BacMet Experimentally Confirmed database

Result: Details of the source of prediction- perR

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
  • BacMet ID: BAC0310
  • Code for: Regulator
  • Family: Fur family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain NCTC 8325)
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Peroxide-responsive repressor PerR; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection
  • Length (amino acid): 148
  • Reference: Horsburgh et al. 2001; Pubmed- 11349039

  • Similar resistance genes in 'BacMet Predicted database'

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