID: BAC0372
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump periplasmic linker SrpA; a component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon Expression level.
  • Length (amino acid): 382
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpB
  • BacMet ID: BAC0373
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant pump membrane transporter SrpB; The inner membrane transporter component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 1049
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpC
  • BacMet ID: BAC0374
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump outer membrane protein SrpC; The outer membrane component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 470
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

    		• Similar resistance genes in 'BacMet Predicted database'
    srpC
  • BacMet ID: BAC0152
  • Code for: Efflux
  • Family: Chromate Ion Transporter (CHR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechococcus elongatus strain PCC 7942 (Anacystis nidulans R2)
  • Location: Plasmid pANL
  • Compound: Chromium (Cr)
  • Description: A homologue of chrA. SrpC is not a sulfate transporter. Functions as a transporter that extrudes chromate ions from cytoplasm under sulfur-deficient conditions.
  • Length (amino acid): 393
  • Reference: Aguilar-Barajas et al. 2012; Pubmed- 22805806

    		• Similar resistance genes in 'BacMet Predicted database'
    srpR
  • BacMet ID: BAC0375
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpR; In conjunction with SrpS represses the srpABC operon.
  • Length (amino acid): 213
  • Reference: Sun et al. 2011; Pubmed- 21441510

    		• Similar resistance genes in 'BacMet Predicted database'
    srpS
  • BacMet ID: BAC0376
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpS; In conjunction with SrpR represses the srpABC operon.
  • Length (amino acid): 259
  • Reference: Sun et al. 2011; Pubmed- 21441510

    		• Similar resistance genes in 'BacMet Predicted database'
    ssmE
  • BacMet ID: BAC0377
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Chlorhexidine [class: Biguanides]
  • Description: Multidrug efflux pump SsmE
  • Length (amino acid): 110
  • Reference: Minato et al. 2008; Pubmed- 18310921

    		• Similar resistance genes in 'BacMet Predicted database'
    sugE
  • BacMet ID: BAC0378
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family (SugE subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram -ve, Escherichia coli
  • Location: Plasmid IncN p541 (Escherichia coli), Plasmid pIW759 (Salmonella typhimurium)
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], and Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Quaternary ammonium compound-resistance protein sugE, Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.
  • Length (amino acid): 105
  • Reference: Chung et al. 2002; Pubmed- 11948170, He et al. 2011; Pubmed- 21576447

    		• Similar resistance genes in 'BacMet Predicted database'
    tbtA
  • BacMet ID: BAC0379
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri (Pseudomonas perfectomarina)
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Tributyltin chloride resistance membrane fusion protein TbtA; has 4 characteristic motifs A, B, C and D; part of the tbtABM efflux system
  • Length (amino acid): 382
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

    		• Similar resistance genes in 'BacMet Predicted database'
    tbtB
  • BacMet ID: BAC0380
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri (Pseudomonas perfectomarina)
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Resistance nodulation cell division family member TbtB; Aanalogous to proton dependent efflux pump belonging to RND family; part of the tbtABM efflux system
  • Length (amino acid): 1046
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

    		• Similar resistance genes in 'BacMet Predicted database'
    tbtM
  • BacMet ID: BAC0381
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Outer membrane protein TbtM, part of the tbtABM efflux system
  • Length (amino acid): 476
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

    		• Similar resistance genes in 'BacMet Predicted database'
    tbtR
  • BacMet ID: BAC0382
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri 
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Efflux pump regulator; a potential regulatory gene of tbtABM, named tbtR, is identified upstream of the operon; TbtR exhibited many similarities with other repressors of the RND efflux systems
  • Length (amino acid): 259
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

    		• Similar resistance genes in 'BacMet Predicted database'
    tcrB
  • BacMet ID: BAC0383
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Enterococcus faecium (Streptococcus faecium)
  • Location: Plasmid pA17sv1 (Enterococcus faecium),
  • Compound: Copper (Cu)
  • Description: The transferable, plasmid-localized Copper resistance efflux ATPase, TcrB
  • Length (amino acid): 710
  • Reference: Hasman te al. 2002; Pubmed- 11959576, Hasman et al. 2005; Pubmed- 16151212

    		• Similar resistance genes in 'BacMet Predicted database'
    tehA
  • BacMet ID: BAC0384
  • Code for: Membrane Transporter
  • Family: Tellurite-resistance/dicarboxylate transporter (TDT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tellurium (Te), Proflavin [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat]
  • Description: Tellurite resistance protein TehA; The gene encodes an integral membrane protein. Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance, otherwise phenotypically silent
  • Length (amino acid): 330
  • Reference: Walter et al 1991; Pubmed- 2060788, Taylor et al. 1994; Pubmed- 8169225, Turner et al. 1997; Pubmed- 9021204

    		• Similar resistance genes in 'BacMet Predicted database'
    tehB
  • BacMet ID: BAC0385
  • Code for: Enzyme
  • Family: TehB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tellurium (Te), Proflavin [class: Acridine]
  • Description: S-adenosyl-L-methionine dependent methyltransferase tehB that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds
  • Length (amino acid): 197
  • Reference: Walter et al 1991; Pubmed- 2060788, Taylor et al. 1994; Pubmed- 8169225

    		• Similar resistance genes in 'BacMet Predicted database'
    terA
  • BacMet ID: BAC0386
  • Code for: Unknown
  • Family: TerA famiy
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pK2044 (Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044)
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerA; Response to tellurium ion
  • Length (amino acid): 339
  • Reference: Jobling et al. 1988; Pubmed- 3049247, Hill et al. 1993; Pubmed- 8232205

    		• Similar resistance genes in 'BacMet Predicted database'
    terB
  • BacMet ID: BAC0387
  • Code for: unknown
  • Family: TerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pPag2 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerB; terBCDE genes are essential for the resistance
  • Length (amino acid): 122
  • Reference: Kormutakova et al. 2000; Pubmed- 11016400

    		• Similar resistance genes in 'BacMet Predicted database'
    terC
  • BacMet ID: BAC0388
  • Code for: Membrane Transporter
  • Family: TerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pK2044 (Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 )
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerC; Could conceivably alter the intracellular level of tellurium in a manner leading to resistance. Alternatively its presence in the membrane may provide a barrier to entry of the tellurium ions.
  • Length (amino acid): 346
  • Reference: Whelan et al. 1995; Pubmed- 7665479, Kormutakova et al. 2000; Pubmed- 11016400

    		• Similar resistance genes in 'BacMet Predicted database'
    terD
  • BacMet ID: BAC0389
  • Code for: Unknown
  • Family: CAPAB/TerDEXZ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae)
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerD; Contribute to the tellurium resistance (Ter) mechanism.
  • Length (amino acid): 192
  • Reference: Whelan et al. 1995; Pubmed- 7665479, Kormutakova et al. 2000; Pubmed- 11016400

    		• Similar resistance genes in 'BacMet Predicted database'
    terE
  • BacMet ID: BAC0390
  • Code for: Unknown
  • Family: CAPAB/TerDEXZ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid IncHI2 R478 (Serratia marcescens)
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerE; Contribute to the tellurium resistance (Ter) mechanism
  • Length (amino acid): 191
  • Reference: Kormutakova et al. 2000; Pubmed- 11016400

    		• Similar resistance genes in 'BacMet Predicted database'
    terW
  • BacMet ID: BAC0391
  • Code for: Regulator
  • Family: Tellurite/Phi/PacB toxicity protection, TerW family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. Marcescens
  • Location: Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae), Plasmid pEC-IMP (Enterobacter cloacae)
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerW; ter operon (terZABCDE) is naturally controlled by the terW gene product
  • Length (amino acid): 155
  • Reference: Vavrova et al. 2006; Pubmed- 16937251, Valkovicova et al. 2011; DOI: 10.2478/s11756-011-0075-5

    		• Similar resistance genes in 'BacMet Predicted database'
    terZ
  • BacMet ID: BAC0392
  • Code for: Unknown
  • Family: CAPAB/TerDEXZ family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. Marcescens
  • Location: Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae)
  • Compound: Tellurium (Te)
  • Description: Tellurium resistance protein TerZ; Contribute to the tellurium resistance (Ter) mechanism. Also involved in phage inhibition (Phi) and colicin resistance (PacB).
  • Length (amino acid): 193
  • Reference: Whelan et al. 1995; Pubmed- 7665479

    		• Similar resistance genes in 'BacMet Predicted database'
    tolC
  • BacMet ID: BAC0393
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone]
  • Description: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump.
  • Length (amino acid): 493
  • Reference: Hackett et al. 1983; Pubmed- 6312426, Fralick et al. 1996; Pubmed- 8824631, Sulavik et al. 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    tolCsm
  • BacMet ID: BAC0507
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat], Plumbagin [class: Naphthoquinone], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide], Menadione [class: Naphthoquinone]
  • Description: Outer membrane protein. pcm and tolCsm genes form an operon. A significant feature of TolCsm different from that of other tolC homologues of Enterobacteriaceae is that tolCsm is not transcribed alone, but is transcribed with the pcm gene.
  • Length (amino acid): 452
  • Reference: Huang et al. 2013; Pubmed- 23629016

    		• Similar resistance genes in 'BacMet Predicted database'
    trgA
  • BacMet ID: BAC0394
  • Code for: Membrane Transporter
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)
  • Location: Chromosome
  • Compound: Tellurium (Te)
  • Description: Tellurite resistance protein TrgA; Confers tellurite resistance; membrane associated protein; Together with TrgB, it forms an operon; trgA gene alone does not encode resistance.
  • Length (amino acid): 146
  • Reference: O'Gara et al. 1997; Pubmed- 9406390

    		• Similar resistance genes in 'BacMet Predicted database'
    trgB
  • BacMet ID: BAC0395
  • Code for: Enzyme
  • Family: Nudix hydrolase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhodobacterales bacterium Y4I, Rhodobacter capsulatus
  • Location: Chromosome
  • Compound: Tellurium (Te), Copper (Cu)
  • Description: Tellurite resistance protein TrgB; Together with TrgA, it forms an operon
  • Length (amino acid): 361
  • Reference: O'Gara et al. 1997; Pubmed- 9406390, Rademacher et al. 2012; Pubmed- 22767205

    		• Similar resistance genes in 'BacMet Predicted database'
    triA
  • BacMet ID: BAC0396
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid pCROD2 (Citrobacter rodentium (strain ICC168))
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriA; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 205
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
    triB
  • BacMet ID: BAC0397
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica)
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriB; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 97
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
    triC
  • BacMet ID: BAC0398
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica)
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux transporter triC; Part of the TriABC-opmH triclosan efflux pump system; TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 915
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
    troA
  • BacMet ID: BAC0399
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Periplasmic zinc-binding protein TroA; encodes the solute binding protein (SBP), Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane.
  • Length (amino acid): 308
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troB
  • BacMet ID: BAC0400
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system ATP-binding protein TroB; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc
  • Length (amino acid): 266
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troC
  • BacMet ID: BAC0401
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system membrane protein TroC; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc
  • Length (amino acid): 298
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troD
  • BacMet ID: BAC0402
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system membrane protein TroD; Part of an ATP-driven transport system TroABCD for zinc.
  • Length (amino acid): 367
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troR
  • BacMet ID: BAC0403
  • Code for: Repressor
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: An iron activated repressor protein TroR of the troABCD transport system
  • Length (amino acid): 153
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgA
  • BacMet ID: BAC0404
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump periplasmic linker protein TtgA; The periplasmic linker protein component of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 384
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgB
  • BacMet ID: BAC0405
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The inner membrane transporter component, ttgB of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 1050
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgC
  • BacMet ID: BAC0406
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The outer membrane component ttgC of a constitutive organic solvent efflux system ttgABC. Is involved in Export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 484
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgD
  • BacMet ID: BAC0407
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The periplasmic linker protein component, ttgD of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux
  • Length (amino acid): 382
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgE
  • BacMet ID: BAC0408
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The inner membrane transporter component, ttgE of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.
  • Length (amino acid): 1046
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgF
  • BacMet ID: BAC0409
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: The outer membrane component, ttgF of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.
  • Length (amino acid): 480
  • Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgG
  • BacMet ID: BAC0410
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The periplasmic linker component ttgG, of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.
  • Length (amino acid): 391
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgH
  • BacMet ID: BAC0411
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The inner membrane transporter component, ttgH of an organic solvent efflux pump ttgGHI. Involved in Export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics
  • Length (amino acid): 1049
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgI
  • BacMet ID: BAC0412
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The outer membrane component, ttgI of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.
  • Length (amino acid): 470
  • Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgR
  • BacMet ID: BAC0413
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump ttgABC operon repressor ttgR; Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.
  • Length (amino acid): 210
  • Reference: Duque et al. 2001; Pubmed- 11251828, Teran et al. 2003; Pubmed- 14506010, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgT
  • BacMet ID: BAC0414
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: Regulator of the ttgDEF efflux pump ttgT; Can regulate the ttgDEF system expression in ttgV-deficient condition; effect of TtgT on ttgGHI Expression is not obvious when TtgV is present but becomes relevant in its absence
  • Length (amino acid): 260
  • Reference: Teran et al. 2007; Pubmed- 17986203, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgV
  • BacMet ID: BAC0415
  • Code for: Regulator
  • Family: Isocitrate lyase regulator (IclR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: HTH-type transcriptional regulator TtgV; Represses the expression of the ttgGHI and ttgVW operons. Binds to the ttgGHI / ttgVW intergenic region, probably preventing binding of RNA polymerase; ttgV dissociates from this region in the presence of 1-hexanol, can regulate the ttgDEF expression as well; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin
  • Length (amino acid): 259
  • Reference: Teran et al. 2007; Pubmed- 17986203, Rojas et al. 2003; Pubmed- 12896994, Rodriguez-Herva et al. 2007; Pubmed- 17504492

    		• Similar resistance genes in 'BacMet Predicted database'
    ttgW
  • BacMet ID: BAC0416
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]
  • Description: HTH-type transcriptional regulator TtgW; does not seem to be involved in regulation of the ttgGHI or ttgVW operons; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin
  • Length (amino acid): 134
  • Reference: Rojas et al. 2003; Pubmed- 12896994, Fernandes et al. 2003; Pubmed- 13678823

    		• Similar resistance genes in 'BacMet Predicted database'
    tunR
  • BacMet ID: BAC0601
  • Code for: Regulator
  • Family: TunR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Desulfovibrio vulgaris Hildenborough (strain GZ6027)
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Tungstate-responsive regulator, TunR. It controls tungstate and molybdate homeostasis in sulfate-reducing deltaproteobacteria. TunR functions as an activator of the modA, modBC, and tunR genes in the absence of tungstate and repressed by tungstate. Regulates the ModABC transport system in Desulfovibrio spp.
  • Length (amino acid): 403
  • Reference: Kazarov et al. 2013; Pubmed- 23913324

    		• Similar resistance genes in 'BacMet Predicted database'
    tupA
  • BacMet ID: BAC0605
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Eubacterium acidaminophilum
  • Location: Chromosome
  • Compound: Tungsten (W)
  • Description: Extracellular tungstate binding protein.
  • Length (amino acid): 286
  • Reference: Makdessi et al. 2001; Pubmed- 11292832

    		• Similar resistance genes in 'BacMet Predicted database'
    tupB
  • BacMet ID: BAC0606
  • Code for: Enzyme
  • Family: ABC superfamily, binding-protein-dependent transport system permease family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Eubacterium acidaminophilum
  • Location: Chromosome
  • Compound: Tungsten (W)
  • Description: Permease component of tungstate ABC transporter. TupB is an inner membrane protein.
  • Length (amino acid): 228
  • Reference: Makdessi et al. 2001; Pubmed- 11292832

    		• Similar resistance genes in 'BacMet Predicted database'
    tupC
  • BacMet ID: BAC0607
  • Code for: Enzyme
  • Family: ABC superfamily, ATPase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Eubacterium acidaminophilum
  • Location: Chromosome
  • Compound: Tungsten (W)
  • Description: ATPase component of tungstate ABC transporter.
  • Length (amino acid): 214
  • Reference: Makdessi et al. 2001; Pubmed- 11292832

    		• Similar resistance genes in 'BacMet Predicted database'
    vcaM
  • BacMet ID: BAC0417
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acridine Orange [class: Acridine]
  • Description: ABC transporter, ATP-binding protein VcaM; Inner membrane protein
  • Length (amino acid): 619
  • Reference: Huda et al. 2003; Pubmed- 12878498

    		• Similar resistance genes in 'BacMet Predicted database'
    vceA
  • BacMet ID: BAC0418
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC
  • Length (amino acid): 395
  • Reference: Colmer et al. 1998; Pubmed- 9466256

    		• Similar resistance genes in 'BacMet Predicted database'
    vceB
  • BacMet ID: BAC0419
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC
  • Length (amino acid): 511
  • Reference: Colmer et al. 1998; Pubmed- 9466256

    		• Similar resistance genes in 'BacMet Predicted database'
    vceC
  • BacMet ID: BAC0420
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Alpha-helical hairpin domain of Vibrio cholerae VceA play important roles in recognition/specificity/recruitment in the assembly of a functional, VceAB-OprM chimeric efflux pump
  • Length (amino acid): 484
  • Reference: Woolley et al. 2005; Pubmed- 16030246, Bai et al. 2010; Pubmed- 20206171

    		• Similar resistance genes in 'BacMet Predicted database'
    vceR
  • BacMet ID: BAC0421
  • Code for: Regulator
  • Family: TetR (tetracycline resistance) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Repressor of the vceCAB operon, VceR; VceR regulates the VceCAB drug efflux pump operon by alternating between mutually exclusive conformations that bind either drugs or promoter DNA
  • Length (amino acid): 200
  • Reference: Woolley et al. 2005; Pubmed- 16030246, Borges-Walmsley et al. 2005; Pubmed- 15890203

    		• Similar resistance genes in 'BacMet Predicted database'
    vcmA
  • BacMet ID: BAC0422
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio chloerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Acriflavine [class: Acridine]
  • Description: Multidrug efflux pump vcmA that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium bromide, 4',6'-diamidino-2-phenylindole and Acriflavine
  • Length (amino acid): 457
  • Reference: Huda et al. 2001; Punmed: 11583854

    		• Similar resistance genes in 'BacMet Predicted database'
    vcrM
  • BacMet ID: BAC0423
  • Code for: Efflux
  • Family: MATE family, DinF-subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae non-O1
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: A Na+/drug antiporter-type multidrug efflux pump vcrM
  • Length (amino acid): 445
  • Reference: Huda et al. 2002; Pubmed- 12906102

    		• Similar resistance genes in 'BacMet Predicted database'
    vexA
  • BacMet ID: BAC0527
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. Works as VexAB-TolC efflux system.
  • Length (amino acid): 368
  • Reference: Bina et al. 2006; Pubmed- 16804679

    		• Similar resistance genes in 'BacMet Predicted database'
    vexB
  • BacMet ID: BAC0424
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: Multidrug efflux transporter VexB. The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. A double mutant of vexAB and vexCD showed a marked increase in deoxycholate susceptibility, whereas no significant change in deoxycholate susceptibility was observed in vexAB or vexCD single-deletion mutants.
  • Length (amino acid): 1036
  • Reference: Bina et al. 2006; Pubmed- 16804679, Bina et al. 2008; Pubmed- 18490456, Rahman et al. 2007; Pubmed- 18037783

    		• Similar resistance genes in 'BacMet Predicted database'
    vexC
  • BacMet ID: BAC0528
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: The function of vexCD efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps.
  • Length (amino acid): 364
  • Reference: Bina et al. 2006; Pubmed- 16804679, Bina et al. 2008; Pubmed- 18490456; Rahman et al. 2007; Pubmed- 18037783

    		• Similar resistance genes in 'BacMet Predicted database'
    vexD
  • BacMet ID: BAC0425
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug efflux transporter VexD. The function of vexCD efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. A double mutant of vexAB and vexCD showed a marked increase in deoxycholate susceptibility, whereas no significant change in deoxycholate susceptibility was observed in vexAB or vexCD single-deletion mutants.
  • Length (amino acid): 1016
  • Reference: Bina et al. 2006; Pubmed- 16804679, Bina et al. 2008; Pubmed- 18490456; Rahman et al. 2007; Pubmed- 18037783

    		• Similar resistance genes in 'BacMet Predicted database'
    vexE
  • BacMet ID: BAC0426
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae 2740-80
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug efflux transporter VexE; part of the vexEF-tolC efflux system; The function of vexEF efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. VexEF-TolC mediates resistance to various antimicrobials; ethidium efflux is Na+-dependent
  • Length (amino acid): 366
  • Reference: Rahman et al. 2007; Pubmed- 18037783, Bina et al. 2008; Pubmed- 18490456

    		• Similar resistance genes in 'BacMet Predicted database'
    vexF
  • BacMet ID: BAC0427
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae 2740-80
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug efflux transporter VexF; part of the vexEF-tolC efflux system; The function of vexEF efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. VexEF-TolC mediates resistance to various antimicrobials; ethidium efflux is Na+-dependent. The VexF and VexM Pumps do not Function in Antimicrobial Resistance in vitro.
  • Length (amino acid): 1039
  • Reference: Rahman et al. 2007; Pubmed- 18037783, Bina et al. 2008; Pubmed- 18490456

    		• Similar resistance genes in 'BacMet Predicted database'
    vexH
  • BacMet ID: BAC0509
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin.
  • Length (amino acid): 1036
  • Reference: Taylor et al. 2012; Pubmed- 22666485

    		• Similar resistance genes in 'BacMet Predicted database'
    vexK
  • BacMet ID: BAC0428
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol]
  • Description: Multidrug efflux transporter vexK
  • Length (amino acid): 1037
  • Reference: Bina et al. 2008; Pubmed- 18490456

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeA
  • BacMet ID: BAC0429
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Membrane fusion protein VmeA
  • Length (amino acid): 379
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeB
  • BacMet ID: BAC0430
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Inner membrane protein VmeB
  • Length (amino acid): 1053
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeC
  • BacMet ID: BAC0510
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 368
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeD
  • BacMet ID: BAC0511
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1040
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeE
  • BacMet ID: BAC0512
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine]
  • Description: VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 364
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeF
  • BacMet ID: BAC0513
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine]
  • Description: VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1037
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeG
  • BacMet ID: BAC0517
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 343
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeH
  • BacMet ID: BAC0518
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeI
  • BacMet ID: BAC0519
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 1033
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeJ
  • BacMet ID: BAC0520
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene]
  • Description: Part of the VexJK efflux transporter. VexJK uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 371
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeK
  • BacMet ID: BAC0521
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene]
  • Description: Part of the VexJK efflux transporter. VexJK uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 1043
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeP
  • BacMet ID: BAC0522
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 380
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeQ
  • BacMet ID: BAC0523
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 1046
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeT
  • BacMet ID: BAC0524
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeU
  • BacMet ID: BAC0525
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 353
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeV
  • BacMet ID: BAC0526
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 1019
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeY
  • BacMet ID: BAC0514
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 375
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeZ
  • BacMet ID: BAC0515
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1050
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmrA
  • BacMet ID: BAC0431
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Na+-coupled multidrug efflux pump VmrA; confers resistance to cationic drugs (4',6'-diamidino-2-phenylindole (DAPI), Tetraphenylphosphonium (TPP), Acriflavine, ethidium)
  • Length (amino acid): 447
  • Reference: Chen et al. 2002; Pubmed- 11751837

    		• Similar resistance genes in 'BacMet Predicted database'
    vpoC
  • BacMet ID: BAC0516
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Homologue of E. coli TolC outer membrane protein, vpoC.
  • Length (amino acid): 442
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    wtpA
  • BacMet ID: BAC0602
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pyrococcus furiosus
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdate/tungstate-binding protein WtpA. Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate.
  • Length (amino acid): 345
  • Reference: Bevers et al. 2006; Pubmed- 16952940

    		• Similar resistance genes in 'BacMet Predicted database'
    wtpB
  • BacMet ID: BAC0603
  • Code for: Enzyme
  • Family: ABC superfamily, binding-protein-dependent transport system permease family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pyrococcus furiosus
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdate/tungstate transport system permease protein WtpB. Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane.
  • Length (amino acid): 249
  • Reference: Bevers et al. 2006; Pubmed- 16952940

    		• Similar resistance genes in 'BacMet Predicted database'
    wtpC
  • BacMet ID: BAC0604
  • Code for: Enzyme
  • Family: ABC transporter superfamily. ATPase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pyrococcus furiosus
  • Location: Chromosome
  • Compound: Tungsten (W), Molybdenum (Mo)
  • Description: Molybdate/tungstate import ATP-binding protein WtpC (ATPase). Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.
  • Length (amino acid): 344
  • Reference: Bevers et al. 2006; Pubmed- 16952940

    		• Similar resistance genes in 'BacMet Predicted database'
    ybtP
  • BacMet ID: BAC0432
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Fe3+-Yersiniabactin uptake transporter, YbtP; inner membrane lipoprotein
  • Length (amino acid): 600
  • Reference: Fetherston et al. 1999; Pubmed- 10231486

    		• Similar resistance genes in 'BacMet Predicted database'
    ybtQ
  • BacMet ID: BAC0433
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Permease and ATP-binding protein of yersiniabactin-iron ABC transport YbtQ
  • Length (amino acid): 600
  • Reference: Fetherston et al. 1999; Pubmed- 10231486

    		• Similar resistance genes in 'BacMet Predicted database'
    ychH
  • BacMet ID: BAC0434
  • Code for: Unknown
  • Family: Contains DUF2583 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Stress protein YchH; response to Hydrogen Peroxide (H2O2), cadmium; plays a role in biofilm formation as well
  • Length (amino acid): 92
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    ycnJ
  • BacMet ID: BAC0556
  • Code for: Membrane protein
  • Family: CopC and CopD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Involved in uptake of extracellular oxidized copper under copper-limiting conditions. Highly induced under copper-limiting conditions. Down-regulated by YcnK, especially under high copper concentrations. Down-regulated by CsoR. Cells lacking this gene show a growth-defective phenotype under copper deprivation as well as a reduced intracellular content of copper.
  • Length (amino acid): 541
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    ycnK
  • BacMet ID: BAC0557
  • Code for: Regulator
  • Family: Contains 1 HTH deoR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis 168
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. Significantly induced under copper-limiting conditions. Cells lacking this gene show little or no difference in growth under copper deprivation, whereas possessing enhanced growth under copper excess conditions. Possess a high intracellular content of copper.
  • Length (amino acid): 190
  • Reference: Chillappagari et al. 2009; Pubmed- 19168619

    		• Similar resistance genes in 'BacMet Predicted database'
    yddg/emrE
  • BacMet ID: BAC0435
  • Code for: Efflux
  • Family: Drug/metabolite transporter (DMT) superfamily; Aromatic amino acid/Paraquat Exporter (ArAA/P-E) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain 14028s/SGSC 2262)
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat]
  • Description: Methyl viologen resistance protein YddG, Probable efflux pump. Required for resistance to methyl viologen. May function with OmpD porin
  • Length (amino acid): 293
  • Reference: Santiviago et al. 2002; Pubmed- 12410826

    		• Similar resistance genes in 'BacMet Predicted database'
    ydeI
  • BacMet ID: BAC0436
  • Code for: Binding protein
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Stress protein YdeI; response to Hydrogen Peroxide (H2O2) and has a role in biofilm formation
  • Length (amino acid): 130
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    ydeO
  • BacMet ID: BAC0437
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: HTH-type transcriptional regulator YdeO; Induces the Expression of gadE and mdtEF. Could also regulate the Expression of other genes involved in acid resistance
  • Length (amino acid): 253
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Nishino et al. 2009; Pubmed- 19329985, Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    ydeP
  • BacMet ID: BAC0438
  • Code for: Enzyme
  • Family: Prokaryotic molybdopterin-containing oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid resistance protein YdeP; Involved in acid resistance
  • Length (amino acid): 759
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    yfeA
  • BacMet ID: BAC0439
  • Code for: Binding protein
  • Family: Bacterial solute-binding protein 9 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe), Manganese (Mn)
  • Description: Periplasmic chelated iron-binding protein YfeA; Part of an ATP-driven transport system YfeABCD for chelated iron
  • Length (amino acid): 311
  • Reference: Bearden et al. 1998; Pubmed- 9495751

    		• Similar resistance genes in 'BacMet Predicted database'
    yfeB
  • BacMet ID: BAC0440
  • Code for: Membrane Transporter
  • Family: ABC transporter superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe), Manganese (Mn)
  • Description: Chelated iron transport system membrane protein YfeB; Part of an ATP-driven transport system YfeABCD for chelated iron
  • Length (amino acid): 296
  • Reference: Bearden et al. 1998; Pubmed- 9495751

    		• Similar resistance genes in 'BacMet Predicted database'
    yfeC
  • BacMet ID: BAC0441
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe), Manganese (Mn)
  • Description: Chelated iron transport system membrane protein YfeC; Part of an ATP-driven transport system YfeABCD for chelated iron
  • Length (amino acid): 294
  • Reference: Bearden et al. 1998; Pubmed- 9495751

    		• Similar resistance genes in 'BacMet Predicted database'
    yfeD
  • BacMet ID: BAC0442
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pestis
  • Location: Chromosome
  • Compound: Iron (Fe), Manganese (Mn)
  • Description: Chelated iron transport system membrane protein YfeD; Part of an ATP-driven transport system YfeABCD for chelated iron
  • Length (amino acid): 297
  • Reference: Bearden et al. 1998; Pubmed- 9495751

    		• Similar resistance genes in 'BacMet Predicted database'
    yfmO
  • BacMet ID: BAC0443
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168) 
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: Multidrug efflux protein YfmO; Acts to efflux copper or a copper complex. YfmO can contribute to copper resistance; Repressed by YfmP
  • Length (amino acid): 396
  • Reference: Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    yfmP
  • BacMet ID: BAC0444
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subutilis (strain 168)
  • Location: Chromosome
  • Compound: Copper (Cu)
  • Description: HTH-type transcriptional regulator YfmP; repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. YfmP is autoregulated. There is no induction with copper or other metals.
  • Length (amino acid): 140
  • Reference: Gaballa et al. 2003; Pubmed- 14663075

    		• Similar resistance genes in 'BacMet Predicted database'
    ygiW
  • BacMet ID: BAC0445
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pMR-1 (Shewanella oneidensis (strain MR-1))
  • Compound: Cadmium (Cd), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Protein YgiW; located in periplasm; responsible for tributyltin (TBT) resistance; response to hydrogen peroxide (H2O2), cadmium ions ; has a role in biofim formation
  • Length (amino acid): 130
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yhcN
  • BacMet ID: BAC0446
  • Code for: Unknown
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer membrane protein YhcN; stress response protein
  • Length (amino acid): 87
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yieF
  • BacMet ID: BAC0541
  • Code for: Enzyme
  • Family: SsuE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli K12
  • Location: Chromosome
  • Compound: Chromium (Cr), Vanadium (V), Molybdenum (Mo), Methylene Blue [class: Thiazinium]
  • Description: A chromate reductase. Reduces chromate (Cr(VI)) to Cr(III)
  • Length (amino acid): 188
  • Reference: Ackerley et al. 2004; Pubmed- 14766567

    		• Similar resistance genes in 'BacMet Predicted database'
    yjaA
  • BacMet ID: BAC0447
  • Code for: Unknown
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress response protein YjaA; a YjaA mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 127
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    ykkC
  • BacMet ID: BAC0448
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) protein family. YkkC/YkkD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat]
  • Description: Multidrug resistance protein YkkC; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials
  • Length (amino acid): 112
  • Reference: Jack et al. 2000; Pubmed- 10735877

    		• Similar resistance genes in 'BacMet Predicted database'
    ykkD
  • BacMet ID: BAC0449
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) protein family. YkkC/YkkD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat]
  • Description: Multidrug resistance protein YkkD; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials
  • Length (amino acid): 105
  • Reference: Jack et al. 2000; Pubmed- 10735877

    		• Similar resistance genes in 'BacMet Predicted database'
    ymgB/ariR
  • BacMet ID: BAC0450
  • Code for: Binding protein
  • Family: AriR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Hydrochloric Acid (HCl) [class: Acid], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Two-component-system connector protein YmgB/AriR; a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H2O2. Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; YmgB probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein. Deletion increases biofilm formation.
  • Length (amino acid): 88
  • Reference: Lee et al. 2007; Pubmed- 17765265

    		• Similar resistance genes in 'BacMet Predicted database'
    yodD
  • BacMet ID: BAC0451
  • Code for: Unknown
  • Family: Contains a DUF2525 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress protein YodD; a yodD mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 75
  • Reference: Lee et al. 2010; Pubmed- 19919618

    		• Similar resistance genes in 'BacMet Predicted database'
    yqjH
  • BacMet ID: BAC0452
  • Code for: Enzyme
  • Family: SIP oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Nickel (Ni)
  • Description: NADPH-dependent ferric-chelate reductase (Ferric siderophore reductase) YqjH; Plays a role in iron homeostasis under excess nickel conditions; Repressed by YqjI and Fur. YqjI is required for nickel-dependent regulation of yqjH, while Fur is required for iron- and cobalt-dependent regulation of yqjh
  • Length (amino acid): 254
  • Reference: Wang et al. 2011; Pubmed- 21097627

    		• Similar resistance genes in 'BacMet Predicted database'
    zevA
  • BacMet ID: BAC0453
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae
  • Length (amino acid): 206
  • Reference: Rosadini et al. 2011; Pubmed- 21576338

    		• Similar resistance genes in 'BacMet Predicted database'
    zevB
  • BacMet ID: BAC0454
  • Code for: Binding protein
  • Family: Contains 1 NicO domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae
  • Length (amino acid): 322
  • Reference: Rosadini et al. 2011; Pubmed- 21576338

    		• Similar resistance genes in 'BacMet Predicted database'
    ziaA
  • BacMet ID: BAC0455
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc-transporting ATPase ziaA
  • Length (amino acid): 721
  • Reference: Thelwell et al. 1998: Pubmed- 9724772

    		• Similar resistance genes in 'BacMet Predicted database'
    ziaR
  • BacMet ID: BAC0456
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Transcriptional repressor (ziaR) of the Expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.
  • Length (amino acid): 132
  • Reference: Thelwell et al. 1998: Pubmed- 9724772

    		• Similar resistance genes in 'BacMet Predicted database'
    zinT/yodA
  • BacMet ID: BAC0457
  • Code for: Binding protein
  • Family: calycin superfamily. ZinT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Metal-binding protein (Cadmium-induced protein) ZinT; Function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn2+ over Cd2+. Contains one high affinity metal binding site, and can bind additional metal ions at other sites; Repressed by Zur
  • Length (amino acid): 216
  • Reference: Stojnev et al. 2007; Pubmed- 17632755

    		• Similar resistance genes in 'BacMet Predicted database'
    zipB
  • BacMet ID: BAC0458
  • Code for: Porter
  • Family: Zrt- and Irt-like Protein (ZIP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: zipB is a selective electrodiffusional channel; facilitates passive zinc uptake driven by zinc concentration gradients that are maintained by cellular zinc homeostasis
  • Length (amino acid): 309
  • Reference: Lin et al. 2010; Pubmed- 20876577

    		• Similar resistance genes in 'BacMet Predicted database'
    zitB/ybgR
  • BacMet ID: BAC0459
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc transporter ZitB; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc; contributes to Zn++ haemostatis at low (non-toxic) concentrations; Appears to be selective for zinc, not conferring resistance to cobalt nor cadmium
  • Length (amino acid): 313
  • Reference: Grass et al. 2001; Pubmed- 11443104, Lee et al. 2002; Pubmed- 12399046

    		• Similar resistance genes in 'BacMet Predicted database'
    zneB/hmxB
  • BacMet ID: BAC0460
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Zinc (Zn)
  • Description: Membrane fusion protein (MFP-RND) heavy metal cation tricomponent efflux zneB
  • Length (amino acid): 385
  • Reference: De Angelis et al. 2010; Pubmed- 20534468

    		• Similar resistance genes in 'BacMet Predicted database'
    zntA/yhhO
  • BacMet ID: BAC0461
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Lead (Pb), Cadmium (Cd), Zinc (Zn)
  • Description: Lead, cadmium, zinc and mercury-transporting ATPase ZntA; Involved in export of lead, cadmium, zinc and mercury; located in inner cell membrane.
  • Length (amino acid): 732
  • Reference: Rensing et al. 1997; Pubmed- 9405611, Beard et al. 1997; Pubmed- 9364914

    		• Similar resistance genes in 'BacMet Predicted database'
    zntR/yhdM
  • BacMet ID: BAC0462
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc-responsive transcriptional regulator zntR; regulates the zntA
  • Length (amino acid): 141
  • Reference: Brocklehurst et al. 1999; Pubmed-10048032, Singh et al. 1999; Pubmed- 10411736

    		• Similar resistance genes in 'BacMet Predicted database'
    znuA/yebL
  • BacMet ID: BAC0463
  • Code for: Membrane Transporter
  • Family: ABC superfamily, bacterial solute-binding protein 9 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: High-affinity zinc uptake system protein ZnuA; Involved in the high-affinity zinc uptake transport system; located in periplasm
  • Length (amino acid): 310
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    znuB/yebI
  • BacMet ID: BAC0464
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: High-affinity zinc uptake system membrane protein ZnuB; Involved in the high-affinity zinc uptake transport system; located in cell inner membrane
  • Length (amino acid): 261
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    znuC/yebM
  • BacMet ID: BAC0465
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Zinc importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc import ATP-binding protein ZnuC; part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations
  • Length (amino acid): 251
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    zraP
  • BacMet ID: BAC0466
  • Code for: Binding protein
  • Family: ZraP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2/SGSC1412/ATCC 700720) 
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc resistance-associated protein ZraP; Undergoes a specific Zn++ induced cleavage to release a carboxy-terminal Zn++ binding region; located in periplasm; Binds zinc. Could be an important component of the zinc-balancing mechanism; located in periplasm
  • Length (amino acid): 151
  • Reference: Noll et al. 1998; Pubmed- 9694902, Appia-Ayme et al. 2012; Pubmed- 22084975

    		• Similar resistance genes in 'BacMet Predicted database'
    zraR/hydH
  • BacMet ID: BAC0467
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain, 1 sigma-54 factor interaction domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Transcriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the Expression of zraP. Positively autoregulates the Expression of the zraSR operon.
  • Length (amino acid): 441
  • Reference: Leonshartsberger et al. 2001; Pubmed- 11243806

    		• Similar resistance genes in 'BacMet Predicted database'
    zraS/hydG
  • BacMet ID: BAC0468
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Lead (Pb)
  • Description: Sensor protein ZraS; Member of the two-component regulatory system ZraS/ZraR. Functions as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium.
  • Length (amino acid): 465
  • Reference: Leonshartsberger et al. 2001; Pubmed- 11243806

    		• Similar resistance genes in 'BacMet Predicted database'
    zupT/ygiE
  • BacMet ID: BAC0469
  • Code for: Porter
  • Family: ZIP transporter family, ZupT subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)
  • Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.
  • Length (amino acid): 257
  • Reference: Grass et al. 2005; Pubmed- 15716430

    		• Similar resistance genes in 'BacMet Predicted database'
    zur/yjbK
  • BacMet ID: BAC0470
  • Code for: Regulator
  • Family: Fur family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc uptake regulation protein zur; Acts as a negative controlling element, employing Zn2+ as a cofactor to bind the operator of the repressed genes (znuACB). Zinc uptake regulation protein.
  • Length (amino acid): 171
  • Reference: Patzer et al. 1998; Pubmed- 9680209, Patzer et al. 2000; Pubmed- 10816566, Li et al. 2009; Pubmed- 19552825

    		• Similar resistance genes in 'BacMet Predicted database'

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