BacMet ID: BAC0156Code for: Enzyme
Family: short-chain dehydrogenases/reductases (SDR) family.Sequence: FASTA
Cross-database IDs: Link
Organism: Escherichia coli (strain K12)Location: Chromosome
Compound: Triclosan [class: Phenolic compounds]Description: Enoyl-[acyl-carrier-protein] reductase [NADH] FabI; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis; enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan; some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK, FabV and FabL.
Length (amino acid): 262
Reference: McMurry et al. 1998; Pubmed- 9707111
|Similar resistance genes in 'BacMet Predicted database'|