BacMet ID: BAC0173Code for: Enzyme
Family: Group II decarboxylase familySequence: FASTA
Cross-database IDs: Link
Organism: Escherichia coli (strain K12)Location: Chromosome
Compound: Hydrochloric acid (HCl) [class: Acid]Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
Length (amino acid): 466
Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761
|Similar resistance genes in 'BacMet Predicted database'|