Browsing Experimentally Confirmed database

Result: Your query found 68 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
dsbA
  • BacMet ID: BAC0136
  • Code for: Enzyme
  • Family: Thioredoxin family. DsbA subfamily.
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Zinc (Zn), Mercury (Hg)
  • Description: Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis
  • Length (amino acid): 208
  • Reference: Rensing et al. 1997; Pubmed- 9098080, Bardwell et al. 1991; Pubmed- 1934062; Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    dsbB
  • BacMet ID: BAC0137
  • Code for: Enzyme
  • Family: DsbB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg)
  • Description: Disulfide oxidoreductase; The dsbB gene codes for a transmembrane protein that is responsible for reoxidizing the periplasmic dsbA-encoded disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA
  • Length (amino acid): 176
  • Reference: Stafford et al. 1999; Pubmed- 10234837

    		• Similar resistance genes in 'BacMet Predicted database'
    emrA
  • BacMet ID: BAC0147
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell.
  • Length (amino acid): 390
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    emrB
  • BacMet ID: BAC0148
  • Code for: Enzyme
  • Family: Major facilitator superfamily (MFS)-EmrB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]
  • Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
  • Length (amino acid): 512
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0224
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus cereus R6007
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 631
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0648
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 460
  • Reference: Griffin et al. 1987; Pubmed- 3033633

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0649
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 568
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0650
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 569
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0651
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 547
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0652
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 561
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0653
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 562
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0657
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 212
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0658
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: plasmid pI258
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 216
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0659
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 212
  • Reference: Griffin et al. 1987; Pubmed- 3033633,

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0660
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 219
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0654
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the first mer operon. MerB1, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0663
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1.
  • Length (amino acid): 214
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0655
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the second mer operon. MerB2, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 209
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0661
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 209
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0656
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the third mer operon. MerB3, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0662
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 242
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merC
  • BacMet ID: BAC0664
  • Code for: Membrane Transporter
  • Family: MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerC. This protein is located in the inner membrane and mediates mercury transport into the cytoplasm.
  • Length (amino acid): 141
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merC
  • BacMet ID: BAC0226
  • Code for: Membrane Transporter
  • Family: MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans (Acidithiobacillus ferrooxidans)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerC; Occurs separately from mer operon; encodes for mercury transport system; This protein is located in the inner membrane and mediates mercury transport into the cytoplasm. Additional alternative to merT; commonly found in E. coli, missing in pseudomonas and other gram negative bacteria; found more often in brackish water than fresh water samples still less in marine environments.
  • Length (amino acid): 144
  • Reference: Inoue et al. 1990; Pubmed- 2265748, Wilson et al. 2000; Pubmed- 10781809, Salhman et al. 1997; Pubmed- 9368013

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0665
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 121
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0666
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 121
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0227
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Brown et al. 1986; Pubmed- 3007931

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0667
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Mukhopadhyay et al. 1991; Pubmed- 1917975, Griffin et al. 1987; Pubmed- 3033633, Nucifora et al. 1989; Pubmed- 2691875

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0668
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Ralstonia metallidurans CH34
  • Location: Plasmid pMOL28, Plasmid pMOL30
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Champier et al. 2004; Pubmed- 15165248

    		• Similar resistance genes in 'BacMet Predicted database'
    merD
  • BacMet ID: BAC0669
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg)
  • Description: HTH-type transcriptional regulator ; most mer operon from gram negative ends up with merD gene; it encodes a secondary regulatory protein that binds to the same DNA site as merR; it can be considered as minor regulatory protein that down-regulates mer operon expression.
  • Length (amino acid): 121
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0670
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon.
  • Length (amino acid): 78
  • Reference: Griffin et al. 1987; Pubmed- 3033633

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0671
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE. Part of the first pPB mer operon.
  • Length (amino acid): 78
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0672
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE. Part of the second pPB mer operon.
  • Length (amino acid): 78
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merE
  • BacMet ID: BAC0673
  • Code for: Membrane Transporter
  • Family: MerE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein MerE.
  • Length (amino acid): 78
  • Reference: Brown et al. 1986; Pubmed- 3007931

    		• Similar resistance genes in 'BacMet Predicted database'
    merF
  • BacMet ID: BAC0228
  • Code for: Membrane Transporter
  • Family: MerF Transpoter family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. CT14 
  • Location: Plasmid pMER327/419 (Pseudomonas fluorescens), Plasmid pECL_A (Enterobacter cloacae subsp. cloacae (strain ATCC 13047 / DSM 30054 / NBRC 13535 / NCDC 279-56))
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance protein F; Additional alternative to merT.
  • Length (amino acid): 81
  • Reference: Wilson et al. 2000; Pubmed- 10781809

    		• Similar resistance genes in 'BacMet Predicted database'
    merG
  • BacMet ID: BAC0229
  • Code for: Membrane Transporter
  • Family: Contains 1 TPR-like helical , 1 Sel1-like repeat
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62), Plasmid pIJB1 (Burkholderia cepacia (Pseudomonas cepacia))
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercuric resistance protein MerG; Known to confer resistance to phenylmercury
  • Length (amino acid): 217
  • Reference: Kiyono et al. 1999; Pubmed- 9922233, Kiyono et al. 1997; Pubmed- 9168120,

    		• Similar resistance genes in 'BacMet Predicted database'
    merH
  • BacMet ID: BAC0230
  • Code for: Enzyme
  • Family: Mercuric Ion Transporter (Mer) superfamily. MerC family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium marinum (strain ATCC BAA-535 / M)
  • Location: Plasmid pMM23 (Mycobacterium marinum), Plasmid pMAB (Mycobacterium abscessus (strain ATCC 19977 / DSM 44196))
  • Compound: Mercury (Hg)
  • Description: Mercuric ion transport protein, MerH
  • Length (amino acid): 171
  • Reference: Schue et al. 2009; Pubmed- 18931130, Barkay et al. 2003; Pubmed- 12829275

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0674
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Periplasmic mercuric ion binding protein.
  • Length (amino acid): 92
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0231
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein periplasmic component; hypersensitivity to the mercuric ions are associated with the merP gene; MerP does not act to transport Hg(II) directly. Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (merA) via the merT protein.
  • Length (amino acid): 91
  • Reference: Hamlett et al. 1992; Pubmed- 1328156

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0675
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercury-binding protein. Mercuric transport protein periplasmic component.
  • Length (amino acid): 91
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0676
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury-binding protein. Mercuric transport protein periplasmic component.
  • Length (amino acid): 116
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0677
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein periplasmic component.
  • Length (amino acid): 113
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0678
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 91
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merP
  • BacMet ID: BAC0679
  • Code for: Membrane Transporter
  • Family: Contains 1 HMA domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 91
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0680
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
  • Length (amino acid): 135
  • Reference: Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0232
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa
  • Location: Plasmid pVS1 (Pseudomonas aeruginosa)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory gene whose product is a unique positively acting activator protein that twists and bends the operator DNA region in the presence of Hg++ allowing RNA polymerse to synthesize mRNA.
  • Length (amino acid): 144
  • Reference: Shewchuk et al. 1989; Pubmed- 2551364, Ni'Bhriain et al. 1983; Pubmed- 6307976

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0685
  • Code for: Regulator
  • Family: ArsR/Smt family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 124
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0686
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury MerR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a potent transcriptional activator, while remaining bound to the mer site.
  • Length (amino acid): 144
  • Reference: Yu et al. 1994; Pubmed- 8195221, Nucifora et al. 1989; Pubmed- 2666393

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0687
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merR
  • BacMet ID: BAC0689
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 151
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merR1
  • BacMet ID: BAC0682
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 132
  • Reference: Helmann et al. 1989; Pubmed- 2492496

    		• Similar resistance genes in 'BacMet Predicted database'
    merR1
  • BacMet ID: BAC0683
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0681
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury resistance operon negative regulator MerR2
  • Length (amino acid): 129
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0684
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric resistance operon regulatory protein.
  • Length (amino acid): 144
  • Reference: Kiyono et al. 1997; Pubmed- 9168120, Kiyono et al. 1999; Pubmed- 10513611

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0688
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial resistance regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0690
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Thiobacillus ferrooxidans
  • Location: Chromosome, Transposon Tn5037
  • Compound: Mercury (Hg)
  • Description: Mercuric ion transport protein.
  • Length (amino acid): 116
  • Reference: Kalyaeva et al. 2001; Pubmed- 11642118

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0691
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the first pPB mer operon.
  • Length (amino acid): 116
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0692
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg)
  • Description: Part of the second pPB mer operon.
  • Length (amino acid): 116
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0693
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA).
  • Length (amino acid): 116
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0233
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Alcaligenes sp.
  • Location: Plasmid IncHI2, pMER610 (Alcaligenes spp.)
  • Compound: Mercury (Hg)
  • Description: Mercuric transport protein MerT; determines hyperaccumulation of Hg++ but not the CH3Hg+; Involved in mercuric transport. Passes a mercury ion from the periplasmic merP protein to the mercuric reductase (merA).
  • Length (amino acid): 116
  • Reference: Hamlett et al. 1992; Pubmed- 1328156, Kiyono et al. 2000; Pubmed- 10726879

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0695
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358 (Serratia marcescens)
  • Compound: Mercury (Hg)
  • Description: Inner mebrane protein. Involved in mercuric transport. Passes a mercury ion from the periplasmic MerP protein to the mercuric reductase (MerA).
  • Length (amino acid): 116
  • Reference: Nucifora et al. 1989; Pubmed- 2691875

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0696
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pI258
  • Compound: Mercury (Hg)
  • Description: Involved in mercuric transport. Passes a mercury ion from the MerP protein to the mercuric reductase MerA.
  • Length (amino acid): 128
  • Reference: Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merT
  • BacMet ID: BAC0697
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: Mercury transport protein
  • Length (amino acid): 98
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merT-P
  • BacMet ID: BAC0694
  • Code for: Membrane Transporter
  • Family: MerT family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Tenacibaculum discolor 9A5
  • Location: Chromosome
  • Compound: Mercury (Hg)
  • Description: A novel putative transport protein consisting of a fusion between the integral membrane Hg(II) transporter MerT and the periplasmic Hg(II)-binding protein MerP.
  • Length (amino acid): 204
  • Reference: Allen et al. 2013; Pubmed- 22816663

    		• Similar resistance genes in 'BacMet Predicted database'
    PA0320
  • BacMet ID: BAC0297
  • Code for: Unknown
  • Family: Bacterial OB fold (BOF) protein family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Location: Chromosome
  • Compound: Cadmium (Cd), Mercury (Hg), Tributyltin (TBT) [class: Organo-tin], Hydrogen Peroxide (H2O2) [class: Peroxides], Hydrochloric acid (HCl) [class: Acid]
  • Description: TBT resistance gene PA0320; homologous to YgiW; PA0320 plays a certain role in stress tolerance against TBT as well as in stressors producing reactive oxygen species
  • Length (amino acid): 116
  • Reference: Fukushima et al. 2012; Pubmed- 22990488

    		• Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

    		• Similar resistance genes in 'BacMet Predicted database'
    smtA
  • BacMet ID: BAC0365
  • Code for: Binding protein
  • Family: Metallothionein superfamily. Type 14 family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Cyanobacteria (e.g. Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)); Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Zinc (Zn), Mercury (Hg)
  • Description: Metallothionein SmtA; Contain 9 cysteine residues; plays a role in essential metal ion homeostasis (especially zinc homeostasis) and resistance to certain non-essential metal ions. Metallothioneins have a high content of cysteine residues that bind various heavy metals. Cells that lack of metallothionein have reduced uptake of Zn++ and reduced tolerance to high Zn++ concentrations (althogh the Cu++ and Hg++ tolerances are unchanged); often Cd++ resistant when cells grow in high level of Cd++.
  • Length (amino acid): 56
  • Reference: Shi et al. 1992, Pubmed- 1607014

    		• Similar resistance genes in 'BacMet Predicted database'
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