Browsing Experimentally Confirmed database

Result: Your query found 85 resistance gene(s) from the BacMet Experimentally Confirmed database

Gene_nameExperimentally Verified Resistance Gene InformationPredicted Resistance Gene Information
abeM
  • BacMet ID: BAC0001
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Triclosan [class: Phenolic compounds], Acriflavine [class: Acridine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: H-coupled multidrug efflux pump. Confers resistance to Antibiotics such as quinolones and aminoglycosides and antibacterial biocides such as dyes, QACs.
  • Length (amino acid): 448
  • Reference: Su et al. 2005; Pubmed- 16189122

    		• Similar resistance genes in 'BacMet Predicted database'
    abeS
  • BacMet ID: BAC0002
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein abeS. It can confer resistance to antibiotics such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin and dyes, QACs etc.
  • Length (amino acid): 109
  • Reference: Srinivasan et al. 2009; Pubmed- 19770280

    		• Similar resistance genes in 'BacMet Predicted database'
    acrE/envC
  • BacMet ID: BAC0009
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein E; May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability. It can confer resistance to novomycin.
  • Length (amino acid): 385
  • Reference: Klein et al. 1991; Pubmed- 1720861, Ma et al. 1993; Pubmed- 8407802, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    acrF/envD
  • BacMet ID: BAC0010
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine]
  • Description: Acriflavine resistance protein F; Involved in cell envelope formation. It is produced in extremely low amounts.
  • Length (amino acid): 1034
  • Reference: Klein et al. 1991; Pubmed- 1720861, Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    adeA
  • BacMet ID: BAC0471
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeA membrane fusion protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 396
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeB
  • BacMet ID: BAC0472
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergise, Wex-cide-128.
  • Description: AdeB RND protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 1035
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeC
  • BacMet ID: BAC0473
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 123 [class: Xanthene], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: AdeC outer membrane protein. Part of the AdeABC efflux system. Confers resistance to antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, tetracycline, tigercycline, trimethoprim, fluoroquinolones and other antibacterial compounds such as dyes, diamidines, biguanides, QACs and anionic detergents.
  • Length (amino acid): 465
  • Reference: Rajamohan et al. 2010; Pubmed- 20008046, Magnet et al. 2001; Pubmed- 11709311

    		• Similar resistance genes in 'BacMet Predicted database'
    adeI
  • BacMet ID: BAC0017
  • Code for: efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii (strain AB0057)
  • Location: Chromosome
  • Compound: Acridine Orange [class: Acridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Methyl Viologen [class: Paraquat], Rhodamine 123 [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Synergize [class: QAC-Glutaraldehyde], Virkon S [class: Peroxysulfate], Wex-cide-128 [class: Phenyl]
  • Description: Part of AdeIJK MDR pump. Contributes to resistance to beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolines, fusidic acid, tigecycline, novobiocin, rifampin, trimethoprim and dyes such as acridine, safranin, pyronin, and anionic detergents such as sodium dodecyl sulfate.
  • Length (amino acid): 416
  • Reference: Damier-Piolle et al. 2008; Pubmed- 18086852, Rajamohan et al. 2010; Pubmed- 20008046

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT1
  • BacMet ID: BAC0478
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni AC0037
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, tetracycline etc.
  • Length (amino acid): 304
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    adeT2
  • BacMet ID: BAC0479
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumanni
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Rhodamine 123 [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Synergize [class: QAC-Glutaraldehyde], Wex-cide-128 [class: Phenyl]
  • Description: It can confer resistant to antibiotics such as chloramphenicol, novobiocin, gentamicin, kanamycin, nalidixic acid, ciprofloxacin, erythromycin etc.
  • Length (amino acid): 238
  • Reference: Srinivasan et al. 2011; Pubmed- 21212056

    		• Similar resistance genes in 'BacMet Predicted database'
    amvA
  • BacMet ID: BAC0025
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Acinetobacter baumannii
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: MFS efflux pump, AmvA (AedF). Mediates drugs, dyes, detergents, antibiotic and disinfectant resistance
  • Length (amino acid): 492
  • Reference: Rajamohan et al. 2010; Pubmed- 20573661

    		• Similar resistance genes in 'BacMet Predicted database'
    blt
  • BacMet ID: BAC0050
  • Code for: Efflux
  • Family: MFS Superfamily (TCR/tet family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus subtilis (strain 168)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acridine Orange [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Energy-dependent efflux pump responsible for decreased drug accumulation in multi-drug-resistant cells. Probably uses a transmembrane proton gradient as the energy source. Causes the efflux of a variety of toxic substances, including such structurally diverse compounds as ethidium bromide, rhodamine and acridine dyes, tetraphenylphosphonium, puromycin, chloramphenicol, doxorubicin, and fluoroquinolone antibiotics.
  • Length (amino acid): 400
  • Reference: Ahmed et al. 1995; Pubmed- 7608059

    		• Similar resistance genes in 'BacMet Predicted database'
    emrA
  • BacMet ID: BAC0147
  • Code for: Efflux
  • Family: Membrane Fusion Protein (MFP)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell.
  • Length (amino acid): 390
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    emrAsm
  • BacMet ID: BAC0499
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 393
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrB
  • BacMet ID: BAC0148
  • Code for: Enzyme
  • Family: Major facilitator superfamily (MFS)-EmrB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], 2-Chlorophenylhydrazine [class: Hydrazine], Carbonylcyanide m-chlorophenyl hydrazone (CCCP) [class: Hydrazone]
  • Description: Multidrug resistance protein B, Located in cell inner membrane, Translocase that confers resistance to substances of high hydrophobicity
  • Length (amino acid): 512
  • Reference: Lomovskaya et al. 1992; Pubmed- 1409590

    		• Similar resistance genes in 'BacMet Predicted database'
    emrBsm
  • BacMet ID: BAC0500
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 528
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrCsm
  • BacMet ID: BAC0501
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: Outer membrane protein EmrCsm. Part of EmrCABsm efflux pump which is a similar pump found in E. coli (EmrCAB) with below 50% amino acid identities. EmrCsm and EmrAB are essential for the function of the EmrCABsm pump. EmrCABsm pump may have a physiological role in evading naturally produced molecules from the environment or host-derived compounds, rather than in antimicrobial extrusion, allowing S. maltophilia to survive in its ecological niche. It can confer resistance to hydrophobic antibiotics nalidixic acid and erythromycin.
  • Length (amino acid): 497
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    emrD-3
  • BacMet ID: BAC0534
  • Code for: Efflux
  • Family: MFS superfamiy, Bcr/CflA subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae O395
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It is an intrinsic membrane protein. Multidrug resistance protein D. EmrD-3-mediated efflux is potentiated by a proton gradient across the membrane. It can confer resistance to antibiotics such as linezolid, rifampin, minocycline etc.
  • Length (amino acid): 379
  • Reference: Smith et al. 2009; Pubmed- 19876617

    		• Similar resistance genes in 'BacMet Predicted database'
    emrE/mvrC
  • BacMet ID: BAC0150
  • Code for: Efflux/Membrane protein
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It codes for a membrane protein emrE/MvrC, exhibits resistance to methyl viologen by reducing permeability. Overexoression of MvrC protein induces or activates the MvrA protein, which reduces the toxic species produced by metyl viologen. It doesn’t confer resistance to plumbagin dye. It expels positively charged hydrophobic drugs across the inner membrane of E. coli., thereby conferring resistance to a wide range of toxic compounds. The drug efflux is coupled to an influx of protons. It is involved in the resistance of E. coli cells to methyl viologen, ethidium bromide and acriflavine. Is also able to transport tetraphenylphosphonium (TPP+) and benzylkonium.
  • Length (amino acid): 110
  • Reference: Morimyo et al. 1992; Pubmed- 1320256, Yerushalmi et al. 1995; Pubmed- 7896833, Yerushalmi et al. 2000; Pubmed- 10681497, Rotem et al. 2004; Pumed- 15371426

    		• Similar resistance genes in 'BacMet Predicted database'
    emrK
  • BacMet ID: BAC0151
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein; overexpression resistance to deoxycholate
  • Length (amino acid): 387
  • Reference: Tanabe et al. 1997; Pubmed- 12501312, Kato et al. 2000; Pubmed- 10923791

    		• Similar resistance genes in 'BacMet Predicted database'
    emrR
  • BacMet ID: BAC0559
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone]
  • Description: Negative regulator of the multidrug operon emrAB.
  • Length (amino acid): 176
  • Reference: Lomovskaya et al. 1995; Pubmed- 7730261

    		• Similar resistance genes in 'BacMet Predicted database'
    emrRsm
  • BacMet ID: BAC0502
  • Code for: Regulator
  • Family: MarR family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide]
  • Description: EmrRCABsm operon is negatively regulated by a MarR-type regulator EmrRsm.
  • Length (amino acid): 147
  • Reference: Huang et al. 2013; Pubmed- 23794602

    		• Similar resistance genes in 'BacMet Predicted database'
    farA
  • BacMet ID: BAC0503
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A membrane fusion protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 394
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    farB
  • BacMet ID: BAC0504
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Neisseria gonorrhoeae F19
  • Location: Chromosome
  • Compound: Phenylmercury Acetate [class: Organo-mercury], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Oleic acid [class: Free Fatty Acids], Linoleic acid [class: Free Fatty Acids], Palmitic acid [class: Free Fatty Acids], Triton X-100 [class: Polyethylene glycol]
  • Description: A cytoplasmic transporter protein. The farAB operon of Neisseria gonorrhoeae encodes an efflux pump which mediates gonococcal resistance to antibacterial fatty acids. This efflux pump requires the MtrE protein as the outer membrane channel to export antibacterial FAs from inside the cell.
  • Length (amino acid): 507
  • Reference: Lee et al. 1999; Pubmed- 10447892

    		• Similar resistance genes in 'BacMet Predicted database'
    hmrM
  • BacMet ID: BAC0189
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Haemophilus influenzae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, Acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate
  • Length (amino acid): 464
  • Reference: Xu et al. 2003; Pubmed- 14695443

    		• Similar resistance genes in 'BacMet Predicted database'
    hsmR
  • BacMet ID: BAC0192
  • Code for: Efflux
  • Family: SMR superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Small multidrug export protein HsmR
  • Length (amino acid): 112
  • Reference: Ninio et al. 2003; Pubmed- 12551892

    		• Similar resistance genes in 'BacMet Predicted database'
    kdeA
  • BacMet ID: BAC0491
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae (strain MGH 78578)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: It can confer resistance to antibiotics such as chloramphenicol, Kanamycin, norfloxacin, puromycin, daunomycin etc.
  • Length (amino acid): 410
  • Reference: Ping et al. 2007; Pubmed- 17917272

    		• Similar resistance genes in 'BacMet Predicted database'
    kexD
  • BacMet ID: BAC0492
  • Code for: Effflux
  • Family: Restriction Nodulation Division (RND) superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid]
  • Description: KexD was shown to function with AcrAEc and TolC from E. coli and AcrAKp and KocC from K. pneumoniae, like AcrD from E. coli
  • Length (amino acid): 1038
  • Reference: Ogawa et al. 2012; Pubmed- 22391093

    		• Similar resistance genes in 'BacMet Predicted database'
    kmrA
  • BacMet ID: BAC0493
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Hoechst 33342 [class: Bisbenzimide], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: It can confer resistance to Antibiotics such as kanamycin, gentamycin, erythromycin etc.
  • Length (amino acid): 499
  • Reference: Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    kpnO
  • BacMet ID: BAC0529
  • Code for: Porin
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Klebsiella pneumoniae NTUH-K2044
  • Location: Chromosome
  • Compound: Hydrogen Peroxide (H2O2) [class: Peroxides], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Sodium Nitrite (NaNo2) [class: Nitrites]
  • Description: KpnO codes for a outer membrane porin. kpnO mediates antibiotic resistance via efflux mechanism and contributes towards disinfectant tolerance. It has a role in oxidative stress tolerance and nitrostative stress tolernace. KpnO also contributes to growth and gastrointestinal stress tolerance in K. pneumoniae.
  • Length (amino acid): 365
  • Reference: Srinivasan et al. 2012; Pubmed- 22848515

    		• Similar resistance genes in 'BacMet Predicted database'
    lmrS
  • BacMet ID: BAC0535
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus subsp. aureus COL
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: LmrS is an efflux protein capable of extruding multiple and structurally unrelated antimicrobial compounds. It can confer resistance to antobiotics such as linezolid, trimethoprim, chloramphenicol etc.
  • Length (amino acid): 480
  • Reference: Floyd et al 2010; Pubmed- 20855745

    		• Similar resistance genes in 'BacMet Predicted database'
    marA
  • BacMet ID: BAC0560
  • Code for: Regulator
  • Family: Contains 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: A transcriptional activator (MarA) of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF. Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 127
  • Reference: Asako et al. 1997; Pubmed- 9097440

    		• Similar resistance genes in 'BacMet Predicted database'
    marR
  • BacMet ID: BAC0561
  • Code for: Regulator
  • Family: Contains 1 HTH marR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Cyclohexane [class: Cycloalkane], Diphenyl Ether [class: Phenyl], n-hexane [class: Alkane]
  • Description: Multiple antibiotic resistance protein MarR; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site. Overexpression of MarR decreases organic solvent tolerance in E. coli. High copy number of MarA and MarR also increases the tolerance level of bacteria to organic solvents.
  • Length (amino acid): 144
  • Reference: Asako et al. 1997; Pubmed- 9097440

    		• Similar resistance genes in 'BacMet Predicted database'
    mdeA
  • BacMet ID: BAC0207
  • Code for: Enzyme
  • Family: Trans-sulfuration enzymes family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas putida (Arthrobacter siderocapsulatus)
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene]
  • Description: Methionine gamma-lyase (MdeA)
  • Length (amino acid): 398
  • Reference: Huang et al. 2004; Pubmed- 14982783, Yamada et al. 2006; Pubmed- 16595922, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    mdfA/cmr
  • BacMet ID: BAC0208
  • Code for: Effux
  • Family: Major facilitator Superfamily (MdfA family)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, E. coli (Strain K12)
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Hydroxide (NaOH) [class: Base], Rhodamine 6G [class: Xanthene]
  • Description: Multidrug transporter MdfA, Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cationic or zwitterionic lipophilic compounds such as ethidium bromide, tetraphenylphosphonium, rhodamine, daunomycin, benzylkonium, rifampicin, tetracycline, puromycin, and to chemically unrelated, clinically important antibiotics such as chloramphenicol, erythromycin, and certain aminoglycosides and fluoroquinolones. OverExpression results in isopropyl-beta-D-thiogalactopyranoside (IPTG) exclusion and spectinomycin sensitivity. Transport of neutral substrates is electrogenic, whereas transport of cationic substrates is electroneutral. In addition to its role in multidrug resistance, confers extreme alkaline pH resistance, allowing the growth under conditions that are close to those used normally by alkaliphiles. This activity requires Na+ or K+; also known as Chloramphenicol resistance pump Cmr
  • Length (amino acid): 410
  • Reference: Edgar et al. 1997; Pubmed- 9079913, Nishino et al. 2001; Pubmed- 11566977, Sulavik et al 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtE/yhiU
  • BacMet ID: BAC0213
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtE; Part of a multidrug resistance efflux system (mdtEF-TolC) that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC. It has a role in biofilm formation of E. coli K12.
  • Length (amino acid): 385
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtF/yhiV
  • BacMet ID: BAC0214
  • Code for: Efflux
  • Family: RND superfamily, AcrB/AcrD/AcrF family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Crystal Violet [class: Triarylmethane], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtF; Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzylkonium. Part of a tripartite efflux system composed of MdtE, MdtF and TolC.
  • Length (amino acid): 1037
  • Reference: Masuda et al. 2002; Pubmed- 12399493

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtK/ydhE
  • BacMet ID: BAC0218
  • Code for: Efflux
  • Family: MATE family, MdtK subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Sodium Deoxycholate (SDC) [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein MdtK; It functions as a Na+/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxacin, enoxacin), tetraphenylphosphonium ion (TPP), deoxycholate, doxorubicin, trimethoprim, chloramphenicol, fosfomycin, Acriflavine, ethidium bromide and benzylkonium
  • Length (amino acid): 457
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtM/yjiO
  • BacMet ID: BAC0219
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtM; Confers resistance to Acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP, tetraphenylarsonium chloride ; part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 410
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mdtN/yjcR
  • BacMet ID: BAC0220
  • Code for: Efflux
  • Family: RND superfamily, MFP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug resistance protein MdtN; Involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Could be part of a tripartite efflux system composed of MdtN, MdtO and MdtP
  • Length (amino acid): 343
  • Reference: Nishino et al. 2001; Pubmed- 11566977

    		• Similar resistance genes in 'BacMet Predicted database'
    mepA
  • BacMet ID: BAC0221
  • Code for: Efflux
  • Family: Multi antimicrobial extrusion (MATE) family (MepA subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Chromosome
  • Compound: Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Rhodamine 6G [class: Xanthene], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Pentadiamine [class: Diamidine], Trimethylamine-diphenylhexatriene (TMA-DPH) [class: Diphenylhexatriene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene]
  • Description: Multidrug Export protein, Multidrug resistance efflux protein By similarity. Contributes to resistance to the glycylcycline antibiotic tigecycline, ciprofloxacin, norfloxacin etc.
  • Length (amino acid): 451
  • Reference: McAleese et al. 2005; Pubmed- 15855508, Kaatz et al. 2005; Pubmed- 15855507, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0224
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus cereus R6007
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 631
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0648
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 460
  • Reference: Griffin et al. 1987; Pubmed- 3033633

    		• Similar resistance genes in 'BacMet Predicted database'
    merA
  • BacMet ID: BAC0650
  • Code for: Enzyme
  • Family: Class-I pyridine nucleotide-disulfide oxidoreductase family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: Mercury reductase enzyme, merA; resistance to Hg2+ in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg0.
  • Length (amino acid): 569
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0657
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury], Methylmercury Acetate [class: Organo-mercury]
  • Description: MerB, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 212
  • Reference: Kiyono et al. 1997; Pubmed- 9168120

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0658
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: plasmid pI258
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 216
  • Reference: Babich et al. 1991; Pubmed- 1954576, Laddaga et al. 1987; Pubmed- 3037534

    		• Similar resistance genes in 'BacMet Predicted database'
    merB
  • BacMet ID: BAC0659
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Plasmid pDU1358
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. One product is Hg2+, which is subsequently detoxified by the mercuric reductase.
  • Length (amino acid): 212
  • Reference: Griffin et al. 1987; Pubmed- 3033633,

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0654
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the first mer operon. MerB1, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB1
  • BacMet ID: BAC0663
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Fragment of merB1. Organomercurial lyase merB (merB1) is part of the first mer operon of the transposon TnMERI1 of Bacillus megaterium MB1.
  • Length (amino acid): 214
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0655
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the second mer operon. MerB2, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 209
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB2
  • BacMet ID: BAC0661
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This second MerB (MerB2: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 209
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0656
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: MerB of the third mer operon. MerB3, encodes the enzyme organomercural lyase that breaks the carbon-mercury bond in toxic substrates such as phenymercury acetate; in gram negative it is rare, need for organomercural resistance.
  • Length (amino acid): 218
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merB3
  • BacMet ID: BAC0662
  • Code for: Enzyme
  • Family: MerB family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus megaterium MB1
  • Location: Chromosome, Transposon TnMERI1
  • Compound: Mercury (Hg), Fluorescein mercuric acetate [class: Organo-mercury], p-chloro-mercuribenzoic acid [class: Organo-mercury], Phenylmercury Acetate [class: Organo-mercury], Thimerosal [class: Organo-mercury], Methylmercury chloride [class: Organo-mercury], Ethylmercury chloride [class: Organo-mercury]
  • Description: Organomercurial lyase merB (merB2) is part of the second mer operon of the transposon TnMERI1 of Bacillus megaterium MB1. This third MerB (MerB3: organomercurial lyse) contributes to confer resistance to a wide range of organomercuric compounds than presence of one merB.
  • Length (amino acid): 242
  • Reference: Huang et al. 1999; Pubmed- 10548738

    		• Similar resistance genes in 'BacMet Predicted database'
    merG
  • BacMet ID: BAC0229
  • Code for: Membrane Transporter
  • Family: Contains 1 TPR-like helical , 1 Sel1-like repeat
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas sp. K-62
  • Location: Plasmid pMR26 (Pseudomonas sp. K-62), Plasmid pIJB1 (Burkholderia cepacia (Pseudomonas cepacia))
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercuric resistance protein MerG; Known to confer resistance to phenylmercury
  • Length (amino acid): 217
  • Reference: Kiyono et al. 1999; Pubmed- 9922233, Kiyono et al. 1997; Pubmed- 9168120,

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0681
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Bacillus sp. (strain RC607)
  • Location: Chromosome
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Mercury resistance operon negative regulator MerR2
  • Length (amino acid): 129
  • Reference: Gupta et al. 1999; Pubmed- 10559175

    		• Similar resistance genes in 'BacMet Predicted database'
    merR2
  • BacMet ID: BAC0688
  • Code for: Regulator
  • Family: Contains 1 HTH merR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Pseudomonas stutzeri
  • Location: Plasmid pPB
  • Compound: Mercury (Hg), Phenylmercury Acetate [class: Organo-mercury]
  • Description: Organomercurial resistance regulatory protein.
  • Length (amino acid): 144
  • Reference: Reniero et al. 1995; Pubmed- 8529897, Reniero et al. 1998; Pubmed- 9479042

    		• Similar resistance genes in 'BacMet Predicted database'
    mmR
  • BacMet ID: BAC0249
  • Code for: Efflux
  • Family: SMR family, mmr subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Mycobacterium tuberculosis
  • Location: Chromosome
  • Compound: Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Safranin O [class: Azin], Pyronin Y [class: Xanthene]
  • Description: Multidrug efflux pump mmR. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O and pyronin Y.
  • Length (amino acid): 107
  • Reference: Rossi et al. 1998; Pubmed- 9811672

    		• Similar resistance genes in 'BacMet Predicted database'
    norA
  • BacMet ID: BAC0282
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Chromosome
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine] , Pentamidine [class: Diamidine], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Quinolone resistance protein norA, Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones.
  • Length (amino acid): 388
  • Reference: Yoshida et al. 1990; Pubmed- 2174864, Huet et al. 2008; Pubmed- 18832320

    		• Similar resistance genes in 'BacMet Predicted database'
    pcm
  • BacMet ID: BAC0506
  • Code for: Enzyme
  • Family: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Acriflavine [class: Acridine]
  • Description: Protein-L-isoaspartate O-methyltransferase. pcm and tolCsm genes form an operon. pcm deletion affects on the expression of tolCsm. pcm alone makes little contribution to resistance.
  • Length (amino acid): 215
  • Reference: Huang et al. 2013; Pubmed- 23629016

    		• Similar resistance genes in 'BacMet Predicted database'
    pdrM
  • BacMet ID: BAC0481
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Streptococcus pneumoniae
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine]
  • Description: It is a Na(+)/drug antiporter in Streptococcus pneumoniae
  • Length (amino acid): 453
  • Reference: Hashimoto et al. 2013; Pubmed- 23555691

    		• Similar resistance genes in 'BacMet Predicted database'
    pmpM
  • BacMet ID: BAC0313
  • Code for: Efflux
  • Family: Member of the MATE family of transporters
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram -ve, Pseudomonas aeruginosa
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Multidrug resistance protein PmpM, Multidrug efflux pump that functions as an H+/drug antiporter. Confers resistance to benzylkonium chloride (BAC), fluoroquinolones, ethidium bromide, Acriflavine and tetraphenylphosphonium chloride.
  • Length (amino acid): 477
  • Reference: He et al. 2004; Pubmed- 14679249

    		• Similar resistance genes in 'BacMet Predicted database'
    qacA
  • BacMet ID: BAC0319
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid VRSAp, pSK1 (S. Aureus)
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Crystal Violet [class: Triarylmethane], Pyronin Y [class: Xanthene], Quinaldine red [class: Quinolines], Rhodamine 6G [class: Xanthene], Safranin O [class: Azin], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Alexidine [class: Biguanides], Amicarbalide [class: Diamidine], Pentamidine [class: Diamidine], Hexamidine [class: Diamidine], Propamidine [class: Diamidine], Diamidinodiphenylamine [class: Diamidine], Dibrompropamidine [class: Diamidine], 1a-62/JC-1-127 [class: Guanylhydrazones], 1i-39/JC-1-134 [class: Guanylhydrazones], Stilbamidine [class: Diamidine], Phenamidine [class: Diamidine], Diminazene [class: Diamidine]
  • Description: Antiseptic resistnce gene qacA; Confers export-mediated resistance against antiseptic and disinfectant compounds such as intercalating dyes, quaternary ammonium salts and diamidines. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Tennent et al 1989; Pubmed- 2778425, Rouch et al. 1990; Pubmed- 2089219, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacB
  • BacMet ID: BAC0320
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Only gram +ve, Staphylococcus aureus
  • Location: Plasmid pTZ2162 (S. Aureus)
  • Compound: Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine], Amicarbalide [class: Diamidine], Hexamidine [class: Diamidine], Stilbamidine [class: Diamidine], 1i-39/JC-1-134 [class: Guanylhydrazones], 1a-62/JC-1-127 [class: Guanylhydrazones]
  • Description: Antiseptic efflux pump qacB. qacA and qacB are different in sequence similarities by just by 7 nucleotides.
  • Length (amino acid): 514
  • Reference: Alam et al. (2003), Pubmed- 12820795, Nakaminami, H. et al. (2008); Littlejon et al. 1992; Pubmed- 1526458, Paulsen et al. 1996; Pubmed- 8622987, Mitchell et al. 1998; Pubmed- 9527814

    		• Similar resistance genes in 'BacMet Predicted database'
    qacEdelta1
  • BacMet ID: BAC0323
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Both gram +ve and -ve , Staphylococcus aureus, E. faecalis, P .aeruginosa
  • Location: Plasmid Rms149, In786, R388-R151 hybrid , pOZ176 , pKM0509, R1033, pKLC102, pLQ1001
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Chlorhexidine [class: Biguanides], Pyronin Y [class: Xanthene], Rhodamine 6G [class: Xanthene], Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamindine], Acridine Orange [class: Acridine], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Deoxycholate (SDC) [class: Acid], Crystal Violet [class: Triarylmethane], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Disinfectant resistance protein QacEdelta 1. It can confer resistance to antibiotics as well such as erythromycin, novomycin, amikacin, ciprofloxacin, norfloxacin, tetracycline, trimethoporin etc.
  • Length (amino acid): 115
  • Reference: Kazama et al. 1999; Pubmed- 10339831, Paulsen et al. 1993; Pubmed- 8494372

    		• Similar resistance genes in 'BacMet Predicted database'
    qacR
  • BacMet ID: BAC0328
  • Code for: Regulator
  • Family: Contains 1 HTH tetR-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Staphylococcus aureus
  • Location: Plasmid pSK1 (S. aureus)
  • Compound: Chlorhexidine [class: Biguanides], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Pentamidine [class: Diamidine], Propamidine [class: Diamidine], Diaminodiphenylamine [class: Diamidine]
  • Description: HTH-type transcriptional regulator QacR, Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
  • Length (amino acid): 188
  • Reference: Grkovic et al. 1998; Pubmed- 9660841

    		• Similar resistance genes in 'BacMet Predicted database'
    robA
  • BacMet ID: BAC0334
  • Code for: Binding protein
  • Family: 1 HTH araC/xylS-type DNA-binding domain
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli O157:H7
  • Location: Chromosome
  • Compound: Silver (Ag), Mercury (Hg), Cadmium (Cd), Cyclohexane [class: Cycloalkane], Pentane [class: Alkane], n-hexane [class: Alkane], Diphenyl Ether [class: Phenyl]
  • Description: Right origin-binding protein RobA; Organic solvent tolerance by robA is dependent on soxRS; Rob acts as a transcriptional activator. It can confer resistance to antibiotics such as tetracycline, chloramphenicol, phosphomycin, kanamycin, novomycin etc.
  • Length (amino acid): 289
  • Reference: Nakajima et al. 1995; Pubmed- 7793951, Jair et al. 1996; Pubmed- 8626315

    		• Similar resistance genes in 'BacMet Predicted database'
    smdA
  • BacMet ID: BAC0353
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdA
  • Length (amino acid): 591
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smdB
  • BacMet ID: BAC0354
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide]
  • Description: Multidrug efflux pump SmdB
  • Length (amino acid): 592
  • Reference: Matsuo et al. 2008; Pubmed- 18024518

    		• Similar resistance genes in 'BacMet Predicted database'
    smfY
  • BacMet ID: BAC0363
  • Code for: Efflux
  • Family: MFS superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Serratia marcescens
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Multidrug efflux pump SmfY
  • Length (amino acid): 490
  • Reference: Shahcheraghi et al. 2007; Pubmed- 17409524

    		• Similar resistance genes in 'BacMet Predicted database'
    smrA
  • BacMet ID: BAC0364
  • Code for: Efflux
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine]
  • Description: ABC-type multidrug efflux pump protein SmrA
  • Length (amino acid): 610
  • Reference: Al-Hamad et al. 2009; Pubmed- 19643774

    		• Similar resistance genes in 'BacMet Predicted database'
    smvA/emrB
  • BacMet ID: BAC0367
  • Code for: Efflux
  • Family: Major facilitator superfamily (MFS), TCR/tet family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Salmonella typhimurium
  • Location: Chromosome
  • Compound: Methyl Viologen [class: Paraquat], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Ethidium Bromide [class: Phenanthridine], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Acriflavine [class: Acridine]
  • Description: Methyl viologen resistance protein SmvA, Major efflux pump for Acriflavine and other quaternary ammonium compounds (QACs). Also required for resistance to methyl viologen, Mutants show increased sensitivity to methyl viologen and Acriflavine.
  • Length (amino acid): 495
  • Reference: Santiviago et al. 2002; Pubmed- 12410826, Hongo et al. 1994; Pubmed- 7926834, Ogawa et al. 2006; Pubmed- 16508165

    		• Similar resistance genes in 'BacMet Predicted database'
    sugE
  • BacMet ID: BAC0378
  • Code for: Efflux
  • Family: Small multidrug resistance (SMR) family (SugE subfamily)
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: only gram -ve, Escherichia coli
  • Location: Plasmid IncN p541 (Escherichia coli), Plasmid pIW759 (Salmonella typhimurium)
  • Compound: Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Cetylpyridinium Chloride (CPC) [class: Quaternary Ammonium Compounds (QACs)], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], and Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate]
  • Description: Quaternary ammonium compound-resistance protein sugE, Quaternary ammonium compound efflux pump. Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; Unlike the other members of the SMR family, SugE exhibits a narrow specificity for a very specific class of compounds.
  • Length (amino acid): 105
  • Reference: Chung et al. 2002; Pubmed- 11948170, He et al. 2011; Pubmed- 21576447

    		• Similar resistance genes in 'BacMet Predicted database'
    tehA
  • BacMet ID: BAC0384
  • Code for: Membrane Transporter
  • Family: Tellurite-resistance/dicarboxylate transporter (TDT) family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Tellurium (Te), Proflavin [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine], Crystal Violet [class: Triarylmethane], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Methyl Viologen [class: Paraquat]
  • Description: Tellurite resistance protein TehA; The gene encodes an integral membrane protein. Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance, otherwise phenotypically silent
  • Length (amino acid): 330
  • Reference: Walter et al 1991; Pubmed- 2060788, Taylor et al. 1994; Pubmed- 8169225, Turner et al. 1997; Pubmed- 9021204

    		• Similar resistance genes in 'BacMet Predicted database'
    tolC
  • BacMet ID: BAC0393
  • Code for: Efflux
  • Family: RND Superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Escherichia coli (strain K12)
  • Location: Chromosome
  • Compound: Phenol [class: Phenolic compounds], Triclosan [class: Phenolic compounds], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Taurodeoxycholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Proflavin [class: Acridine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Rhodamine 6G [class: Xanthene], Tetraphenylarsonium (TPA) [class: Quaternary Ammonium Compounds (QACs)], Cetrimide (CTM) [class: Quaternary Ammonium Compounds (QACs)], Dequalinium [class: Quaternary Ammonium Compounds (QACs)], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Plumbagin [class: Naphthoquinone]
  • Description: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria. Required for acrAB, mar efflux pumps to act as multidrug efflux pump.
  • Length (amino acid): 493
  • Reference: Hackett et al. 1983; Pubmed- 6312426, Fralick et al. 1996; Pubmed- 8824631, Sulavik et al. 2001; Pubmed- 11257026

    		• Similar resistance genes in 'BacMet Predicted database'
    tolCsm
  • BacMet ID: BAC0507
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Stenotrophomonas maltophilia (strain K279a)
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) [class: Hydrazone], Crystal Violet [class: Triarylmethane], Methyl Viologen [class: Paraquat], Plumbagin [class: Naphthoquinone], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Tetrachlorosalicylanilide (TCS) [class: Salicylanilide], Menadione [class: Naphthoquinone]
  • Description: Outer membrane protein. pcm and tolCsm genes form an operon. A significant feature of TolCsm different from that of other tolC homologues of Enterobacteriaceae is that tolCsm is not transcribed alone, but is transcribed with the pcm gene.
  • Length (amino acid): 452
  • Reference: Huang et al. 2013; Pubmed- 23629016

    		• Similar resistance genes in 'BacMet Predicted database'
    vcaM
  • BacMet ID: BAC0417
  • Code for: Binding protein
  • Family: ABC superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Acridine Orange [class: Acridine]
  • Description: ABC transporter, ATP-binding protein VcaM; Inner membrane protein
  • Length (amino acid): 619
  • Reference: Huda et al. 2003; Pubmed- 12878498

    		• Similar resistance genes in 'BacMet Predicted database'
    vcmA
  • BacMet ID: BAC0422
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio chloerae
  • Location: Chromosome
  • Compound: Ethidium Bromide [class: Phenanthridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Acriflavine [class: Acridine]
  • Description: Multidrug efflux pump vcmA that functions as a Na+/drug antiporter. Confers resistance to norfloxacin, ciprofloxacin, ofloxacin, daunomycin, doxorubicin, streptomycin, kanamycin, ethidium bromide, 4',6'-diamidino-2-phenylindole and Acriflavine
  • Length (amino acid): 457
  • Reference: Huda et al. 2001; Punmed: 11583854

    		• Similar resistance genes in 'BacMet Predicted database'
    vcrM
  • BacMet ID: BAC0423
  • Code for: Efflux
  • Family: MATE family, DinF-subfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio cholerae non-O1
  • Location: Chromosome
  • Compound: Acriflavine [class: Acridine], 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Hoechst 33342 [class: Bisbenzimide], Rhodamine 6G [class: Xanthene], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Ethidium Bromide [class: Phenanthridine]
  • Description: A Na+/drug antiporter-type multidrug efflux pump vcrM
  • Length (amino acid): 445
  • Reference: Huda et al. 2002; Pubmed- 12906102

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeC
  • BacMet ID: BAC0510
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 368
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeD
  • BacMet ID: BAC0511
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Glycocholate [class: Acid], Sodium Taurocholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Cholate [class: Acid], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Rhodamine 6G [class: Xanthene], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide]
  • Description: VmeCD uses a outer memberane protein such as TolC in E. coli or TolC-like VpoC in V. parahaemolyticus to function properly but complexes with VpoC can extrude various antimicrobial agents more effectively than complexes with TolC.
  • Length (amino acid): 1040
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeT
  • BacMet ID: BAC0524
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 361
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeU
  • BacMet ID: BAC0525
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 353
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmeV
  • BacMet ID: BAC0526
  • Code for: Efflux
  • Family: RND superfamily
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid], Ethidium Bromide [class: Phenanthridine], Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Part of the VexTUV efflux transporter.
  • Length (amino acid): 1019
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
    vmrA
  • BacMet ID: BAC0431
  • Code for: Efflux
  • Family: MATE family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus
  • Location: Chromosome
  • Compound: 4,6-diamidino-2-phenylindole (DAPI) [class: Diamidine], Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)]
  • Description: Na+-coupled multidrug efflux pump VmrA; confers resistance to cationic drugs (4',6'-diamidino-2-phenylindole (DAPI), Tetraphenylphosphonium (TPP), Acriflavine, ethidium)
  • Length (amino acid): 447
  • Reference: Chen et al. 2002; Pubmed- 11751837

    		• Similar resistance genes in 'BacMet Predicted database'
    vpoC
  • BacMet ID: BAC0516
  • Code for: Efflux
  • Family: RND superfamily, OMP family
  • Sequence: FASTA
  • Cross-database IDs: Link
  • Organism: Vibrio parahaemolyticus RIMD2210633
  • Location: Chromosome
  • Compound: Benzylkonium Chloride (BAC) [class: Quaternary Ammonium Compounds (QACs)], Chlorhexidine [class: Biguanides], Ethidium Bromide [class: Phenanthridine], Rhodamine 6G [class: Xanthene], Acriflavine [class: Acridine], Tetraphenylphosphonium (TPP) [class: Quaternary Ammonium Compounds (QACs)], Hoechst 33342 [class: Bisbenzimide], Sodium Dodecyl Sulfate (SDS) [class: Organo-sulfate], Sodium Cholate [class: Acid], Sodium Deoxycholate (SDC) [class: Acid], Sodium Glycocholate [class: Acid]
  • Description: Homologue of E. coli TolC outer membrane protein, vpoC.
  • Length (amino acid): 442
  • Reference: Matsuo et al. 2013; Pubmed- 23894076

    		• Similar resistance genes in 'BacMet Predicted database'
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