BacMet Experimentally Confirmed database

Result: Details of the source of prediction- gadB

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
  • BacMet ID: BAC0173
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

  • Similar resistance genes in 'BacMet Predicted database'

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