Browsing Experimentally Confirmed database

Result: Your query found 33 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
acrA
  • BacMet ID: BAC0005
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 397
  • Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

  • Similar resistance genes in 'BacMet Predicted database'
    acrB
  • BacMet ID: BAC0006
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]
  • Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
  • Length (amino acid): 1049
  • Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631

  • Similar resistance genes in 'BacMet Predicted database'
    marA
  • BacMet ID: BAC0560
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 127
  • Reference: Asako et al. 1997; Pubmed- 9097440

  • Similar resistance genes in 'BacMet Predicted database'
    marR
  • BacMet ID: BAC0561
  • Code for: Regulator
  • Family: Contains 1 HTH marR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 144
  • Reference: Asako et al. 1997; Pubmed- 9097440

  • Similar resistance genes in 'BacMet Predicted database'
    mepB
  • BacMet ID: BAC0222
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump membrane transporter MepB; the inner membrane transporter component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 1050
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

  • Similar resistance genes in 'BacMet Predicted database'
    mepC
  • BacMet ID: BAC0223
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: Toluene [class: Aromatic hydrocarbons] [class: Aromatic hydrocarbons], n-hexane [class: Alkane]
  • Description: Multidrug/solvent efflux pump outer membrane protein MepC; the outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.
  • Length (amino acid): 484
  • Reference: Fukumori et al. 1998; Pubmed- 9827328

  • Similar resistance genes in 'BacMet Predicted database'
    mexA
  • BacMet ID: BAC0234
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.
  • Length (amino acid): 383
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

  • Similar resistance genes in 'BacMet Predicted database'
    mexB
  • BacMet ID: BAC0235
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.
  • Length (amino acid): 1046
  • Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684

  • Similar resistance genes in 'BacMet Predicted database'
    mexC
  • BacMet ID: BAC0236
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 387
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

  • Similar resistance genes in 'BacMet Predicted database'
    mexD
  • BacMet ID: BAC0237
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.
  • Length (amino acid): 1042
  • Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892

  • Similar resistance genes in 'BacMet Predicted database'
    mexE
  • BacMet ID: BAC0238
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas entomophila (strain L48)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 413
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

  • Similar resistance genes in 'BacMet Predicted database'
    mexF
  • BacMet ID: BAC0239
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operon
  • Length (amino acid): 1059
  • Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892

  • Similar resistance genes in 'BacMet Predicted database'
    oprJ
  • BacMet ID: BAC0291
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon.
  • Length (amino acid): 479
  • Reference: Li et al. 1998; Pubmed- 9603892, Poole et al. 1996; Pubmed- 8878035

  • Similar resistance genes in 'BacMet Predicted database'
    oprM/oprK
  • BacMet ID: BAC0292
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter
  • Length (amino acid): 485
  • Reference: Li et al. 1995; Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892

  • Similar resistance genes in 'BacMet Predicted database'
    oprN
  • BacMet ID: BAC0562
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]
  • Description: Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa.
  • Length (amino acid): 472
  • Reference: Li et al. 1998; Pubmed- 9603892, Kohler et al. 1997; Pubmed- 9044268

  • Similar resistance genes in 'BacMet Predicted database'
    ostA/lptD
  • BacMet ID: BAC0296
  • Code for: Porin
  • Family: LptD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane]
  • Description: Organic solvent tolerance protein ostA/lptD; Together with LptE, is involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis
  • Length (amino acid): 784
  • Reference: Aono et al. 1994; Pubmed- 7811102

  • Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

  • Similar resistance genes in 'BacMet Predicted database'
    sdeA
  • BacMet ID: BAC0336
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Legionella longbeachae D-4968
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance secretion protein SdeA; part of the sdeAB-tolC efflux system
  • Length (amino acid): 336
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2002; Pubmed- 12356807, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

  • Similar resistance genes in 'BacMet Predicted database'
    sdeB
  • BacMet ID: BAC0337
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. marcescens
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein SdeB; part of the sdeAB-tolC efflux system
  • Length (amino acid): 1047
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

  • Similar resistance genes in 'BacMet Predicted database'
    soxS
  • BacMet ID: BAC0371
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cyclohexane [class: Cycloalkane]
  • Description: Regulatory protein SoxS; Increases the Zn uptake system znuACB; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.
  • Length (amino acid): 107
  • Reference: Nakajima et al. 1995; Pubmed- 7670195, Warner et al. 2012; Pubmed- 22210763

  • Similar resistance genes in 'BacMet Predicted database'
    srpA
  • BacMet ID: BAC0372
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump periplasmic linker SrpA; a component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon Expression level.
  • Length (amino acid): 382
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

  • Similar resistance genes in 'BacMet Predicted database'
    srpB
  • BacMet ID: BAC0373
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant pump membrane transporter SrpB; The inner membrane transporter component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 1049
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

  • Similar resistance genes in 'BacMet Predicted database'
    srpC
  • BacMet ID: BAC0374
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent-resistant efflux pump outer membrane protein SrpC; The outer membrane component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.
  • Length (amino acid): 470
  • Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016

  • Similar resistance genes in 'BacMet Predicted database'
    srpR
  • BacMet ID: BAC0375
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpR; In conjunction with SrpS represses the srpABC operon.
  • Length (amino acid): 213
  • Reference: Sun et al. 2011; Pubmed- 21441510

  • Similar resistance genes in 'BacMet Predicted database'
    srpS
  • BacMet ID: BAC0376
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]
  • Description: Solvent efflux pump srpABC operon corepressor SrpS; In conjunction with SrpR represses the srpABC operon.
  • Length (amino acid): 259
  • Reference: Sun et al. 2011; Pubmed- 21441510

  • Similar resistance genes in 'BacMet Predicted database'
    tbtA
  • BacMet ID: BAC0379
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri (Pseudomonas perfectomarina)
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Tributyltin chloride resistance membrane fusion protein TbtA; has 4 characteristic motifs A, B, C and D; part of the tbtABM efflux system
  • Length (amino acid): 382
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

  • Similar resistance genes in 'BacMet Predicted database'
    tbtB
  • BacMet ID: BAC0380
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri (Pseudomonas perfectomarina)
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Resistance nodulation cell division family member TbtB; Aanalogous to proton dependent efflux pump belonging to RND family; part of the tbtABM efflux system
  • Length (amino acid): 1046
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

  • Similar resistance genes in 'BacMet Predicted database'
    tbtM
  • BacMet ID: BAC0381
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Outer membrane protein TbtM, part of the tbtABM efflux system
  • Length (amino acid): 476
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

  • Similar resistance genes in 'BacMet Predicted database'
    tbtR
  • BacMet ID: BAC0382
  • Code for: Regulator
  • Family: Contains 1¬†HTH iclR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri¬†
  • Location: Chromosome
  • Compound: Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane]
  • Description: Efflux pump regulator; a potential regulatory gene of tbtABM, named tbtR, is identified upstream of the operon; TbtR exhibited many similarities with other repressors of the RND efflux systems
  • Length (amino acid): 259
  • Reference: Fukagawa et al. 1993; Pubmed- 8343157, Jude et al. 2004; Pubmed- 15019728

  • Similar resistance genes in 'BacMet Predicted database'
    ttgA
  • BacMet ID: BAC0404
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump periplasmic linker protein TtgA; The periplasmic linker protein component of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 384
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

  • Similar resistance genes in 'BacMet Predicted database'
    ttgB
  • BacMet ID: BAC0405
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The inner membrane transporter component, ttgB of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 1050
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

  • Similar resistance genes in 'BacMet Predicted database'
    ttgC
  • BacMet ID: BAC0406
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: The outer membrane component ttgC of a constitutive organic solvent efflux system ttgABC. Is involved in Export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.
  • Length (amino acid): 484
  • Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823

  • Similar resistance genes in 'BacMet Predicted database'
    ttgR
  • BacMet ID: BAC0413
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]
  • Description: Toluene efflux pump ttgABC operon repressor ttgR; Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.
  • Length (amino acid): 210
  • Reference: Duque et al. 2001; Pubmed- 11251828, Teran et al. 2003; Pubmed- 14506010, Fernandes et al. 2003; Pubmed- 13678823

  • Similar resistance genes in 'BacMet Predicted database'

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