Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
emrA | BacMet ID: BAC0147Code for:
EffluxFamily: Membrane Fusion Protein (MFP)Sequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell.Length (amino acid):
390Reference: Lomovskaya et al. 1992; Pubmed- 1409590
| Similar
resistance genes in 'BacMet Predicted database' |
emrAsm | BacMet ID: BAC0499Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. Length (amino acid):
393Reference: Huang et al. 2013; Pubmed- 23794602
| Similar
resistance genes in 'BacMet Predicted database' |
emrB | BacMet ID: BAC0148Code for:
EnzymeFamily: Major facilitator superfamily (MFS)-EmrB familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicityLength (amino acid):
512Reference: Lomovskaya et al. 1992; Pubmed- 1409590
| Similar
resistance genes in 'BacMet Predicted database' |
emrBsm | BacMet ID: BAC0500Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. Length (amino acid):
528Reference: Huang et al. 2013; Pubmed- 23794602
| Similar
resistance genes in 'BacMet Predicted database' |
emrCsm | BacMet ID: BAC0501Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: Outer membrane protein EmrCsm. Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. Length (amino acid):
497Reference: Huang et al. 2013; Pubmed- 23794602
| Similar
resistance genes in 'BacMet Predicted database' |
emrR | BacMet ID: BAC0559Code for:
RegulatorFamily: MarR familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone]Description: Negative regulator of the multidrug operon emrAB.Length (amino acid):
176Reference: Lomovskaya et al. 1995; Pubmed- 7730261
| Similar
resistance genes in 'BacMet Predicted database' |
emrRsm | BacMet ID: BAC0502Code for:
RegulatorFamily: MarR familySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: EmrRCABsm operon is negatively regulated by a MarR-type regulator EmrRsm.Length (amino acid):
147Reference: Huang et al. 2013; Pubmed- 23794602
| Similar
resistance genes in 'BacMet Predicted database' |
farA | BacMet ID: BAC0503Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Neisseria gonorrhoeae F19Location:
ChromosomeCompound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.Length (amino acid):
394Reference: Lee et al. 1999; Pubmed- 10447892
| Similar
resistance genes in 'BacMet Predicted database' |
farB | BacMet ID: BAC0504Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Neisseria gonorrhoeae F19Location:
ChromosomeCompound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.Length (amino acid):
507Reference: Lee et al. 1999; Pubmed- 10447892
| Similar
resistance genes in 'BacMet Predicted database' |
kpnO | BacMet ID: BAC0529Code for:
PorinFamily: RND superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Klebsiella pneumoniae NTUH-K2044Location:
ChromosomeCompound: Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites]Description: KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae.Length (amino acid):
365Reference: Srinivasan et al. 2012; Pubmed- 22848515
| Similar
resistance genes in 'BacMet Predicted database' |
pcm | BacMet ID: BAC0506Code for:
EnzymeFamily: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) familySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Acriflavine [class: Acridine]Description: Protein-L-isoaspartate O-methyltransferase. pcm and tolCsm genes form an operon. pcm deletion affects on the expression of tolCsm. pcm alone makes little contribution to resistance.Length (amino acid):
215Reference: Huang et al. 2013; Pubmed- 23629016
| Similar
resistance genes in 'BacMet Predicted database' |
qacA | BacMet ID: BAC0319Code for:
EffluxFamily: Major facilitator superfamily (MFS)Sequence: FASTACross-database IDs: LinkOrganism: Only gram +ve, Staphylococcus aureusLocation:
Plasmid VRSAp, pSK1 (S. Aureus)Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides. Length (amino acid):
514Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814
| Similar
resistance genes in 'BacMet Predicted database' |
qacB | BacMet ID: BAC0320Code for:
EffluxFamily: Major facilitator superfamily (MFS)Sequence: FASTACross-database IDs: LinkOrganism: Only gram +ve, Staphylococcus aureusLocation:
Plasmid pTZ2162 (S. Aureus)Compound: Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones]Description: Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides. Length (amino acid):
514Reference: Alam et al. (2003), Pubmed- 12820795, Nakaminami, H. et al. (2008); Littlejon et al. 1992; Pubmed- 1526458, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814
| Similar
resistance genes in 'BacMet Predicted database' |
tolCsm | BacMet ID: BAC0507Code for:
EffluxFamily: RND superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Stenotrophomonas maltophilia (strain K279a)Location:
ChromosomeCompound: Acriflavine [class: Acridine], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat], Plumbagin [class: Naphthoquinone], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide], Menadione [class: Naphthoquinone]Description: Outer membrane protein. pcm and tolCsm genes form an operon. A significant feature of TolCsm different from that of other tolC homologues of Enterobacteriaceae is that tolCsm is not transcribed alone, but is transcribed with the pcm gene.Length (amino acid):
452Reference: Huang et al. 2013; Pubmed- 23629016
| Similar
resistance genes in 'BacMet Predicted database' |