BacMet Experimentally Confirmed database

Result: Details of the source of prediction- pmrB

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
  • BacMet ID: BAC0488
  • Code for: Regulator
  • Family: Contains a sensor kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Erwinia carotovora ssp. Carotovora
  • Location: Chromosome
  • Compound: Iron (Fe)
  • Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PmrA in response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments.
  • Length (amino acid): 364
  • Reference: Hyytiainen et al. 2003; Pubmed- 14617142, Wosten et al. 2000; Pubmed- 1105155

  • Similar resistance genes in 'BacMet Predicted database'

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