BacMet ID: BAC0234Code for: Efflux
Family: Membrane fusion protein (MFP)Sequence: FASTA
Cross-database IDs: Link
Organism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)Location: Chromosome
Compound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.
Length (amino acid): 383
Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684
|Similar resistance genes in 'BacMet Predicted database'|