BacMet ID: BAC0053Code for: Efflux
Family: MFS superfamilySequence: FASTA
Cross-database IDs: Link
Organism: Bacillus subtilis (strain 168)Location: Chromosome
Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
Length (amino acid): 389
Reference: Neyfakh et al. 1991; Pubmed- 1675788
|Similar resistance genes in 'BacMet Predicted database'|