BacMet Database

Result: Details of the source of prediction- gadA

Gene_name	Experimentally Verified Resistance Gene Information	Predicted Resistance Gene Information
gadA	BacMet ID: BAC0172 Code for: Enzyme Family: Group II decarboxylase family Sequence: FASTA Cross-database IDs: Link Organism: Escherichia coli (strain K12) Location: Chromosome Compound: Hydrochloric acid (HCl) [class: Acid] Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. Length (amino acid): 466 Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761	Similar resistance genes in 'BacMet Predicted database'

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