BacMet Experimentally Confirmed database

Result: Details of the source of prediction- fabI

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
  • BacMet ID: BAC0156
  • Code for: Enzyme
  • Family: short-chain dehydrogenases/reductases (SDR) family.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds]
  • Description: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis; enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan; some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK, FabV and FabL.
  • Length (amino acid): 262
  • Reference: McMurry et al. 1998; Pubmed- 9707111

  • Similar resistance genes in 'BacMet Predicted database'

    BacMet database and website is designed and maintained by Chandan Pal

    Copyright © 2013 All rights reserved

    GU logo