Browsing Experimentally Confirmed database

Result: Your query found 17 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeM
  • BacMet ID: BAC0001
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs.
  • Length (amino acid): 448
  • Reference: Su et al. 2005; Pubmed- 16189122

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrM
  • BacMet ID: BAC0189
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate
  • Length (amino acid): 464
  • Reference: Xu et al. 2003; Pubmed- 14695443

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacB
  • BacMet ID: BAC0320
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid pTZ2162 (S. Aureus)
  • Compound: Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones]
  • Description: Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Alam et al. (2003), Pubmed- 12820795, Nakaminami, H. et al. (2008); Littlejon et al. 1992; Pubmed- 1526458, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacR
  • BacMet ID: BAC0328
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pSK1 (S. aureus)
  • Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]
  • Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
  • Length (amino acid): 188
  • Reference: Grkovic et al. 1998; Pubmed- 9660841

    		• Similar resistance genes in 'BacMet Predicted database'
    smdA
  • BacMet ID: BAC0353
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdA
  • Length (amino acid): 591
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smdB
  • BacMet ID: BAC0354
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdB
  • Length (amino acid): 592
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smfY
  • BacMet ID: BAC0363
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump SmfY
  • Length (amino acid): 490
  • Reference: Shahcheraghi et al. 2007; Pubmed- 17409524

    		• Similar resistance genes in 'BacMet Predicted database'
    smrA
  • BacMet ID: BAC0364
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine]
  • Description: ABC-type multidrug efflux pump protein SmrA
  • Length (amino acid): 610
  • Reference: Al-Hamad et al. 2009; Pubmed- 19643774

    		• Similar resistance genes in 'BacMet Predicted database'
    vcaM
  • BacMet ID: BAC0417
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acridine Orange [class: Acridine]
  • Description: ABC transporter, ATP-binding protein VcaM; Inner membrane protein
  • Length (amino acid): 619
  • Reference: Huda et al. 2003; Pubmed- 12878498

    		• Similar resistance genes in 'BacMet Predicted database'
    vcmA
  • BacMet ID: BAC0422
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio chloerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Acriflavine [class: Acridine]
  • Description: Multidrug efflux pump vcmA that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium bromide, 4',6'-diamidino-2-phenylindole and Acriflavine
  • Length (amino acid): 457
  • Reference: Huda et al. 2001; Punmed: 11583854

    		• Similar resistance genes in 'BacMet Predicted database'
    vcrM
  • BacMet ID: BAC0423
  • Code for: Efflux
  • Family: MATE family, DinF-subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae non-O1
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: A Na+/drug antiporter-type multidrug efflux pump vcrM
  • Length (amino acid): 445
  • Reference: Huda et al. 2002; Pubmed- 12906102

    		• Similar resistance genes in 'BacMet Predicted database'
    vmrA
  • BacMet ID: BAC0431
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Na+-coupled multidrug efflux pump VmrA; confers resistance to cationic drugs (4',6'-diamidino-2-phenylindole (DAPI), Tetraphenylphosphonium (TPP), Acriflavine, ethidium)
  • Length (amino acid): 447
  • Reference: Chen et al. 2002; Pubmed- 11751837

    		• Similar resistance genes in 'BacMet Predicted database'
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