Browsing Experimentally Confirmed database

Result: Your query found 34 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT2
  • BacMet ID: BAC0479
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc.
  • Length (amino acid): 238
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    bepC
  • BacMet ID: BAC0042
  • Code for: Efflux
  • Family: RND superfamily, OMP/TolC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. It can form a tripartite pump with BepD and BepE or with BepF and BepG.
  • Length (amino acid): 456
  • Reference: Posada et al. 2007; Pubmed- 17088356

    		• Similar resistance genes in 'BacMet Predicted database'
    bepD
  • BacMet ID: BAC0043
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump periplasmic linker BepD. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics such as ampicillin, norfloxacin, ciprofloxacin, tetracycline, and doxycycline.
  • Length (amino acid): 397
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    bepE
  • BacMet ID: BAC0044
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump membrane transporter BepE. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics.
  • Length (amino acid): 1051
  • Reference: Martin et al. 2009; Pubmed- 19201794

    		• Similar resistance genes in 'BacMet Predicted database'
    emhA
  • BacMet ID: BAC0142
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux transporter, membrane fusion protein subunit EmhA
  • Length (amino acid): 385
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhB
  • BacMet ID: BAC0143
  • Code for: Efflux
  • Family: Hydrophobe/amphiphile efflux-1 (HAE1) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Protein export membrane protein emhB
  • Length (amino acid): 1054
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhC
  • BacMet ID: BAC0144
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux transporter, outer membrane factor lipoprotein EmhC
  • Length (amino acid): 486
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emhR
  • BacMet ID: BAC0145
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Regulator of emhABC efflux system, EmhR
  • Length (amino acid): 210
  • Reference: Tian et al. 2010; Pubmed- 19833777, Hearn et al. 2003; Pubmed- 14563857

    		• Similar resistance genes in 'BacMet Predicted database'
    emrK
  • BacMet ID: BAC0151
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate
  • Length (amino acid): 387
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791

    		• Similar resistance genes in 'BacMet Predicted database'
    gesA
  • BacMet ID: BAC0178
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 408
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    gesB
  • BacMet ID: BAC0179
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 1055
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    gesC
  • BacMet ID: BAC0180
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • Location: Chromosome
  • Compound: Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane]
  • Description: The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol.
  • Length (amino acid): 503
  • Reference: Pontel et al. 2007; Pubmed- 17919284, Conroy et al. 2010; Pubmed- 20497225

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtE/yhiU
  • BacMet ID: BAC0213
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12.
  • Length (amino acid): 385
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtF/yhiV
  • BacMet ID: BAC0214
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC.
  • Length (amino acid): 1037
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrC
  • BacMet ID: BAC0257
  • Code for: Efflux
  • Family: MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: Membrane fusion protein MtrC; part of MtrCDE efflux pump; Cell membrane lipoprotein, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents
  • Length (amino acid): 412
  • Reference: Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176, Veal et al. 1998; Pubmed- 9534233

    		• Similar resistance genes in 'BacMet Predicted database'
    mtrR
  • BacMet ID: BAC0261
  • Code for: Regulator
  • Family: TetR (tetracycline resistance) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane]
  • Description: HTH-type transcriptional regulator MtrR; Repressor of the mtrC gene. the major repressor of mtrCDE expression; Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents
  • Length (amino acid): 210
  • Reference: Pan et al. 1994; Pubmed- 8196548, Hagman et al. 1995; Pubmed- 7711899

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacC/qacD/smr
  • BacMet ID: BAC0321
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pTZ20, pWBG32, pTZ22, pKH8
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein QacC (also called as QacD or smr); Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide. It confers resistance to toxic organic cations via proton-dependent export.
  • Length (amino acid): 107
  • Reference: Paulsen et al. 1995; Pubmed- 7751293, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacE
  • BacMet ID: BAC0322
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa
  • Location: Plasmid IncP-beta R751 (E. coli), Plasmid IncP-beta R751 (Enterobacter aerogenes)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quaternary ammonium compound-resistance protein qacE, Multidrug exporter. It is implicated for the resistance to bacteriocidal quaternary ammonium compounds.
  • Length (amino acid): 110
  • Reference: Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    smeD
  • BacMet ID: BAC0358
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Membrane fusion protein of RND family multidrug efflux pump smeD; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 394
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeE
  • BacMet ID: BAC0359
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: RND efflux system, inner membrane transporter smeE; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 1040
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    smeF
  • BacMet ID: BAC0360
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS
  • Description: Multidrug resistance outer membrane protein smeF; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics.
  • Length (amino acid): 466
  • Reference: Sanchez et al. 2005; Pubmed- 15673767, Alonso et al. 2000; Pubmed- 11036026, Zhang et al. 2001, Pubmed- 11709330

    		• Similar resistance genes in 'BacMet Predicted database'
    tehA
  • BacMet ID: BAC0384
  • Code for: Membrane Transporter
  • Family: Tellurite-resistance/dicarboxylate transporter (TDT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tellurium (Te), Proflavin [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat]
  • Description: Tellurite resistance protein TehA; The gene encodes an integral membrane protein. Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance, otherwise phenotypically silent
  • Length (amino acid): 330
  • Reference: Walter et al 1991; Pubmed- 2060788, Taylor et al. 1994; Pubmed- 8169225, Turner et al. 1997; Pubmed- 9021204

    		• Similar resistance genes in 'BacMet Predicted database'
    tolCsm
  • BacMet ID: BAC0507
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat], Plumbagin [class: Naphthoquinone], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide], Menadione [class: Naphthoquinone]
  • Description: Outer membrane protein. pcm and tolCsm genes form an operon. A significant feature of TolCsm different from that of other tolC homologues of Enterobacteriaceae is that tolCsm is not transcribed alone, but is transcribed with the pcm gene.
  • Length (amino acid): 452
  • Reference: Huang et al. 2013; Pubmed- 23629016

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeA
  • BacMet ID: BAC0429
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Membrane fusion protein VmeA
  • Length (amino acid): 379
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeB
  • BacMet ID: BAC0430
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Inner membrane protein VmeB
  • Length (amino acid): 1053
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

    		• Similar resistance genes in 'BacMet Predicted database'
    ykkC
  • BacMet ID: BAC0448
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) protein family. YkkC/YkkD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat]
  • Description: Multidrug resistance protein YkkC; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials
  • Length (amino acid): 112
  • Reference: Jack et al. 2000; Pubmed- 10735877

    		• Similar resistance genes in 'BacMet Predicted database'
    ykkD
  • BacMet ID: BAC0449
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) protein family. YkkC/YkkD subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat]
  • Description: Multidrug resistance protein YkkD; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials
  • Length (amino acid): 105
  • Reference: Jack et al. 2000; Pubmed- 10735877

    		• Similar resistance genes in 'BacMet Predicted database'
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