Gene_name | Experimentally Verified Resistance Gene Information |
Predicted Resistance Gene Information |
pmrA | BacMet ID: BAC0314Code for: Efflux
Family: Major facilitator superfamily. TCR/tet familySequence: FASTA
Cross-database IDs: Link
Organism: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)Location: Chromosome
Compound: Acriflavine [class: Acridine], Ethidium Bromide [class: Phenanthridine]Description: Multi-drug resistance efflux pump PmrA; Efflux pump for various substrates. It is associated with fluoroquinolone resistance in Streptococcus pneumoniae.
Length (amino acid): 399
Reference: Gill et al. 1999; Pubmed- 9869592
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Similar resistance genes in 'BacMet Predicted database' |
pmrA | BacMet ID: BAC0487Code for: Regulator
Family: Contains response regulatory domainSequence: FASTA
Cross-database IDs: Link
Organism: Erwinia carotovora ssp. CarotovoraLocation: Chromosome
Compound: Iron (Fe)Description: Member of the PmrA-PmrB two-component system required in regulation of virulence in bacteria. It is involved in controlling of bacterial response to external pH and iron and is crucial for bacterial virulence. PmrA-PmrB system is also required for resistance to the peptide antibiotic polymyxin B and other cationic antimicrobial peptides. It is activated in vivo by direct or indirect means and regulates genes that modify lipopolysaccharide, aiding survival in host (and non-host) environments. Unphosphorylated PmrA represses extracellular enzyme genes. Phosphorylation of PmrA by PmrB relieves such repression, which leads to activation of extracellular enzyme genes. Phosphorylated PmrA seems to repress expression of the pmrCAB operon.
Length (amino acid): 222
Reference: Hyytiainen et al. 2003; Pubmed- 14617142; Wosten et al. 2000; Pubmed- 11051552
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Similar resistance genes in 'BacMet Predicted database' |