BacMet ID: BAC0328Code for: Regulator
Family: Contains 1 HTH tetR-type DNA-binding domainSequence: FASTA
Cross-database IDs: Link
Organism: Staphylococcus aureusLocation: Plasmid pSK1 (S. aureus)
Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
Length (amino acid): 188
Reference: Grkovic et al. 1998; Pubmed- 9660841
|Similar resistance genes in 'BacMet Predicted database'|