BacMet ID: BAC0509Code for: Efflux
Family: RND superfamilySequence: FASTA
Cross-database IDs: Link
Organism: Vibrio cholerae serotype O1Location: Chromosome
Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid] Description: VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin.
Length (amino acid): 1036
Reference: Taylor et al. 2012; Pubmed- 22666485
|Similar resistance genes in 'BacMet Predicted database'|