BacMet ID: BAC0488Code for: Regulator
Family: Contains a sensor kinase domainSequence: FASTA
Cross-database IDs: Link
Organism: Erwinia carotovora ssp. CarotovoraLocation: Chromosome
Compound: Iron (Fe)Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PmrA in response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments.
Length (amino acid): 364
Reference: Hyytiainen et al. 2003; Pubmed- 14617142, Wosten et al. 2000; Pubmed- 1105155
|Similar resistance genes in 'BacMet Predicted database'|