BacMet Database

Result: Details of the source of prediction- vexH

Gene_name	Experimentally Verified Resistance Gene Information	Predicted Resistance Gene Information
vexH	BacMet ID: BAC0509 Code for: Efflux Family: RND superfamily Sequence: FASTA Cross-database IDs: Link Organism: Vibrio cholerae serotype O1 Location: Chromosome Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid] Description: VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin. Length (amino acid): 1036 Reference: Taylor et al. 2012; Pubmed- 22666485	Similar resistance genes in 'BacMet Predicted database'

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