BacMet Experimentally Confirmed database

Result: Details of the source of prediction- bmr

Gene_nameExperimentally Verified Resistance Gene Information Predicted Resistance Gene Information
bmr
  • BacMet ID: BAC0053
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 389
  • Reference: Neyfakh et al. 1991; Pubmed- 1675788

  • Similar resistance genes in 'BacMet Predicted database'
    bmrR
  • BacMet ID: BAC0054
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine]
  • Description: Multidrug-efflux transporter 1 regulator; Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer.
  • Length (amino acid): 278
  • Reference: Ahmed et al. 1994; Pubmed- 7961792

  • Similar resistance genes in 'BacMet Predicted database'


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