BacMet Experimentally Confirmed database

Result: Details of the source of prediction- emrE/mvrC

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
  • BacMet ID: BAC0150
  • Code for: Efflux/Membrane protein
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium.
  • Length (amino acid): 110
  • Reference: Morimyo et al. 1992; Pubmed- 1320256, Yerushalmi et al. 1995; Pubmed- 7896833, Yerushalmi et al. 2000; Pubmed- 10681497, Rotem et al. 2004; Pumed- 15371426

  • Similar resistance genes in 'BacMet Predicted database'

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