BacMet Experimentally Confirmed database

Result: Details of the source of prediction- emrB

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
emrB
  • BacMet ID: BAC0148
  • Code for: Enzyme
  • Family: Major facilitator superfamily (MFS)-EmrB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]
  • Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
  • Length (amino acid): 512
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

  • Similar resistance genes in 'BacMet Predicted database'
    emrBsm
  • BacMet ID: BAC0500
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 528
  • Reference: Huang et al. 2013; Pubmed- 23794602

  • Similar resistance genes in 'BacMet Predicted database'
    smvA/emrB
  • BacMet ID: BAC0367
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS),¬†TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine.
  • Length (amino acid): 495
  • Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834, Ogawa et al. 2006; Pubmed- 16508165

  • Similar resistance genes in 'BacMet Predicted database'


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