BacMet ID: BAC0150Code for: Efflux/Membrane protein
Family: Small multidrug resistance (SMR) familySequence: FASTA
Cross-database IDs: Link
Organism: Escherichia coli (Strain K12)Location: Chromosome
Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]Description: It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium.
Length (amino acid): 110
Reference: Morimyo et al. 1992; Pubmed- 1320256, Yerushalmi et al. 1995; Pubmed- 7896833, Yerushalmi et al. 2000; Pubmed- 10681497, Rotem et al. 2004; Pumed- 15371426
|Similar resistance genes in 'BacMet Predicted database'|