Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
acrA | BacMet ID: BAC0005Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well. It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.Length (amino acid):
397Reference: Ma et al. 1993; Pubmed- 8407802, Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998, Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631
| Similar
resistance genes in 'BacMet Predicted database' |
acrB | BacMet ID: BAC0006Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Acriflavine [class: Acridine], Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], p-xylene [class: Aromatic hydrocarbons], Cyclohexane [class: Cycloalkane], Pentane [class: Alkane]Description: AcrAB is a drug efflux protein with a broad substrate specificity. It can confer resistant to ampicillin, chloramphenicol as well.It requires TolC outer memberane protein to function and form the AcrAB-TolC efflux operon. AcrAB-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.Length (amino acid):
1049Reference: Ma et al. 1995; Pubmed- 7651136, White et al. 1997; Pubmed- 9324261, Aono et al. 1998; Pubmed- 9473050, Fralick et al. 1996; Pubmed- 8824631
| Similar
resistance genes in 'BacMet Predicted database' |
mexA | BacMet ID: BAC0234Code for:
EffluxFamily: Membrane fusion protein (MFP)Sequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug resistance protein MexA; The periplasmic linker component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Required for assembly of the mexA/mexB/oprM complex. Implicated in the secretion of the siderophore pyoverdine; The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporter.Length (amino acid):
383Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684
| Similar
resistance genes in 'BacMet Predicted database' |
mexB | BacMet ID: BAC0235Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug resistance protein MexB; The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine; The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.Length (amino acid):
1046Reference: Li et al. 1995: Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892, Poole et al. 1993; Pubmed- 8226684
| Similar
resistance genes in 'BacMet Predicted database' |
mexC | BacMet ID: BAC0236Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosaLocation:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Membrane fusion protein MexC; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.Length (amino acid):
387Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892
| Similar
resistance genes in 'BacMet Predicted database' |
mexD | BacMet ID: BAC0237Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosaLocation:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug efflux RND transporter MexD; part of mexCD-oprJ efflux operon; The mexCD-oprJ is a second efflux pump besides mexAB-oprM operon in Pseudomonas aeruginosa.Length (amino acid):
1042Reference: Poole et al. 1996; Pubmed- 8878035, Li et al. 1998; Pubmed- 9603892
| Similar
resistance genes in 'BacMet Predicted database' |
mexE | BacMet ID: BAC0238Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas entomophila (strain L48)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug efflux RND membrane fusion protein MexE; part of mexE-mexF-oprN efflux operonLength (amino acid):
413Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892
| Similar
resistance genes in 'BacMet Predicted database' |
mexF | BacMet ID: BAC0239Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas fluorescens (strain Pf-5/ATCC BAA-477)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug efflux RND transporter, permease protein MexF; part of mexE-mexF-oprN efflux operonLength (amino acid):
1059Reference: Kohler et al. 1997; Pubmed- 9044268, Li et al. 1998; Pubmed- 9603892
| Similar
resistance genes in 'BacMet Predicted database' |
oprJ | BacMet ID: BAC0291Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Outer membrane protein oprJ, Channel-forming component of a multidrug resistance efflux pump. Part of the MexCD-OprJ efflux operon.Length (amino acid):
479Reference: Li et al. 1998; Pubmed- 9603892, Poole et al. 1996; Pubmed- 8878035
| Similar
resistance genes in 'BacMet Predicted database' |
oprM/oprK | BacMet ID: BAC0292Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosaLocation:
ChromosomeCompound: n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Outer membrane protein OprM; The outer membrane component of the mexAB-oprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-Expression of the pump increases antibiotic and solvent efflux capacities. Can replace the oprJ outer membrane component of the mexCD-oprJ pump; the antibiotics Exported are those Exported by the intact mexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the mexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane, The ability to Export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB subunit is a proton antiporterLength (amino acid):
485Reference: Li et al. 1995; Pubmed- 8540696, Li et al. 1998; Pubmed- 9603892
| Similar
resistance genes in 'BacMet Predicted database' |
oprN | BacMet ID: BAC0562Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692/PAO1/1C/PRS 101/LMG 12228)Location:
ChromosomeCompound: Triclosan [class: Phenolic compounds], n-hexane [class: Alkane], p-xylene [class: Aromatic hydrocarbons]Description: Multidrug efflux outer membrane protein OprN; part of the mexEF-oprN multidrug efflux system of Pseudomonas aeruginosa.Length (amino acid):
472Reference: Li et al. 1998; Pubmed- 9603892, Kohler et al. 1997; Pubmed- 9044268
| Similar
resistance genes in 'BacMet Predicted database' |