Browsing Experimentally Confirmed database

Result: Your query found 34 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeM
  • BacMet ID: BAC0001
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs.
  • Length (amino acid): 448
  • Reference: Su et al. 2005; Pubmed- 16189122

    		• Similar resistance genes in 'BacMet Predicted database'
    acrA
  • BacMet ID: BAC0005
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 397
  • Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    acrB
  • BacMet ID: BAC0006
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 1049
  • Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

    		• Similar resistance genes in 'BacMet Predicted database'
    fabI
  • BacMet ID: BAC0156
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis; enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan; some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK, FabV and FabL.
  • Length (amino acid): 262
  • Reference: McMurry et al. 1998; Pubmed- 9707111

    		• Similar resistance genes in 'BacMet Predicted database'
    fabK
  • BacMet ID: BAC0157
  • Code for: Enzyme
  • Family: Nitronate monooxygenase (NMO) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus pneumoniae
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Trans-2-enoyl-ACP reductase II; a TIM barrel triclosan-resistannt flavoprotein; It is one of the taret sites for antibacterial triclosan; expression of FabK confers triclosan resistance.
  • Length (amino acid): 324
  • Reference: Heath et al. 2000; Pubmed- 10910344

    		• Similar resistance genes in 'BacMet Predicted database'
    fabL/ygaA
  • BacMet ID: BAC0158
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-(acyl-carrier-protein) reductase (NADPH) FabL; It catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It confers resistance to triclosan. It is an alternative target site where fabI is absent for antibacterial compound triclosan.
  • Length (amino acid): 250
  • Reference: Heath et al. 2000; Pubmed- 11007778

    		• Similar resistance genes in 'BacMet Predicted database'
    fabV
  • BacMet ID: BAC0159
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio chloerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-(acyl-carrier-protein) (ACP) reductase is a key enzyme in type II fatty-acid synthases that catalyzes the last step in each elongation cycle; Predominately found in Vibrio species and closely related organisms where it seems to be the sole enoyl-ACP reductase. It is a antibacterial target site for triclosan where fabI and other isoforms such as fabL, fabI or fabK are absent. Triclosan expression of FabV in organism results in markedly increased resistance to triclosan. There may be bacteria that have both FabV and FabK such as various of the Clostridia such as Clostridium tetani.
  • Length (amino acid): 401
  • Reference: Massengo-Tiasse et al. 2008; Pubmed- 18032386, Zhu et al. 2010; Pubmed- 19933806,

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnE
  • BacMet ID: BAC0476
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin.
  • Length (amino acid): 120
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnF
  • BacMet ID: BAC0477
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    mexA
  • BacMet ID: BAC0234
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.
  • Length (amino acid): 383
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexB
  • BacMet ID: BAC0235
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.
  • Length (amino acid): 1046
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

    		• Similar resistance genes in 'BacMet Predicted database'
    mexC
  • BacMet ID: BAC0236
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 387
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexD
  • BacMet ID: BAC0237
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 1042
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexE
  • BacMet ID: BAC0238
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas entomophila (strain L48)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 413
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexF
  • BacMet ID: BAC0239
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 1059
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

    		• Similar resistance genes in 'BacMet Predicted database'
    mexI
  • BacMet ID: BAC0240
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa 138244
  • Location: Chromosome
  • Compound: Vanadium (V), Triclosan [class: Phenolic compounds]
  • Description: RND Multidrug efflux transporter mexI; Part of mexGHI-ompD efflux pump operon. The efflux pump also involved in N-acyl-homoserine lactones (AHLs) homeostsis in Pseudomonas aeruginosa.
  • Length (amino acid): 1029
  • Reference: Aendekerk et al. 2002; Pubmed- 12177331

    		• Similar resistance genes in 'BacMet Predicted database'
    mexJ
  • BacMet ID: BAC0241
  • Code for: Efflux
  • Family: RND Superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein mexJ; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system
  • Length (amino acid): 367
  • Reference: Chuanchuen et al. 2002; Pubmed- 12193619

    		• Similar resistance genes in 'BacMet Predicted database'
    mexK
  • BacMet ID: BAC0242
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: RND efflux transporter mexK; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system
  • Length (amino acid): 1025
  • Reference: Chuanchuen et al. 2002; Pubmed- 12193619

    		• Similar resistance genes in 'BacMet Predicted database'
    mexR
  • BacMet ID: BAC0243
  • Code for: Regulator
  • Family: RND superfamily, MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Repressor of the mexAB-oprM multidrug resistance operon mexR. Also represses its own Expression. Many variants lead to increased Expression of the mexAB-oprM operon
  • Length (amino acid): 147
  • Reference: Poole et al. 1996; Pubmed- 8878574

    		• Similar resistance genes in 'BacMet Predicted database'
    mexT
  • BacMet ID: BAC0244
  • Code for: Regulator
  • Family: Contains 1 HTH lysR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Transcriptional regulator MexT; the regulator of the MexEF-OprN efflux operon
  • Length (amino acid): 304
  • Reference: Kohler et al. 1999; Pubmed- 10515918

    		• Similar resistance genes in 'BacMet Predicted database'
    oprJ
  • BacMet ID: BAC0291
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon.
  • Length (amino acid): 479
  • Reference: Li et al. 1998; Pubmed- 9603892, Poole et al. 1996; Pubmed- 8878035

    		• Similar resistance genes in 'BacMet Predicted database'
    oprN
  • BacMet ID: BAC0562
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa.
  • Length (amino acid): 472
  • Reference: Li et al. 1998; Pubmed- 9603892, Kohler et al. 1997; Pubmed- 9044268

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxA
  • BacMet ID: BAC0294
  • Code for: Enzyme
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid p0LA52 (E. coli), Plasmid pGDGK3 (Klebsiella pneumoniae)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxA; part of oqxAB efflux system, can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 391
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxB
  • BacMet ID: BAC0295
  • Code for: Enzyme
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pOLA52 (E. coli),
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxB; part of the oqxAB efflux system; can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 1050
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeX
  • BacMet ID: BAC0338
  • Code for: Efflux
  • Family: RND superfmaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeX 
  • Length (amino acid): 393
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeY
  • BacMet ID: BAC0339
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeY
  • Length (amino acid): 1051
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    smeD
  • BacMet ID: BAC0358
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Membrane fusion protein of RND family multidrug efflux pump smeD; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 394
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeE
  • BacMet ID: BAC0359
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: RND efflux system, inner membrane transporter smeE; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 1040
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeF
  • BacMet ID: BAC0360
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Multidrug resistance outer membrane protein smeF; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 466
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeT
  • BacMet ID: BAC0362
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: SmeT repressor protein for the the multidrug efflux system smeDEF
  • Length (amino acid): 219
  • Reference: Sanchez et al. 2002; Pubmed- 12384340, Hernandez et al. 2011; Pubmed- 21738470

    		• Similar resistance genes in 'BacMet Predicted database'
    tolC
  • BacMet ID: BAC0393
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone]
  • Description: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump.
  • Length (amino acid): 493
  • Reference: Hackett et al. 1983; Pubmed- 6312426, Fralick et al. 1996; Pubmed- 8824631, Sulavik et al. 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    triA
  • BacMet ID: BAC0396
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid pCROD2 (Citrobacter rodentium (strain ICC168))
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriA; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 205
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
    triB
  • BacMet ID: BAC0397
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica)
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriB; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 97
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
    triC
  • BacMet ID: BAC0398
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Yersinia pseudotuberculosis serotype I (strain IP32953)
  • Location: Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica)
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Resistance-Nodulation-Cell Division (RND) efflux transporter triC; Part of the TriABC-opmH triclosan efflux pump system; TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work
  • Length (amino acid): 915
  • Reference: Mima et al. 2007; Pubmed- 17720796

    		• Similar resistance genes in 'BacMet Predicted database'
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