Browsing Experimentally Confirmed database

Result: Your query found 37 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

    		• Similar resistance genes in 'BacMet Predicted database'
    adeA
  • BacMet ID: BAC0471
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 396
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeB
  • BacMet ID: BAC0472
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128.
  • Description: AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 1035
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeC
  • BacMet ID: BAC0473
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 465
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    amvA
  • BacMet ID: BAC0025
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance
  • Length (amino acid): 492
  • Reference: Rajamohan et al. 2010; Pubmed- 20573661

    		• Similar resistance genes in 'BacMet Predicted database'
    cepA
  • BacMet ID: BAC0061
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family (FieF subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides]
  • Description: Cation-efflux pump cepA, Cation-efflux transporter that may have a role in detoxification by similarity. Associated with chlorhexidine resistance.
  • Length (amino acid): 300
  • Reference: Fang et al. 2002; Pubmed- 12019132

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxA
  • BacMet ID: BAC0532
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Sensor protein of stress-related two-component regulatory system of CpxAR. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 457
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    cpxR
  • BacMet ID: BAC0533
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Response regulator of stress-related two-component regulatory system. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
  • Length (amino acid): 232
  • Reference: Srinivasan et al. 2012; Pubmed- 22496764

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnE
  • BacMet ID: BAC0476
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin.
  • Length (amino acid): 120
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnF
  • BacMet ID: BAC0477
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnO
  • BacMet ID: BAC0529
  • Code for: Porin
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites]
  • Description: KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae.
  • Length (amino acid): 365
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxA
  • BacMet ID: BAC0294
  • Code for: Enzyme
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid p0LA52 (E. coli), Plasmid pGDGK3 (Klebsiella pneumoniae)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxA; part of oqxAB efflux system, can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 391
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    oqxB
  • BacMet ID: BAC0295
  • Code for: Enzyme
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli
  • Location: Plasmid pOLA52 (E. coli),
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine]
  • Description: RND family multidrug efflux permease oqxB; part of the oqxAB efflux system; can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli.
  • Length (amino acid): 1050
  • Reference: Hansen et al. 2007; Pubmed- 17526501

    		• Similar resistance genes in 'BacMet Predicted database'
    phoB
  • BacMet ID: BAC0530
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges. (NB: THIS GENE IS MORE LIKELY TO BE 'PhoP' THOUGH AUTHORS MENTIONED IT AS 'PhoB'. THE SYSTEM MIGHT BE 'PhoPQ' INSTEAD OF 'PhoBR'.)
  • Length (amino acid): 237
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    phoR
  • BacMet ID: BAC0531
  • Code for: Regulator
  • Family: Contains 1 response regulator domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges.
  • Length (amino acid): 488
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacR
  • BacMet ID: BAC0328
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pSK1 (S. aureus)
  • Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]
  • Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
  • Length (amino acid): 188
  • Reference: Grkovic et al. 1998; Pubmed- 9660841

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeA
  • BacMet ID: BAC0336
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Legionella longbeachae D-4968
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance secretion protein SdeA; part of the sdeAB-tolC efflux system
  • Length (amino acid): 336
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2002; Pubmed- 12356807, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeB
  • BacMet ID: BAC0337
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens subsp. marcescens
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux protein SdeB; part of the sdeAB-tolC efflux system
  • Length (amino acid): 1047
  • Reference: Maseda et al. 2009; Pubmed- 19752278, Kumar et al. 2005; Pubmed- 15793131, Begic et al. 2008; Pubmed- 18227249

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeX
  • BacMet ID: BAC0338
  • Code for: Efflux
  • Family: RND superfmaily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeX 
  • Length (amino acid): 393
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sdeY
  • BacMet ID: BAC0339
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Serratia marcescens
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug efflux pump SdeY
  • Length (amino acid): 1051
  • Reference: Chen et al. 2003 ; Pubmed- 12837741

    		• Similar resistance genes in 'BacMet Predicted database'
    sepA
  • BacMet ID: BAC0340
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine]
  • Description: Multidrug resistance efflux pump sepA; Involved in multidrug efflux. Confers low level resistance to drugs such as Acriflavine, benzylkonium chloride (BAC), chlorhexidine gluconate and ethidium bromide
  • Length (amino acid): 382
  • Reference: Narui et al. 2002; Pubmed- 12499635

    		• Similar resistance genes in 'BacMet Predicted database'
    ssmE
  • BacMet ID: BAC0377
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Chlorhexidine [class: Biguanides]
  • Description: Multidrug efflux pump SsmE
  • Length (amino acid): 110
  • Reference: Minato et al. 2008; Pubmed- 18310921

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeC
  • BacMet ID: BAC0510
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 368
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeD
  • BacMet ID: BAC0511
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1040
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeG
  • BacMet ID: BAC0517
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 343
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeH
  • BacMet ID: BAC0518
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeI
  • BacMet ID: BAC0519
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 1033
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeT
  • BacMet ID: BAC0524
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeU
  • BacMet ID: BAC0525
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 353
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeV
  • BacMet ID: BAC0526
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 1019
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vpoC
  • BacMet ID: BAC0516
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Homologue of E. coli TolC outer membrane protein, vpoC.
  • Length (amino acid): 442
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
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