BacMet ID: BAC0159Code for: Enzyme
Family: short-chain dehydrogenases/reductases (SDR) family.Sequence: FASTA
Cross-database IDs: Link
Organism: Vibrio chloerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Location: Chromosome
Compound: Triclosan [class: Phenolic compounds]Description: Enoyl-(acyl-carrier-protein) (ACP) reductase is a key enzyme in type II fatty-acid synthases that catalyzes the last step in each elongation cycle; Predominately found in Vibrio species and closely related organisms where it seems to be the sole enoyl-ACP reductase. It is a antibacterial target site for triclosan where fabI and other isoforms such as fabL, fabI or fabK are absent. Triclosan expression of FabV in organism results in markedly increased resistance to triclosan. There may be bacteria that have both FabV and FabK such as various of the Clostridia such as Clostridium tetani.
Length (amino acid): 401
Reference: Massengo-Tiasse et al. 2008; Pubmed- 18032386, Zhu et al. 2010; Pubmed- 19933806,
|Similar resistance genes in 'BacMet Predicted database'|