Compound name: Chlorhexidine
Chemical Class:
Biguanides
Description: Biguanide group. It is a divalent cation. A clinically relevant biocide used as antiseptic, preservative, detergent, disinfectant. It is one of the more widely used disinfectants. It is used mainly in 3 salt forms such as Digluconate 20% solution, Diacetate and Dihydrochlorhide. A 4% emulsion of chlorhexidine gluconate is used as a skin cleanser, a 0.5% (w/v) solution in 70% isopropanol as a general antiseptic, and a 0.5% solution in 70% isopropanol with emollients as a hand rinse. A 1% chlorhexidine acetate ointment is used as a topical antiseptic in treatment of external wounds in dogs, cats, and horses. It has potent antimicrobial activity against most gram-positive and some gram-negative bacteria but not against spores. A 0.1% aqueous solution is bactericidal against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa in 15 sec. However, it is relatively ineffective against other gram-negative organisms, spores, fungi, and most viruses.
Database Links: CHEBI:3614
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