hefA | BacMet ID: BAC0187Code for: Efflux
Family: RND Superfamily, OMP familySequence: FASTA
Cross-database IDs: Link
Organism: Helicobacter pylori (strain P12)Location: Chromosome
Compound: Hydrochloric acid (HCl) [class: Acid]Description: Outer-membrane protein of the HefABC efflux system HefA; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
Length (amino acid): 477
Reference: Liu et al. 2008; Pubmed- 18777600
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Similar resistance genes in 'BacMet Predicted database' |