BacMet ID: BAC0487Code for: Regulator
Family: Contains response regulatory domainSequence: FASTA
Cross-database information: Link
Organism: Erwinia carotovora ssp. CarotovoraLocation: Chromosome
Compound: Iron (Fe)Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. It is involved in controlling of bacterial response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments. Unphosphorylated PmrA represses extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves such repression, which leads to activation of extracellular enzyme genes. Phosphorylated PmrA seems to repress expression of the pmrCAB operon.
Length (amino acid): 222
Reference: Hyytiainen et al. 2003; Pubmed- 14617142; Wosten et al. 2000; Pubmed- 11051552
|Similar resistance genes in 'BacMet Predicted database'|