Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
mepB | BacMet ID: BAC0222Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putidaLocation:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons], n-hexane [class: Alkane]Description: Multidrug/solvent efflux pump membrane transporter MepB; the inner membrane transporter component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.Length (amino acid):
1050Reference: Fukumori et al. 1998; Pubmed- 9827328
| Similar
resistance genes in 'BacMet Predicted database' |
mepC | BacMet ID: BAC0223Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putidaLocation:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons] [class: Aromatic hydrocarbons], n-hexane [class: Alkane]Description: Multidrug/solvent efflux pump outer membrane protein MepC; the outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline.Length (amino acid):
484Reference: Fukumori et al. 1998; Pubmed- 9827328
| Similar
resistance genes in 'BacMet Predicted database' |
srpA | BacMet ID: BAC0372Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]Description: Solvent-resistant efflux pump periplasmic linker SrpA; a component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon Expression level.Length (amino acid):
382Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016
| Similar
resistance genes in 'BacMet Predicted database' |
srpB | BacMet ID: BAC0373Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]Description: Solvent-resistant pump membrane transporter SrpB; The inner membrane transporter component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.Length (amino acid):
1049Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016
| Similar
resistance genes in 'BacMet Predicted database' |
srpC | BacMet ID: BAC0374Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putidaLocation:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]Description: Solvent-resistant efflux pump outer membrane protein SrpC; The outer membrane component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level.Length (amino acid):
470Reference: Kieboom et al. 1998; Pubmed- 9417051, Kieboom eta l. 1998; Pubmed- 9852029, Kim et al. 1998; Pubmed- 9658016
| Similar
resistance genes in 'BacMet Predicted database' |
srpR | BacMet ID: BAC0375Code for:
RegulatorFamily: Contains 1 HTH tetR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putidaLocation:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]Description: Solvent efflux pump srpABC operon corepressor SrpR; In conjunction with SrpS represses the srpABC operon.Length (amino acid):
213Reference: Sun et al. 2011; Pubmed- 21441510
| Similar
resistance genes in 'BacMet Predicted database' |
srpS | BacMet ID: BAC0376Code for:
RegulatorFamily: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domainSequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putidaLocation:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate]Description: Solvent efflux pump srpABC operon corepressor SrpS; In conjunction with SrpR represses the srpABC operon.Length (amino acid):
259Reference: Sun et al. 2011; Pubmed- 21441510
| Similar
resistance genes in 'BacMet Predicted database' |
ttgA | BacMet ID: BAC0404Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: Toluene efflux pump periplasmic linker protein TtgA; The periplasmic linker protein component of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.Length (amino acid):
384Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgB | BacMet ID: BAC0405Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: The inner membrane transporter component, ttgB of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.Length (amino acid):
1050Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgC | BacMet ID: BAC0406Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: The outer membrane component ttgC of a constitutive organic solvent efflux system ttgABC. Is involved in Export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline.Length (amino acid):
484Reference: Ramos et al. 1998; Pubmed- 9642183, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgD | BacMet ID: BAC0407Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: The periplasmic linker protein component, ttgD of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP effluxLength (amino acid):
382Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgE | BacMet ID: BAC0408Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: The inner membrane transporter component, ttgE of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.Length (amino acid):
1046Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgF | BacMet ID: BAC0409Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: The outer membrane component, ttgF of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux.Length (amino acid):
480Reference: Mosqueda et al. 2000; Pubmed- 10648517, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgG | BacMet ID: BAC0410Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: The periplasmic linker component ttgG, of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.Length (amino acid):
391Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgH | BacMet ID: BAC0411Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: The inner membrane transporter component, ttgH of an organic solvent efflux pump ttgGHI. Involved in Export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibioticsLength (amino acid):
1049Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgI | BacMet ID: BAC0412Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: The outer membrane component, ttgI of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics.Length (amino acid):
470Reference: Rojas et al. 2001; Pubmed- 11395460, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgR | BacMet ID: BAC0413Code for:
RegulatorFamily: Contains 1 HTH tetR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons]Description: Toluene efflux pump ttgABC operon repressor ttgR; Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics.Length (amino acid):
210Reference: Duque et al. 2001; Pubmed- 11251828, Teran et al. 2003; Pubmed- 14506010, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgT | BacMet ID: BAC0414Code for:
RegulatorFamily: Contains 1 HTH iclR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
ChromosomeCompound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: Regulator of the ttgDEF efflux pump ttgT; Can regulate the ttgDEF system expression in ttgV-deficient condition; effect of TtgT on ttgGHI Expression is not obvious when TtgV is present but becomes relevant in its absenceLength (amino acid):
260Reference: Teran et al. 2007; Pubmed- 17986203, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |
ttgV | BacMet ID: BAC0415Code for:
RegulatorFamily: Isocitrate lyase regulator (IclR) familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: HTH-type transcriptional regulator TtgV; Represses the expression of the ttgGHI and ttgVW operons. Binds to the ttgGHI / ttgVW intergenic region, probably preventing binding of RNA polymerase; ttgV dissociates from this region in the presence of 1-hexanol, can regulate the ttgDEF expression as well; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicinLength (amino acid):
259Reference: Teran et al. 2007; Pubmed- 17986203, Rojas et al. 2003; Pubmed- 12896994, Rodriguez-Herva et al. 2007; Pubmed- 17504492
| Similar
resistance genes in 'BacMet Predicted database' |
ttgW | BacMet ID: BAC0416Code for:
RegulatorFamily: Contains 1 HTH tetR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (Arthrobacter siderocapsulatus)Location:
Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes]Description: HTH-type transcriptional regulator TtgW; does not seem to be involved in regulation of the ttgGHI or ttgVW operons; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicinLength (amino acid):
134Reference: Rojas et al. 2003; Pubmed- 12896994, Fernandes et al. 2003; Pubmed- 13678823
| Similar
resistance genes in 'BacMet Predicted database' |