| oprM/oprK |
BacMet ID: BAC0292Code for: Efflux
Family: RND Superfamily, OMP familySequence: FASTA
Cross-database IDs: Link
Organism: Pseudomonas aeruginosaLocation: Chromosome
Compound: n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter
Length (amino acid): 485
Reference: Li et al. 1995; Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892
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Similar resistance genes in 'BacMet Predicted database' |
