BacMet ID: BAC0370Code for: Regulator
Family: Contains 1 HTH merR-type DNA-binding domainSequence: FASTA
Cross-database IDs: Link
Organism: Escherichia coli (strain K12)Location: Chromosome
Compound: Methyl Viologen [class: Paraquat]Description: Redox-sensitive transcriptional activator SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.
Length (amino acid): 154
Reference: Nakajima et al. 1995; Pubmed- 7670195, Wu et al. 1991; Pubmed- 1708380
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