Browsing Experimentally Confirmed database

Result: Your query found 101 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

  • Similar resistance genes in 'BacMet Predicted database'
    acrD/yffA
  • BacMet ID: BAC0008
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances.
  • Length (amino acid): 1037
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Nakamura et al. 1979; Pubmed- 378962

  • Similar resistance genes in 'BacMet Predicted database'
    acrE/envC
  • BacMet ID: BAC0009
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein E; May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability. It can confer resistance to novomycin.
  • Length (amino acid): 385
  • Reference: Klein et al. 1991; Pubmed- 1720861, Ma et al. 1993; Pubmed- 8407802, Nishino et al. 2001; Pubmed- 11566977

  • Similar resistance genes in 'BacMet Predicted database'
    acrF/envD
  • BacMet ID: BAC0010
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein F; Involved in cell envelope formation. It is produced in extremely low amounts.
  • Length (amino acid): 1034
  • Reference: Klein et al. 1991; Pubmed- 1720861, Nishino et al. 2001; Pubmed- 11566977

  • Similar resistance genes in 'BacMet Predicted database'
    actA
  • BacMet ID: BAC0567
  • Code for: Enzyme
  • Family: CN hydrolase family. Apolipoprotein N-acyltransferase subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti TG2-6
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid]
  • Description: Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti.
  • Length (amino acid): 531
  • Reference: Tiwari et al. 1996; Pubmed- 8868435, Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    actP/yjcG
  • BacMet ID: BAC0564
  • Code for: Membrane transporter/Enzyme
  • Family: Sodium:solute symporter (SSF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium acetate [class: Acetate]
  • Description: Transports acetate. Also able to transport glycolate.
  • Length (amino acid): 549
  • Reference: Gimenez et al. 2003; Pubmed- 14563880

  • Similar resistance genes in 'BacMet Predicted database'
    actR
  • BacMet ID: BAC0565
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 194
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    actS
  • BacMet ID: BAC0566
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 433
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    adeA
  • BacMet ID: BAC0471
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 396
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

  • Similar resistance genes in 'BacMet Predicted database'
    adeB
  • BacMet ID: BAC0472
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128.
  • Description: AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 1035
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

  • Similar resistance genes in 'BacMet Predicted database'
    adeC
  • BacMet ID: BAC0473
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 465
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

  • Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

  • Similar resistance genes in 'BacMet Predicted database'
    adeT1
  • BacMet ID: BAC0478
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni AC0037
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, tetracycline etc.
  • Length (amino acid): 304
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

  • Similar resistance genes in 'BacMet Predicted database'
    adeT2
  • BacMet ID: BAC0479
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc.
  • Length (amino acid): 238
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

  • Similar resistance genes in 'BacMet Predicted database'
    amvA
  • BacMet ID: BAC0025
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance
  • Length (amino acid): 492
  • Reference: Rajamohan et al. 2010; Pubmed- 20573661

  • Similar resistance genes in 'BacMet Predicted database'
    asr
  • BacMet ID: BAC0038
  • Code for: Unknown
  • Family: asr family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid shock protein Asr; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0).
  • Length (amino acid): 102
  • Reference: Seputiene et al. 2003; Pubmed- 12670971

  • Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0039
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. Overexpression of BaeR increases resistance to novobiocin and deoxycholate. BaeR upregulates the mdtABCD locus and acrD and thereby increases the resistance to deoxycholate, metals and antibiotics.
  • Length (amino acid): 240
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

  • Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0596
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 240
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

  • Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0040
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

  • Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0597
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

  • Similar resistance genes in 'BacMet Predicted database'
    bepC
  • BacMet ID: BAC0042
  • Code for: Efflux
  • Family: RND superfamily, OMP/TolC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. It can form a tripartite pump with BepD and BepE or with BepF and BepG.
  • Length (amino acid): 456
  • Reference: Posada et al. 2007; Pubmed- 17088356

  • Similar resistance genes in 'BacMet Predicted database'
    bepD
  • BacMet ID: BAC0043
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump periplasmic linker BepD. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics such as ampicillin, norfloxacin, ciprofloxacin, tetracycline, and doxycycline.
  • Length (amino acid): 397
  • Reference: Martin et al. 2009; Pubmed- 19201794

  • Similar resistance genes in 'BacMet Predicted database'
    bepE
  • BacMet ID: BAC0044
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane]
  • Description: Efflux pump membrane transporter BepE. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics.
  • Length (amino acid): 1051
  • Reference: Martin et al. 2009; Pubmed- 19201794

  • Similar resistance genes in 'BacMet Predicted database'
    bepF
  • BacMet ID: BAC0045
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux pump periplasmic linker BepF; Contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE
  • Length (amino acid): 411
  • Reference: Martin et al. 2009; Pubmed- 19201794

  • Similar resistance genes in 'BacMet Predicted database'
    bepG
  • BacMet ID: BAC0046
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Brucella suis biovar 1 (strain 1330)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Efflux pump membrane transporter BepG; Contributes to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.
  • Length (amino acid): 1074
  • Reference: Martin et al. 2009; Pubmed- 19201794

  • Similar resistance genes in 'BacMet Predicted database'
    cmeA
  • BacMet ID: BAC0068
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: RND efflux system, a periplasmic fusion protein CmeA. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 367
  • Reference: Lin et al. 2002; Pubmed- 12069964

  • Similar resistance genes in 'BacMet Predicted database'
    cmeB
  • BacMet ID: BAC0613
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Acridine orange [class: Acridine]
  • Description: An inner membrane efflux transporter. Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 1040
  • Reference: Lin et al. 2002; Pubmed- 12069965, Pumbwe et al. 2004; Pubmed- 15201231

  • Similar resistance genes in 'BacMet Predicted database'
    cmeC
  • BacMet ID: BAC0614
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine]
  • Description: An outer membrane protein (CmeC). Part of the CmeABC multidrug efflux system in Campylobacter jejuni.
  • Length (amino acid): 492
  • Reference: Lin et al. 2002; Pubmed- 12069966

  • Similar resistance genes in 'BacMet Predicted database'
    cmeD
  • BacMet ID: BAC0615
  • Code for: Efflux
  • Family: RND superfamily, OMF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeD is the outer membrane protein.
  • Length (amino acid): 424
  • Reference: Akiba et al. 2006, Pubmed- 16303882

  • Similar resistance genes in 'BacMet Predicted database'
    cmeE
  • BacMet ID: BAC0616
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: CmeE is a periplasmic fusion protein
  • Length (amino acid): 246
  • Reference: Akiba et al. 2006, Pubmed- 16303882

  • Similar resistance genes in 'BacMet Predicted database'
    cmeF
  • BacMet ID: BAC0069
  • Code for: Efflux
  • Family: RND superfamily; AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid]
  • Description: Integral membrane component of efflux system (Multidrug efflux system CmeDEF)
  • Length (amino acid): 1005
  • Reference: Akiba et al. 2006, Pubmed- 16303882

  • Similar resistance genes in 'BacMet Predicted database'
    cmeR
  • BacMet ID: BAC0070
  • Code for: Regulator
  • Family: TetR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Campylobacter jejuni 81-176
  • Location: Chromosome
  • Compound: Sodium Cholate [class: Acid]
  • Description: Transcriptional repressor. CmeABC is controlled by CmeR, a transcriptional repressor encoded by a gene located immediately upstream of cmeABC. CmeR binds to the inverted repeat in the promoter region of cmeABC and inhibits the expression of the efflux operon.
  • Length (amino acid): 210
  • Reference: Lin et al. 2005; Pubmed- 15728904

  • Similar resistance genes in 'BacMet Predicted database'
    eefA
  • BacMet ID: BAC0494
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: A periplasmic intermediate, EefA. Part of the EefXABC operon. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 374
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

  • Similar resistance genes in 'BacMet Predicted database'
    eefX
  • BacMet ID: BAC0495
  • Code for: Unknown
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae LM21
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Part of eefXABC operon in K. pneumoniae. This gene is absent in the similar efflux system eefABC in other bacteria (such as Enterobacter aerogenes). Comaparative study suggests that it could be a regulator of the EefABC tripartite efflux system. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments.
  • Length (amino acid): 61
  • Reference: Coudeyras et al. 2008; Pubmed- 18644883

  • Similar resistance genes in 'BacMet Predicted database'
    emrK
  • BacMet ID: BAC0151
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate
  • Length (amino acid): 387
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791

  • Similar resistance genes in 'BacMet Predicted database'
    evgA
  • BacMet ID: BAC0154
  • Code for: Regulator
  • Family: Contains 1 HTH luxR-type DNA-binding domain, Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon.
  • Length (amino acid): 204
  • Reference: Kato et al. 2000; Pubmed- 10923791, Nishino et al. 2001; Pubmed- 11157960

  • Similar resistance genes in 'BacMet Predicted database'
    evgS
  • BacMet ID: BAC0155
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain, 1 response regulatory domain, 1 HPt domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Sensor protein EvgS; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals
  • Length (amino acid): 1197
  • Reference: Kato et al. 2000; Pubmed- 10923791, Nishino et al. 2001; Pubmed- 11157960

  • Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

  • Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

  • Similar resistance genes in 'BacMet Predicted database'
    farR
  • BacMet ID: BAC0505
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae, Neisseria meningitidis serogroup B (strain MC58)
  • Location: Chromosome
  • Compound: Palmitic acid [class: Free Fatty Acids]
  • Description: FarR negatively controls expression of farAB by directly binding to the farAB promoter. MtrR binds to the farR promoter, thereby repressing farR expression. MtrR regulates farAB in a positive fashion by modulating farR expression.
  • Length (amino acid): 146
  • Reference: Lee et al. 2003; Pubmed- 14645274

  • Similar resistance genes in 'BacMet Predicted database'
    gadA
  • BacMet ID: BAC0172
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

  • Similar resistance genes in 'BacMet Predicted database'
    gadB
  • BacMet ID: BAC0173
  • Code for: Enzyme
  • Family: Group II decarboxylase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.
  • Length (amino acid): 466
  • Reference: De Biase et al. 1996; Pubmed- 8954890, De Biase et al. 1999; Pubmed- 10383761

  • Similar resistance genes in 'BacMet Predicted database'
    gadC/xasA
  • BacMet ID: BAC0174
  • Code for: Enzyme
  • Family: Amino acid-polyamine-organocation (APC) superfamily. Glutamate:GABA antiporter (GGA) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: GadC functions as a transporter for the product of glutamate decarboxylase, g-aminobutyrate
  • Length (amino acid): 511
  • Reference: Hersh et al. 1996; Pubmed- 8682809, Waterman et al. 1996; Pubmed- 8885264

  • Similar resistance genes in 'BacMet Predicted database'
    gadE/yhiE
  • BacMet ID: BAC0175
  • Code for: Regulator
  • Family: Contains 1 HTH luxR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci.
  • Length (amino acid): 175
  • Reference: Ma et al. 2003; Pubmed- 12940989, Hommais et al. 2004; Pubmed- 14702398

  • Similar resistance genes in 'BacMet Predicted database'
    gadW/yhiW
  • BacMet ID: BAC0176
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters.
  • Length (amino acid): 242
  • Reference: Ma et al. 2002; Pubmed- 12446650

  • Similar resistance genes in 'BacMet Predicted database'
    gadX
  • BacMet ID: BAC0177
  • Code for: Regulator
  • Family: AraC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Role in acid resistance, increases multidrug resistance in E. coli by activating the MdtEF multidrug efflux pump; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. It can confer resistance to antibiotics such as oxacillin, cloxacillin, nafcillin, erythromycin etc.
  • Length (amino acid): 274
  • Reference: Nishino et al. 2008; Pubmed- 18297445, Shin et al. 2001; Pubmed- 11555293

  • Similar resistance genes in 'BacMet Predicted database'
    hdeA/yhiB
  • BacMet ID: BAC0185
  • Code for: Chaperone
  • Family: HdeA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeA; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 110
  • Reference: Hong et al. 2005; Pubmed- 15911614

  • Similar resistance genes in 'BacMet Predicted database'
    hdeB/yhiC
  • BacMet ID: BAC0186
  • Code for: Chaperone
  • Family: HdeB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid stress chaperone HdeB; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.
  • Length (amino acid): 108
  • Reference: Kern et al. 2007; Pubmed- 17085547

  • Similar resistance genes in 'BacMet Predicted database'
    hefA
  • BacMet ID: BAC0187
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer-membrane protein of the HefABC efflux system HefA; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA
  • Length (amino acid): 477
  • Reference: Liu et al. 2008; Pubmed- 18777600

  • Similar resistance genes in 'BacMet Predicted database'
    hefC
  • BacMet ID: BAC0188
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain P12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Cytoplasmic pump protein of the HefABC efflux system HefC
  • Length (amino acid): 1028
  • Reference: Kutschke et al. 2005; Pubmed- 15980386

  • Similar resistance genes in 'BacMet Predicted database'
    hmrM
  • BacMet ID: BAC0189
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate
  • Length (amino acid): 464
  • Reference: Xu et al. 2003; Pubmed- 14695443

  • Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0569
  • Code for: Regulator
  • Family: Contains response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium leguminosarum bv. Viciae
  • Location: Chromosome
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 129
  • Reference: Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    hmrR
  • BacMet ID: BAC0190
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae), Plasmid pSymA (Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti))
  • Location: Plasmid pSMED01
  • Compound: Copper (Cu), Hydrochloric acid (HCl) [class: Acid]
  • Description: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP
  • Length (amino acid): 147
  • Reference: Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    kexD
  • BacMet ID: BAC0492
  • Code for: Effflux
  • Family: Restriction Nodulation Division (RND) superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: KexD was shown to function with AcrAEc and TolC from E. coli and AcrAKp and KocC from K. pneumoniae, like AcrD from E. coli
  • Length (amino acid): 1038
  • Reference: Ogawa et al. 2012; Pubmed- 22391093

  • Similar resistance genes in 'BacMet Predicted database'
    kpnE
  • BacMet ID: BAC0476
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin.
  • Length (amino acid): 120
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

  • Similar resistance genes in 'BacMet Predicted database'
    kpnF
  • BacMet ID: BAC0477
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2013; Pubmed- 23836167

  • Similar resistance genes in 'BacMet Predicted database'
    mdtA/yegM
  • BacMet ID: BAC0210
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtA; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function
  • Length (amino acid): 415
  • Reference: Baranova et al. 2002; Pubmed- 12107134,

  • Similar resistance genes in 'BacMet Predicted database'
    mdtB/yegN
  • BacMet ID: BAC0211
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Hydrochloric acid (HCl) [class: Acid]
  • Description: Multidrug resistance protein MdtB; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
  • Length (amino acid): 1040
  • Reference: Deininger et al. 2011; Pubmed- 21541325

  • Similar resistance genes in 'BacMet Predicted database'
    mdtC/yegO
  • BacMet ID: BAC0212
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtC; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdABC requires TolC for its function.
  • Length (amino acid): 1025
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Nagakubo et al. 2002; Pubmed- 12107133

  • Similar resistance genes in 'BacMet Predicted database'
    mdtE/yhiU
  • BacMet ID: BAC0213
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12.
  • Length (amino acid): 385
  • Reference: Masuda et al. 2002; Pubmed- 12399493

  • Similar resistance genes in 'BacMet Predicted database'
    mdtF/yhiV
  • BacMet ID: BAC0214
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC.
  • Length (amino acid): 1037
  • Reference: Masuda et al. 2002; Pubmed- 12399493

  • Similar resistance genes in 'BacMet Predicted database'
    mdtG/yceE
  • BacMet ID: BAC0215
  • Code for: Membrane Transporter
  • Family: MFS superfamily, DHA1 family, MdtG subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Multidrug resistance protein MdtG; Confers resistance to fosfomycin and deoxycholate
  • Length (amino acid): 408
  • Reference: Nishino et al. 2001; Pubmed- 11566977

  • Similar resistance genes in 'BacMet Predicted database'
    mdtI/ydgE
  • BacMet ID: BAC0216
  • Code for: Enzyme
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Spermidine [class: Polyamines]
  • Description: Spermidine export protein MdtI; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS
  • Length (amino acid): 109
  • Reference: Nishino et al. 2001; Pubmed- 11566977, Higashi et al. 2008; Pubmed- 18039771

  • Similar resistance genes in 'BacMet Predicted database'
    mdtK/ydhE
  • BacMet ID: BAC0218
  • Code for: Efflux
  • Family: MATE family, MdtK subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein MdtK; It functions as a Na+/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin), tetraphenylphosphonium ion (TPP), deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, Acriflavine, ethidium bromide and benzylkonium
  • Length (amino acid): 457
  • Reference: Nishino et al. 2001; Pubmed- 11566977

  • Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0663
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1.
  • Length (amino acid): 214
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0661
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 209
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0662
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 242
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    mtrE
  • BacMet ID: BAC0259
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae (strain NCCP11945)
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid]
  • Description: Antibiotic resistance efflux pump component ; Outer membrane protein mtrE; part of MtrCDE efflux pump
  • Length (amino acid): 467
  • Reference: Delahay et al. 1997; Pubmed- 9245802, Hagman et al. 1995; Pubmed- 7711899, Lucas et al. 1995; Pubmed- 7476176

  • Similar resistance genes in 'BacMet Predicted database'
    oxyRkp
  • BacMet ID: BAC0536
  • Code for: Regulator
  • Family: LysR-family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Sodium Deoxycholate (SDC) [class: Acid], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Activator of hydrogen peroxide-inducible genes. It has contributory role towards varied stress tolerance in K. pneumoniae.
  • Length (amino acid): 305
  • Reference: Srinivasan et al. 2013; Pubmed- 23619002

  • Similar resistance genes in 'BacMet Predicted database'
    PA0320
  • BacMet ID: BAC0297
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species
  • Length (amino acid): 116
  • Reference: Fukushima et al. 2012; Pubmed- 22990488

  • Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

  • Similar resistance genes in 'BacMet Predicted database'
    rpoS
  • BacMet ID: BAC0335
  • Code for: Regulator
  • Family: sigma-70 factor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli, Shigella flexneri
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Sodium hydroxide (NaOH) [class: Base]
  • Description: RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RpoS is required for optimal maintenance of pH homeostasis of stationary phase cells exposed to extreme acid.
  • Length (amino acid): 330
  • Reference: Small et al. 1994; Pubmed- 8132468

  • Similar resistance genes in 'BacMet Predicted database'
    tolC
  • BacMet ID: BAC0393
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone]
  • Description: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump.
  • Length (amino acid): 493
  • Reference: Hackett et al. 1983; Pubmed- 6312426, Fralick et al. 1996; Pubmed- 8824631, Sulavik et al. 2001; Pubmed- 11257026

  • Similar resistance genes in 'BacMet Predicted database'
    vceA
  • BacMet ID: BAC0418
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC
  • Length (amino acid): 395
  • Reference: Colmer et al. 1998; Pubmed- 9466256

  • Similar resistance genes in 'BacMet Predicted database'
    vceB
  • BacMet ID: BAC0419
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC
  • Length (amino acid): 511
  • Reference: Colmer et al. 1998; Pubmed- 9466256

  • Similar resistance genes in 'BacMet Predicted database'
    vceC
  • BacMet ID: BAC0420
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Alpha-helical hairpin domain of Vibrio cholerae VceA play important roles in recognition/specificity/recruitment in the assembly of a functional, VceAB-OprM chimeric efflux pump
  • Length (amino acid): 484
  • Reference: Woolley et al. 2005; Pubmed- 16030246, Bai et al. 2010; Pubmed- 20206171

  • Similar resistance genes in 'BacMet Predicted database'
    vceR
  • BacMet ID: BAC0421
  • Code for: Regulator
  • Family: TetR (tetracycline resistance) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
  • Location: Chromosome
  • Compound: Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Repressor of the vceCAB operon, VceR; VceR regulates the VceCAB drug efflux pump operon by alternating between mutually exclusive conformations that bind either drugs or promoter DNA
  • Length (amino acid): 200
  • Reference: Woolley et al. 2005; Pubmed- 16030246, Borges-Walmsley et al. 2005; Pubmed- 15890203

  • Similar resistance genes in 'BacMet Predicted database'
    vexH
  • BacMet ID: BAC0509
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae serotype O1
  • Location: Chromosome
  • Compound: Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin.
  • Length (amino acid): 1036
  • Reference: Taylor et al. 2012; Pubmed- 22666485

  • Similar resistance genes in 'BacMet Predicted database'
    vmeA
  • BacMet ID: BAC0429
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Membrane fusion protein VmeA
  • Length (amino acid): 379
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

  • Similar resistance genes in 'BacMet Predicted database'
    vmeB
  • BacMet ID: BAC0430
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Inner membrane protein VmeB
  • Length (amino acid): 1053
  • Reference: Matsuo et al. 2007; Pubmed- 18048926

  • Similar resistance genes in 'BacMet Predicted database'
    vmeC
  • BacMet ID: BAC0510
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 368
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeD
  • BacMet ID: BAC0511
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1040
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeE
  • BacMet ID: BAC0512
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine]
  • Description: VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 364
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeF
  • BacMet ID: BAC0513
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine]
  • Description: VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1037
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeG
  • BacMet ID: BAC0517
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 343
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeH
  • BacMet ID: BAC0518
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeI
  • BacMet ID: BAC0519
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides]
  • Description: Part of VexGHI efflux transporter.
  • Length (amino acid): 1033
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeP
  • BacMet ID: BAC0522
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 380
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeQ
  • BacMet ID: BAC0523
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes.
  • Length (amino acid): 1046
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeT
  • BacMet ID: BAC0524
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeU
  • BacMet ID: BAC0525
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 353
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeV
  • BacMet ID: BAC0526
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 1019
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeY
  • BacMet ID: BAC0514
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 375
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vmeZ
  • BacMet ID: BAC0515
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1050
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    vpoC
  • BacMet ID: BAC0516
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Homologue of E. coli TolC outer membrane protein, vpoC.
  • Length (amino acid): 442
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

  • Similar resistance genes in 'BacMet Predicted database'
    ydeO
  • BacMet ID: BAC0437
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: HTH-type transcriptional regulator YdeO; Induces the Expression of gadE and mdtEF. Could also regulate the Expression of other genes involved in acid resistance
  • Length (amino acid): 253
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Nishino et al. 2009; Pubmed- 19329985, Masuda et al. 2002; Pubmed- 12399493

  • Similar resistance genes in 'BacMet Predicted database'
    ydeP
  • BacMet ID: BAC0438
  • Code for: Enzyme
  • Family: Prokaryotic molybdopterin-containing oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Hydrochloric acid (HCl) [class: Acid]
  • Description: Acid resistance protein YdeP; Involved in acid resistance
  • Length (amino acid): 759
  • Reference: Masuda et al. 2003; Pubmed- 12694615, Masuda et al. 2002; Pubmed- 12399493

  • Similar resistance genes in 'BacMet Predicted database'
    yhcN
  • BacMet ID: BAC0446
  • Code for: Unknown
  • Family: BhsA/McbA family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Outer membrane protein YhcN; stress response protein
  • Length (amino acid): 87
  • Reference: Lee et al. 2010; Pubmed- 19919618

  • Similar resistance genes in 'BacMet Predicted database'
    yjaA
  • BacMet ID: BAC0447
  • Code for: Unknown
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress response protein YjaA; a YjaA mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 127
  • Reference: Lee et al. 2010; Pubmed- 19919618

  • Similar resistance genes in 'BacMet Predicted database'
    ymgB/ariR
  • BacMet ID: BAC0450
  • Code for: Binding protein
  • Family: AriR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)))
  • Compound: Hydrochloric Acid (HCl) [class: Acid], Hydrogen Peroxide (H2O2) [class: Peroxides]
  • Description: Two-component-system connector protein YmgB/AriR; a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H2O2. Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; YmgB probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein. Deletion increases biofilm formation.
  • Length (amino acid): 88
  • Reference: Lee et al. 2007; Pubmed- 17765265

  • Similar resistance genes in 'BacMet Predicted database'
    yodD
  • BacMet ID: BAC0451
  • Code for: Unknown
  • Family: Contains a DUF2525 domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: Stress protein YodD; a yodD mutant strain is sensitive to hydrogen peroxide and acid
  • Length (amino acid): 75
  • Reference: Lee et al. 2010; Pubmed- 19919618

  • Similar resistance genes in 'BacMet Predicted database'

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