BacMet ID: BAC0532Code for: Regulator
Family: Contains 1 histidine kinase domainSequence: FASTA
Cross-database IDs: Link
Organism: Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044Location: Chromosome
Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]Description: Sensor protein of stress-related two-component regulatory system of CpxAR. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon.
Length (amino acid): 457
Reference: Srinivasan et al. 2012; Pubmed- 22496764
|Similar resistance genes in 'BacMet Predicted database'|