| Gene_name | Experimentally Verified Resistance Gene Information |
Predicted Resistance Gene Information |
| emrB |
BacMet ID: BAC0148Code for: Enzyme
Family: Major facilitator superfamily (MFS)-EmrB familySequence: FASTA
Cross-database IDs: Link
Organism: Escherichia coli (strain K12)Location: Chromosome
Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
Length (amino acid): 512
Reference: Lomovskaya et al. 1992; Pubmed- 1409590
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Similar resistance genes in 'BacMet Predicted database' |
| emrBsm |
BacMet ID: BAC0500Code for: Efflux
Family: MFS superfamilySequence: FASTA
Cross-database IDs: Link
Organism: Stenotrophomonas maltophilia (strain K279a)Location: Chromosome
Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
Length (amino acid): 528
Reference: Huang et al. 2013; Pubmed- 23794602
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Similar resistance genes in 'BacMet Predicted database' |
| smvA/emrB |
BacMet ID: BAC0367Code for: Efflux
Family: Major facilitator superfamily (MFS), TCR/tet familySequence: FASTA
Cross-database IDs: Link
Organism: Salmonella typhimuriumLocation: Chromosome
Compound: Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]Description: Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine.
Length (amino acid): 495
Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834, Ogawa et al. 2006; Pubmed- 16508165
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Similar resistance genes in 'BacMet Predicted database' |
