Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
acrA | BacMet ID: BAC0005Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.Length (amino acid):
397Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631
| Similar
resistance genes in 'BacMet Predicted database' |
acrB | BacMet ID: BAC0006Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.Length (amino acid):
1049Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631
| Similar
resistance genes in 'BacMet Predicted database' |
marA | BacMet ID: BAC0560Code for:
RegulatorFamily: Contains 1 HTH araC/xylS-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]Description: A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.Length (amino acid):
127Reference: Asako et al. 1997; Pubmed- 9097440
| Similar
resistance genes in 'BacMet Predicted database' |
marR | BacMet ID: BAC0561Code for:
RegulatorFamily: Contains 1 HTH marR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]Description: Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.Length (amino acid):
144Reference: Asako et al. 1997; Pubmed- 9097440
| Similar
resistance genes in 'BacMet Predicted database' |
robA | BacMet ID: BAC0334Code for:
Binding proteinFamily: 1 HTH araC/xylS-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli O157:H7Location:
ChromosomeCompound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.Length (amino acid):
289Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315
| Similar
resistance genes in 'BacMet Predicted database' |
soxS | BacMet ID: BAC0371Code for:
RegulatorFamily: Contains 1 HTH araC/xylS-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Zinc (Zn), Cyclohexane [class: Cycloalkane]Description: Regulatory protein SoxS; Increases the Zn uptake system znuACB; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.Length (amino acid):
107Reference: Nakajima et al. 1995; Pubmed- 7670195, Warner et al. 2012; Pubmed- 22210763
| Similar
resistance genes in 'BacMet Predicted database' |