Browsing Experimentally Confirmed database

Result: Your query found 67 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
acrD
  • BacMet ID: BAC0563
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn)
  • Description: Acriflavine resistance protein D; participates in the efflux of aminoglycosides. It confers resistance to a variety of these substances. It contributes to copper and zinc resistance in Salmonella.
  • Length (amino acid): 1037
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    actA
  • BacMet ID: BAC0567
  • Code for: Enzyme
  • Family: CN hydrolase family. Apolipoprotein N-acyltransferase subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti TG2-6
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid]
  • Description: Apolipoprotein N-acyltransferase. Transfers the fatty acyl group on membrane lipoproteins. It has an essential role in acid tolerance of Rhizobium meliloti.
  • Length (amino acid): 531
  • Reference: Tiwari et al. 1996; Pubmed- 8868435, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actR
  • BacMet ID: BAC0565
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Acid tolerance regulatory protein ActR. Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 194
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    actS
  • BacMet ID: BAC0566
  • Code for: Regulator
  • Family: Contains histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Rhizobium meliloti strain WSM419
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Hydrochloric acid (HCl) [class: Acid], Sodium azide [class: Azide]
  • Description: Member of the two-component regulatory system ActS/ActR acting in acid tolerance. These data implicate that a two-component sensor may be involved in pH sensing and/or response.
  • Length (amino acid): 433
  • Reference: Tiwari et al. 1996; Pubmed- 8757734, Glen et al. 1999; Pubmed- 10207916, Reeve et al. 2002; Pubmed- 11936079

    		• Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0039
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons. Overexpression of BaeR increases resistance to novobiocin and deoxycholate. BaeR upregulates the mdtABCD locus and acrD and thereby increases the resistance to deoxycholate, metals and antibiotics.
  • Length (amino acid): 240
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

    		• Similar resistance genes in 'BacMet Predicted database'
    baeR
  • BacMet ID: BAC0596
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 240
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0040
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Baranova et al. 2002; Pubmed- 12107134, Yamamoto et al. 2008; Pubmed- 17884222, Lee et al. 2005; Pubmed- 15659689, Leblanc et al 2011; Pubmed- 21515766

    		• Similar resistance genes in 'BacMet Predicted database'
    baeS
  • BacMet ID: BAC0597
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella Typhimurium
  • Location: Chromosome
  • Compound: Copper (Cu), Zinc (Zn), Tungsten (W), Sodium Deoxycholate (SDC) [class: Acid]
  • Description: Member of the two-component regulatory system BaeS/BaeR. Activates BaeR by phosphorylation which then activates the mdtABCD and probably the casABCDE-ygbT-ygbF operons.
  • Length (amino acid): 467
  • Reference: Nishino et al. 2007; Pubmed- 17933888, Appia-Ayme et al. 2011; Pubmed- 21886814

    		• Similar resistance genes in 'BacMet Predicted database'
    cadA/yvgW
  • BacMet ID: BAC0055
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter pylori (strain ATCC 700392/26695)(Campylobacter pylori)
  • Location: Plasmids pI258 (S. aureus), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium efflux ATPase, has two domains (phosphatase, aspartyl kinase); Cadmium, zinc and cobalt-transporting ATPase; Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell
  • Length (amino acid): 686
  • Reference: Herrman et al. 1999; Pubmed- 10417643, Nucifera et al. 1989; Pubmed- 2524829, Lee et al. 2001; Pubmed- 11282588

    		• Similar resistance genes in 'BacMet Predicted database'
    cadC
  • BacMet ID: BAC0056
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258 (Staphylococcus aureus)
  • Compound: Cadmium (Cd), Bismuth (Bi), Zinc (Zn), Lead (Pb)
  • Description: Found in cad operon; bind to cad operator/promoter, its a repressor protein in the operon; Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA
  • Length (amino acid): 122
  • Reference: Endo et al. 1995; Pubmed- 7543476

    		• Similar resistance genes in 'BacMet Predicted database'
    cadD
  • BacMet ID: BAC0057
  • Code for: Enzyme
  • Family: CadD family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus (strain N315)
  • Location: Plasmid pN315 (Staphylococcus aureus (strain N315)), Plasmid pLUH02 (Staphylococcus aureus (strain ECT-R 2) ), Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance permease; These proteins are members of the Cadmium Resistance (CadD) Family. To date, this family of proteins has only been found in Gram-positive bacteria. The CadD family includes two close orthologues in two Staphylococcus species that have been reported to function in cadmium resistance, and another staphylococcal protein that has been reported to possibly function in quaternary ammonium ion Export.
  • Length (amino acid): 205
  • Reference: Crupper et al. 1999; Pubmed- 10383976, Kuroda et al. 2001; Pubmed- 11418146

    		• Similar resistance genes in 'BacMet Predicted database'
    cadX
  • BacMet ID: BAC0059
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus salivarius
  • Location: Plasmid pLUG10 (Staphylococcus lugdunensis)
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Cadmium resistance regulatory protein CadX
  • Length (amino acid): 112
  • Reference: Chen et al. 2008; Pubmed- 18165364

    		• Similar resistance genes in 'BacMet Predicted database'
    ctpC
  • BacMet ID: BAC0098
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type)family. Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Manganese (Mn), Zinc (Zn)
  • Description: Probable manganese/zinc-exporting P-type ATPase
  • Length (amino acid): 718
  • Reference: Padilla-Benavides et al. 2013; Pubmed- 23482562

    		• Similar resistance genes in 'BacMet Predicted database'
    czcA
  • BacMet ID: BAC0119
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein; the basic inner membrane transport protein; Has a low cation transport activity for cobalt, it is essential for the expression of cobalt, zinc, and cadmium resistance. CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete CZC efflux system (CzcABC).
  • Length (amino acid): 1063
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcB
  • BacMet ID: BAC0120
  • Code for: Efflux
  • Family: Membrane fusion protein (MFP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Cobalt-zinc-cadmium resistance protein CzcB; Membrane fusion protein bridges inner and outer cell membranes (in periplasm); CzcA and CzcB together would act in zinc efflux nearly as effectively as the complete czc efflux system (CzcABC). The CzcB protein is thought to funnel zinc cations to the CzcA transport protein.
  • Length (amino acid): 520
  • Reference: Nies et al. 1989; Pubmed- 2678100, Waidner et al. 2002; Pubmed- 12426358

    		• Similar resistance genes in 'BacMet Predicted database'
    czcC
  • BacMet ID: BAC0121
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Muter membrane protein; CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt.
  • Length (amino acid): 418
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcD
  • BacMet ID: BAC0122
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transporter gene influence Zn++ and Cd++ resistance; Necessary for activation of the czc determinant; may function as a membrane-bound sensor protein or as a metal ion transporter.
  • Length (amino acid): 316
  • Reference: Nies et al. 1989; Pubmed- 2678100

    		• Similar resistance genes in 'BacMet Predicted database'
    czcE
  • BacMet ID: BAC0123
  • Code for: Binding protein
  • Family: Cation efflux family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: CzcE, involved in Cd(II), Zn(II), Co(II) resistance; copH like protein; Co/Zn/Cd efflux system transmembrane protein
  • Length (amino acid): 133
  • Reference: Zoropogui et al. 2007; Pubmed- 18029263

    		• Similar resistance genes in 'BacMet Predicted database'
    czcP
  • BacMet ID: BAC0124
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cupriavidus metallidurans CH34
  • Location: Plasmid pMOL30 (Cupriavidus metallidurans CH34)
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: P(IB4)-type ATPases; CzcP seemed to enhance metal resistance but relies on the action of the P(IB2)-type ATPases such as zntA, cadA, pbrA etc.
  • Length (amino acid): 829
  • Reference: Scherer et al. 2009; Pubmed- 19602147

    		• Similar resistance genes in 'BacMet Predicted database'
    czcR
  • BacMet ID: BAC0125
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) ),
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Transcriptional activator protein CzcR; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis
  • Length (amino acid): 225
  • Reference: Nies et al. 1992; Pubmed- 1459958

    		• Similar resistance genes in 'BacMet Predicted database'
    czcS
  • BacMet ID: BAC0126
  • Code for: Regulator
  • Family: Contains 1 HAMP domain, 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)
  • Location: Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839) )
  • Compound: Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Sensor protein CzcS; Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis. Probably activates CzcR by phosphorylation.
  • Length (amino acid): 476
  • Reference: Van der Lelie et al. 1997; Pubmed- 9044283

    		• Similar resistance genes in 'BacMet Predicted database'
    cznA
  • BacMet ID: BAC0127
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznA
  • Length (amino acid): 1019
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznB
  • BacMet ID: BAC0128
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel resistance protein cznB
  • Length (amino acid): 351
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    cznC
  • BacMet ID: BAC0129
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)
  • Description: Cadmium-zinc-nickel outer membrane efflux protein cznC
  • Length (amino acid): 424
  • Reference: Stahler et al. 2006; Pubmed- 16790756

    		• Similar resistance genes in 'BacMet Predicted database'
    czrA
  • BacMet ID: BAC0130
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: A repressor for thr czr operon; part of the czrSRCBA resistance operon
  • Length (amino acid): 1051
  • Reference: Valencia et al. 2013; Pubmed- 23578014; Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    czrB
  • BacMet ID: BAC0131
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: czrB involved in cadmium and zinc resistance; part of the czrSRCBA resistance operon
  • Length (amino acid): 405
  • Reference: Hassan et al. 1999; Pubmed- 10570969, Kuroda et al. 1999; Pubmed- 10229265

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbA
  • BacMet ID: BAC0136
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbA subfamily.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Mercury (Hg)
  • Description: Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis
  • Length (amino acid): 208
  • Reference: Rensing et al. 1997; Pubmed- 9098080, Bardwell et al. 1991; Pubmed- 1934062; Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    fieF/yiip
  • BacMet ID: BAC0167
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)
  • Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.
  • Length (amino acid): 300
  • Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276

    		• Similar resistance genes in 'BacMet Predicted database'
    fpvA
  • BacMet ID: BAC0169
  • Code for: Porin
  • Family: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)
  • Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membrane
  • Length (amino acid): 815
  • Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567

    		• Similar resistance genes in 'BacMet Predicted database'
    irlR
  • BacMet ID: BAC0197
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Transcriptional activator protein IrlR; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance
  • Length (amino acid): 229
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    irlS
  • BacMet ID: BAC0198
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain, 1 HAMP domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Burkholderia pseudomallei (strain K96243)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Sensor protein IrlS; Member of the two-component regulatory system IrlR/IrlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance. Probably activates IrlR by phosphorylation.
  • Length (amino acid): 464
  • Reference: Jones et al. 1997; Pubmed- 9393784

    		• Similar resistance genes in 'BacMet Predicted database'
    mdrL/yfmO
  • BacMet ID: BAC0209
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Listeria monocytogenes
  • Location: Chromosome
  • Compound: Zinc (Zn), Cobalt (Cobalt), Chromium (Cr), Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance transporter mdrL/YfmO. It can confer resistance to antibiotics such as erythromycin, josamycin, clindamycin etc.
  • Length (amino acid): 397
  • Reference: Mata et al. 2000; Pubmed- 10856655

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtA
  • BacMet ID: BAC0645
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtA. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 413
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtB
  • BacMet ID: BAC0646
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtB. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 1040
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtC
  • BacMet ID: BAC0647
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella enterica serovar Typhimurium
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Multidrug resistance protein MdtC. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC. MdtABC multidrug efflux systems has a role in metal resistance.
  • Length (amino acid): 1026
  • Reference: Nishino et al. 2007; Pubmed- 17933888

    		• Similar resistance genes in 'BacMet Predicted database'
    mntH/yfeP
  • BacMet ID: BAC0251
  • Code for: Membrane Transporter
  • Family: NRAMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Manganese (Mn), Iron (Fe), Cadmium (Cd), Cobalt (Co), Zinc (Zn)
  • Description: Divalent metal cation transporter MntH; H+-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent nickel and copper. Involved in response to reactive oxygen.
  • Length (amino acid): 412
  • Reference: Makui et al. 2000; Pubmed- 10712688

    		• Similar resistance genes in 'BacMet Predicted database'
    mrdH
  • BacMet ID: BAC0254
  • Code for: Membrane Transporter
  • Family: NicO family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))
  • Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)
  • Description: Membrane protein transpoeter mrdH
  • Length (amino acid): 377
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mreA
  • BacMet ID: BAC0255
  • Code for: Regulator
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (strain KT2440)
  • Location: Chromosome
  • Compound: Nickel (Ni), Zinc (Zn)
  • Description: Metal-sensitive repressor mreA, involved in resistance to metal ions. Bind nickel or zinc ions via conserved cysteine and histidine residues. In the absence of metal ions, this protein bind to promoter regions and repress transcription
  • Length (amino acid): 95
  • Reference: Haritha et al. 2009; Pubmed- 19648243

    		• Similar resistance genes in 'BacMet Predicted database'
    mymT
  • BacMet ID: BAC0262
  • Code for: Binding protein
  • Family: Metallothionein superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Copper (Cu), Nickel (Ni), Zinc (Zn)
  • Description: Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese.
  • Length (amino acid): 53
  • Reference: Gold et al. 2011; Pubmed- 18724363, Festa et al. 2011; Pubmed- 21166899

    		• Similar resistance genes in 'BacMet Predicted database'
    nczA
  • BacMet ID: BAC0267
  • Code for: Regulator
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Caulobacter crescentus (strain NA1000 / CB15N)
  • Location: Chromosome
  • Compound: Nickel (Ni), Cobalt (Co), Zinc (Zn)
  • Description: Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+
  • Length (amino acid): 1057
  • Reference: Valencia et al. 2013; Pubmed- 23578014

    		• Similar resistance genes in 'BacMet Predicted database'
    pitA
  • BacMet ID: BAC0312
  • Code for: Porter
  • Family: Inorganic-Phospahte Transporter (PiT) family, Pit subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Tellurium (Te)
  • Description: Low-affinity inorganic phosphate transporter 1, PitA; Can also transport arsenate
  • Length (amino acid): 499
  • Reference: Elias et al. 2012; Pubmed- 23189244, Willsky & Malamy 1980; Pubmed- 6998959, Beard et al. 2000; Pubmed- 10713426

    		• Similar resistance genes in 'BacMet Predicted database'
    smtA
  • BacMet ID: BAC0365
  • Code for: Binding protein
  • Family: Metallothionein superfamily. Type 14 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)); Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Mercury (Hg)
  • Description: Metallothionein SmtA; Contain 9 cysteine residues; plays a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions. Metallothioneins have a high content of cysteine residues that bind various heavy metals. Cells that lack of metallothionein have reduced uptake of Zn++ and reduced tolerance to high Zn++ concentrations (althogh the Cu++ and Hg++ tolerances are unchanged); often Cd++ resistant when cells grow in high level of Cd++.
  • Length (amino acid): 56
  • Reference: Shi et al. 1992, Pubmed- 1607014

    		• Similar resistance genes in 'BacMet Predicted database'
    smtB/ziaR
  • BacMet ID: BAC0366
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2))
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Repressor protein smtB; regulates the metallothionein synthesis in transcrition level negatively; its a helix-turn-helix protein in the same family of arsR and cadC; binds at imperfect inverted repeat TGAAACA-GT-TATTCA between the transcription initiation site and the ribosome binding site for smtA; Transcriptional repressor of the Expression of the smtA gene. Binds two zinc ions per dimer. The complex of DNA and smtB is dissociated by zinc ions.
  • Length (amino acid): 122
  • Reference: Huckle et al. 1993; Pubmed- 8446025

    		• Similar resistance genes in 'BacMet Predicted database'
    soxS
  • BacMet ID: BAC0371
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cyclohexane [class: Cycloalkane]
  • Description: Regulatory protein SoxS; Increases the Zn uptake system znuACB; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Binds the DNA sequence 5'-GCACN7CAA-3'. It also facilitates the subsequent binding of RNA polymerase to the micF and the nfo promoters.
  • Length (amino acid): 107
  • Reference: Nakajima et al. 1995; Pubmed- 7670195, Warner et al. 2012; Pubmed- 22210763

    		• Similar resistance genes in 'BacMet Predicted database'
    troA
  • BacMet ID: BAC0399
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Periplasmic zinc-binding protein TroA; encodes the solute binding protein (SBP), Part of an ATP-driven transport system TroABCD for zinc. Substrate-binding protein involved in the transport of zinc across the cytoplasmic membrane.
  • Length (amino acid): 308
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troB
  • BacMet ID: BAC0400
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system ATP-binding protein TroB; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc
  • Length (amino acid): 266
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troC
  • BacMet ID: BAC0401
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system membrane protein TroC; cytoplasmic membrane permeases; Part of an ATP-driven transport system TroABCD for zinc
  • Length (amino acid): 298
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troD
  • BacMet ID: BAC0402
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: Zinc transport system membrane protein TroD; Part of an ATP-driven transport system TroABCD for zinc.
  • Length (amino acid): 367
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    troR
  • BacMet ID: BAC0403
  • Code for: Repressor
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Treponema pallidum (strain Nichols)
  • Location: Chromosome
  • Compound: Zinc (Zn), Manganese (Mn), Iron (Fe)
  • Description: An iron activated repressor protein TroR of the troABCD transport system
  • Length (amino acid): 153
  • Reference: Hazlett et al. 2003; Pubmed- 12668673

    		• Similar resistance genes in 'BacMet Predicted database'
    zevA
  • BacMet ID: BAC0453
  • Code for: Binding protein
  • Family: unknown
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae
  • Length (amino acid): 206
  • Reference: Rosadini et al. 2011; Pubmed- 21576338

    		• Similar resistance genes in 'BacMet Predicted database'
    zevB
  • BacMet ID: BAC0454
  • Code for: Binding protein
  • Family: Contains 1 NicO domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Part of a zinc binding system, ZevAB, is critical for survival of nontypeable Haemophilus influenzae
  • Length (amino acid): 322
  • Reference: Rosadini et al. 2011; Pubmed- 21576338

    		• Similar resistance genes in 'BacMet Predicted database'
    ziaA
  • BacMet ID: BAC0455
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family, Type IB subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc-transporting ATPase ziaA
  • Length (amino acid): 721
  • Reference: Thelwell et al. 1998: Pubmed- 9724772

    		• Similar resistance genes in 'BacMet Predicted database'
    ziaR
  • BacMet ID: BAC0456
  • Code for: Regulator
  • Family: Contains 1 HTH arsR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Synechocystis sp. (strain PCC 6803 / Kazusa)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Transcriptional repressor (ziaR) of the Expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.
  • Length (amino acid): 132
  • Reference: Thelwell et al. 1998: Pubmed- 9724772

    		• Similar resistance genes in 'BacMet Predicted database'
    zinT/yodA
  • BacMet ID: BAC0457
  • Code for: Binding protein
  • Family: calycin superfamily. ZinT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn)
  • Description: Metal-binding protein (Cadmium-induced protein) ZinT; Function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. Binds zinc with high affinity, and can also bind cadmium, mercury or nickel. Preferentially binds Zn2+ over Cd2+. Contains one high affinity metal binding site, and can bind additional metal ions at other sites; Repressed by Zur
  • Length (amino acid): 216
  • Reference: Stojnev et al. 2007; Pubmed- 17632755

    		• Similar resistance genes in 'BacMet Predicted database'
    zipB
  • BacMet ID: BAC0458
  • Code for: Porter
  • Family: Zrt- and Irt-like Protein (ZIP) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
  • Location: Chromosome
  • Compound: Zinc (Zn), Cadmium (Cd)
  • Description: zipB is a selective electrodiffusional channel; facilitates passive zinc uptake driven by zinc concentration gradients that are maintained by cellular zinc homeostasis
  • Length (amino acid): 309
  • Reference: Lin et al. 2010; Pubmed- 20876577

    		• Similar resistance genes in 'BacMet Predicted database'
    zitB/ybgR
  • BacMet ID: BAC0459
  • Code for: Efflux
  • Family: Cation diffusion facilitator (CDF) transporter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc transporter ZitB; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc; contributes to Zn++ haemostatis at low (non-toxic) concentrations; Appears to be selective for zinc, not conferring resistance to cobalt nor cadmium
  • Length (amino acid): 313
  • Reference: Grass et al. 2001; Pubmed- 11443104, Lee et al. 2002; Pubmed- 12399046

    		• Similar resistance genes in 'BacMet Predicted database'
    zneB/hmxB
  • BacMet ID: BAC0460
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)
  • Location: Plasmid megaplasmid CH34 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),
  • Compound: Zinc (Zn)
  • Description: Membrane fusion protein (MFP-RND) heavy metal cation tricomponent efflux zneB
  • Length (amino acid): 385
  • Reference: De Angelis et al. 2010; Pubmed- 20534468

    		• Similar resistance genes in 'BacMet Predicted database'
    zntA/yhhO
  • BacMet ID: BAC0461
  • Code for: Enzyme
  • Family: Cation transport ATPase (P-type) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Lead (Pb), Cadmium (Cd), Zinc (Zn)
  • Description: Lead, cadmium, zinc and mercury-transporting ATPase ZntA; Involved in export of lead, cadmium, zinc and mercury; located in inner cell membrane.
  • Length (amino acid): 732
  • Reference: Rensing et al. 1997; Pubmed- 9405611, Beard et al. 1997; Pubmed- 9364914

    		• Similar resistance genes in 'BacMet Predicted database'
    zntR/yhdM
  • BacMet ID: BAC0462
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc-responsive transcriptional regulator zntR; regulates the zntA
  • Length (amino acid): 141
  • Reference: Brocklehurst et al. 1999; Pubmed-10048032, Singh et al. 1999; Pubmed- 10411736

    		• Similar resistance genes in 'BacMet Predicted database'
    znuA/yebL
  • BacMet ID: BAC0463
  • Code for: Membrane Transporter
  • Family: ABC superfamily, bacterial solute-binding protein 9 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: High-affinity zinc uptake system protein ZnuA; Involved in the high-affinity zinc uptake transport system; located in periplasm
  • Length (amino acid): 310
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    znuB/yebI
  • BacMet ID: BAC0464
  • Code for: Membrane Transporter
  • Family: ABC-3 integral membrane protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: High-affinity zinc uptake system membrane protein ZnuB; Involved in the high-affinity zinc uptake transport system; located in cell inner membrane
  • Length (amino acid): 261
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    znuC/yebM
  • BacMet ID: BAC0465
  • Code for: Binding protein
  • Family: ABC transporter superfamily. Zinc importer family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc import ATP-binding protein ZnuC; part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Transcriptionally repressed by zur (zinc uptake regulator), in response to high extracellular zinc concentrations
  • Length (amino acid): 251
  • Reference: Patzer et al. 1998; Pubmed- 9680209

    		• Similar resistance genes in 'BacMet Predicted database'
    zraP
  • BacMet ID: BAC0466
  • Code for: Binding protein
  • Family: ZraP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium (strain LT2/SGSC1412/ATCC 700720) 
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc resistance-associated protein ZraP; Undergoes a specific Zn++ induced cleavage to release a carboxy-terminal Zn++ binding region; located in periplasm; Binds zinc. Could be an important component of the zinc-balancing mechanism; located in periplasm
  • Length (amino acid): 151
  • Reference: Noll et al. 1998; Pubmed- 9694902, Appia-Ayme et al. 2012; Pubmed- 22084975

    		• Similar resistance genes in 'BacMet Predicted database'
    zraR/hydH
  • BacMet ID: BAC0467
  • Code for: Regulator
  • Family: Contains 1 response regulatory domain, 1 sigma-54 factor interaction domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Transcriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the Expression of zraP. Positively autoregulates the Expression of the zraSR operon.
  • Length (amino acid): 441
  • Reference: Leonshartsberger et al. 2001; Pubmed- 11243806

    		• Similar resistance genes in 'BacMet Predicted database'
    zraS/hydG
  • BacMet ID: BAC0468
  • Code for: Regulator
  • Family: Contains 1 histidine kinase domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Lead (Pb)
  • Description: Sensor protein ZraS; Member of the two-component regulatory system ZraS/ZraR. Functions as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium.
  • Length (amino acid): 465
  • Reference: Leonshartsberger et al. 2001; Pubmed- 11243806

    		• Similar resistance genes in 'BacMet Predicted database'
    zupT/ygiE
  • BacMet ID: BAC0469
  • Code for: Porter
  • Family: ZIP transporter family, ZupT subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)
  • Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.
  • Length (amino acid): 257
  • Reference: Grass et al. 2005; Pubmed- 15716430

    		• Similar resistance genes in 'BacMet Predicted database'
    zur/yjbK
  • BacMet ID: BAC0470
  • Code for: Regulator
  • Family: Fur family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn)
  • Description: Zinc uptake regulation protein zur; Acts as a negative controlling element, employing Zn2+ as a cofactor to bind the operator of the repressed genes (znuACB). Zinc uptake regulation protein.
  • Length (amino acid): 171
  • Reference: Patzer et al. 1998; Pubmed- 9680209, Patzer et al. 2000; Pubmed- 10816566, Li et al. 2009; Pubmed- 19552825

    		• Similar resistance genes in 'BacMet Predicted database'
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