Browsing Experimentally Confirmed database

Result: Your query found 24 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
actP
  • BacMet ID: BAC0012
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
  • Location: Plasmid pSMED01 (Sinorhizobium medicae (strain WSM419))
  • Compound: Copper (Cu), Sodium acetate [class: Acetate]
  • Description: Copper-transporting P-type ATPase; Involved in copper efflux; Transcriptionally regulated by HmrR in response to Cu+ ions.
  • Length (amino acid): 827
  • Reference: Reeve et al. 2002; Pubmed- 11936079

  • Similar resistance genes in 'BacMet Predicted database'
    actP/yjcG
  • BacMet ID: BAC0564
  • Code for: Membrane transporter/Enzyme
  • Family: Sodium:solute symporter (SSF) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium acetate [class: Acetate]
  • Description: Transports acetate. Also able to transport glycolate.
  • Length (amino acid): 549
  • Reference: Gimenez et al. 2003; Pubmed- 14563880

  • Similar resistance genes in 'BacMet Predicted database'
    emrA
  • BacMet ID: BAC0147
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell.
  • Length (amino acid): 390
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

  • Similar resistance genes in 'BacMet Predicted database'
    emrB
  • BacMet ID: BAC0148
  • Code for: Enzyme
  • Family: Major facilitator superfamily (MFS)-EmrB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]
  • Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
  • Length (amino acid): 512
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

  • Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

  • Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

  • Similar resistance genes in 'BacMet Predicted database'
    iclR
  • BacMet ID: BAC0196
  • Code for: Regulator
  • Family: Contains 1 HTH iclR-type DNA-binding domain, 1 iclR-ED (iclR effector binding) domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Sodium acetate [class: Acetate]
  • Description: Acetate operon repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form.
  • Length (amino acid): 274
  • Reference: Spencer et al. 2007; Pubmed- 17238290, Sunnarborg et al. 1990; Pubmed- 2185227

  • Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0224
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus cereus R6007
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 631
  • Reference: Gupta et al. 1999; Pubmed- 10559175

  • Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0648
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 460
  • Reference: Griffin et al. 1987; Pubmed- 3033633

  • Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0650
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 569
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

  • Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0657
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 212
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

  • Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0658
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: plasmid pI258
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 216
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

  • Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0659
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 212
  • Reference: Griffin et al. 1987; Pubmed- 3033633,

  • Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0654
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the first mer operon. MerB1, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

  • Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0663
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1.
  • Length (amino acid): 214
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0655
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the second mer operon. MerB2, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 209
  • Reference: Gupta et al. 1999; Pubmed- 10559175

  • Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0661
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 209
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0656
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the third mer operon. MerB3, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

  • Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0662
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 242
  • Reference: Huang et al. 1999; Pubmed- 10548738

  • Similar resistance genes in 'BacMet Predicted database'
    merG
  • BacMet ID: BAC0229
  • Code for: Membrane Transporter
  • Family: Contains 1 TPR-like helical , 1 Sel1-like repeat
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62), Plasmid pIJB1 (Burkholderia cepacia (Pseudomonas cepacia))
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercuric resistance protein MerG; Known to confer resistance to phenylmercury
  • Length (amino acid): 217
  • Reference: Kiyono et al. 1999; Pubmed- 9922233, Kiyono et al. 1997; Pubmed- 9168120,

  • Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0681
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury resistance operon negative regulator MerR2
  • Length (amino acid): 129
  • Reference: Gupta et al. 1999; Pubmed- 10559175

  • Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0688
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial resistance regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

  • Similar resistance genes in 'BacMet Predicted database'
    oscA
  • BacMet ID: BAC0358
  • Code for: Binding protein
  • Family: Unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr), Dodine [class: Acetate]
  • Description: oscA gene involved in the sulphur starvation response and in Cr(VI) resistance in Pseudomonas corrugata 28. oscA is located upstream of a gene cluster that encodes the components of the sulphate ABC transporter, and it forms a single transcriptional unit with sbp, which encodes the periplasmic sulphate-binding protein. It has been shown that oscA is essential for the utilization of various organosulphur compounds and that it induces upregulation of the cysTWA operon under conditions of chromate exposure. oscA may also have a regulatory role in the sulphur starvation response, but the exact mechanism through which it acts is not well understood.
  • Length (amino acid): 60
  • Reference: Viti et al. 2009; Pubmed- 19118350

  • Similar resistance genes in 'BacMet Predicted database'
    ruvB
  • BacMet ID: BAC0293
  • Code for: Enzyme
  • Family: Malic enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas corrugata 28
  • Location: Chromosome
  • Compound: Chromium (Cr), Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dodine [class: Acetate], 2-nitroimidazole [class: imidazole]
  • Description: It is a fragment of ruvB gene product. It is a oxidoreductase from malic enzyme family.
  • Length (amino acid): 379
  • Reference: Decorosi et al. 2009; Pubmed- 19768364

  • Similar resistance genes in 'BacMet Predicted database'

    BacMet database and website is designed and maintained by Chandan Pal

    Copyright © 2013-2016 All rights reserved

    GU logo