Accession BacMet_ID Gene_name Location Organism Compound Description Q5FAM9 BAC0001 abeM Chromosome Acinetobacter baumanni 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs. Q2FD83 BAC0002 abeS Chromosome Acinetobacter baumannii Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc. O53166 BAC0003 acn Chromosome Mycobacterium tuberculosis H37Rv Iron (Fe) Aconitate hydratase, Acn B5LX01 BAC0004 acr3 Chromosome Campylobacter jejuni Arsenic (As) Arsenical-resistance membrane transporter; part of the an arsenic (ars) four-gene operon, containing genes encoding a putative membrane permease (ArsP), a transcriptional repressor (ArsR), an arsenate reductase (ArsC) and an arsenical-resistance membrane transporter (Acr3) P0AE06 BAC0005 acrA Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane] AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. P31224 BAC0006 acrB Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane] AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. Q1LMP2 BAC0007 acrC Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine] Cation/multidrug efflux system outer membrane porin arcC. Q8ZN77 BAC0563 acrD Chromosome Salmonella enterica serovar Typhimurium Copper (Cu), Zinc (Zn) Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances. It contributes to copper and zinc resistance in Salmonella. P24177 BAC0008 acrD/yffA Chromosome Escherichia coli (strain K12) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid] Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances. P24180 BAC0009 acrE/envC Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine] Acriflavine resistance protein E; May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability. It can confer resistance to novomycin. P24181 BAC0010 acrF/envD Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine] Acriflavine resistance protein F; Involved in cell envelope formation. It is produced in extremely low amounts. P0ACS9 BAC0011 acrR/ybaH Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine] HTH-type potential regulator protein for the acrAB genes. Q52910 BAC0567 actA Chromosome Rhizobium meliloti TG2-6 Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid] Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti. Q9X5X3 BAC0012 actP Plasmid pSMED01 (Sinorhizobium medicae (strain WSM419)) Sinorhizobium medicae (strain WSM419) (Ensifer medicae) Copper (Cu), Sodium acetate [class: Acetate] Copper-transporting P-type ATPase; Involved in copper efflux; Transcriptionally regulated by HmrR in response to Cu+ ions. Q9X5V3 BAC0568 actP Chromosome Rhizobium leguminosarum bv. Viciae Copper (Cu) Copper-transporting P-type ATPase. Involved in copper efflux. Transcriptionally regulated by HmrR in response to Cu+ ions. D5AU53 BAC0570 actP Chromosome Rhodobacter capsulatus B100 Tellurium (Te) Acetate Permease (ActP) is responsible for tellurite uptake and resistance in cells of the facultative phototroph Rhodobacter capsulatus. P32705 BAC0564 actP/yjcG Chromosome Escherichia coli (strain K12) Sodium Glycocholate [class: Acid], Sodium acetate [class: Acetate] Transports acetate. Also able to transport glycolate. A6UEL7 BAC0565 actR Chromosome Rhizobium meliloti strain WSM419 Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide] Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response. Q52912 BAC0566 actS Chromosome Rhizobium meliloti strain WSM419 Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide] Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response. Q93E20 BAC0471 adeA Chromosome Acinetobacter baumanni Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl] AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents. Q93E19 BAC0472 adeB Chromosome Acinetobacter baumanni Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128. AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents. Q93E18 BAC0473 adeC Chromosome Acinetobacter baumanni Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl] AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents. Q67GM1 BAC0474 adeD Chromosome Acinetobacter sp. 4365 Ethidium Bromide [class: Phenanthridine] Resistance-nodulation-cell division efflux system AdeDE in Acinetobacter; AdeDE increases the host resistance to ceftazidime and rifampicin. The outer-membrane protein (OMP) for AdeDE has not been identified yet (Oct 2013). Q8GKU1 BAC0013 adeE Chromosome Acinetobacter sp. 4356 Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine] Resistance-nodulation-cell division efflux system AdeDE in Acinetobacter. AdeDE increases the host resistance to ceftazidime and rifampicin. The outer-membrane protein (OMP) for AdeDE has not been identified yet (Oct 2013). Q2FD82 BAC0014 adeF Chromosome Acinetobacter baumanni Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine] Putative RND family drug transporter AdeF; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents. Q2FD81 BAC0015 adeG Chromosome Acinetobacter baumannii (strain AB0057) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine] Cation/multidrug efflux pump AdeG; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents. Q2FD80 BAC0016 adeH Chromosome Acinetobacter baumannii (strain AB0057) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine] Putative RND family drug transporter AdeH; Part of AdeFGH efflux system. Confers resistance to antibiotics such as tetracyclines, chloramphenicol, fluoroquinolones, trimethoprim and other antibacterial biocides such as dyes, anionic detergents. Q2FD95 BAC0017 adeI Chromosome Acinetobacter baumannii (strain AB0057) Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl] Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate. Q24LT7 BAC0018 adeJ Chromosome Acinetobacter baumannii (strain AB0057) Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate. Q24LT6 BAC0019 adeK Chromosome Acinetobacter baumannii (strain AB0057) Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detregents such as sodium dodecyl sulfate. A3M732 BAC0508 adeL Chromosome Acinetobacter baumanni Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Acridine Orange [class: Acridine] Regulator of adeFGH efflux system B7H1T7 BAC0496 adeN Chromosome Acinetobacter baumanni Safranin O [class: Azin], Acridine Orange [class: Acridine], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Repressor of AdeIJK expression C7F8K6 BAC0478 adeT1 Chromosome Acinetobacter baumanni AC0037 Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl] It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, tetracycline etc. C7F8K7 BAC0479 adeT2 Chromosome Acinetobacter baumanni Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl] It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc. Q8GGJ6 BAC0020 aioA/aoxB Chromosome Herminiimonas arsenicoxydans Arsenic (As) It is a structural gene which codes for small subunit of Arsenite oxidase aioAB; Involved in the detoxification of arsenic. Oxidizes As(III)O3- (arsenite) to the somewhat less toxic As(V)O4- (arsenate). Q8GGJ7 BAC0021 aioB/aoxA Chromosome Herminiimonas arsenicoxydans Arsenic (As) It is a structural gene which codes for small subunit of Arsenite oxidase, AioAB; Involved in the detoxification of arsenic. Oxidizes As(III)O3- (arsenite) to the somewhat less toxic As(V)O4- (arsenate). Q2VGB1 BAC0022 aioR/aoxR Chromosome Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) Arsenic (As) Transcriptional regulator. Part of a two-component As(III) responsive system (AioSR) Q2VGB2 BAC0023 aioS/aoxS Chromosome Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) Arsenic (As) Sensor histidine kinase; signal transduction protein G8XNW6 BAC0024 aioX/aoxX Chromosome Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium radiobacter) Arsenic (As) A periplasmic oxyanion-binding protein involved in regulating arsenite oxidation O52119 BAC0489 ALU1-P Chromosome Arthrobacter viscosus ALRJJ6 Aluminium (Al) Fragment of the ALU1 resistance gene called ALU1-P but the frament has the potential to confer tolerance to aluminium . It has 65% identity in amino acid level with the protein of YbaX gene in Escherichia coli, and 51.1% identity with YB91 Haein hypothetical protein of HI1191 gene in Haemophilus influenzae. C4PAW9 BAC0025 amvA Chromosome Acinetobacter baumannii Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid] MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance P52145 BAC0030 arsA Plasmid IncN R46 Escherichia coli Arsenic (As), Antimony (Sb) Anion-transporting ATPase; Determinants of a membrane-associated oxyanion-stimulated ATPase protein; energizes the arsenite efflux pump by ATP hydrolysis; Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. O50593 BAC0571 arsA Plasmid pKW301 Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301) Arsenic (As), Antimony (Sb) Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. P08690 BAC0572 arsA Plasmid R773 Escherichia coli Arsenic (As), Antimony (Sb) Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. P08691 BAC0031 arsB Plasmid R773 (E. coli), Plasmid IncN R46 (E. coli), Plasmid R46 (Salmonella typhimurium) Escherichia coli Arsenic (As), Antimony (Sb) Arsenic pump membrane protein, located in cell inner membrane. Involved in arsenite and antimonite resistance. Thought to form a channel of an arsenite pump. P45946 BAC0573 arsB Chromosome Bacillus subtilis (strain 168) Arsenic (As) Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. Deletion of the arsB gene results in both an aresenite- and arsenate-sensitive phenotype in the absence of IPTG. P30329 BAC0574 arsB Plasmid pI258 Staphylococcus aureus Arsenic (As), Antimony (Sb) Involved in arsenical resistance. Thought to form the channel of an arsenite pump. Q01255 BAC0575 arsB Plasmid pSX267 Staphylococcus xylosus Arsenic (As), Antimony (Sb) Involved in arsenical resistance. Thought to form the channel of an arsenite pump. P52146 BAC0576 arsB Plasmid IncN R46 Escherichia coli Arsenic (As), Antimony (Sb) Involved in arsenical resistance. Thought to form the channel of an arsenite pump. P74985 BAC0577 arsB Plasmid pYV Yersinia enterocolitica Arsenic (As) Involved in arsenical resistance. Thought to form the channel of an arsenite pump. O50594 BAC0578 arsB Plasmid pKW301 Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301) Arsenic (As), Antimony (Sb) Part of arsenic resistance operon of Acidiphilium multivorum AIU 301 plasmid pKW301. P74311 BAC0579 arsB Chromosome Synechocystis sp. PCC 6803 Arsenic (As), Antimony (Sb) Able to export both As(III) and Sb(III) and providies a example of convergent evolution between both families of arsenite transporters. P0A006 BAC0032 arsC Plasmid pI258 Staphylococcus aureus Arsenic (As) Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances. Q01257 BAC0580 arsC Plasmid pSX267 Staphylococcus xylosus Arsenic (As) Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances. P45947 BAC0581 arsC Chromosome Bacillus subtilis (strain 168) Arsenic (As) Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances. P08692 BAC0582 arsC Plasmid R773 Escherichia coli Arsenic (As), Antimony (Sb) Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance. P52147 BAC0583 arsC Plasmid IncN R46 Escherichia coli Arsenic (As), Antimony (Sb) Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance. O50595 BAC0584 arsC Plasmid pKW301 Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / AIU301) Arsenic (As), Antimony (Sb) Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance P74984 BAC0585 arsC Plasmid pYV Yersinia enterocolitica Arsenic (As), Antimony (Sb) Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance. P74313 BAC0586 arsC Chromosome Synechocystis sp. PCC 6803 Arsenic (As) Arsenate reductase. Reduces arsenate [As(V)] to arsenite [As(III)]. P46003 BAC0033 arsD Plasmid R773 (E. coli), Plasmid R64 (Salmonella typhimurium) Escherichia coli Arsenic (As) An arsenic metallochaperone for an arsenic detoxification pump P52148 BAC0587 arsD Plasmid IncN R46 Escherichia coli Arsenic (As), Antimony (Sb) Arsenical resistance operon trans-acting repressor ArsD. E8PS81 BAC0034 arsH Plasmid pKPN-IT (Klebsiella pneumoniae), Plasmid R485 (Morganella morganii (Proteus morganii)) Yersinia pestis Java 9 Arsenic (As) Arsenical resistance protein ArsH; ArsH is not required for arsenate resistance in some systems; arsH encodes an NADPH-flavin mononucleotide oxidoreductase and has been shown to be involved in arsenic resistance in Yersinia enterocolitica and Sinorhizobium meliloti. It is an essential component in a new four gene arsenical resistance transposon associated operon, arsHRBC. P74312 BAC0595 arsH Chromosome Synechocystis sp. PCC 6803 Menadione [class: Naphthoquinone] ArsH from Synechocystis sp. does not cofer resistance to arsenic (reduction of arsenate) as the arsH of Synechocystis sp. lacks cyestein residues. arsH encodes an NADPH-flavin mononucleotide oxidoreductase. ArsH plays a role in the response to oxidative stress caused by arsenite. Q6N3Y0 BAC0035 arsM Chromosome Rhodopseudomonas palustris CGA009 Arsenic (As) Arsenite S-adenosylmethyltransferase; involved in arsenite methyltransferase activity; arsM encodes an arsenite S-adenosylmethionine methyltransferase that methylates arsenite to volatile trimethylarsine, contributing to arsenic detoxification in bacteria. B5LWZ8 BAC0036 arsP Chromosome Campylobacter jejuni Arsenic (As) arsenic resistance membrane permease P74986 BAC0588 arsR Plasmid pYV Yersinia enterocolitica Arsenic (As) Arsenite inducible repressor ArsR P15905 BAC0589 arsR Plasmid R773 Escherichia coli Arsenic (As), Antimony (Sb), Bismuth (Bi) Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)). P30338 BAC0590 arsR Plasmid pI258 Staphylococcus aureus Arsenic (As), Antimony (Sb), Bismuth (Bi) Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)). P52144 BAC0591 arsR Plasmid IncN R46 Escherichia coli Arsenic (As), Antimony (Sb), Bismuth (Bi) Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)). Q01256 BAC0592 arsR Plasmid pSX267 Staphylococcus xylosus Arsenic (As), Antimony (Sb), Bismuth (Bi) Transcriptional repressor for the ars operon. ArsR is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsR is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)). P45949 BAC0593 arsR Chromosome Bacillus subtilis (strain 168) Arsenic (As) Transcriptional repressor for the ars operon. P37309 BAC0594 arsR Chromosome Escherichia coli (strain K12) Arsenic (As) Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)). P36560 BAC0038 asr Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Acid shock protein Asr; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely low pH (pH 2.0). P69228 BAC0039 baeR Chromosome Escherichia coli (strain K12) Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid] Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. Overexpression of BaeR increases resistance to novobiocin and deoxycholate. BaeR upregulates the mdtABCD locus and acrD and thereby increases the resistance to deoxycholate, metals and antibiotics. D0ZNE3 BAC0596 baeR Chromosome Salmonella Typhimurium Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid] Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. P30847 BAC0040 baeS Chromosome Escherichia coli (strain K12) Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid] Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. D0ZNE2 BAC0597 baeS Chromosome Salmonella Typhimurium Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid] Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. P28246 BAC0041 bcr Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine] Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. Q8G0Y6 BAC0042 bepC Chromosome Brucella suis biovar 1 (strain 1330) Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. It can form a tripartite pump with BepD and BepE or with BepF and BepG. Q8G2M7 BAC0043 bepD Chromosome Brucella suis biovar 1 (strain 1330) Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane] Efflux pump periplasmic linker BepD. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics such as ampicillin, norfloxacin, ciprofloxacin, tetracycline, and doxycycline. Q8G2M6 BAC0044 bepE Chromosome Brucella suis biovar 1 (strain 1330) Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane] Efflux pump membrane transporter BepE. Resistance conferred by BepDE is dependent on BepC. Involved in resistance to several unrelated toxic compounds, such as dyes, detergents and antibiotics. Q8FWV8 BAC0045 bepF Chromosome Brucella suis biovar 1 (strain 1330) Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Efflux pump periplasmic linker BepF; Contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE Q8FWV9 BAC0046 bepG Chromosome Brucella suis biovar 1 (strain 1330) Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Efflux pump membrane transporter BepG; Contributes to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE. Q93HR0 BAC0047 bexA Chromosome Bacteroides thetaiotaomicron Ethidium Bromide [class: Phenanthridine] A MATE family multidrug efflux transporter pump bexA; Confers resistance to norfloxacin, ciprofloxacin, and ethidium bromide P63697 BAC0048 bfrA Chromosome Mycobacterium tuberculosis Iron (Fe) Bacterioferritin bfrA; Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex P0AB40 BAC0049 bhsA/ycfR/comC Chromosome Escherichia coli (strain K12) Copper (Cu) Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction P39843 BAC0050 blt Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics. P39909 BAC0051 bltD Chromosome Bacillus subtilis (strain 168) Spermidine [class: Polyamines], Spermine [class: Polyamines] Spermine/spermidine acetyltransferase bltD; Acetylates both spermidine and spermine at primary propyl amine moieties, with spermine being the preferred substrate. P39842 BAC0052 bltR Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine] Multidrug-efflux transporter 2 regulator; Activates transcription of the blt gene in response to structurally dissimilar drugs. P33449 BAC0053 bmr Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)] Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics. P39075 BAC0054 bmrR Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine] Multidrug-efflux transporter 1 regulator; Activates transcription of the bmr gene in response to structurally dissimilar drugs. Binds rhodamine as an inducer. Q59465 BAC0055 cadA/yvgW Plasmids pI258 (S. aureus), Chromosome Helicobacter pylori (strain ATCC 700392/26695)(Campylobacter pylori) Cadmium (Cd), Zinc (Zn) Cadmium efflux ATPase, has two domains (phosphatase, aspartyl kinase); Cadmium, zinc and cobalt-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell P20047 BAC0056 cadC Plasmid pI258 (Staphylococcus aureus) Staphylococcus aureus Cadmium (Cd), Bismuth (Bi), Zinc (Zn), Lead (Pb) Found in cad operon; bind to cad operator/promoter, its a repressor protein in the operon; Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA Q7A320 BAC0057 cadD Plasmid pN315 (Staphylococcus aureus (strain N315)), Plasmid pLUH02 (Staphylococcus aureus (strain ECT-R 2) ), Chromosome Staphylococcus aureus (strain N315) Cadmium (Cd), Zinc (Zn) Cadmium resistance permease; These proteins are members of the Cadmium Resistance (CadD) Family. To date, this family of proteins has only been found in Gram-positive bacteria. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, and another staphylococcal protein that has been reported to possibly function in quaternary ammonium ion Export. Q93TP7 BAC0058 cadR Plasmid pECd1 (uncultured bacterium), Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Cadmium (Cd) Transcriptional regulator CadR; Responsible for cadmium resistance A7LHQ4 BAC0059 cadX Plasmid pLUG10 (Staphylococcus lugdunensis) Streptococcus salivarius Cadmium (Cd), Zinc (Zn) Cadmium resistance regulatory protein CadX Q7WZ38 BAC0060 cdeA Chromosome Clostridium difficile Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine] A multidrug efflux transporter of the MATE family, CdeA Q8RR17 BAC0061 cepA Chromosome Klebsiella pneumoniae Chlorhexidine [class: Biguanides] Cation-efflux pump cepA, Cation-efflux transporter that may have a role in detoxification by similarity. Associated with chlorhexidine resistance. D3UGE4 BAC0062 ceuE Plasmid pUM505 (pseudomonas aeruginosa), Plasmid pB4 (uncultured bacterium), Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839)) Psudomonas aeruginosa Chromium (Cr) Periplasmic iron-binding protein Iron(III) ABC transporter CeuE; Encodes for membrane proteins; This protein reduces chromate (CrO4) accumulation and is essential for chromate resistance. P14285 BAC0063 chrA Plasmid pUM505 (pseudomonas aeruginosa) Psudomonas aeruginosa Chromium (Cr) Chromate (CrO4) transport protein ChrA; Responsible for the inducibility of the resistance A4UQR4 BAC0026 chrA Chromosome (transposon TnOtChr) Ochrobactrum tritici Chromium (Cr) Part of chrBACF operon from the transposable element TnOtChr. It pumps chromate out of the cell. P17551 BAC0548 chrA1 Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) This protein reduces chromate accumulation and is essential for chromate resistance. A4UQR5 BAC0027 chrB Chromosome (transposon TnOtChr) Ochrobactrum tritici Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone] Part of chrBACF operon from the transposable element TnOtChr. Has a regulatory role for expression of the ChrA transporter. P17552 BAC0064 chrB1 Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) Together with ChrA, this protein reduces chromate accumulation and is essential for chromate (CrO4) resistance, possibly as a regulatory protein. P17550 BAC0547 chrC Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) Fe-dependent Superoxide dismutase. This protein is not essential for chromate resistance, however it may contribute to resistance under certain environmental conditions. Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. A4UQR3 BAC0028 chrC Chromosome (transposon TnOtChr) Ochrobactrum tritici Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone] Part of chrBACF operon from the transposable element TnOtChr. ChrC encodes a superoxide dismutase. Q5NUZ8 BAC0065 chrE Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) ChrE, involved in the processing of chromium-glutathione-complexes Q5NUZ7 BAC0066 chrF Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) ChrF, regulatory protein, involved in Chromate (CrO4) resistance A4UQR2 BAC0029 chrF Chromosome (transposon TnOtChr) Ochrobactrum tritici Chromium (Cr), Methyl Viologen [class: Paraquat], Menadione [class: Naphthoquinone] Part of chrBACF operon from the transposable element TnOtChr. Q1L9W3 BAC0361 chrI Plasmid pMOL28 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Plasmid pB4 (uncultured bacterium) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM2839) Chromium (Cr) ChrI, regulatory protein, involved in Chromate resistance. Q7BD45 BAC0538 chrR Chromosome Pseudomonas putida Chromium (Cr), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], 2,6-dichloroindophenol [class: Phenolic Compounds] A soluble quinone reductase of Pseudomonas putida that defends against H2O2. ChrR is a dimeric flavin mononucleotide-binding flavoprotein that is able to catalyze a full reduction of Cr(VI) to Cr(III). ChrR may also contribute to the survival of P. putida in the environment by preventing redox cycling of soluble quinones. Confers resistance to Pottasium Ferricyanide (Fe++ salt) as well. P96977 BAC0539 chrR Chromosome Pseudomonas sp. (strain G-1) Chromium (Cr) Cr(VI) reductase. Absent in P. putida. Q9I036 BAC0067 cinA Chromosome Pseudomonas aeruginosa PAO1 Copper (Cu) Copper-containing azurin-like protein cinA; CinA is similar to the P. fluorescens DF57 Cot protein which is involved in copper tolerance; cinA Influences the ability of Pseudomonas aeruginosa PAO1 to resist the bactericidal effect of copper Q8RTE5 BAC0068 cmeA Chromosome Campylobacter jejuni Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine] RND efflux system, a periplasmic fusion protein CmeA. Part of the CmeABC multidrug efflux system in Campylobacter jejuni. Q8RTE4 BAC0613 cmeB Chromosome Campylobacter jejuni Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Acridine orange [class: Acridine] An inner membrane efflux transporter. Part of the CmeABC multidrug efflux system in Campylobacter jejuni. Q8RTE3 BAC0614 cmeC Chromosome Campylobacter jejuni Copper (Cu), Cobalt (Co), Sodium Chenodeoxycholate [class: Acid], Sodium Deoxycholate [class: Acid], Sodium Cholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine] An outer membrane protein (CmeC). Part of the CmeABC multidrug efflux system in Campylobacter jejuni. Q0P9M1 BAC0615 cmeD Chromosome Campylobacter jejuni Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid] CmeD is the outer membrane protein. Q0P9M0 BAC0616 cmeE Chromosome Campylobacter jejuni Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid] CmeE is a periplasmic fusion protein Q0P9L9 BAC0069 cmeF Chromosome Campylobacter jejuni Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol], Tween 20 [class: Polyoxyethylene], Empigen [class: Amine betaine], Sodium Cholate [class: Acid], Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Chenodeoxycholate [class: Acid] Integral membrane component of efflux system (Multidrug efflux system CmeDEF) Q7B8P6 BAC0070 cmeR Chromosome Campylobacter jejuni 81-176 Sodium Cholate [class: Acid] Transcriptional repressor. CmeABC is controlled by CmeR, a transcriptional repressor encoded by a gene located immediately upstream of cmeABC. CmeR binds to the inverted repeat in the promoter region of cmeABC and inhibits the expression of the efflux operon. P67731 BAC0071 cmtR Chromosome Mycobacterium tuberculosis Cobalt (Co), Nickel (Ni) Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA. P37972 BAC0203 cnrA Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) Nickel and cobalt resistance protein CnrA. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. B0B0H8 BAC0542 cnrA Chromosome Bradyrhizobium sp. STM 2465 Cobalt (Co), Nickel (Ni) Fragment of nccA-like protein A9DF56 BAC0543 cnrA Chromosome Bradyrhizobium sp. STM 2464 Cobalt (Co), Nickel (Ni) Fragment of nccA-like protein A9DF42 BAC0544 cnrA Chromosome Bradyrhizobium sp. STM 2457 Cobalt (Co), Nickel (Ni) Fragment of nccA-like protein A9DF51 BAC0545 cnrA Chromosome Bradyrhizobium sp. STM 2460 Cobalt (Co), Nickel (Ni) Fragment of nccA-like protein A9DF47 BAC0546 cnrA Chromosome Bradyrhizobium sp. STM 2458 Cobalt (Co), Nickel (Ni) Fragment of nccA-like protein P37973 BAC0204 cnrB Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) Nickel and cobalt resistance protein CnrB. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. P37974 BAC0072 cnrC Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) Nickel and cobalt resistance protein CnrC; The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter. P37978 BAC0073 cnrH Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) RNA polymerase sigma factor CnrH; CnrH alone is able to activate cnr Expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor. P37975 BAC0291 cnrR/cnrX Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) Nickel and cobalt resistance operon regulator CnrR. CnrH alone is able to activate cnr expression, while both CnrY and CnrR (CnrX) are needed for nickel induction of CnrH. Has been suggested to bind nickel. Q5NUX6 BAC0074 cnrT Plasmid pMOL28 (Cupriavidus metallidurans) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) CnrT, Cation Diffusion Facilitator, involved in Co(II), Ni(II) resistance P56621 BAC0075 cnrY Plasmid pMOL28 (Cupriavidus metallidurans) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cobalt (Co), Nickel (Ni) Nickel and cobalt resistance protein CnrY; CnrY and CnrX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift) or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor. P75952 BAC0076 comR/ycfQ Chromosome Escherichia coli (strain K12) Copper (Cu) Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper. P12374 BAC0077 copA Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pRJ1004 (E. coli) Pseudomonas syringae pv. Tomato Copper (Cu), Silver (Ag) Encode for copper uptake ATPases; also resistant to Ag+ ; periplasmic protein; Probably involved in copper and silver Export. Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity. O32220 BAC0078 copA Chromosome Bacillus subtilis (strain 168) Copper (Cu) Involved in copper export; The copZA operon is activated by CueR and indirectly repressed by YfmP Q7WYH1 BAC0619 copA Chromosome Pseudomonas putida PNL-MK25 Copper (Cu) Part of copABCD operon, that encodes copper-binding and sequestering proteins for copper homeostasis in the copper-sensitive strain Pseudomonas putida PNL-MK25. P32113 BAC0620 copA Chromosome Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258) Copper (Cu) Probably involved in copper import under copper limiting conditions. F4ZBX3 BAC0621 copA Chromosome Xanthomonas citri subsp. Citri Copper (Cu) Copper resistance protein A. O29777 BAC0622 copA Chromosome Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) Copper (Cu), Silver (Ag) Involved in copper and silver export. Q59467 BAC0623 copA Chromosome Helicobacter pylori (Campylobacter pylori) Copper (Cu) Probably involved in copper export. Part of copAP operons of Helicobacter pylori and Helicobacter felis. O32619 BAC0624 copA Chromosome Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1) Copper (Cu) Copper-transporting ATPase. part of copAP operon. F4ZCZ9 BAC0625 copA Chromosome Xanthomonas alfalfae subsp. Citrumelonis Copper (Cu) Copper resistance protein A. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. P12375 BAC0626 copB Plasmid pPT23D Pseudomonas syringae pv. Tomato Copper (Cu) Copper resistance protein B. It mediates copper resistance by its sequestration in the outer membrane. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. F4ZD00 BAC0627 copB Chromosome Xanthomonas alfalfae subsp. Citrumelonis Copper (Cu) Copper resistance protein B. F4ZBX4 BAC0628 copB Chromosome Xanthomonas citri subsp. Citri Copper (Cu) Copper resistance protein B. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. O30085 BAC0629 copB Chromosome Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) Copper (Cu) It is a thermophilic Cu2+-ATPase in Archaeoglobus fulgidus. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. P05425 BAC0079 copB Chromosome Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258) Copper (Cu), Silver (Ag) Efflux ATPases, located in same operone with copA; outer membrane protein, have 4 impefect repeats of octapeptide Asp-His-Ser-Gln/Lys-Met-Gln-Met; Required for the copper-inducible Expression of copper resistance. It is a pump for the extrusion of monovalent copper and silver ions, with copper probably being the natural substrate. P12376 BAC0630 copC Plasmid pPT23D Pseudomonas syringae pv. Tomato Copper (Cu) Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. F4ZBX9 BAC0631 copC Chromosome Xanthomonas citri subsp. Citri Copper (Cu) Copper resistance protein C. C6FFR6 BAC0639 copC Chromosome Pseudomonas fluorescens Copper (Cu) Copper ion binding protein copC. Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens. P12377 BAC0632 copD Plasmid pPT23D Pseudomonas syringae pv. Tomato Copper (Cu) Involved in copper resistance. Appears to be involved in copper uptake in conjunction with CopC. Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. Q7WYG8 BAC0633 copD Chromosome Pseudomonas putida PNL-MK25 Copper (Cu) Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system. C6FFR7 BAC0640 copD Chromosome Pseudomonas fluorescens Copper (Cu) Part of the copRSCD cluster required for full copper resistance and regulated at the transcription level by Cu in Pseudomonas fluorescens. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens. Q58AE1 BAC0080 copJ Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Copper (Cu) CopJ cytochrome c protein involved in Cu(II)/Cu(I) resistance; Structural genes like copA and copB; periplasmic protein; Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopA Q58AD3 BAC0081 copK Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Copper (Cu) Copper resistance protein K; Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+ Q5YKV8 BAC0082 copL Chromosome Xanthomonas perforans Copper (Cu) Involved in resistance to copper. Can bind up to 2 copper ions. Has higher affinity for Cu+ than for Cu2+. O32620 BAC0634 copP Chromosome Helicobacter felis (strain ATCC 49179 / NCTC 12436 / CS1) Copper (Cu) Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the cells. Q9ZM70 BAC0635 copP Chromosome Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99) Copper (Cu) Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H. pylori cells. Q02540 BAC0083 copR Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae) Pseudomonas syringae pv. Tomato Copper (Cu) Transcriptional activator protein CopR; Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce Expression of the cop operon by binding to a specific site on the cop operon promoter (cop box) and possibly by facilitating the binding of RNA polymerase to the cop promoter. CopR also binds to the chromosomally encoded cop operon promoter. May also be involved in basic copper metabolism. C6FFR4 BAC0638 copR Chromosome Pseudomonas fluorescens Copper (Cu) Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism. Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression in Pseudomonas fluorescens. C6FFR5 BAC0637 copS Chromosome Pseudomonas fluorescens Copper (Cu) Member of the two-component regulatory system CopS/CopR. May also be involved in basic copper metabolism. Q02541 BAC0537 copS Plasmid pPT23D (Pseudomonas syringae pv. Tomato), Plasmid pPaCu1 (Pseudomonas syringae) Pseudomonas syringae Copper (Cu) Sensor protein CopS. Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cytoplasm. CopS/CopR may also regulate chromosomally encoded genes. May also be involved in basic copper metabolism. Q47839 BAC0084 copY/tcrY Chromosome Enterococcus hirae Copper (Cu) CopA and CopB upstream repressor CopY, regulates the cop operon; Binds to DNA in complex with Zn2+, repressing the transcription of the CopYZAB operon. Exchange of the bound zinc by two copper ions delivered by CopZ Cu1+-bound form causes release of CopY from the promoter, leading to the transcription of the operon Q47840 BAC0085 copZ Chromosome Enterococcus hirae Copper (Cu) Copper chaperone CopZ; copA and copB anti-repressor, regulates the cop operon P0ABI4 BAC0086 corA Chromosome Escherichia coli (strain K12) Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn) Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron. P0A2R8 BAC0641 corA Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn) Mediates both influx and efflux of magnesium ions. Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron. Q9X621 BAC0643 corB Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Cobalt (Co), Magnesium (Mg) Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol. P0A2L3 BAC0088 corC Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Cobalt (Co), Magnesium (Mg) Magnesium and cobalt efflux protein CorC; Plays a role in the transport of magnesium and cobalt ions Q56017 BAC0644 corD Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Cobalt (Co), Magnesium (Mg) mutations in apaG/corD give a phenotype of low-level Co2+ resistance. They also decrease Mg2+ efflux but not influx via the CorA Mg2+ transport system. Q1D6V8 BAC0089 corR Chromosome Myxococcus xanthus (strain DK 1622) Copper (Cu) Sigma-54 dependent DNA-binding response regulator CorR; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB. H0P0Y2 BAC0090 corR/coaR Chromosome Synechocystis sp. PCC 6803 substr. GT-I Cobalt (Co), Magnesium (Mg) Cobalt-dependent transcriptional regulator, CorR Q1D6V7 BAC0091 corS Chromosome Myxococcus xanthus (strain DK 1622) Copper (Cu) Sensor histidine kinase CorS; corSR copper-responsive two component system that induces carotenoid production. It also regulates three multicopper oxidases: cuoA, cuoB, cuoC, and two P-type ATPases: copA and copB. H0P0Y3 BAC0092 corT/coaT Chromosome Synechocystis sp. PCC 6803 substr. GT-I Cobalt (Co) Cation-transporting ATPase E1-E2 ATPase, CorT C4WZK5 BAC0532 cpxA Chromosome Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Sensor protein of stress-related two-component regulatory system of CpxAR. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon. C4WZK6 BAC0533 cpxR Chromosome Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 Hydrogen Peroxide (H2O2) [class: Peroxides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Response regulator of stress-related two-component regulatory system. It has role in oxidative stress tolerance. It has a regulatory role on MDR efflux pumps. It can confer resistance to cefepime, cefotaxime, ceftazidime and chloramphenicol which possibly are the preferred substrates of the resistance determinants for e.g. efflux pumps perhaps regulated by the Cpx regulon. O25884 BAC0093 crdA Chromosome Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) Copper (Cu) Copper resistance determinant, CrdA. It is required for adaptation to copper-rich environmental conditions. O25885 BAC0094 crdB Chromosome Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) Copper (Cu) Putative copper resistance determinant, CrdC. It is required for adaptation to copper-rich environmental conditions. O25918 BAC0095 crdR Chromosome Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) Copper (Cu) Response regulator; part of two-component regulatory system crdR/crdS O25917 BAC0096 crdS Chromosome Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) Copper (Cu) Histidine kinase sensor protein; part of two-component regulatory system crdR/crdS O32222 BAC0558 csoR Chromosome Bacillus subtilis 168 Copper (Cu) Copper-sensing transcriptional repressor CsoR. Copper-sensitive repressor that has a key role in copper homeostasis. Negatively regulates expression of the copZA operon and of ycnJ. In the absence of copper ions, binds with high affinity to the copZA promoter and represses the transcription. In the presence of copper ions, CsoR binds Cu1+, which significantly decreases its DNA binding affinity and leads to the transcription of the genes. Cells lacking this gene display a slightly enhanced ability to grow into medium containing high levels of copper. P0A502 BAC0098 ctpC Chromosome Mycobacterium tuberculosis Manganese (Mn), Zinc (Zn) Probable manganese/zinc-exporting P-type ATPase A0R3A7 BAC0099 ctpD Chromosome Mycobacterium smegmatis Cobalt (Co), Nickel (Ni) Probable cobalt/nickel-exporting P-type ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell. P63689 BAC0100 ctpG Chromosome Mycobacterium tuberculosis Copper (Cu) Cation-transporting ATPase G; Response to copper ion P77894 BAC0101 ctpV Chromosome Mycobacterium tuberculosis Copper (Cu) Copper-exporting P-type ATPase V; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence. Q8KWW2 BAC0102 cueA Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Copper (Cu), Silver (Ag) Copper transporter CueA; Periplasmic protein P36649 BAC0103 cueO Chromosome Escherichia coli (strain K12) Copper (Cu) Copper efflux oxidase (blue copper oxidase); Involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. Q8ZL99 BAC0104 cueP Chromosome Salmonella enterica serovar Typhimurium Copper (Cu) Periplasmic copper-binding protein and has been implicated in the transfer of copper ions to SodCII in the periplasm; evolved to survive in the phagosomes of macrophages in Salmonella enterica serovar Typhimurium; CueP can functionally replace the Cus complex for periplasmic copper resistance, in particular under anaerobic conditions; CueP does not confer silver or gold resistance to Salmonella P0A9G4 BAC0105 cueR/ybbI Chromosome Escherichia coli (strain K12) Copper (Cu) Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. CueR is a direct regulator of copZA transcription that mediates copper induction Q8ZRS2 BAC0106 cuiD Chromosome Salmonella enterica serovar Typhimurium Copper (Cu), Hydrogen Peroxide (H2O2) [class: Peroxides] A multi-copper oxidase gene code for Cu-inducible periplasmic protein; CuiD is required for both copper homeostasis and the copper resistance response in the presence and in the absence of oxygen; Probably involved in periplasmic detoxification of copper by oxidizing Cu+ to Cu2+ and thus preventing its uptake into the cytoplasm; cuiD may be involved in oxidative stress response P38054 BAC0107 cusA/ybdE Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Escherichia coli (strain K12) Copper (Cu), Silver (Ag) Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; located in cell inner membrane; Belongs to the AcrB/AcrD/AcrF family P77239 BAC0108 cusB Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) Copper (Cu), Silver (Ag) Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver; Belongs to the membrane fusion protein (MFP) family P77211 BAC0109 cusC/ylcB Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)) Escherichia coli (strain K12) Copper (Cu), Silver (Ag) Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver P77214 BAC0110 cusF/cusX Plasmid pkPN3 (Klebsiella pneumoniae subsp. pneumoniae MGH 78578), Plasmid pAPEC-O2-R Escherichia coli (strain K12) Copper (Cu), Silver (Ag) Cation efflux system periplasmic protein CusF; Part of a cation efflux system (CusA, CusB, CusC and CusF) that mediates resistance to copper and silver. Binds one copper per polypeptide ; located in Periplasm P0ACZ8 BAC0111 cusR/ylcA Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)) Escherichia coli (strain K12) Copper (Cu), Silver (Ag) Member of the two-component regulatory system CusS/CusR. Activates the Expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level Expression of copper resistance gene operon pcoABCD; located in cytoplasm P77485 BAC0112 cusS Chromosome Escherichia coli (strain K12) Copper (Cu), Silver (Ag) Sensor kinase CusS; Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Activates CusR by phosphorylation; located in inner cell membrane P69488 BAC0113 cutA Chromosome Escherichia coli (strain K12) Copper (Cu) Divalent-cation tolerance protein CutA; Involved in resistance toward heavy metals P67826 BAC0114 cutC Chromosome Escherichia coli (strain K12) Copper (Cu) Copper homeostasis protein CutC; Involved in copper homeostasis; Located in cytoplasm P23930 BAC0115 cutE/lnt Chromosome Escherichia coli (strain K12) Copper (Cu) Apolipoprotein N-acyltransferas, it attaches a fatty acid to apo-nlpE (cutF) P40710 BAC0116 cutF/nlpE Chromosome Escherichia coli (strain K12) Copper (Cu) Copper homeostasis protein CutF, encodes for outer membrane lipoprotein might affect on copper permeability; Involved in copper homeostasis. Could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. When overproduced induces degP through the activation of the two-component system CpxA/CpxR D5AV58 BAC0117 cutO Chromosome Rhodobacter capsulatus Copper (Cu) Multi copper oxidase CutO; Involved in copper resistance; CutO confers copper tolerance not only under aerobic conditions, as described for the well-characterized E. coli multicopper oxidase CueO, but also under anaerobic conditions. D5AV59 BAC0118 cutR Chromosome Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) Copper (Cu) CutR acts as a repressor of cutO Expression under low copper concentrations; Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. P13511 BAC0119 czcA Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Cobalt-zinc-cadmium resistance protein; the basic inner membrane transport protein; Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC). P13510 BAC0120 czcB Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Cobalt-zinc-cadmium resistance protein CzcB; Membrane fusion protein bridges inner and outer cell membranes (in periplasm); CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein. P13509 BAC0121 czcC Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Muter membrane protein; CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt. P13512 BAC0122 czcD Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Transporter gene influence Zn++ and Cd++ resistance; Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter. Q1LAJ1 BAC0123 czcE Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) CzcE, involved in Cd(II), Zn(II), Co(II) resistance; copH like protein; Co/Zn/Cd efflux system transmembrane protein Q1LAJ7 BAC0124 czcP Plasmid pMOL30 (Cupriavidus metallidurans CH34) Cupriavidus metallidurans CH34 Cadmium (Cd), Zinc (Zn), Cobalt (Co) P(IB4)-type ATPases; CzcP seemed to enhance metal resistance but relies on the action of the P(IB2)-type ATPases such as zntA, cadA, pbrA etc. Q44006 BAC0125 czcR Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ), Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Transcriptional activator protein CzcR; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis Q44007 BAC0126 czcS Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Cadmium (Cd), Zinc (Zn), Cobalt (Co) Sensor protein CzcS; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation. D3UHQ0 BAC0127 cznA Chromosome Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae) Cadmium (Cd), Zinc (Zn), Nickel (Ni) Cadmium-zinc-nickel resistance protein cznA D3UHP9 BAC0128 cznB Chromosome Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae) Cadmium (Cd), Zinc (Zn), Nickel (Ni) Cadmium-zinc-nickel resistance protein cznB D3UHP8 BAC0129 cznC Chromosome Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae) Cadmium (Cd), Zinc (Zn), Nickel (Ni) Cadmium-zinc-nickel outer membrane efflux protein cznC Q9RLI8 BAC0130 czrA Chromosome Pseudomonas aeruginosa Zinc (Zn), Cadmium (Cd) A repressor for thr czr operon; part of the czrSRCBA resistance operon Q9RLI9 BAC0131 czrB Chromosome Pseudomonas aeruginosa Zinc (Zn), Cadmium (Cd) czrB involved in cadmium and zinc resistance; part of the czrSRCBA resistance operon Q1LRZ2 BAC0132 dmeF Plasmid pMOL28 (Wautersia metallidurans CH34) Wautersia metallidurans CH34 Cobalt (Co), Cadmium (Cd), Nickel (Ni) DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34. Q1MJL2 BAC0482 dmeF Chromosome Rhizobium leguminosarum bv. viciae UPM791 Cobalt (Co), Nickel (Ni) Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. Q1MJL3 BAC0475 dmeR Chromosome Rhizobium leguminosarum bv. viciae UPM791 Cobalt (Co), Nickel (Ni) Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. P0A5B9 BAC0133 dnaK Chromosome Mycobacterium tuberculosis Copper (Cu) Chaperone protein DnaK P0CB53 BAC0134 dpr/dps Chromosome Streptococcus suis Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] DNA protection during starvation protein; Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction. It binds and incorporates Fe2+ iron. Is responsible for hydrogen peroxide resistance. Does not bind DNA. Q8KR86 BAC0135 dpsA Chromosome Burkholderia pseudomallei 1710b Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] dpsA respsonses to stress, iron-binding protein; has role in iron ion homeostasis P0AEG4 BAC0136 dsbA Chromosome Escherichia coli (strain K12) Cadmium (Cd), Zinc (Zn), Mercury (Hg) Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis P0A6M2 BAC0137 dsbB Chromosome Escherichia coli (strain K12) Cadmium (Cd), Mercury (Hg) Disulfide oxidoreductase; The dsbB gene codes for a transmembrane protein that is responsible for reoxidizing the periplasmic dsbA-encoded disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA P0AEG6 BAC0138 dsbC Chromosome Escherichia coli (strain K12) Copper (Cu) Disulfide isomerase; DsbC rearranges incorrect disulfide bonds formed by dsbA during oxidative protein folding under non-stress conditions. DsbC, a periplasmic thiol-disulfide oxidoreductase, appears to function as a disulfide isomerase both in vitro and in vivo. In vitro, DsbC has been shown to rearrange non-native disulfides in well studied isomerization substrates such as BPTI and RNase A. In vivo, DsbC is required for full activity of a handful of proteins containing at least one non-consecutive disulfide bond. P0CW81 BAC0139 ebrA Chromosome Bacillus subtilis Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Pyronin Y [class: Xanthene], Safranin O [class: Azin] Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, Acriflavine, pyronin Y and safranin O. The efflux is probably coupled to an influx of proton P0CW83 BAC0140 ebrB Chromosome Bacillus subtilis Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Pyronin Y [class: Xanthene], Safranin O [class: Azin] Part of a multidrug efflux pump. Confers resistance to cationic lipophilic dyes such as ethidium bromide, Acriflavine, pyronin Y and safranin O. The efflux is probably coupled to an influx of protons A8CY69 BAC0494 eefA Chromosome Klebsiella pneumoniae LM21 Hydrochloric acid (HCl) [class: Acid] A periplasmic intermediate, EefA. Part of the EefXABC operon. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments. A8CY68 BAC0495 eefX Chromosome Klebsiella pneumoniae LM21 Hydrochloric acid (HCl) [class: Acid] Part of eefXABC operon in K. pneumoniae. This gene is absent in the similar efflux system eefABC in other bacteria (such as Enterobacter aerogenes). Comaparative study suggests that it could be a regulator of the EefABC tripartite efflux system. The tripartite efflux system confers measurable ecological benefits in K. pneumoniae with high competition potential on surviving in inorganic acid environments. Q8GR72 BAC0141 emeA Chromosome Only gram -ve, Enterococcus faecalis (Streptococcus faecalis) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug efflux pump emeA Q4KH22 BAC0142 emhA Chromosome Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Efflux transporter, membrane fusion protein subunit EmhA C1KA85 BAC0143 emhB Chromosome Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Protein export membrane protein emhB Q4KH24 BAC0144 emhC Chromosome Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Efflux transporter, outer membrane factor lipoprotein EmhC Q4KH21 BAC0145 emhR Chromosome Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Regulator of emhABC efflux system, EmhR D5CJ69 BAC0146 emmdR Chromosome Enterobacter cloacae Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene] MATE efflux family protein; EmmdR is an H+-drug antiporter but not a Na+ driven efflux pump P27303 BAC0147 emrA Chromosome Escherichia coli (strain K12) Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide] The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell. B2FIC9 BAC0499 emrAsm Chromosome Stenotrophomonas maltophilia (strain K279a) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide] Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. P0AEJ0 BAC0148 emrB Chromosome Escherichia coli (strain K12) Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone] Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity B2FID0 BAC0500 emrBsm Chromosome Stenotrophomonas maltophilia (strain K279a) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide] Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. B2FIC8 BAC0501 emrCsm Chromosome Stenotrophomonas maltophilia (strain K279a) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide] Outer membrane protein EmrCsm. Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin. P31442 BAC0149 emrD Chromosome Escherichia coli (strain K12) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Multidrug resistance pump that participates in a low energy shock adaptative response A5EYZ6 BAC0534 emrD-3 Chromosome Vibrio cholerae O395 Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] It is an intrinsic membrane protein. Multidrug resistance protein D. EmrD-3-mediated efflux is potentiated by a proton gradient across the membrane. It can confer resistance to antibiotics such as linezolid, rifampin, minocycline etc. P23895 BAC0150 emrE/mvrC Chromosome Escherichia coli (Strain K12) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium. P52599 BAC0151 emrK Chromosome Escherichia coli (strain K12) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate P0ACR9 BAC0559 emrR Chromosome Escherichia coli (strain K12) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone] Negative regulator of the multidrug operon emrAB. B2FIC7 BAC0502 emrRsm Chromosome Stenotrophomonas maltophilia (strain K279a) Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide] EmrRCABsm operon is negatively regulated by a MarR-type regulator EmrRsm. P52600 BAC0153 emrY Chromosome Escherichia coli (strain K12) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine] Multidrug resistance protein Y P0ACZ4 BAC0154 evgA Chromosome Only gram -ve, Escherichia coli (Strain K12) Sodium Deoxycholate (SDC) [class: Acid] Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control expression of at least one other multidrug efflux operon. P58402 BAC0155 evgS Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid] Sensor protein EvgS; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response to environmental signals P0AEK4 BAC0156 fabI Chromosome Escherichia coli (strain K12) Triclosan [class: Phenolic compounds] Enoyl-[acyl-carrier-protein] reductase [NADH] FabI; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis; enoyl-ACP reductase is the FabI protein of Escherichia coli that is the target of the antibacterial compound, triclosan; some Gram-positive bacteria are naturally resistant to triclosan due to the presence of the triclosan-resistant enoyl-ACP reductase isoforms, FabK, FabV and FabL. Q9FBC5 BAC0157 fabK Chromosome Streptococcus pneumoniae Triclosan [class: Phenolic compounds] Trans-2-enoyl-ACP reductase II; a TIM barrel triclosan-resistannt flavoprotein; It is one of the taret sites for antibacterial triclosan; expression of FabK confers triclosan resistance. P71079 BAC0158 fabL/ygaA Chromosome Bacillus subtilis (strain 168) Triclosan [class: Phenolic compounds] Enoyl-(acyl-carrier-protein) reductase (NADPH) FabL; It catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It confers resistance to triclosan. It is an alternative target site where fabI is absent for antibacterial compound triclosan. Q9KRA3 BAC0159 fabV Chromosome Vibrio chloerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Triclosan [class: Phenolic compounds] Enoyl-(acyl-carrier-protein) (ACP) reductase is a key enzyme in type II fatty-acid synthases that catalyzes the last step in each elongation cycle; Predominately found in Vibrio species and closely related organisms where it seems to be the sole enoyl-ACP reductase. It is a antibacterial target site for triclosan where fabI and other isoforms such as fabL, fabI or fabK are absent. Triclosan expression of FabV in organism results in markedly increased resistance to triclosan. There may be bacteria that have both FabV and FabK such as various of the Clostridia such as Clostridium tetani. Q9RQ30 BAC0503 farA Chromosome Neisseria gonorrhoeae F19 Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol] A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell. Q9RQ29 BAC0504 farB Chromosome Neisseria gonorrhoeae F19 Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol] A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell. Q7DD70 BAC0505 farR Chromosome Neisseria gonorrhoeae, Neisseria meningitidis serogroup B (strain MC58) Palmitic acid [class: Free Fatty Acids] FarR negatively controls expression of farAB by directly binding to the farAB promoter. MtrR binds to the farR promoter, thereby repressing farR expression. MtrR regulates farAB in a positive fashion by modulating farR expression. P35755 BAC0160 fbpA Chromosome Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Iron (Fe), Gallium (Ga) Fe(3+)-binding/Iron-utilization periplasmic protein FbpA; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport P71338 BAC0161 fbpB Chromosome Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Iron (Fe), Gallium (Ga) Fe(3+)-transport system permease protein FbpB; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport P44513 BAC0162 fbpC Chromosome Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Iron (Fe), Gallium (Ga) Fe(3+) ions import ATP-binding protein FbpC; Part of the ABC transporter complex FbpABC involved in Fe3+ ions import. Responsible for energy coupling to the transport system P15029 BAC0163 fecD Chromosome Escherichia coli (strain K12) Nickel (Ni), Cobalt (Co) Fe(3+) dicitrate transport system permease protein FecD; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane. P15031 BAC0164 fecE Chromosome Escherichia coli (strain K12) Nickel (Ni), Cobalt (Co) Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for energy coupling to the transport system P77279 BAC0165 fetA/ybbL Chromosome Escherichia coli (strain K12) Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] FetA, the ATP binding component subunit; FetAB allows for increased resistance to oxidative stress in the presence of iron P77307 BAC0166 fetB/ybbM Chromosome Escherichia coli (strain K12) Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] FetB/YbbM is a membrane protein. FetAB allows for increased resistance to oxidative stress in the presence of iron P69380 BAC0167 fieF/yiip Chromosome Escherichia coli (strain K12) Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni) Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli. P42512 BAC0168 fptA Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Iron (Fe), Cobalt (Co), Nickel (Ni), Gallium (Ga) Fe(3+)-pyochelin receptor FptA; High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin P48632 BAC0169 fpvA Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga) Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane Q9RWK7 BAC0170 frnE Chromosome Deinococcus radiodurans Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides] Disulfide Isomerase Chaperone; It is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation; is a protein disulfide isomerase in vitro and has a role in oxidative stress tolerance of D. radiodurans possibly by protecting the damaged cellular proteins from inactivation P0A582 BAC0171 furA Chromosome Mycobacterium tuberculosis Iron (Fe) Transcriptional regulator FurA; Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner B0FSM1 BAC0490 G2alt Chromosome Anoxybacillus gonensis G2 Aluminium (Al) The ATPase activity of G2alt requires Mg2+ and Na+ ions, while Zn2+ and Al3+ stimulate the activity, Cd2+ and Ag+ reduces the activity and Li+, Cu2+ and Co2+ inhibits the activity. P69908 BAC0172 gadA Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. P69910 BAC0173 gadB Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] TolC is required for expression of glutamate decarboxylase (GadA, GadB), a key component of glutamate-dependent acid resistance (Gad); Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. P63235 BAC0174 gadC/xasA Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] GadC functions as a transporter for the product of glutamate decarboxylase, g-aminobutyrate P63204 BAC0175 gadE/yhiE Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci. P63201 BAC0176 gadW/yhiW Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters. P37639 BAC0177 gadX Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Role in acid resistance, increases multidrug resistance in E. coli by activating the MdtEF multidrug efflux pump; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions (growth phase and medium), can repress gadW. It can confer resistance to antibiotics such as oxacillin, cloxacillin, nafcillin, erythromycin etc. Q8ZRG8 BAC0178 gesA Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane] The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol. Q8ZRG9 BAC0179 gesB Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane] The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol. Q8ZRH0 BAC0180 gesC Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Gold (Au), Methylene Blue [class: Thiazinium], Crystal Violet [class: Triarylmethane] The gold (Au2+) resistance efflux pump, GesABC (induced by GolS in the presence of Au2+; also mediates drug resistance when induced by Au2+. Also exports a variety of organic chemicals including chloramphenicol. P0AER0 BAC0181 glpF Chromosome Escherichia coli (strain K12) Antimony (Sb), Arsenic (As), Glycerol [class: Alcohol] Glycerol uptake facilitator protein GlpF; Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols Q8ZRG6 BAC0182 golS Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Gold (Au) merR-type regulator; GolS directly controls the expression of golT and golB; Each component of the GolS regulon, i.e. the P-type ATPase GolT; and the metal-binding polypeptide GolB, are required for full gold-tolerance Q8ZRG7 BAC0183 golT Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Copper (Cu), Gold (Au) Cation transporting P-type ATPase; belongs to the gold-responsive, gol regulon; In the absence of CopA, GolS becomes responsive to copper, inducing the expression of golT, which functionally substitutes CopA for cytosolic copper export Q6GW09 BAC0184 hasF Chromosome Serratia marcescens Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine] TolC-homologue hasF involved in energy-dependent efflux P0AES9 BAC0185 hdeA/yhiB Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Acid stress chaperone HdeA; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Important for survival of enteric bacteria in the acidic environment of the host stomach. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA P0AET2 BAC0186 hdeB/yhiC Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Acid stress chaperone HdeB; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. B6JLI8 BAC0187 hefA Chromosome Helicobacter pylori (strain P12) Hydrochloric acid (HCl) [class: Acid] Outer-membrane protein of the HefABC efflux system HefA; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment. Exhibits a chaperone-like activity only at pH below 3 by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Also promotes the solubilization at neutral pH of proteins that had aggregated in their presence at acidic pHs. May cooperate with other periplasmic chaperones such as DegP and SurA B6JLJ0 BAC0188 hefC Chromosome Helicobacter pylori (strain P12) Hydrochloric acid (HCl) [class: Acid] Cytoplasmic pump protein of the HefABC efflux system HefC P45272 BAC0189 hmrM Chromosome Haemophilus influenzae Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide] Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate Q9X5V4 BAC0569 hmrR Chromosome Rhizobium leguminosarum bv. Viciae Copper (Cu), Hydrochloric acid (HCl) [class: Acid] Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP Q9X5X4 BAC0190 hmrR Plasmid pSMED01 Sinorhizobium medicae (strain WSM419) (Ensifer medicae), Plasmid pSymA (Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)) Copper (Cu), Hydrochloric acid (HCl) [class: Acid] Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP P23516 BAC0191 hoxN Plasmid megaplasmid pHG1 (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)), Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) Nickel (Ni) High-affinity nickel transporter hoxN responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease. P77871 BAC0617 hpcopA Chromosome Helicobacter pylori (Campylobacter pylori) Copper (Cu) Involved in copper export. Q48271 BAC0618 hpcopP Chromosome Helicobacter pylori (Campylobacter pylori) Copper (Cu) Copper ion-binding protein. Part of a cation-transporting system which is associated with copper export out of the H.pylori cells. B0R6K7 BAC0192 hsmR Chromosome Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Small multidrug export protein HsmR P27650 BAC0483 hupE Plasmid pSym (Rhizobium leguminosarum bv. viciae) Rhizobium leguminosarum bv. Viciae Nickel (Ni) It is a metal permease. hupE gene, part of a highly conserved hup cluster and evolutionarily related to hydrogenase genes. It has a potential role as a nickel permease. It encodes a nickel transporter required for hydrogenase activity. D2WPE1 BAC0484 hupE2 Plasmid pRLUPM791b (Rhizobium leguminosarum bv. viciae UPM791b) Rhizobium leguminosarum bv. viciae UPM791 Nickel (Ni) A hupE-homolog. It is a metal permease. There is a low level of amino acid sequence identity between hupE and hupE2. It is involved in hydrogen oxidation in R. leguminosarum bv. Viciae. Q43955 BAC0193 hupN Chromosome Azotobacter chroococcum mcd 1 Nickel (Ni) Hydrogenase nickel incorporation protein HupN P0C054 BAC0194 ibpA Chromosome Escherichia coli (strain K12) Hydrogen Peroxide (H2O2) [class: Peroxides] Small heat shock protein IbpA; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; Its activity is ATP-independent P0C058 BAC0195 ibpB Chromosome Escherichia coli (strain K12) Hydrogen Peroxide (H2O2) [class: Peroxides] Small heat shock protein IbpA; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Its activity is ATP-independent. P16528 BAC0196 iclR Chromosome Escherichia coli (strain K12) Sodium acetate [class: Acetate] Acetate operon repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. P0A672 BAC0498 ideR Chromosome Mycobacterium tuberculosis Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides], Plumbagin [class: Naphthoquinone] Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynthesis and as a Positive modulator of iron storage. Also regulates expression of transporters, proteins involved in siderophore synthesis, iron storage and transcriptional regulators. Has a role in oxidative streee tolerance. O31395 BAC0197 irlR Chromosome Burkholderia pseudomallei (strain K96243) Cadmium (Cd), Zinc (Zn) Transcriptional activator protein IrlR; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance O31396 BAC0198 irlS Chromosome Burkholderia pseudomallei (strain K96243) Cadmium (Cd), Zinc (Zn) Sensor protein IrlS; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation. A6T6T9 BAC0491 kdeA Chromosome Klebsiella pneumoniae (strain MGH 78578) Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] It can confer resistance to antibiotics such as chloramphenicol, Kanamycin, norfloxacin, puromycin, daunomycin etc. A6TA71 BAC0492 kexD Chromosome Klebsiella pneumoniae Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid] KexD was shown to function with AcrAEc and TolC from E. coli and AcrAKp and KocC from K. pneumoniae, like AcrD from E. coli Q52328 BAC0199 klaB/telA/kilB Plasmid IncP-alpha RK2 (E. coli), Plasmid pBS228 (Pseudomonas aeruginosa) Escherichia coli Tellurium (Te) Protein KlaB; Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition. Q52329 BAC0200 klaC/telB Plasmid IncP-alpha RK2 (E. coli), Plasmid pBS228 (Pseudomonas aeruginosa) Escherichia coli Tellurium (Te) Protein KlaC; Belongs to the kla operon, which is associated with cryptic tellurite resistance, and IncW plasmid fertility inhibition. C4X8X9 BAC0493 kmrA Chromosome Klebsiella pneumoniae Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Hoechst 33342 [class: Bisbenzimide], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)] It can confer resistance to Antibiotics such as kanamycin, gentamycin, erythromycin etc. O53838 BAC0201 kmtR Chromosome Mycobacterium tuberculosis Nickel (Ni), Cobalt (Co) HTH-type transcriptional regulator KmtR; response to cobalt and nickel ions; Negatively auto-regulated C4X7Z3 BAC0476 kpnE Chromosome Klebsiella pneumoniae NTUH-K2044 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides] KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin. C4X7Z4 BAC0477 kpnF Chromosome Klebsiella pneumoniae NTUH-K2044 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides] KpnEF is a EbrAB homolog. kpnEF is involved in oxidative stress tolerance, nitrosative stress tolerance, heat stress tolerance, osmotic stress toerance etc. in Klebsiella pneumoniae. It can confer resistance to antibiotics such as cefepime, ceftriaxone, colistin, erythromycin, rifamycin, tetracycline and streptomycin C4XBC3 BAC0529 kpnO Chromosome Klebsiella pneumoniae NTUH-K2044 Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites] KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae. G2JVL2 BAC0202 lde Chromosome Listeria monocytogenes Acridine Orange [class: Acridine], Ethidium Bromide [class: Phenanthridine] Efflux pump Lde Q5HE38 BAC0535 lmrS Chromosome Staphylococcus aureus subsp. aureus COL Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)] LmrS is an efflux protein capable of extruding multiple and structurally unrelated antimicrobial compounds. It can confer resistance to antobiotics such as linezolid, trimethoprim, chloramphenicol etc. P0ACH5 BAC0560 marA Chromosome Escherichia coli (strain K12) Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane] A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents. P27245 BAC0561 marR Chromosome Escherichia coli (strain K12) Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane] Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents. Q69HT9 BAC0205 mco Chromosome Staphylococcus aureus Copper (Cu), Cobalt (Co) Multicopper oxidase Mco; Involved in copper homeostasis and oxidative stress response. Oxidizes the substrate 3,3'-dimethoxybenzidine in vitro. Also possesses low levels of phenoloxidase and ferroxidase activities. A transposon-induced mutant showed copper and cobalt sensitivity and H2O2 tolerance. P64883 BAC0206 mctB Chromosome Mycobacterium tuberculosis Copper (Cu) Pore-forming protein MctB, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration. Required for virulence. P13254 BAC0207 mdeA Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene] Methionine gamma-lyase (MdeA) P0AEY8 BAC0208 mdfA/cmr Chromosome Only gram -ve, E. coli (Strain K12) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Hydroxide (NaOH) [class: Base], Rhodamine 6G [class: Xanthene] Multidrug transporter MdfA, Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzylkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. OverExpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na+ or K+; also known as Chloramphenicol resistance pump Cmr Q9X769 BAC0209 mdrL/yfmO Chromosome Listeria monocytogenes Zinc (Zn), Cobalt (Cobalt), Chromium (Cr), Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance transporter mdrL/YfmO. It can confer resistance to antibiotics such as erythromycin, josamycin, clindamycin etc. D0ZND8 BAC0645 mdtA Chromosome Salmonella enterica serovar Typhimurium Zinc (Zn) Multidrug resistance protein MdtA. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance. P76397 BAC0210 mdtA/yegM Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid] Multidrug resistance protein MdtA; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function D0ZND9 BAC0646 mdtB Chromosome Salmonella enterica serovar Typhimurium Zinc (Zn) Multidrug resistance protein MdtB. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance. P76398 BAC0211 mdtB/yegN Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid], Hydrochloric acid (HCl) [class: Acid] Multidrug resistance protein MdtB; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. D0ZNE0 BAC0647 mdtC Chromosome Salmonella enterica serovar Typhimurium Zinc (Zn) Multidrug resistance protein MdtC. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance. P76399 BAC0212 mdtC/yegO Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid] Multidrug resistance protein MdtC; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdABC requires TolC for its function. P37636 BAC0213 mdtE/yhiU Chromosome Escherichia coli (strain K12) Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12. P37637 BAC0214 mdtF/yhiV Chromosome Escherichia coli (strain K12) Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. P25744 BAC0215 mdtG/yceE Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid] Multidrug resistance protein MdtG; Confers resistance to fosfomycin and deoxycholate P69210 BAC0216 mdtI/ydgE Chromosome Escherichia coli (strain K12) Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Spermidine [class: Polyamines] Spermidine export protein MdtI; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS Q3Z1V3 BAC0217 mdtJ/ebrB/ydgF Chromosome Shigella sonnei (strain Ss046) Spermidine [class: Polyamines] Spermidine export protein MdtJ; Catalyzes the excretion of spermidine P37340 BAC0218 mdtK/ydhE Chromosome Escherichia coli (strain K12) Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine] Multidrug resistance protein MdtK; It functions as a Na+/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin), tetraphenylphosphonium ion (TPP), deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, Acriflavine, ethidium bromide and benzylkonium P39386 BAC0219 mdtM/yjiO Chromosome Escherichia coli (strain K12) Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance protein MdtM; Confers resistance to Acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP, tetraphenylarsonium chloride ; part of a tripartite efflux system composed of MdtN, MdtO and MdtP P32716 BAC0220 mdtN/yjcR Chromosome Escherichia coli (strain K12) Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance protein MdtN; Involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP Q7A7N0 BAC0221 mepA Chromosome Only gram +ve, Staphylococcus aureus Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene] Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc. P0C070 BAC0222 mepB Chromosome Pseudomonas putida Toluene [class: Aromatic hydrocarbons], n-hexane [class: Alkane] Multidrug/solvent efflux pump membrane transporter MepB; the inner membrane transporter component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline. P0C071 BAC0223 mepC Chromosome Pseudomonas putida Toluene [class: Aromatic hydrocarbons] [class: Aromatic hydrocarbons], n-hexane [class: Alkane] Multidrug/solvent efflux pump outer membrane protein MepC; the outer membrane component of an organic solvent and antibiotic efflux pump; confers resistance to toluene, hexane, p-xylene, ampicillin, penicillin G, erythromycin, novobiocin and tetracycline. P16171 BAC0224 merA Chromosome Bacillus cereus R6007 Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. P08662 BAC0648 merA Plasmid pDU1358 Serratia marcescens Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. E3VST6 BAC0649 merA Chromosome Tenacibaculum discolor 9A5 Mercury (Hg) Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. O08449 BAC0650 merA Plasmid pMR26 Pseudomonas sp. K-62 Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury] Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. P0A0E5 BAC0651 merA Plasmid pI258 Staphylococcus aureus Mercury (Hg) Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. O66017 BAC0652 merA Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. Q934S5 BAC0653 merA Chromosome, Transposon Tn5037 Thiobacillus ferrooxidans Mercury (Hg) Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0. O07303 BAC0657 merB Plasmid pMR26 Pseudomonas sp. K-62 Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury] MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance. P08653 BAC0658 merB plasmid pI258 Staphylococcus aureus Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase. P08664 BAC0659 merB Plasmid pDU1358 Serratia marcescens Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase. Q52396 BAC0660 merB Plasmid pPB Pseudomonas stutzeri Mercury (Hg) MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance. P16172 BAC0654 merB1 Chromosome Bacillus sp. (strain RC607) Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] MerB of the first mer operon. MerB1, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance. Q9XDX3 BAC0663 merB1 Chromosome, Transposon TnMERI1 Bacillus megaterium MB1 Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury] Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. Q9WWL2 BAC0655 merB2 Chromosome Bacillus sp. (strain RC607) Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] MerB of the second mer operon. MerB2, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance. Q7DJN2 BAC0661 merB2 Chromosome, Transposon TnMERI1 Bacillus megaterium MB1 Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury] Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB. Q7DHE7 BAC0656 merB3 Chromosome Bacillus sp. (strain RC607) Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] MerB of the third mer operon. MerB3, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance. Q9RHR0 BAC0662 merB3 Chromosome, Transposon TnMERI1 Bacillus megaterium MB1 Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury] Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB. O66048 BAC0664 merC Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Mercuric resistance protein MerC. This protein is located in the inner membrane and mediates mercury transport into the cytoplasm. P22905 BAC0226 merC Chromosome Thiobacillus ferrooxidans (Acidithiobacillus ferrooxidans) Mercury (Hg) Mercuric resistance protein MerC; Occurs separately from mer operon; encodes for mercury transport system; This protein is located in the inner membrane and mediates mercury transport into the cytoplasm. Additional alternative to merT; commonly found in E. coli, missing in pseudomonas and other gram negative bacteria; found more often in brackish water than fresh water samples still less in marine environments. O66022 BAC0665 merD Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the first pPB mer operon. O66018 BAC0666 merD Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the second pPB mer operon. P06689 BAC0227 merD Plasmid pVS1 Pseudomonas aeruginosa Mercury (Hg) HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression. P08654 BAC0667 merD Plasmid pDU1358 Serratia marcescens Mercury (Hg) HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression. Q5NUV1 BAC0668 merD Plasmid pMOL28, Plasmid pMOL30 Ralstonia metallidurans CH34 Mercury (Hg) HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression. Q9Z3Y7 BAC0669 merD Plasmid pMR26 Pseudomonas sp. K-62 Mercury (Hg) HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression. Q52104 BAC0670 merE Plasmid pDU1358 (Serratia marcescens) Serratia marcescens Mercury (Hg) The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon. Q79BG5 BAC0671 merE Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Mercuric resistance protein MerE. Part of the first pPB mer operon. Q79BE4 BAC0672 merE Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Mercuric resistance protein MerE. Part of the second pPB mer operon. P06690 BAC0673 merE Plasmid pVS1 Pseudomonas aeruginosa Mercury (Hg) Mercuric resistance protein MerE. Q2QCN0 BAC0228 merF Plasmid pMER327/419 (Pseudomonas fluorescens), Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56)) Pseudomonas sp. CT14  Mercury (Hg) Mercuric resistance protein F; Additional alternative to merT. O07302 BAC0229 merG Plasmid pMR26 (Pseudomonas sp. K-62), Plasmid pIJB1 (Burkholderia cepacia (Pseudomonas cepacia)) Pseudomonas sp. K-62 Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Mercuric resistance protein MerG; Known to confer resistance to phenylmercury B2I419 BAC0230 merH Plasmid pMM23 (Mycobacterium marinum), Plasmid pMAB (Mycobacterium abscessus (strain ATCC 19977 / DSM 44196)) Mycobacterium marinum (strain ATCC BAA-535 / M) Mercury (Hg) Mercuric ion transport protein, MerH Q934S6 BAC0674 merP Chromosome, Transposon Tn5037 Thiobacillus ferrooxidans Mercury (Hg) Periplasmic mercuric ion binding protein. P13113 BAC0231 merP Plasmid pDU1358 (Serratia marcescens) Serratia marcescens Mercury (Hg) Mercuric transport protein periplasmic component; hypersensitivity to the mercuric ions are associated with the merP gene; MerP does not act to transport Hg(II) directly. Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (merA) via the merT protein. O07301 BAC0675 merP Plasmid pMR26 (Pseudomonas sp. K-62) Pseudomonas sp. K-62 Mercury (Hg) Mercury-binding protein. Mercuric transport protein periplasmic component. Q7DHE4 BAC0676 merP Chromosome Bacillus sp. (strain RC607) Mercury (Hg) Mercury-binding protein. Mercuric transport protein periplasmic component. H6WCN4 BAC0677 merP Chromosome Tenacibaculum discolor 9A5 Mercury (Hg) Mercuric transport protein periplasmic component. O66016 BAC0678 merP Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the first pPB mer operon. O66047 BAC0679 merP Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the second pPB mer operon. P22874 BAC0680 merR Plasmid pI258 Staphylococcus aureus Mercury (Hg) Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site. P0A183 BAC0232 merR Plasmid pVS1 (Pseudomonas aeruginosa) Pseudomonas aeruginosa Mercury (Hg) Mercuric resistance operon regulatory gene whose product is a unique positively acting activator protein that twists and bends the operator DNA region in the presence of Hg++ allowing RNA polymerse to synthesize mRNA. H6WCN2 BAC0685 merR Chromosome Tenacibaculum discolor 9A5 Mercury (Hg) Mercuric resistance operon regulatory protein. P13111 BAC0686 merR Plasmid pDU1358 (Serratia marcescens) Serratia marcescens Mercury (Hg) Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site. Q79BG7 BAC0687 merR Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Mercuric resistance operon regulatory protein. Q934S8 BAC0689 merR Chromosome, Transposon Tn5037 Thiobacillus ferrooxidans Mercury (Hg) Mercuric resistance operon regulatory protein. P22853 BAC0682 merR1 Chromosome Bacillus sp. (strain RC607) Mercury (Hg) Mercuric resistance operon regulatory protein. O07300 BAC0683 merR1 Plasmid pMR26 (Pseudomonas sp. K-62) Pseudomonas sp. K-62 Mercury (Hg) Mercuric resistance operon regulatory protein. Q9WWL1 BAC0681 merR2 Chromosome Bacillus sp. (strain RC607) Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Mercury resistance operon negative regulator MerR2 Q7DKL2 BAC0684 merR2 Plasmid pMR26 (Pseudomonas sp. K-62) Pseudomonas sp. K-62 Mercury (Hg) Mercuric resistance operon regulatory protein. Q79B70 BAC0688 merR2 Plasmid pPB Pseudomonas stutzeri Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury] Organomercurial resistance regulatory protein. Q934S7 BAC0690 merT Chromosome, Transposon Tn5037 Thiobacillus ferrooxidans Mercury (Hg) Mercuric ion transport protein. Q52397 BAC0691 merT Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the first pPB mer operon. Q79BG6 BAC0692 merT Plasmid pPB Pseudomonas stutzeri Mercury (Hg) Part of the second pPB mer operon. Q79F00 BAC0693 merT Plasmid pMR26 (Pseudomonas sp. K-62) Pseudomonas sp. K-62 Mercury (Hg) Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA). P94185 BAC0233 merT Plasmid IncHI2, pMER610 (Alcaligenes spp.) Alcaligenes sp. Mercury (Hg) Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA). P13112 BAC0695 merT Plasmid pDU1358 (Serratia marcescens) Serratia marcescens Mercury (Hg) Inner mebrane protein. Involved in mercuric transport. Passes a mercury ion from the periplasmic MerP protein to the mercuric reductase (MerA). P08656 BAC0696 merT Plasmid pI258 Staphylococcus aureus Mercury (Hg) Involved in mercuric transport. Passes a mercury ion from the MerP protein to the mercuric reductase MerA. Q7DHE5 BAC0697 merT Chromosome Bacillus sp. (strain RC607) Mercury (Hg) Mercury transport protein H6WCN3 BAC0694 merT-P Chromosome Tenacibaculum discolor 9A5 Mercury (Hg) A novel putative transport protein consisting of a fusion between the integral membrane Hg(II) transporter MerT and the periplasmic Hg(II)-binding protein MerP. P52477 BAC0234 mexA Chromosome Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter. P52002 BAC0235 mexB Chromosome Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter. Q51395 BAC0236 mexC Chromosome Pseudomonas aeruginosa Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa. Q51396 BAC0237 mexD Chromosome Pseudomonas aeruginosa Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa. Q1IB41 BAC0238 mexE Chromosome Pseudomonas entomophila (strain L48) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operon Q4KBN7 BAC0239 mexF Chromosome Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operon Q9HWH4 BAC0240 mexI Chromosome Pseudomonas aeruginosa 138244 Vanadium (V), Triclosan [class: Phenolic compounds] RND Multidrug efflux transporter mexI; Part of mexGHI-ompD efflux pump operon. The efflux pump also involved in N-acyl-homoserine lactones (AHLs) homeostsis in Pseudomonas aeruginosa. Q9HXW3 BAC0241 mexJ Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Triclosan [class: Phenolic compounds] Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein mexJ; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system Q9HXW4 BAC0242 mexK Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Triclosan [class: Phenolic compounds] RND efflux transporter mexK; part of mexJ-mexK-oprM efflux system; OprJ and OprN do not function with MexJK; Triclosan efflux required neither of the outer membrane protein but must associate with OprM to form a tripartite antibiotic efflux system P52003 BAC0243 mexR Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Triclosan [class: Phenolic compounds] Repressor of the mexAB-oprM multidrug resistance operon mexR. Also represses its own Expression. Many variants lead to increased Expression of the mexAB-oprM operon O87785 BAC0244 mexT Chromosome Pseudomonas aeruginosa Triclosan [class: Phenolic compounds] Transcriptional regulator MexT; the regulator of the MexEF-OprN efflux operon Q9HW28 BAC0245 mexV Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine] Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein mexV; part of mexVW-oprM efflux system Q9HW27 BAC0246 mexW Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine] Resistance-Nodulation-Cell Division (RND) efflux transporter mexW; part of mexVW-oprM efflux system Q9ZNG9 BAC0247 mexX Chromosome Pseudomonas aeruginosa Ethidium Bromide [class: Phenanthridine] Resistance-Nodulation-Cell Division (RND) efflux transporter mexX; E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system Q9ZNG8 BAC0248 mexY Chromosome Pseudomonas aeruginosa Ethidium Bromide [class: Phenanthridine] Resistance-Nodulation-Cell Division (RND) efflux transporter mexY; E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system P36640 BAC0642 mgtA Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Cobalt (Co), Magnesium (Mg) Mediates magnesium influx to the cytosol. P0ABB8 BAC0087 mgtA Chromosome Escherichia coli (strain K12) Cobalt (Co), Magnesium (Mg) Magnesium-transporting ATPase, P-type 1; Mediates magnesium influx to the cytosol. O53858 BAC0480 mmco Chromosome Mycobacterium tuberculosis Copper (Cu) Mmco is required for copper resistance in Mycobacterium tuberculosis. It acts by oxidation of toxic Cu(I) in the periplasm. P69926 BAC0249 mmR Chromosome Mycobacterium tuberculosis Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene] Multidrug efflux pump mmR. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y. O34385 BAC0250 mntA/ytgA Chromosome Bacillus subtilis (strain 168) Manganese (Mn), Cadmium (Cd) Manganese-binding lipoprotein MntA; This protein is a component of a manganese permease, a binding protein-dependent, ATP-driven transport system. May be the major manganese uptake system during sporulation P0A769 BAC0251 mntH/yfeP Chromosome Escherichia coli (strain K12) Manganese (Mn), Iron (Fe), Cadmium (Cd), Cobalt (Co), Zinc (Zn) Divalent metal cation transporter MntH; H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen. P76264 BAC0252 mntP/yebN Chromosome Escherichia coli K-12 Manganese (Mn), Magnesium (Mg), Methyl Viologen [class: Paraquat], Hydrogen Peroxide (H2O2) [class: Peroxides] MntP; Functions as a manganese efflux pump P0A9F1 BAC0253 mntR Chromosome Escherichia coli Manganese (Mn), Magnesium (Mg) Manganese transport regulator mntR; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP Q72FN6 BAC0598 modA Chromosome Desulfovibrio vulgaris Hildenborough (strain GZ6027) Tungsten (W), Molybdenum (Mo) Molybdenum ABC transporter, periplasmic molybdenum-binding protein. Part of the ModABC transport system. P37329 BAC0609 modA Chromosome Escherichia coli (strain K12) Tungsten (W), Molybdenum (Mo) Molybdate-binding periplasmic protein. Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity. Q72FN2 BAC0599 modB Chromosome Desulfovibrio vulgaris Hildenborough (strain GZ6027) Tungsten (W), Molybdenum (Mo) Molybdenum ABC transporter, permease protein. Part of the ModABC transport system. Responsible for the translocation of the substrate across the membrane. modB gene encodes the integral membrane protein ModB, which builds the membrane channel of the ModABC transporter. P0AF01 BAC0610 modB Chromosome Escherichia coli (strain K12) Tungsten (W), Molybdenum (Mo) Molybdenum transport system permease protein ModB. Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. Q72FN3 BAC0600 modC Chromosome Desulfovibrio vulgaris Hildenborough (strain GZ6027) Tungsten (W), Molybdenum (Mo) Molybdenum ABC transporter, ATPase subunit of the ModABC complex. Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system. P09833 BAC0611 modC Chromosome Escherichia coli (strain K12) Tungsten (W), Molybdenum (Mo) Molybdenum import ATP-binding protein ModC. Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system. P0A9G8 BAC0608 modE Chromosome Escherichia coli (strain K12) Tungsten (W), Molybdenum (Mo) Transcriptional regulator ModE. The ModE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. It controls tungstate and molybdate homeostasis in bacteria. Q88IN1 BAC0254 mrdH Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (strain KT2440) Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co) Membrane protein transpoeter mrdH Q88IN0 BAC0255 mreA Chromosome Pseudomonas putida (strain KT2440) Nickel (Ni), Zinc (Zn) Metal-sensitive repressor mreA, involved in resistance to metal ions. Bind nickel or zinc ions via conserved cysteine and histidine residues. In the absence of metal ions, this protein bind to promoter regions and repress transcription Q9WW32 BAC0256 mtrA Chromosome Neisseria gonorrhoeae Triton X-100 [class: Polyethylene glycol] Two component sensory transduction transcriptional regulatory protein MtrA; play an important role in enhancing transcription of the mtrCDE operon P43505 BAC0257 mtrC Chromosome Neisseria gonorrhoeae Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane] Membrane fusion protein MtrC; part of MtrCDE efflux pump; Cell membrane lipoprotein, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents Q5F725 BAC0258 mtrD Chromosome Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) Triton X-100 [class: Polyethylene glycol] Antibiotic resistance efflux pump component mtrD; part of MtrCDE efflux pump B4RN86 BAC0259 mtrE Chromosome Neisseria gonorrhoeae (strain NCCP11945) Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid] Antibiotic resistance efflux pump component ; Outer membrane protein mtrE; part of MtrCDE efflux pump B4RN92 BAC0260 mtrF Chromosome Neisseria gonorrhoeae (strain NCCP11945) Triton X-100 [class: Polyethylene glycol] Antibiotic resistance efflux pump component mtrF; inner membrane protein P39897 BAC0261 mtrR Chromosome Neisseria gonorrhoeae Triton X-100 [class: Polyethylene glycol], Crystal Violet [class: Triarylmethane] HTH-type transcriptional regulator MtrR; Repressor of the mtrC gene. the major repressor of mtrCDE expression; Controls the permeability of the cell envelope to hydrophobic compounds such as antibiotics and detergents P0CI28 BAC0262 mymT Chromosome Mycobacterium tuberculosis Copper (Cu), Nickel (Ni), Zinc (Zn) Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese. Q44586 BAC0549 nccA Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane. Q44585 BAC0550 nccB Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. Q44584 BAC0551 nccC Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. Q44583 BAC0555 nccH Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Q44587 BAC0554 nccN Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport. Q44582 BAC0553 nccX Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc. Q44581 BAC0552 nccY Plasmid pTOM9 Alcaligenes xylosoxidans 31A Nickel (Ni), Cobalt (Co), Cadmium (Cd) Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc. Q06VT3 BAC0263 ncrA Chromosome Leptospirillum ferriphilum Nickel (Ni) Chromosomal nickel-resistant determinant ncrA found both in chromosome and plasmids. Part of ncrABCY nickel resistance Chromosomal determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Q1KLR2 BAC0698 ncrA Chromosome Serratia marcescens strain C-1 Cobalt (Co), Nickel (Ni) Part of the ncrABC determinant sytem. NcrA contributes to nickel and cobalt resistance in this bacterium. Q8VTR6 BAC0702 ncrA Plasmid pNRS148 Hafnia alvei 5-5 Cobalt (Co), Nickel (Ni) Plasmid-borne ncrA protein. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Part of ncrABCY nickel resistance determinant system. Q06VT2 BAC0264 ncrB Chromosome Leptospirillum ferriphilum Nickel (Ni) Chromosomal nickel-resistant determinant ncrB which is cytoplasmic, histidine-rich protein found in both chromosome and plasmids; probabale metal-sensitive repressor, involved in resistance to nickel ions Q1KLR1 BAC0699 ncrB Chromosome Serratia marcescens strain C-1 Cobalt (Co), Nickel (Ni) Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system. Q8VTR5 BAC0703 ncrB Plasmid pNRS148 Hafnia alvei 5-5 Cobalt (Co), Nickel (Ni) Plasmid-borne ncrB protein. Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system. D5CKG5 BAC0265 ncrC Chromosome Leptospirillum ferriphilum Nickel (Ni) Chromosomal nickel-resistant membrane protein NcrC found both in chromosome and plasmids. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA. Q1KLR0 BAC0700 ncrC Chromosome Serratia marcescens strain C-1 Cobalt (Co), Nickel (Ni) Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA. Q8VTR4 BAC0704 ncrC Plasmid pNRS148 Hafnia alvei 5-5 Cobalt (Co), Nickel (Ni) Plasmid-borne ncrC protein. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA. Q06VT0 BAC0266 ncrY Chromosome Leptospirillum ferriphilum Nickel (Ni) Chromosoaml nickel-resistant determinant ncrY found both in chromosome and plasmids; some claims it has a negative effect on nickel resistance. Q8VTR3 BAC0701 ncrY Plasmid pNRS148 Hafnia alvei 5-5 Cobalt (Co), Nickel (Ni) Plasmid-borne NcrY protein. Part of ncrABCY nickel resistance determinant system. Some claims it has a negative effect on nickel resistance. B8GZE9 BAC0267 nczA Chromosome Caulobacter crescentus (strain NA1000 / CB15N) Nickel (Ni), Cobalt (Co), Zinc (Zn) Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+ P17117 BAC0540 nfsA Chromosome Escherichia coli K12 Chromium (Cr) A major oxygen-insensitive nitroreductase of Escherichia coli, is a flavoprotein that is able to reduce chromate to less soluble and less toxic Cr(III). Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen-insensitive nitroreductase activity in E.coli. P96454 BAC0268 nhlF Chromosome Rhodococcus rhodochrous Cobalt (Co) Cobalt transporter nhlF. It has a significant sequence similarity to hoxN from Alcaligenes eutrophus, hupN from Bradyrhizobium japonicum, nixA from Helicobacter pylori etc. The protein has eight hydrophobic putative membrane-spanning domains. Q92Z60 BAC0269 nia Plasmid pSymA (Sinorhizobium melitoli) Sinorhizobium melitoli Iron (Fe), Nickel (Ni) P1B-5-ATPase; Has role in detoxification of Fe (II)+ and Ni (II)+ under free living conditions as well as in symbiosis. P33590 BAC0270 nikA Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel-binding periplasmic protein nikA; Involved in a nickel transport system, represents the nickel binder. Part of the Nik operon (NikABCDE), Solute-binding protein P33591 BAC0271 nikB Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel transport system permease protein NikB; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE) P0AFA9 BAC0272 nikC Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel transport system permease protein NikC; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE) P33593 BAC0273 nikD Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel import ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Part of the Nik operon (NikABCDE) P33594 BAC0274 nikE Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel import ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. P0A6Z6 BAC0275 nikR Chromosome Escherichia coli (strain K12) Nickel (Ni) Nickel-responsive regulator nikR; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. Q6RUG3 BAC0276 nirA Chromosome Klebsiella oxytoca Nickel (Ni) Chromosomal nickel resistance determinant nirA. C-terminal of the nirA protien contains a histidine rich region tat might possess high affinity to nickel. Q6RUG2 BAC0277 nirB Chromosome Klebsiella oxytoca Nickel (Ni) Chromosomal nickel resistance determinant nirB. It has 98% amino acid sequence similarity to chromosomal ncrB. Q6RUG1 BAC0278 nirC Chromosome Klebsiella oxytoca Nickel (Ni) Chromosomal nickel resistance determinant nirC. It is a memebrane protein like ABC-type transport proteins and also possess a histidine rich region with high affinity for nickel binding. Q6RUG0 BAC0279 nirD Chromosome Klebsiella oxytoca Nickel (Ni) Chromosomal nickel resistance determinant nirD; has 75% amino acid sequence similarity to chromomosomal ncrY. Q48262 BAC0280 nixA Plasmid pRHL2 (Rhodococcus sp. (strain RHA1)) Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) Nickel (Ni) High-affinity nickel intake protein nixA. Imports nickel ions in an energy-dependent fashion. Necessary for the Expression of catalytically active urease. O69711 BAC0281 nmtR Chromosome Mycobacterium tuberculosis Nickel (Ni), Cadmium (Cd), Lead (Pb) Represses transcription of ctpJ/nmtA, by binding to its promoter region P0A0J7 BAC0282 norA Chromosome Staphylococcus aureus Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones. Q8NWQ5 BAC0283 norB Chromosome Staphylococcus aureus (strain MW2) Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)] Quinolone resistance protein norB, Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds By similarity. Can facilitate bacterial survival in vivo when overexpressed in an abscess and may contribute to the relative resistance of staphylococcal abscesses to antimicrobial therapy Q9F5N7 BAC0284 norM/pmpM Chromosome Only gram -ve, N. gonorrhoeae, N. meningitidis, Burkholderia vietnamiensis Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance protein NorM, inner cell-membrane, Multidrug efflux pump. Confers probably resistance to the cationic peptide polymyxin B (PMB). F0KND8 BAC0285 nreB Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Acromobacter xylosoxidans 31A, Synechocystis spp. Cobalt (Co), Nickel (Ni) Nickel resistance protein nreB (also known as nrsD or entS); nickel permease involved in nickel and cobalt tolerance. The histidine-rich C-terminal region of the nreB is not essential but contributes to maximal Ni(II) resistance. Q55935 BAC0286 nrsA Chromosome Synechocystis sp. (strain PCC 6803 / Kazusa) Nickel (Ni) Cation or drug efflux system protein nrsA F7UKI9 BAC0287 nrsD/nreB Chromosome Acinetobacter calcoaceticus (strain PHEA-2), Synechocystis sp. (strain PCC 6803 / Kazusa) Nickel (Ni), Cobalt (Co) nrsD gene encodes a Ni(II) permease whose carboxy-terminal region is a metal binding domain; nickel permease involved in nickel and cobalt tolerance F7UKI5 BAC0288 nrsR Chromosome Synechocystis sp. (strain PCC 6803 / GT-S) Nickel (Ni) OmpR subfamily protein NrsR/RppA/Rre33 F7UKI4 BAC0289 nrsS Chromosome Synechocystis sp. (strain PCC 6803 / GT-S) Nickel (Ni) Sensory transduction histidine kinase NrsS/RppB/Hik30 P37592 BAC0290 opmD/nmpC Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Methyl Viologen [class: Paraquat] Outer membrane porin protein OmpD; Forms pores that allow passive diffusion of small molecules across the outer membrane Q51397 BAC0291 oprJ Chromosome Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon. Q51487 BAC0292 oprM/oprK Chromosome Pseudomonas aeruginosa n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter P95423 BAC0562 oprN Chromosome Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228) Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons] Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa. Q69HW3 BAC0294 oqxA Plasmid p0LA52 (E. coli), Plasmid pGDGK3 (Klebsiella pneumoniae) Escherichia coli Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine] RND family multidrug efflux permease oqxA; part of oqxAB efflux system, can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli. Q69HW2 BAC0295 oqxB Plasmid pOLA52 (E. coli), Escherichia coli Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Clorine Dioxide (ClO2) [class: Halogens], Triclosan [class: Phenolic compounds], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine] RND family multidrug efflux permease oqxB; part of the oqxAB efflux system; can co-select antibiotics such as Chloramphenicol, Ciprofloxacin, nofloxacin, trimethoprim etc. oqxAB efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli. B6CM35 BAC0358 oscA Chromosome Pseudomonas corrugata 28 Chromium (Cr), Dodine [class: Acetate] oscA gene involved in the sulphur starvation response and in Cr(VI) resistance in Pseudomonas corrugata 28. oscA is located upstream of a gene cluster that encodes the components of the sulphate ABC transporter, and it forms a single transcriptional unit with sbp, which encodes the periplasmic sulphate-binding protein. It has been shown that oscA is essential for the utilization of various organosulphur compounds and that it induces upregulation of the cysTWA operon under conditions of chromate exposure. oscA may also have a regulatory role in the sulphur starvation response, but the exact mechanism through which it acts is not well understood. P31554 BAC0296 ostA/lptD Chromosome Escherichia coli (strain K12) n-hexane [class: Alkane] Organic solvent tolerance protein ostA/lptD; Together with LptE, is involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis C4WZN6 BAC0536 oxyRkp Chromosome Klebsiella pneumoniae NTUH-K2044 Hydrogen Peroxide (H2O2) [class: Peroxides], Sodium Deoxycholate (SDC) [class: Acid], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Activator of hydrogen peroxide-inducible genes. It has contributory role towards varied stress tolerance in K. pneumoniae. Q9I6H1 BAC0297 PA0320 Chromosome Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid] TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species Q58AJ6 BAC0298 pbrA Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839), Plasmid pLVPK (Klebsiella pneumoniae) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Lead (Pb) pbrA, a P-type ATPase (involved in efflux); involved in Pb(II) resistance; part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II) Q58AJ7 BAC0299 pbrB/pbrC Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)), Plasmid pLVPK (Klebsiella pneumoniae) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Lead (Pb) Lipoprotein signal peptidase 3 (pbrB); a predicted integral membrane protein and a putative signal peptidase (involved in efflux); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II) Q1LAL8 BAC0300 pbrD Plasmid pMOL30 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)) Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839) Lead (Pb) PbrD, Pb(II) binding protein involved in Pb(II) resistance; a intracellular Pb binding protein (involved in Pb++ accumulation); function as a chaperone for Pb(II) or involved in Pb(II) sequestration ; PbrD is not absolutely required for Pb(II) resistance, but cells lacking PbrD show a decreased accumulation of Pb(II); part of the lead resistance determinant pbr operon (pbrABCD) which combines functions involved in uptake, efflux, and accumulation of Pb(II) D8IQ72 BAC0301 pbrR Plasmid pLVPK (Klebsiella pneumoniae), Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)) Herbaspirillum seropedicae (strain SmR1) Lead (Pb) A transcription factor, pbrR belonging to the merR family Q5GR69 BAC0302 pbrT Plasmid pA81 Alcaligenes xylosoxydans xylosoxydans Lead (Pb) A lead (Pb++) uptake protein PbrT R4IUI7 BAC0506 pcm Chromosome Stenotrophomonas maltophilia (strain K279a) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Acriflavine [class: Acridine] Protein-L-isoaspartate O-methyltransferase. pcm and tolCsm genes form an operon. pcm deletion affects on the expression of tolCsm. pcm alone makes little contribution to resistance. Q47452 BAC0303 pcoA Plasmid pRJ1004 Escherichia coli Copper (Cu) Copper resistance protein PcoA; required for the copper-inducible expression of copper resistance. May have oxidase activity; part of the copper resistance determinant system (pcoABCDRSE) Q47453 BAC0304 pcoB Plasmid pRJ1004 Escherichia coli Copper (Cu) Copper resistance protein PcoB; required for the copper-inducible expression of copper resistance; located in cell outer membrane; it's peripheral membrane protein Q47454 BAC0305 pcoC Plasmid pRJ1004 Escherichia coli Copper (Cu) Copper resistance protein PcoC; required for the copper-inducible expression of copper resistance; located in periplasm; part of the copper resistance determinant system (pcoABCDRSE) Q47455 BAC0306 pcoD Plasmid pRJ1004 Escherichia coli Copper (Cu) Copper resistance protein D; Required for the copper-inducible expression of copper resistance; part of the copper resistance determinant system (pcoABCDRSE) Q47459 BAC0307 pcoE Plasmid pRJ1004 Escherichia coli Copper (Cu), Silver (Ag) Copper-binding protein PcoE; lies distal, downstram from the regulatory genes (gene order in the operon- pcoABCDRSE); Required for the copper-inducible Expression of copper resistance. Activated by the two-component regulatory system CusS/CusR; part of the copper resistance determinant system (pcoABCDRSE) Q47456 BAC0308 pcoR Plasmid pRJ1004 Escherichia coli Copper (Cu) Transcriptional regulatory protein PcoR; member of a two-component regulatory system pcoS/pcoR. Involved in the activation of copper resistance gene operon pcoABCD by binding to a specific site on the cop operon promoter (copper box). part of the copper resistance determinant system (pcoABCDRSE) Q47457 BAC0309 pcoS Plasmid pRJ1004 Escherichia coli Copper (Cu) Sensor protein PcoS; member of a two-component regulatory system PcoS/PcoR. Activate PcoR by phosphorylation; part of the copper resistance determinant system (pcoABCDRSE) Q8DPQ6 BAC0481 pdrM Chromosome Streptococcus pneumoniae Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine] It is a Na(+)/drug antiporter in Streptococcus pneumoniae D5AQ60 BAC0612 perO Chromosome Rhodobacter capsulatus Molybdenum (Mo), Tungsten (W), Vanadium (V) PerO is involved in molybdate uptake. In addition to importing molybdate, PerO probably importssulfate, tungstate, and vanadate. Q2G282 BAC0310 perR Chromosome Staphylococcus aureus (strain NCTC 8325) Hydrogen Peroxide (H2O2) [class: Peroxides] Peroxide-responsive repressor PerR; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection P52093 BAC0497 pfr Chromosome Helicobacter pylori Iron (Fe), Copper (Cu), Manganese (Mn) pfr gene encodes ferritin protein. Has role in iron metabolism of H. pylori. Binding and sequestration of metals by Pfr is not specific for iron. Iron resistance mediated by ferritin might be important for survival of the pathogen within its natural habitat, where it is faced with iron and other metals which originate from the diet. P21441 BAC0311 pgpA/ltpgpA Chromosome Leishmania tarentolae (Sauroleishmania tarentolae) Arsenic (As), Antimony (Sb) Multidrug resistance protein PgpA C4X6T6 BAC0530 phoB Chromosome Klebsiella pneumoniae NTUH-K2044 Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges. (NB: THIS GENE IS MORE LIKELY TO BE 'PhoP' THOUGH AUTHORS MENTIONED IT AS 'PhoB'. THE SYSTEM MIGHT BE 'PhoPQ' INSTEAD OF 'PhoBR'.) C4X6T5 BAC0531 phoR Chromosome Klebsiella pneumoniae NTUH-K2044 Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Part of the two-component regulatory system PhoBR. It regulates kpnO in K. pneumoniae. It has a role in role in capsule production and bacterial growth in K. pneumoniae. It has no role in oxidative stress tolerance and nitrostative stress tolernace, but in gastrointestinal like challenges. P0AFJ7 BAC0312 pitA Chromosome Escherichia coli (strain K12) Zinc (Zn), Tellurium (Te) Low-affinity inorganic phosphate transporter 1, PitA; Can also transport arsenate Q9I3Y3 BAC0313 pmpM Chromosome Only gram -ve, Pseudomonas aeruginosa Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine] Multidrug resistance protein PmpM, Multidrug efflux pump that functions as an H+/drug antiporter. Confers resistance to benzylkonium chloride (BAC), fluoroquinolones, ethidium bromide, Acriflavine and tetraphenylphosphonium chloride. P0A4K4 BAC0314 pmrA Chromosome Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine] Multi-drug resistance efflux pump PmrA; Efflux pump for various substrates. It is associated with fluoroquinolone resistance in Streptococcus pneumoniae. Q70FH0 BAC0487 pmrA Chromosome Erwinia carotovora ssp. Carotovora Iron (Fe) Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. It is involved in controlling of bacterial response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments. Unphosphorylated PmrA represses extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves such repression, which leads to activation of extracellular enzyme genes. Phosphorylated PmrA seems to repress expression of the pmrCAB operon. Q70FG9 BAC0488 pmrB Chromosome Erwinia carotovora ssp. Carotovora Iron (Fe) Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PmrA in response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments. Q70FH1 BAC0485 pmrC Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Iron (Fe) Putative cytoplasmic membrane protein pmrC. PmrA-activated pmrC gene is required for Fe(III) resistance. Q8ZNF4 BAC0486 pmrG Chromosome Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Iron (Fe) It is a phodphatase and catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core and localizes to the periplasm. Required for iron(III)+ resistance. P07654 BAC0315 pstA Chromosome Escherichia coli (strain K12) Arsenic (As) An integral membrane protein. Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. P0AAH0 BAC0316 pstB Chromosome Escherichia coli (strain K12) Arsenic (As) Phosphate transporting ATPase; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system. P0AGH8 BAC0317 pstC Chromosome Escherichia coli (strain K12) Arsenic (As) An integral membrane permease protein; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. P0AG82 BAC0318 pstS Chromosome Escherichia coli (strain K12) Arsenic (As) A periplasmic phosphate binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. P0A0J9 BAC0319 qacA Plasmid VRSAp, pSK1 (S. Aureus) Only gram +ve, Staphylococcus aureus Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine] Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides. Q7WUJ5 BAC0320 qacB Plasmid pTZ2162 (S. Aureus) Only gram +ve, Staphylococcus aureus Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones] Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides. P14319 BAC0321 qacC/qacD/smr Plasmid pTZ20, pWBG32, pTZ22, pKH8 Staphylococcus aureus Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] Quaternary ammonium compound-resistance protein QacC (also called as QacD or smr); Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide. It confers resistance to toxic organic cations via proton-dependent export. P0AGC9 BAC0322 qacE Plasmid IncP-beta R751 (E. coli), Plasmid IncP-beta R751 (Enterobacter aerogenes) Only gram -ve, Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] Quaternary ammonium compound-resistance protein qacE, Multidrug exporter. It is implicated for the resistance to bacteriocidal quaternary ammonium compounds. Q7BQY4 BAC0323 qacEdelta1 Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001 Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)] Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc. Q9X2N9 BAC0324 qacF Plasmid pIP833 (E. aerogenes) Only gram -ve, E. aerogenes, E. cloacae Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)] Quaternary ammonium compound-resistance protein qacF, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds O87866 BAC0325 qacG Plasmid pST94 (Staphylococcus spp.) both gram +ve (s. aureus) and gram -ve (p.aeruginosa, A. salmonicida) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] Quaternary ammonium compound-resistance protein qacG, Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds O87868 BAC0326 qacH/qacI Plasmid pST2H6 ( Staphylococcus saprophyticus) only gram +ve, Staphylococcus aureus Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine] Quaternary ammonium compound-resistance protein qacH (also known as qacI), Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds. Q84EL2 BAC0327 qacJ Plasmid pNVH01(S. aureus) only gram +ve, Staphylococcus spp. Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug efflux protein QacJ P0A0N4 BAC0328 qacR Plasmid pSK1 (S. aureus) Staphylococcus aureus Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine] HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA. Q82YU7 BAC0329 qacZ Plasmid pTEF1 Enterococcus faecalis (strain ATCC 700802 / V583) Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance transporter qacZ; qacZ gene in tolerance to the quaternary ammonium compound benzylkonium chloride, but not ethidium bromide or chlorhexidine. P76425 BAC0330 rcnA/yohM Chromosome Escherichia coli (strain K12) Cobalt (Co), Nickel (Ni), Iron (Fe) Efflux system rcnA for nickel and cobalt; Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcription P64534 BAC0331 rcnB/yohN Chromosome Escherichia coli (strain K12) Nickel (Ni), Cobalt (Co) Nickel/cobalt homeostasis protein RcnB; Act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. Repressed by RcnR. Induced by nickel and cobalt P64530 BAC0332 rcnR/yohL Chromosome Escherichia coli (strain K12) Cobalt (Co), Nickel (Ni), Iron (Fe) Repressor of rcnA, rcnR. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Can repress the rcnB expression as well. Q9HTL3 BAC0356 recG Chromosome Pseudomonas aeruginosa PAO1 Chromium (Cr), Tellurium (Te), Selenium (Se) ATP-dependent DNA helicase RecG. It is involved in repairing DNA damage caused by chromate or its derivatives. Can confer resistant to tellurite, selenite but not arsenite, paraquat or hydrogen peroxide. B5L350 BAC0357 recG Chromosome Pseudomonas corrugata 28 Chromium (Cr) fragment of the recG helicase. O07434 BAC0333 ricR Chromosome Mycobacterium tuberculosis H37Rv Copper (Cu) Copper repressor ricR P0ACI0 BAC0334 robA Chromosome Escherichia coli O157:H7 Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl] Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc. P35540 BAC0335 rpoS Chromosome Escherichia coli, Shigella flexneri Hydrochloric acid (HCl) [class: Acid], Sodium hydroxide (NaOH) [class: Base] RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RpoS is required for optimal maintenance of pH homeostasis of stationary phase cells exposed to extreme acid. Q51426 BAC0355 ruvB Chromosome Pseudomonas aeruginosa PAO1 Chromium (Cr), Tellurium (Te), Selenium (Se) ATP-dependent DNA helicase RuvB. It is involved in repairing DNA damage caused by chromate or its derivatives. Can confer resistant to tellurite, selenite but not arsenite, paraquat or hydrogen peroxide. B5L348 BAC0293 ruvB Chromosome Pseudomonas corrugata 28 Chromium (Cr), Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dodine [class: Acetate], 2-nitroimidazole [class: imidazole] It is a fragment of ruvB gene product. It is a oxidoreductase from malic enzyme family. D1RKV4 BAC0336 sdeA Chromosome Legionella longbeachae D-4968 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug resistance secretion protein SdeA; part of the sdeAB-tolC efflux system Q84GI9 BAC0337 sdeB Chromosome Serratia marcescens subsp. marcescens Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], n-hexane [class: Alkane], Chlorhexidine [class: Biguanides], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug efflux protein SdeB; part of the sdeAB-tolC efflux system Q7WSD6 BAC0338 sdeX Chromosome Only gram -ve, Serratia marcescens Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene] Multidrug efflux pump SdeX  Q7WSD5 BAC0339 sdeY Chromosome Only gram -ve, Serratia marcescens Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Triclosan [class: Phenolic compounds], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene] Multidrug efflux pump SdeY Q849Q9 BAC0340 sepA Chromosome Staphylococcus aureus Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine] Multidrug resistance efflux pump sepA; Involved in multidrug efflux. Confers low level resistance to drugs such as Acriflavine, benzylkonium chloride (BAC), chlorhexidine gluconate and ethidium bromide Q9ZHC9 BAC0341 silA Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) SilA is a inner membrane chemiosmotic, cation/proton antiporter; Component of the sil cation-efflux system (silABC) that confers resistance to silver Q9ZHD0 BAC0342 silB Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) SilB, a membrane fusion protein that brings together the inner and outer membranes of Gram-negative bacteria; Component of the sil cation-efflux system (silABC) that confers resistance to silver Q9ZHD2 BAC0343 silC Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) SilC is an outer membrane lipoprotein; Component of the sil cation-efflux system (silABC) that confers resistance to silver Q9Z4N3 BAC0344 silE Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) Component of the sil cation-efflux system that confers resistance to silver; it also can participate in resistance to Ag+ individually Q9ZHD1 BAC0345 silF Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) Silver efflux system periplasmic chaperone; It is a small gene resides in between SilC and SilB of SilCFBA(ORF105)P operon; It carries Ag+ from its periplasmic site of release by SilP to the periplasmic uptake site of SilA, as part of the SilCBA complex Q9ZHC7 BAC0346 silP Plasmid pMG101 (Salmonella typhimurium), Plasmid pLVPK (Klebsiella pneumoniae) Salmonella typhimurium Silver (Ag) Silver exporting P-type ATPase silP; Component of the sil cation-efflux system that confers resistance to silver; silP can participate in resistance to Ag+ individually; located in cell membrane. Q9ZHD3 BAC0347 silR Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) silR encodes an transcriptional regulator; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR. Q9ZHD4 BAC0348 silS Plasmid pMG101 (Salmonella typhimurium) Salmonella typhimurium Silver (Ag) silS encodes a membrane sensor kinase; Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system SilS/SilR. May activate SilR by phosphorylation Q9XCS2 BAC0349 sitA Plasmid pECOS88 (Escherichia coli O45:K1 (strain S88 / ExPEC)), Plasmid pCVM29188_146 (Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188) Escherichia coli O45:K1 (strain S88 / ExPEC) Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] Iron/Mn transport protein, periplasmic-binding protein SitA; sitA gene encodes a periplasmic binding protein Q9XCS1 BAC0350 sitB Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pCS0010A (Salmonella enterica subsp. enterica serovar Kentucky) Escherichia coli (strain SMS-3-5 / SECEC) Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] sitB encodes an ATP-binding protein Q9XCS0 BAC0351 sitC Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1))) Escherichia coli (strain SMS-3-5 / SECEC) Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] sitC encodes a permease (integral membrane protein); part of the sitABCD transport system Q9XCR9 BAC0352 sitD Plasmid pSMS35_130 (Escherichia coli (strain SMS-3-5 / SECEC)), Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1))) Escherichia coli (strain SMS-3-5 / SECEC Manganese (Mn), Iron (Fe), Hydrogen Peroxide (H2O2) [class: Peroxides] sitD encode a permease (integral membrane protein); part of the sitABCD transport system A7VN01 BAC0353 smdA Chromosome Serratia marcescens 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide] Multidrug efflux pump SmdA A7VN02 BAC0354 smdB Chromosome Serratia marcescens 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide] Multidrug efflux pump SmdB I0KSX9 BAC0358 smeD Chromosome Stenotrophomonas maltophilia Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS Membrane fusion protein of RND family multidrug efflux pump smeD; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics. I0KSX8 BAC0359 smeE Chromosome Stenotrophomonas maltophilia Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS RND efflux system, inner membrane transporter smeE; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics. Q9F239 BAC0360 smeF Chromosome Stenotrophomonas maltophilia Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Proflavin [class: Acridine], SDS Multidrug resistance outer membrane protein smeF; part of the smeDEF efflus system. It confers resisance to a wide range of antibiotics. Q5MXJ5 BAC0362 smeT Chromosome Stenotrophomonas maltophilia Triclosan [class: Phenolic compounds] SmeT repressor protein for the the multidrug efflux system smeDEF Q2AAU2 BAC0363 smfY Chromosome Serratia marcescens Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)] Multidrug efflux pump SmfY C7SLZ1 BAC0364 smrA Chromosome Stenotrophomonas maltophilia Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine] ABC-type multidrug efflux pump protein SmrA P30331 BAC0365 smtA Chromosome Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)); Escherichia coli (strain K12) Zinc (Zn), Mercury (Hg) Metallothionein SmtA; Contain 9 cysteine residues; plays a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions. Metallothioneins have a high content of cysteine residues that bind various heavy metals. Cells that lack of metallothionein have reduced uptake of Zn++ and reduced tolerance to high Zn++ concentrations (althogh the Cu++ and Hg++ tolerances are unchanged); often Cd++ resistant when cells grow in high level of Cd++. P30340 BAC0366 smtB/ziaR Chromosome Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)) Zinc (Zn) Repressor protein smtB; regulates the metallothionein synthesis in transcrition level negatively; its a helix-turn-helix protein in the same family of arsR and cadC; binds at imperfect inverted repeat TGAAACA-GT-TATTCA between the transcription initiation site and the ribosome binding site for smtA; Transcriptional repressor of the Expression of the smtA gene. Binds two zinc ions per dimer. The complex of DNA and smtB is dissociated by zinc ions. D0ZXQ3 BAC0367 smvA/emrB Chromosome Salmonella typhimurium Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine] Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine. P00448 BAC0368 sodA Chromosome Escherichia coli K12 Selenium (Se), Hydrogen Peroxide (H2O2) [class: Peroxides] Mn-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. P53652 BAC0705 sodA Chromosome Pseudomonas aeruginosa Hydrogen Peroxide (H2O2) [class: Peroxides] Mn-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. P53641 BAC0706 sodB Chromosome Pseudomonas aeruginosa Hydrogen Peroxide (H2O2) [class: Peroxides] Fe-dependent superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. P0AGD3 BAC0707 sodB Chromosome Escherichia coli K12 Selenium (Se), Hydrogen Peroxide (H2O2) [class: Peroxides] Fe-dependent superoxide dismutase. Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. P0ACS2 BAC0370 soxR Chromosome Escherichia coli (strain K12) Methyl Viologen [class: Paraquat] Redox-sensitive transcriptional activator SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity. P0A9E2 BAC0371 soxS Chromosome Escherichia coli (strain K12) Zinc (Zn), Cyclohexane [class: Cycloalkane] Regulatory protein SoxS; Increases the Zn uptake system znuACB; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters. O31099 BAC0372 srpA Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate] Solvent-resistant efflux pump periplasmic linker SrpA; a component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon Expression level. O31100 BAC0373 srpB Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate] Solvent-resistant pump membrane transporter SrpB; The inner membrane transporter component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level. O31101 BAC0374 srpC Chromosome Pseudomonas putida n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate] Solvent-resistant efflux pump outer membrane protein SrpC; The outer membrane component of an organic solvent efflux pump srpABC. Involved in export of a number of low log POW compounds including hexane (log POW 3.5), toluene (log POW 2.5) and dimethylphthalate (log POW 2.3). The solvent resistance phenotype has been postulated to depend on the operon expression level. Q55027 BAC0152 srpC Plasmid pANL Synechococcus elongatus strain PCC 7942 (Anacystis nidulans R2) Chromium (Cr) A homologue of chrA. SrpC is not a sulfate transporter. Functions as a transporter that extrudes chromate ions from cytoplasm under sulfur-deficient conditions. Q9R9T9 BAC0375 srpR Chromosome Pseudomonas putida n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate] Solvent efflux pump srpABC operon corepressor SrpR; In conjunction with SrpS represses the srpABC operon. Q9R9U0 BAC0376 srpS Chromosome Pseudomonas putida n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate] Solvent efflux pump srpABC operon corepressor SrpS; In conjunction with SrpR represses the srpABC operon. A7VN75 BAC0377 ssmE Chromosome Serratia marcescens Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Chlorhexidine [class: Biguanides] Multidrug efflux pump SsmE P69937 BAC0378 sugE Plasmid IncN p541 (Escherichia coli), Plasmid pIW759 (Salmonella typhimurium) only gram -ve, Escherichia coli Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], and Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Quaternary ammonium compound-resistance protein sugE, Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds. Q71UZ7 BAC0379 tbtA Chromosome Pseudomonas stutzeri (Pseudomonas perfectomarina) Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane] Tributyltin chloride resistance membrane fusion protein TbtA; has 4 characteristic motifs A, B, C and D; part of the tbtABM efflux system Q71UZ6 BAC0380 tbtB Chromosome Pseudomonas stutzeri (Pseudomonas perfectomarina) Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane] Resistance nodulation cell division family member TbtB; Aanalogous to proton dependent efflux pump belonging to RND family; part of the tbtABM efflux system Q71UZ5 BAC0381 tbtM Chromosome Pseudomonas stutzeri Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane] Outer membrane protein TbtM, part of the tbtABM efflux system Q71UZ4 BAC0382 tbtR Chromosome Pseudomonas stutzeri  Tributyltin (TBT) [class: Organo-tin], n-hexane [class: Alkane] Efflux pump regulator; a potential regulatory gene of tbtABM, named tbtR, is identified upstream of the operon; TbtR exhibited many similarities with other repressors of the RND efflux systems Q8VPE6 BAC0383 tcrB Plasmid pA17sv1 (Enterococcus faecium), Enterococcus faecium (Streptococcus faecium) Copper (Cu) The transferable, plasmid-localized Copper resistance efflux ATPase, TcrB P25396 BAC0384 tehA Chromosome Escherichia coli (strain K12) Tellurium (Te), Proflavin [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat] Tellurite resistance protein TehA; The gene encodes an integral membrane protein. Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance, otherwise phenotypically silent P25397 BAC0385 tehB Chromosome Escherichia coli (strain K12) Tellurium (Te), Proflavin [class: Acridine] S-adenosyl-L-methionine dependent methyltransferase tehB that catalyzes the methylation of tellurite and is responsible for tellurite resistance when present in high copy number. Can also methylate selenite and selenium dioxide. Is thus able to detoxify different chalcogens. Can not methylate arsenic compounds P18778 BAC0386 terA Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pK2044 (Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044) Alcaligenes sp. Tellurium (Te) Tellurium resistance protein TerA; Response to tellurium ion P18779 BAC0387 terB Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pPag2 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1))) Alcaligenes sp. Tellurium (Te) Tellurium resistance protein TerB; terBCDE genes are essential for the resistance P18780 BAC0388 terC Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid pK2044 (Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 ) Alcaligenes sp. Tellurium (Te) Tellurium resistance protein TerC; Could conceivably alter the intracellular level of tellurium in a manner leading to resistance. Alternatively its presence in the membrane may provide a barrier to entry of the tellurium ions. P18781 BAC0389 terD Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae) Alcaligenes sp. Tellurium (Te) Tellurium resistance protein TerD; Contribute to the tellurium resistance (Ter) mechanism. P18782 BAC0390 terE Plasmid IncHI2 pMER610 (Alcaligenes sp.), Plasmid IncHI2 R478 (Serratia marcescens) Alcaligenes sp. Tellurium (Te) Tellurium resistance protein TerE; Contribute to the tellurium resistance (Ter) mechanism P75010 BAC0391 terW Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae), Plasmid pEC-IMP (Enterobacter cloacae) Serratia marcescens subsp. Marcescens Tellurium (Te) Tellurium resistance protein TerW; ter operon (terZABCDE) is naturally controlled by the terW gene product Q52353 BAC0392 terZ Plasmid IncHI2 R478 (Serratia marcescens), Plasmid pK29 (Klebsiella pneumoniae) Serratia marcescens subsp. Marcescens Tellurium (Te) Tellurium resistance protein TerZ; Contribute to the tellurium resistance (Ter) mechanism. Also involved in phage inhibition (Phi) and colicin resistance (PacB). P02930 BAC0393 tolC Chromosome Escherichia coli (strain K12) Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone] Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump. R4ITT0 BAC0507 tolCsm Chromosome Stenotrophomonas maltophilia (strain K279a) Acriflavine [class: Acridine], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat], Plumbagin [class: Naphthoquinone], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide], Menadione [class: Naphthoquinone] Outer membrane protein. pcm and tolCsm genes form an operon. A significant feature of TolCsm different from that of other tolC homologues of Enterobacteriaceae is that tolCsm is not transcribed alone, but is transcribed with the pcm gene. O33548 BAC0394 trgA Chromosome Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) Tellurium (Te) Tellurite resistance protein TrgA; Confers tellurite resistance; membrane associated protein; Together with TrgB, it forms an operon; trgA gene alone does not encode resistance. O07841 BAC0395 trgB Chromosome Rhodobacterales bacterium Y4I, Rhodobacter capsulatus Tellurium (Te), Copper (Cu) Tellurite resistance protein TrgB; Together with TrgA, it forms an operon Q663F0 BAC0396 triA Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid pCROD2 (Citrobacter rodentium (strain ICC168)) Yersinia pseudotuberculosis serotype I (strain IP32953) Triclosan [class: Phenolic compounds] Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriA; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work Q663E9 BAC0397 triB Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica) Yersinia pseudotuberculosis serotype I (strain IP32953) Triclosan [class: Phenolic compounds] Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein TriB; Part of the TriABC-opmH triclosan efflux pump system. TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work Q663E8 BAC0398 triC Plasmid pYptb32953 (Yersinia pseudotuberculosis serotype I (strain IP32953) ), Plasmid p29930 (Yersinia enterocolitica) Yersinia pseudotuberculosis serotype I (strain IP32953) Triclosan [class: Phenolic compounds] Resistance-Nodulation-Cell Division (RND) efflux transporter triC; Part of the TriABC-opmH triclosan efflux pump system; TriABC-opmH is the only known RND pump system requires two MFPs (TriA and TriB) to work P96116 BAC0399 troA Chromosome Treponema pallidum (strain Nichols) Zinc (Zn), Manganese (Mn), Iron (Fe) Periplasmic zinc-binding protein TroA; encodes the solute binding protein (SBP), Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane. P96117 BAC0400 troB Chromosome Treponema pallidum (strain Nichols) Zinc (Zn), Manganese (Mn), Iron (Fe) Zinc transport system ATP-binding protein TroB; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc P96118 BAC0401 troC Chromosome Treponema pallidum (strain Nichols) Zinc (Zn), Manganese (Mn), Iron (Fe) Zinc transport system membrane protein TroC; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc P96119 BAC0402 troD Chromosome Treponema pallidum (strain Nichols) Zinc (Zn), Manganese (Mn), Iron (Fe) Zinc transport system membrane protein TroD; Part of an ATP-driven transport system TroABCD for zinc. P96120 BAC0403 troR Chromosome Treponema pallidum (strain Nichols) Zinc (Zn), Manganese (Mn), Iron (Fe) An iron activated repressor protein TroR of the troABCD transport system Q9WWZ9 BAC0404 ttgA Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] Toluene efflux pump periplasmic linker protein TtgA; The periplasmic linker protein component of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline. O52248 BAC0405 ttgB Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] The inner membrane transporter component, ttgB of a constitutive organic solvent efflux system ttgABC. Involved in export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also Exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline. Q9WWZ8 BAC0406 ttgC Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] The outer membrane component ttgC of a constitutive organic solvent efflux system ttgABC. Is involved in Export of toluene, styrene, m-xylene, propylbenzene and ethylbenzene. Also exports AMP and the antibiotics carbenicillin, nalidixic acid, chloramphenicol and tetracycline. Q9KWV5 BAC0407 ttgD Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] The periplasmic linker protein component, ttgD of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux Q9KWV4 BAC0408 ttgE Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] The inner membrane transporter component, ttgE of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux. Q9KWV3 BAC0409 ttgF Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] The outer membrane component, ttgF of an inducible organic solvent efflux pump ttgDEF. Involved in export of toluene and styrene but not of m-xylene, propylbenzene or ethylbenzene. Is not involved in antibiotic or AMP efflux. Q93PU5 BAC0410 ttgG Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] The periplasmic linker component ttgG, of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics. Q93PU4 BAC0411 ttgH Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] The inner membrane transporter component, ttgH of an organic solvent efflux pump ttgGHI. Involved in Export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics Q93PU3 BAC0412 ttgI Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] The outer membrane component, ttgI of an organic solvent efflux pump ttgGHI. Involved in export of a number of organic solvents, including toluene and styrene. This is the most important solvent efflux pump in this strain, although it can Export AMP and some antibiotics. Q9AIU0 BAC0413 ttgR Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) n-hexane [class: Alkane], Toluene [class: Aromatic hydrocarbons], Dimethylphthalate [class: Pthalate], Styrene [class: Polystyrenes], m-xylene [class: Aromatic hydrocarbons], Ethylbenzene [class: Aromatic hydrocarbons], Propylbenzene [class: Aromatic hydrocarbons] Toluene efflux pump ttgABC operon repressor ttgR; Represses expression from the ttgABC operon promoter and its own expression. Binds to a promoter region between the divergently transcribed ttgR and ttgABC genes/operons; in the presence of chloramphenicol or tetracycline this binding no longer occurs and ttgR and ttgABC are derepressed. This suggests that TtgR binds these antibiotics. E0X9D2 BAC0414 ttgT Chromosome Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] Regulator of the ttgDEF efflux pump ttgT; Can regulate the ttgDEF system expression in ttgV-deficient condition; effect of TtgT on ttgGHI Expression is not obvious when TtgV is present but becomes relevant in its absence Q93PU6 BAC0415 ttgV Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] HTH-type transcriptional regulator TtgV; Represses the expression of the ttgGHI and ttgVW operons. Binds to the ttgGHI / ttgVW intergenic region, probably preventing binding of RNA polymerase; ttgV dissociates from this region in the presence of 1-hexanol, can regulate the ttgDEF expression as well; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin Q93PU7 BAC0416 ttgW Plasmid pGRT1 (Pseudomonas putida (Arthrobacter siderocapsulatus)) Pseudomonas putida (Arthrobacter siderocapsulatus) Toluene [class: Aromatic hydrocarbons], Styrene [class: Polystyrenes] HTH-type transcriptional regulator TtgW; does not seem to be involved in regulation of the ttgGHI or ttgVW operons; The ttgVW operon is induced by toluene and styrene, but not by the antibiotics carbenicillin, chloramphenicol, nalidixic acid, tetracycline or gentamicin Q72FN4 BAC0601 tunR Chromosome Desulfovibrio vulgaris Hildenborough (strain GZ6027) Tungsten (W), Molybdenum (Mo) Tungstate-responsive regulator, TunR. It controls tungstate and molybdate homeostasis in sulfate-reducing deltaproteobacteria. TunR functions as an activator of the modA, modBC, and tunR genes in the absence of tungstate and repressed by tungstate. Regulates the ModABC transport system in Desulfovibrio spp. Q93KD6 BAC0605 tupA Chromosome Eubacterium acidaminophilum Tungsten (W) Extracellular tungstate binding protein. Q93KD5 BAC0606 tupB Chromosome Eubacterium acidaminophilum Tungsten (W) Permease component of tungstate ABC transporter. TupB is an inner membrane protein. Q93KD4 BAC0607 tupC Chromosome Eubacterium acidaminophilum Tungsten (W) ATPase component of tungstate ABC transporter. Q9KKV4 BAC0417 vcaM Chromosome Vibrio cholerae Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acridine Orange [class: Acridine] ABC transporter, ATP-binding protein VcaM; Inner membrane protein O51918 BAC0418 vceA Chromosome Vibrio cholerae Sodium Deoxycholate (SDC) [class: Acid] Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC O51919 BAC0419 vceB Chromosome Vibrio cholerae Sodium Deoxycholate (SDC) [class: Acid] Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Can function with outer membrane OprM, an OMF family member instead of VceC Q9KS51 BAC0420 vceC Chromosome Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Sodium Deoxycholate (SDC) [class: Acid] Part of the The VceCAB multidrug (hydrophobic compounds including deoxycholate (DOC), antibiotics, such as chloramphenicol and nalidixic acid, and the proton motive force uncoupler, cyanide carbonyl m-chlorophenylhydrazone (CCCP)) resistance pump; Alpha-helical hairpin domain of Vibrio cholerae VceA play important roles in recognition/specificity/recruitment in the assembly of a functional, VceAB-OprM chimeric efflux pump Q9KS52 BAC0421 vceR Chromosome Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Sodium Deoxycholate (SDC) [class: Acid] Repressor of the vceCAB operon, VceR; VceR regulates the VceCAB drug efflux pump operon by alternating between mutually exclusive conformations that bind either drugs or promoter DNA Q9KRU4 BAC0422 vcmA Chromosome Vibrio chloerae Ethidium Bromide [class: Phenanthridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Acriflavine [class: Acridine] Multidrug efflux pump vcmA that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium bromide, 4',6'-diamidino-2-phenylindole and Acriflavine F8RKZ1 BAC0423 vcrM Chromosome Vibrio cholerae non-O1 Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] A Na+/drug antiporter-type multidrug efflux pump vcrM Q9KVI1 BAC0527 vexA Chromosome Vibrio cholerae serotype O1 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol] The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. Works as VexAB-TolC efflux system. Q9KVI2 BAC0424 vexB Chromosome Vibrio cholerae serotype O1 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol] Multidrug efflux transporter VexB. The function of vexAB efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. A double mutant of vexAB and vexCD showed a marked increase in deoxycholate susceptibility, whereas no significant change in deoxycholate susceptibility was observed in vexAB or vexCD single-deletion mutants. Q9KR86 BAC0528 vexC Chromosome Vibrio cholerae serotype O1 Ethidium Bromide [class: Phenanthridine] The function of vexCD efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. Q9KR85 BAC0425 vexD Chromosome Vibrio cholerae serotype O1 Ethidium Bromide [class: Phenanthridine] Multidrug efflux transporter VexD. The function of vexCD efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. A double mutant of vexAB and vexCD showed a marked increase in deoxycholate susceptibility, whereas no significant change in deoxycholate susceptibility was observed in vexAB or vexCD single-deletion mutants. A6P7H2 BAC0426 vexE Chromosome Vibrio cholerae 2740-80 Ethidium Bromide [class: Phenanthridine] Multidrug efflux transporter VexE; part of the vexEF-tolC efflux system; The function of vexEF efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. VexEF-TolC mediates resistance to various antimicrobials; ethidium efflux is Na+-dependent A6P7H3 BAC0427 vexF Chromosome Vibrio cholerae 2740-80 Ethidium Bromide [class: Phenanthridine] Multidrug efflux transporter VexF; part of the vexEF-tolC efflux system; The function of vexEF efflux systems are redundant with one or more of the other V. cholerae RND efflux pumps. VexEF-TolC mediates resistance to various antimicrobials; ethidium efflux is Na+-dependent. The VexF and VexM Pumps do not Function in Antimicrobial Resistance in vitro. Q9KTI8 BAC0509 vexH Chromosome Vibrio cholerae serotype O1 Triton X-100 [class: Polyethylene glycol], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid] VexH contributes to antimicrobial resistance and exhibits broad substrate specificity. VexH is important for intestinal colonization and virulence factor production. V. cholerae RND efflux pumps (e.g. vexAB, vexCD etc.) have redundant functions, not only in antimicrobial resistance, but also in virulence factor production. RND efflux system contribute to V. cholerae pathogenesis in two ways. First, the RND efflux systems function to provide the bacterium with protection against antimicrobial compounds that are present in the host. Second, the RND efflux systems are required for efficient production of virulence factors. VexH can confer resistance to antibitics such as ampicillin and novobiocin. Q9KRG9 BAC0428 vexK Chromosome Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Triton X-100 [class: Polyethylene glycol] Multidrug efflux transporter vexK Q2AAU4 BAC0429 vmeA Chromosome Vibrio parahaemolyticus Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid] Membrane fusion protein VmeA Q2AAU3 BAC0430 vmeB Chromosome Vibrio parahaemolyticus Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Crystal Violet [class: Triarylmethane], Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid] Inner membrane protein VmeB Q87TN0 BAC0510 vmeC Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide] VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q87TN1 BAC0511 vmeD Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide] VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q87R58 BAC0512 vmeE Chromosome Vibrio parahaemolyticus RIMD2210633 Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine] VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q87R57 BAC0513 vmeF Chromosome Vibrio parahaemolyticus RIMD2210633 Ethidium Bromide [class: Phenanthridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Acriflavine [class: Acridine] VmeEF uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q87QH3 BAC0517 vmeG Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Part of VexGHI efflux transporter. Q87QH2 BAC0518 vmeH Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Part of VexGHI efflux transporter. Q87QH1 BAC0519 vmeI Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides] Part of VexGHI efflux transporter. Q87LY5 BAC0520 vmeJ Chromosome Vibrio parahaemolyticus RIMD2210633 Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene] Part of the VexJK efflux transporter. VexJK uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes. Q87LY6 BAC0521 vmeK Chromosome Vibrio parahaemolyticus RIMD2210633 Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene] Part of the VexJK efflux transporter. VexJK uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes. Q87IY6 BAC0522 vmeP Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid] Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes. Q87IY5 BAC0523 vmeQ Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid] Part of the VexPQ efflux transpporter. VexPQ VexGHI uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes. Q87HZ9 BAC0524 vmeT Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Part of the VexTUV efflux transporter. Q87HZ8 BAC0525 vmeU Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Part of the VexTUV efflux transporter. Q87HZ7 BAC0526 vmeV Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Part of the VexTUV efflux transporter. Q87GX4 BAC0514 vmeY Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q87GX5 BAC0515 vmeZ Chromosome Vibrio parahaemolyticus RIMD2210633 Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] Part of the VexYZ efflux transporter. VmeYZ uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC. Q93HR7 BAC0431 vmrA Chromosome Vibrio parahaemolyticus 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)] Na+-coupled multidrug efflux pump VmrA; confers resistance to cationic drugs (4',6'-diamidino-2-phenylindole (DAPI), Tetraphenylphosphonium (TPP), Acriflavine, ethidium) Q87SJ8 BAC0516 vpoC Chromosome Vibrio parahaemolyticus RIMD2210633 Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid] Homologue of E. coli TolC outer membrane protein, vpoC. Q8U4K5 BAC0602 wtpA Chromosome Pyrococcus furiosus Tungsten (W), Molybdenum (Mo) Molybdate/tungstate-binding protein WtpA. Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate. Q8U4K4 BAC0603 wtpB Chromosome Pyrococcus furiosus Tungsten (W), Molybdenum (Mo) Molybdate/tungstate transport system permease protein WtpB. Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane. Q8U4K3 BAC0604 wtpC Chromosome Pyrococcus furiosus Tungsten (W), Molybdenum (Mo) Molybdate/tungstate import ATP-binding protein WtpC (ATPase). Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system. Q9R7V3 BAC0432 ybtP Chromosome Yersinia pestis Iron (Fe) Fe3+-Yersiniabactin uptake transporter, YbtP; inner membrane lipoprotein Q9Z375 BAC0433 ybtQ Chromosome Yersinia pestis Iron (Fe) Permease and ATP-binding protein of yersiniabactin-iron ABC transport YbtQ P0AB49 BAC0434 ychH Chromosome Escherichia coli (strain K12) Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides] Stress protein YchH; response to Hydrogen Peroxide (H2O2), cadmium; plays a role in biofilm formation as well C0SP95 BAC0556 ycnJ Chromosome Bacillus subtilis168 Copper (Cu) Involved in uptake of extracellular oxidized copper under copper-limiting conditions. Highly induced under copper-limiting conditions. Down-regulated by YcnK, especially under high copper concentrations. Down-regulated by CsoR. Cells lacking this gene show a growth-defective phenotype under copper deprivation as well as a reduced intracellular content of copper. P94433 BAC0557 ycnK Chromosome Bacillus subtilis 168 Copper (Cu) May act as a negative transcriptional regulator of ycnJ in the presence of copper. May use copper as a corepressor. Significantly induced under copper-limiting conditions. Cells lacking this gene show little or no difference in growth under copper deprivation, whereas possessing enhanced growth under copper excess conditions. Possess a high intracellular content of copper. D0ZXP9 BAC0435 yddg/emrE Chromosome Salmonella typhimurium (strain 14028s/SGSC 2262) Methyl Viologen [class: Paraquat] Methyl viologen resistance protein YddG, Probable efflux pump. Required for resistance to methyl viologen. May function with OmpD porin P31130 BAC0436 ydeI Chromosome Escherichia coli (strain K12) Hydrogen Peroxide (H2O2) [class: Peroxides] Stress protein YdeI; response to Hydrogen Peroxide (H2O2) and has a role in biofilm formation P76135 BAC0437 ydeO Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate] HTH-type transcriptional regulator YdeO; Induces the Expression of gadE and mdtEF. Could also regulate the Expression of other genes involved in acid resistance P77561 BAC0438 ydeP Chromosome Escherichia coli (strain K12) Hydrochloric acid (HCl) [class: Acid] Acid resistance protein YdeP; Involved in acid resistance Q56952 BAC0439 yfeA Chromosome Yersinia pestis Iron (Fe), Manganese (Mn) Periplasmic chelated iron-binding protein YfeA; Part of an ATP-driven transport system YfeABCD for chelated iron Q56953 BAC0440 yfeB Chromosome Yersinia pestis Iron (Fe), Manganese (Mn) Chelated iron transport system membrane protein YfeB; Part of an ATP-driven transport system YfeABCD for chelated iron Q56954 BAC0441 yfeC Chromosome Yersinia pestis Iron (Fe), Manganese (Mn) Chelated iron transport system membrane protein YfeC; Part of an ATP-driven transport system YfeABCD for chelated iron Q56955 BAC0442 yfeD Chromosome Yersinia pestis Iron (Fe), Manganese (Mn) Chelated iron transport system membrane protein YfeD; Part of an ATP-driven transport system YfeABCD for chelated iron O06473 BAC0443 yfmO Chromosome Bacillus subtilis (strain 168)  Copper (Cu) Multidrug efflux protein YfmO; Acts to efflux copper or a copper complex. YfmO can contribute to copper resistance; Repressed by YfmP O06474 BAC0444 yfmP Chromosome Bacillus subutilis (strain 168) Copper (Cu) HTH-type transcriptional regulator YfmP; repressor of the yfmOP operon. A mutation in yfmP leads to overexpression of yfmO, probably causing a decrease in cellular copper that is eventually responsible for a reduced copper induction of copZA. YfmP is autoregulated. There is no induction with copper or other metals. P0ADU5 BAC0445 ygiW Plasmid pMR-1 (Shewanella oneidensis (strain MR-1)) Escherichia coli Cadmium (Cd), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides] Protein YgiW; located in periplasm; responsible for tributyltin (TBT) resistance; response to hydrogen peroxide (H2O2), cadmium ions ; has a role in biofim formation P64614 BAC0446 yhcN Chromosome Escherichia coli (strain K12) Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid] Outer membrane protein YhcN; stress response protein P0AGE6 BAC0541 yieF Chromosome Escherichia coli K12 Chromium (Cr), Vanadium (V), Molybdenum (Mo), Methylene Blue [class: Thiazinium] A chromate reductase. Reduces chromate (Cr(VI)) to Cr(III) P09162 BAC0447 yjaA Chromosome Escherichia coli (strain K12) Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid] Stress response protein YjaA; a YjaA mutant strain is sensitive to hydrogen peroxide and acid P49856 BAC0448 ykkC Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat] Multidrug resistance protein YkkC; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials P49857 BAC0449 ykkD Chromosome Bacillus subtilis (strain 168) Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat] Multidrug resistance protein YkkD; Part of a heterooligomeric drug resistance efflux pump ykkCD; Confers resistance to a broad range of toxic compounds such as cationic dyes, neutral and anionic antimicrobials P75993 BAC0450 ymgB/ariR Plasmid pPag3 (Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1))) Escherichia coli (strain K12) Hydrochloric Acid (HCl) [class: Acid], Hydrogen Peroxide (H2O2) [class: Peroxides] Two-component-system connector protein YmgB/AriR; a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB/C two-component system. May be a non-specific DNA-binding protein that binds genes and/or intergenic regions via a geometric recognition. Also confers resistance to H2O2. Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB; YmgB probably acts upstream of the RcsB/C system to stimulate the activity and not transcription of RcsB/C. 5-fluorouracil reduction in biofilm formation requires this protein. Deletion increases biofilm formation. P64519 BAC0451 yodD Chromosome Escherichia coli (strain K12) Cadmium (Cd), Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid] Stress protein YodD; a yodD mutant strain is sensitive to hydrogen peroxide and acid Q46871 BAC0452 yqjH Chromosome Escherichia coli (strain K12) Iron (Fe), Nickel (Ni) NADPH-dependent ferric-chelate reductase (Ferric siderophore reductase) YqjH; Plays a role in iron homeostasis under excess nickel conditions; Repressed by YqjI and Fur. YqjI is required for nickel-dependent regulation of yqjH, while Fur is required for iron- and cobalt-dependent regulation of yqjh P44137 BAC0453 zevA Chromosome Haemophilus influenzae Zinc (Zn) Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae P44136 BAC0454 zevB Chromosome Haemophilus influenzae Zinc (Zn) Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae Q59998 BAC0455 ziaA Chromosome Synechocystis sp. (strain PCC 6803 / Kazusa) Zinc (Zn) Zinc-transporting ATPase ziaA Q55940 BAC0456 ziaR Chromosome Synechocystis sp. (strain PCC 6803 / Kazusa) Zinc (Zn) Transcriptional repressor (ziaR) of the Expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm. P76344 BAC0457 zinT/yodA Chromosome Escherichia coli (strain K12) Cadmium (Cd), Zinc (Zn) Metal-binding protein (Cadmium-induced protein) ZinT; Function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn2+ over Cd2+. Contains one high affinity metal binding site, and can bind additional metal ions at other sites; Repressed by Zur Q7WJT8 BAC0458 zipB Chromosome Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) Zinc (Zn), Cadmium (Cd) zipB is a selective electrodiffusional channel; facilitates passive zinc uptake driven by zinc concentration gradients that are maintained by cellular zinc homeostasis P75757 BAC0459 zitB/ybgR Chromosome Escherichia coli (strain K12) Zinc (Zn) Zinc transporter ZitB; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc; contributes to Zn++ haemostatis at low (non-toxic) concentrations; Appears to be selective for zinc, not conferring resistance to cobalt nor cadmium Q1LCD7 BAC0460 zneB/hmxB Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)), Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) Zinc (Zn) Membrane fusion protein (MFP-RND) heavy metal cation tricomponent efflux zneB P37617 BAC0461 zntA/yhhO Chromosome Escherichia coli (strain K12) Lead (Pb), Cadmium (Cd), Zinc (Zn) Lead, cadmium, zinc and mercury-transporting ATPase ZntA; Involved in export of lead, cadmium, zinc and mercury; located in inner cell membrane. P0ACS5 BAC0462 zntR/yhdM Chromosome Escherichia coli (strain K12) Zinc (Zn) Zinc-responsive transcriptional regulator zntR; regulates the zntA P39172 BAC0463 znuA/yebL Chromosome Escherichia coli (strain K12) Zinc (Zn) High-affinity zinc uptake system protein ZnuA; Involved in the high-affinity zinc uptake transport system; located in periplasm P39832 BAC0464 znuB/yebI Chromosome Escherichia coli (strain K12) Zinc (Zn) High-affinity zinc uptake system membrane protein ZnuB; Involved in the high-affinity zinc uptake transport system; located in cell inner membrane P0A9X1 BAC0465 znuC/yebM Chromosome Escherichia coli (strain K12) Zinc (Zn) Zinc import ATP-binding protein ZnuC; part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations Q9L9I0 BAC0466 zraP Chromosome Salmonella typhimurium (strain LT2/SGSC1412/ATCC 700720)  Zinc (Zn) Zinc resistance-associated protein ZraP; Undergoes a specific Zn++ induced cleavage to release a carboxy-terminal Zn++ binding region; located in periplasm; Binds zinc. Could be an important component of the zinc-balancing mechanism; located in periplasm P14375 BAC0467 zraR/hydH Chromosome Escherichia coli (strain K12) Zinc (Zn) Transcriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the Expression of zraP. Positively autoregulates the Expression of the zraSR operon. P14377 BAC0468 zraS/hydG Chromosome Escherichia coli (strain K12) Zinc (Zn), Lead (Pb) Sensor protein ZraS; Member of the two-component regulatory system ZraS/ZraR. Functions as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium. P0A8H3 BAC0469 zupT/ygiE Chromosome Escherichia coli (strain K12) Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd) Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions. P0AC51 BAC0470 zur/yjbK Chromosome Escherichia coli (strain K12) Zinc (Zn) Zinc uptake regulation protein zur; Acts as a negative controlling element, employing Zn2+ as a cofactor to bind the operator of the repressed genes (znuACB). Zinc uptake regulation protein.